Key points Physical activity is known to protect against cancer. We found that the resistance exercise method whole‐body electromyostimulation (WB‐EMS) has a significant anti‐cancer effect. WB‐EMS‐conditioned serum from advanced prostate cancer patients decreased human prostate carcinoma cell growth and viability in vitro . Multiplex analysis revealed that genes associated with human prostate cancer cell proliferation and apoptosis are sensitive for exercise. Feasible exercise should be part...
Thu Jul 09, 2020 19:19
Abstract Macronutrient intake is associated with cardiometabolic health, aging, and longevity, but the mechanisms underlying its regulation have remained unclear. Most rodents increase carbohydrate selection under certain physiological and pathological conditions such as fasting. When presented with a choice between a basally preferable high‐fat diet (HFD) and a high‐carbohydrate diet (HCD) such as a high‐sucrose diet, fasted mice first eat the HFD and then switch to the HCD during the first few...
Thu Jul 09, 2020 12:47
Phylogenetic relationships and divergence time estimates between species of the genus Cheracebus . Abstract Cheracebus is a new genus of New World primate of the family Pitheciidae, subfamily Callicebinae. Until recently, Cheracebus was classified as the torquatus species group of the genus Callicebus . The genus Cheracebus has six species: C. lucifer, C. lugens, C. regulus, C. medemi, C. torquatus , and C. purinus , which are all endemic to the Amazon biome. Before the present study,...
Sat Jul 11, 2020 22:57
Abstract In nearly four decades our research and that of others on chemical signaling in callitrichid primates suggest a high degree of contextual complexity in both the use of signals and the response to these signals. We describe our research including observational field studies, behavioral bioassays (“playbacks”), functional imaging, and conditioning studies. Scent marking in both captivity and the wild is used for more than just territorial marking. Social contextual effects are seen...
Thu Jul 09, 2020 11:24
Abstract Vitamin D is produced in the skin under the influence of UVB‐light from the sun or obtained via the diet by eating fatty fish, enriched dairy products or supplements. Vitamin D is known to support a healthy bone and severe deficiency may lead to osteomalacia or the rickets, which still occur in poor areas of the world. In addition, vitamin D support key functions in many organs, including the brain, muscle and the immune systems (Holick, 2007). In fact, the vitamin D receptor (VDR) is expressed...
Sat Jul 11, 2020 21:41
Translation of recent discoveries in cardiovascular disease research to novel therapeutic strategies
Fri Jul 10, 2020 11:05
Abstract Background Primary lymphedema is an anomaly of the regional lymphatic system with long symptom duration or severe lymphatic obstruction. Few microsurgical treatments for primary lymphedema have been reported. This aim of this study was to investigate the outcomes of microsurgical treatments in pediatric primary lymphedema patients. Methods Between 2013 and 2017, pediatric primary lymphedema patients who underwent either lymphovenous anastomosis (LVA) or vascularized lymph node...
Sat Jul 11, 2020 11:14
Thu Jul 09, 2020 17:16
Thu Jul 09, 2020 17:16
The development of systemic therapies, including vascular endothelial growth factor‐tyrosine kinase inhibitors (VEGF‐TKI) and mammalian target of rapamycin (mTOR) inhibitors, represents a major breakthrough in the treatment of patients with renal cell carcinoma (RCC). However, inherent resistance is observed in some patients and acquired resistance commonly develops in many patients within several months of the initiation of systemic therapies. Since these treatments rarely cure patients, their aim...
Sat Jul 11, 2020 21:55
Follicular T‐cell lymphoma (FTCL) is considered to originate from follicular helper T‐cell (Tfh) cells. Angioimmunoblastic T‐cell lymphoma (AITL) and peripheral T‐cell lymphomas with the Tfh phenotype, derived from Tfh cells, often harbor RHOA G17V mutation. We investigated whether RHOA mutations affect the clinicopathological features of FTCL. We performed deep sequencing and Sanger sequencing for RHOA exon 2 in 16 cases of FTCL. Nine cases showed RHOA mutations, including eight with c.G50T,...
Thu Jul 09, 2020 21:34
Abstract Gray hair is a visible sign of tissue degeneration during aging. Graying is attributed to dysfunction of melanocyte stem cells (McSCs) that results in depletion of their melanin‐producing progeny. This non‐lethal phenotype makes the hair follicle and its pigment system an attractive model for investigating mechanisms that contribute to tissue aging as well as therapeutic strategies to combat this process. One potential combination therapeutic is RT1640, which is comprised of two drugs that...
Sat Jul 11, 2020 21:55
Abstract Acute renal damage is the most frequent toxic reaction induced by parenteral administration of iodinated contrast media (ICM), leading to a condition named contrast‐induced nephropathy (CIN). This pathology was described by Bartels et al. in 1954 and, in most cases, it is transient and does not imply any relevant modifications of renal function. However, it is related to an increase in morbidity and mortality, being considered the third cause of acute renal failure in hospitalized patients.
Sat Jul 11, 2020 21:08
Abstract Background Children are often diagnosed with an antibiotic allergy, with little investigation to confirm if it is a true allergy. Recent studies support the use of oral challenges to confirm antibiotic allergy. Yet, little is known about families’ perceptions of these challenges, or experiences of living with a misdiagnosis, often for many years. Objective To describe how families with a child previously labelled as “antibiotic allergic”, but who has subsequently been delabelled,...
Fri Jul 10, 2020 17:59
Abstract Background Bioaccessibility of food allergens may be a key determinant of allergic reactions. Objective To develop a protocol allowing the detection of the major peanut allergen, Ara h 6, in the bloodstream following ingestion of low amounts of peanut, and to compare Ara h 6 bioaccessibility by food matrix. We further assessed for differences in absorption in healthy versus peanut‐allergic volunteers. Methods A blood pretreatment combining acidic shock and thermal treatment...
Fri Jul 10, 2020 14:09
ABSTRACT Alport syndrome (AS) is a genetic disorder involving mutations in the genes encoding collagen IV α3, α4 or α5 chains, resulting in the impairment of glomerular basement membrane. Podocytes are responsible for production and correct assembly of collagen IV isoforms; however, data on the phenotypic characteristics of human AS podocytes and their functional alterations are currently limited. The evident loss of viable podocytes into the urine of patients with active glomerular disease enables...
Sat Jul 11, 2020 22:48
Abstract In contrast to other cancer types, melanoma incidence has been increasing over the last 50 years, and while it still represents less than 5% of all cutaneous malignancies, melanoma accounts for the majority of skin cancer deaths, due to its propensity to metastasise. Whilst melanoma most commonly affects the skin, it can also arise in mucosal surfaces, the eye and the brain. For new therapies to be developed, a better understanding of the genetic landscape, signalling pathways and tumour‐microenvironmental...
Sat Jul 11, 2020 22:41
Abstract The subscapularis muscle is the largest muscle of the rotator cuff and its main function is internal rotation. It is morphologically variable in both point of origin and insertion. The presence of an accessory subscapularis muscle can lead to brachial plexus neuropathy. This report presents a very rare accessory subscapularis muscle originating from two distinct bands on the subscapularis and teres major muscles. The insertion was divided among four tendons. The fourth...
Sun Jul 12, 2020 03:00
Abstract Purpose Determination of intra-oral surface areas might contribute to our understanding of the physiology of the oral cavity and oral diseases. In previous studies, the intra-oral surface area was determined using a laborious and technically challenging method. Our aim was to develop an easy and non-invasive method to determine the intra-oral surface areas. Methods...
Sat Jul 11, 2020 03:00
Abstract Background This study aimed to inspect anatomical variations in the insertion of the peroneus longus tendon (PLT) using a large sample of cadavers. Methods In total, 104 legs from 52 Japanese cadavers were used. The PLT was identified behind the lateral malleolus and carefully followed up to its insertion in the foot. All insertion slips of...
Fri Jul 10, 2020 03:00
Quaternary climate fluctuations are an engine of biotic diversification. Global cooling cycles, such as the Last Glacial Maximum (LGM), are known to have fragmented the ranges of higher-latitude fauna and flor...
Sat Jul 11, 2020 03:00
The origin of turtles and crocodiles and their easily recognized body forms dates to the Triassic and Jurassic. Despite their long-term success, extant species diversity is low, and endangerment is extremely h...
Fri Jul 10, 2020 03:00
Prosthetic joint infections (PJI) complicate up to 2% of arthroplasties and are usually caused by typical bacterial agents (e.g., staphylococci and streptococci). Although an infrequent cause of PJI, mycobacterial species are difficult to eradicate, as they adhere to hardware, form biofilms, and have high rates of antimicrobial resistance. Mycobacterium mageritense is a rapidly growing Mycobacterium that has been infrequently described as a cause of surgical and device-related infections. We herein...
Sat Jul 11, 2020 13:50
Mitochondria-encoded ribosomal RNA (rRNA) genes in humans are expressed at a higher rate than protein coding genes of the mitochondria. The organization of the human mitochondrial genome (mtDNA) is amenable to...
Sat Jul 11, 2020 03:00
Cyanide is a highly toxic compound, and the consumption of products containing cyanide is a significant public health concern. Conversely, β-carotene possesses essential nutritional attributes for human health, t...
Sat Jul 11, 2020 03:00
In 2015, Georgia launched HCV elimination program. Initially, patients with advanced liver disease were treated with sofosbuvir-based regimen—the only DAA available for all genotypes. Purpose of the study was ...
Sat Jul 11, 2020 03:00
The objective of the research presented here was to determine whether autonomous replication sequences (ARS) discovered in the eccDNA replicon of glyphosate resistant Amaranthus palmeri enable self-replication in...
Fri Jul 10, 2020 03:00
We evaluated the internal consistencies and the correlation between measures of adverse childhood experiences (ACE), bully victimization, self-esteem, resilience, and social support in children/adolescents in ...
Fri Jul 10, 2020 03:00
To determine the presence of the 7-bp deletion c.169+50delTAAACAG in intron 2 of Superoxide Dismutase-1 gene in keratoconic patients from the State of São Paulo, Brazil, which promotes splicing variations, result...
Thu Jul 09, 2020 03:00
Genome sequences are a vital resource for accelerating the biological exploration of an organism of interest. Pythium destruens (a synonym of Pythium insidiosum) causes a difficult-to-treat infectious disease cal...
Thu Jul 09, 2020 03:00
A groundbreaking study is the first to analyze the relationship between group behaviors, group type, group dynamics, and kinship of beluga whales in 10 locations across the Arctic. Results show that not only do beluga whales regularly interact with close kin, including close maternal kin, they also frequently associate with more distantly related and unrelated individuals. Findings will improve the understanding of why some species are social, how individuals learn from group members and how animal...
Sat Jul 11, 2020 04:22
Over time goldenrod plants and the gall flies that feed on them have been one-upping each other in an ongoing competition for survival. Now, a team of researchers has discovered that by detecting the plants' chemical defenses, the insects may have taken the lead.
Thu Jul 09, 2020 15:53
Some mandarin fish species (Sinipercidae) are pure fish-eaters, which feed exclusively on living juvenile fish - also of their own species. A research team has described the genome of four mandarin fish species and thus also identified genes for cannibalistic eating behavior. Knowledge of the connections between the genome and feeding behavior is of interest for sustainable aquaculture.
Thu Jul 09, 2020 18:35
Evolutionary biologists resolve a century-old question regarding the asymmetric genitals of internally fertilizing fishes of the family Anablepidae. Surprisingly, the direction of genital asymmetry in these fishes is random rather than hereditary.
Wed Jul 08, 2020 17:59
This method demonstrates use of the northern hybridization technique to detect miRNAs from total RNA extract.
Sat Jul 11, 2020 21:00
Recombinant BDNF containing an Avi sequence (BDNFAvi) is produced in HEK293 cells in a cost-effective manner and is purified by affinity chromatography. BDNFavi is then directly mono-biotinylated with the enzyme BirA in a tube. BDNFavi and mono-biotinylated BDNFavi retain their biological activity when compared to commercially available BDNF.
Sat Jul 11, 2020 20:00
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