IJMS, Vol. 21, Pages 4907: Polymorphic Forms of Valinomycin Investigated by NMR Crystallography International Journal of Molecular Sciences doi: 10.3390/ijms21144907 Authors: Jiří Czernek Jiří Brus A dodecadepsipeptide valinomycin (VLM) has been most recently reported to be a potential anti-coronavirus drug that could be efficiently produced on a large scale. It is thus of importance to study solid-phase forms of VLM in order to be able to ensure its polymorphic purity in drug formulations....
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4906: Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21144906 Authors: Ryota Masuzaki Tatsuo Kanda Reina Sasaki Naoki Matsumoto Masahiro Ogawa Shunichi Matsuoka Seth J. Karp Mitsuhiko Moriyama Liver fibrosis is one of the risk factors for hepatocellular carcinoma (HCC) development. The staging of liver fibrosis can be evaluated only...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4904: Family’s History Based on the CDH1 Germline Variant (c.360delG) and a Suspected Hereditary Gastric Cancer Form International Journal of Molecular Sciences doi: 10.3390/ijms21144904 Authors: Laura Caggiari Mara Fornasarig Mariangela De Zorzi Renato Cannizzaro Agostino Steffan Valli De Re Hereditary diffuse gastric cancer (HDGC) is a cancer susceptibility syndrome caused by germline pathogenic variant in CDH1, the gene encoding E-cadherin. The...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4903: Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21144903 Authors: Elena Campione Terenzio Cosio Luigi Rosa Caterina Lanna Stefano Di Girolamo Roberta Gaziano Piera Valenti Luca Bianchi Recently, the world has been dealing with a devastating global pandemic coronavirus infection, with more than 12 million...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4902: SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21144902 Authors: Thorsten Schaefer Rebekah Steiner Claudia Lengerke Stemness and reprogramming involve transcriptional master regulators that suppress cell differentiation while promoting self-renewal. A distinguished example thereof is SOX2, a high mobility group (HMG)-box transcription...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4901: Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model International Journal of Molecular Sciences doi: 10.3390/ijms21144901 Authors: Minsook Ye Bong Hee Han Jin Su Kim Kyungsoo Kim Insop Shim Background: Trimethyltin (TMT) is a potent neurotoxin affecting various regions of the central nervous system, including the neocortex, the cerebellum, and the hippocampus. Phosphatidylserine (PS) is a membrane phospholipid,...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4905: Genome-Wide Identification and Expression Profile Analysis of the PHT1 Gene Family in Gossypium hirsutum and Its Two Close Relatives of Subgenome Donor Species International Journal of Molecular Sciences doi: 10.3390/ijms21144905 Authors: Sheng Cai Fujie Liu Baoliang Zhou Phosphate transporter (PHT) is responsible for plant phosphorus (P) absorption and transport. PHT1 is a component of the high-affinity phosphate transporter system and plays pivotal...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4898: The Interaction Network and Signaling Specificity of Two-Component System in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21144898 Authors: Ruxue Huo Zhenning Liu Xiaolin Yu Zongyun Li Two-component systems (TCS) in plants have evolved into a more complicated multi-step phosphorelay (MSP) pathway, which employs histidine kinases (HKs), histidine-containing phosphotransfer proteins (HPts), and response regulators (RRs) to...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4899: Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21144899 Authors: Gaia Pedriali Giampaolo Morciano Simone Patergnani Paolo Cimaglia Cristina Morelli Elisa Mikus Roberto Ferrari Vincenzo Gasbarro Carlotta Giorgi Mariusz R. Wieckowski Paolo Pinton Calcific aortic stenosis is a disorder that impacts the physiology of heart valves....
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4897: Comprehensive Characterization of Secondary Metabolites from Colebrookea oppositifolia (Smith) Leaves from Nepal and Assessment of Cytotoxic Effect and Anti-Nf-κB and AP-1 Activities In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21144897 Authors: Gregorio Peron Jan Hošek Ganga Prasad Phuyal Dharma Raj Kandel Rameshwar Adhikari Stefano Dall’Acqua Here we report the comprehensive characterization of the secondary metabolites...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4900: Attenuation of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTOR and p70 S6K International Journal of Molecular Sciences doi: 10.3390/ijms21144900 Authors: Danja J. Den Hartogh Filip Vlavcheski Adria Giacca Evangelia Tsiani Insulin resistance, a main characteristic of type 2 diabetes mellitus (T2DM), is linked to obesity and excessive levels of plasma free fatty...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4894: Molecular Characterization of a Novel Lytic Enzyme LysC from Clostridium intestinale URNW and Its Antibacterial Activity Mediated by Positively Charged N-Terminal Extension International Journal of Molecular Sciences doi: 10.3390/ijms21144894 Authors: Plotka Szadkowska Håkansson Kovačič Al-Karadaghi Walse Werbowy Kaczorowska Kaczorowski Peptidoglycan hydrolytic enzymes are considered to be a promising alternative to conventional...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4896: The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function International Journal of Molecular Sciences doi: 10.3390/ijms21144896 Authors: João S. Teodoro João A. Amorim Ivo F. Machado Ana C. Castela Clemens Steegborn David A. Sinclair Anabela P. Rolo Carlos M. Palmeira Hepatic ischemia/reperfusion (I/R) injury is a leading cause of organ dysfunction and failure...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4895: Effects of Short-Chain Fatty Acids on Human Oral Epithelial Cells and the Potential Impact on Periodontal Disease: A Systematic Review of In Vitro Studies International Journal of Molecular Sciences doi: 10.3390/ijms21144895 Authors: Gabriel Leonardo Magrin Franz Josef Strauss Cesar Augusto Magalhães Benfatti Lucianne Cople Maia Reinhard Gruber Short-chain fatty acids (SCFA), bacterial metabolites released from dental biofilm, are supposed to target...
Sat Jul 11, 2020 03:00
IJMS, Vol. 21, Pages 4893: Peripheral Dopamine 2-Receptor Antagonist Reverses Hypertension in a Chronic Intermittent Hypoxia Rat Model International Journal of Molecular Sciences doi: 10.3390/ijms21144893 Authors: Elena Olea Inmaculada Docio Miguel Quintero Asunción Rocher Ana Obeso Ricardo Rigual Angela Gomez-Niño The sleep apnea-hypopnea syndrome (SAHS) involves periods of intermittent hypoxia, experimentally reproduced by exposing animal models to oscillatory PO2...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4892: Gram-Negative Bacterial Endotoxin LPS Induces NeuGc Loss through Ets1-Dependent Downregulation of Intestine-Specific pcmah Transcript in Porcine Intestinal Cells International Journal of Molecular Sciences doi: 10.3390/ijms21144892 Authors: Choong-Hwan Kwak Kwon-Ho Song Cheorl-Ho Kim N-glycolylneuraminic acid (NeuGc), a non-human sialic acid derivative synthesized by cytidine-5′-monophospho-N-acetylneuraminic acid hydroxylase (CMAH), plays a...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4891: Intracellular Fate and Impact on Gene Expression of Doxorubicin/Cyclodextrin-Graphene Nanomaterials at Sub-Toxic Concentration International Journal of Molecular Sciences doi: 10.3390/ijms21144891 Authors: Daniela Caccamo Monica Currò Riccardo Ientile Elisabetta AM Verderio Angela Scala Antonino Mazzaglia Rosamaria Pennisi Maria Musarra-Pizzo Roberto Zagami Giulia Neri Consolato Rosmini Monica Potara Monica Focsan Simion Astilean...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4889: Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus International Journal of Molecular Sciences doi: 10.3390/ijms21144889 Authors: Javad Tavakoli Ashish D. Diwan Joanne L. Tipper Damage to the annulus fibrosus (AF), the outer region of the intervertebral disc (IVD), results in an undesirable condition that may accelerate IVD degeneration causing low back pain. Despite intense research interest, attempts to regenerate the IVD have...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4888: Gradient Chitosan Hydrogels Modified with Graphene Derivatives and Hydroxyapatite: Physiochemical Properties and Initial Cytocompatibility Evaluation International Journal of Molecular Sciences doi: 10.3390/ijms21144888 Authors: Karolina Kosowska Patrycja Domalik-Pyzik Małgorzata Sekuła-Stryjewska Sylwia Noga Joanna Jagiełło Magdalena Baran Ludwika Lipińska Ewa Zuba-Surma Jan Chłopek In this study, we investigated preparation of gradient...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4887: A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21144887 Authors: Tim Weigand Florian Colbatzky Tilman Pfeffer Sven F. Garbade Kristina Klingbeil Florian Colbatzky Michael Becker Johanna Zemva Ruben Bulkescher Robin Schürfeld Christian Thiel Nadine Volk David Reuss Georg F. Hoffmann...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4890: Approaching Sex Differences in Cardiovascular Non-Coding RNA Research International Journal of Molecular Sciences doi: 10.3390/ijms21144890 Authors: Amela Jusic Antonio Salgado-Somoza Ana Paes Francesca Stefanizzi Núria Martínez-Alarcón Florence Pinet Fabio Martelli Yvan Devaux Emma Robinson Susana Novella on behalf of the EU-CardioRNA COST Action Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4886: The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis International Journal of Molecular Sciences doi: 10.3390/ijms21144886 Authors: Nai-Yu Ko Li-Ru Chen Kuo-Hu Chen Osteoporosis is a major concern worldwide and can be attributed to an imbalance between osteoblastic bone formation and osteoclastic bone resorption due to the natural aging process. Heritable factors account for 60–80% of optimal bone mineralization; however, the finer...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4884: Genetic Markers for Later Remission in Response to Early Improvement of Antidepressants International Journal of Molecular Sciences doi: 10.3390/ijms21144884 Authors: Hee-Ju Kang Ki-Tae Kim Kyung-Hun Yoo Yoomi Park Ju-Wan Kim Sung-Wan Kim Il-Seon Shin Ju Han Kim Jae-Min Kim Planning subsequent treatment strategies based on early responses rather than waiting for delayed antidepressant action can be helpful. We identified genetic markers...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4885: Nucleophosmin in Its Interaction with Ligands International Journal of Molecular Sciences doi: 10.3390/ijms21144885 Authors: Ilaria Cela Adele Di Di Matteo Luca Federici Nucleophosmin (NPM1) is a mainly nucleolar protein that shuttles between nucleoli, nucleoplasm and cytoplasm to fulfill its many functions. It is a chaperone of both nucleic acids and proteins and plays a role in cell cycle control, centrosome duplication, ribosome maturation and export,...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4882: Changes in Expression Level of OsHKT1;5 Alters Activity of Membrane Transporters Involved in K+ and Ca2+ Acquisition and Homeostasis in Salinized Rice Roots International Journal of Molecular Sciences doi: 10.3390/ijms21144882 Authors: Mohammad Al Nayef Celymar Solis Lana Shabala Takaaki Ogura Zhonghua Chen Jayakumar Bose Frans J.M. Maathuis Gayatri Venkataraman Keitaro Tanoi Min Yu Meixue Zhou Tomoaki Horie Sergey Shabala ...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4883: Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch International Journal of Molecular Sciences doi: 10.3390/ijms21144883 Authors: Shirin Kahremany Lukas Hofmann Arie Gruzman Guy Cohen Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4881: TRANSPARENT TESTA GLABRA1, a Key Regulator in Plants with Multiple Roles and Multiple Function Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21144881 Authors: Hainan Tian Shucai Wang TRANSPARENT TESTA GLABRA1 (TTG1) is a WD40 repeat protein. The phenotypes caused by loss-of-function of TTG1 were observed about half a century ago, but the TTG1 gene was identified only about twenty years ago. Since then, TTG1 has been found to be...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4880: Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21144880 Authors: Sebastian Zięba Anne-Floor W. Pouwer Artur Kowalik Kamil Zalewski Natalia Rusetska Elwira Bakuła-Zalewska Janusz Kopczyński Johanna M. A. Pijnenborg Joanne A. de Hullu Magdalena Kowalewska Vulvar squamous cell carcinoma (VSCC) originates from the progression of either a...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4879: Environmental DNA and RNA as Records of Human Exposome, Including Biotic/Abiotic Exposures and Its Implications in the Assessment of the Role of Environment in Chronic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21144879 Authors: Indu Shekhar Thakur Deodutta Roy Most of environment-related diseases often result from multiple exposures of abiotic and/or biotic stressors across various life stages. The application of environmental...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4878: Nephrotoxicity Associated with Novel Anticancer Agents (Aflibercept, Dasatinib, Nivolumab): Case Series and Nephrological Considerations International Journal of Molecular Sciences doi: 10.3390/ijms21144878 Authors: Luca Piscitani Vittorio Sirolli Lorenzo Di Liberato Manrico Morroni Mario Bonomini Cancer patients have an incidence of about 60% kidney disease development and are at elevated risk of acute renal damage. Kidney disease in these patients...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4877: A Review of T-Cell Related Therapy for Osteosarcoma International Journal of Molecular Sciences doi: 10.3390/ijms21144877 Authors: Yoshida Okamoto Aoki Takahashi Saito Osteosarcoma is one of the most common primary malignant tumors of bone. The combination of chemotherapy and surgery makes the prognosis better than before, but therapy has not dramatically improved over the last three decades. This is partially because of the lack of a novel...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4876: Effect of Auxin (IAA) on the Fast Vacuolar (FV) Channels in Red Beet (Beta vulgaris L.) Taproot Vacuoles International Journal of Molecular Sciences doi: 10.3390/ijms21144876 Authors: Zbigniew Burdach Agnieszka Siemieniuk Waldemar Karcz In contrast to the well-studied effect of auxin on the plasma membrane K+ channel activity, little is known about the role of this hormone in regulating the vacuolar K+ channels. Here, the patch-clamp technique was used...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4875: Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke? International Journal of Molecular Sciences doi: 10.3390/ijms21144875 Authors: Agnese Gugliandolo Placido Bramanti Emanuela Mazzon Stroke represents one of the main causes of disability and death worldwide. The pathological subtypes of stroke are ischemic stroke, the most frequent, and hemorrhagic stroke. Nrf2 is a transcription factor that regulates redox homeostasis....
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4874: A Novel Peptide, CK2.3, Improved Bone Formation in Ovariectomized Sprague Dawley Rats International Journal of Molecular Sciences doi: 10.3390/ijms21144874 Authors: Linda Sequeira John Nguyen Liyun Wang Anja Nohe Osteoporosis is a bone disease that has no definite cure. Current treatments for osteoporosis are divided into two categories: anti-resorptive and anabolic. However, these treatments are not perfect and have considerable risks. In addition,...
Fri Jul 10, 2020 03:00
IJMS, Vol. 21, Pages 4873: A Clean and Tunable Mussel-Inspired Coating Technology by Enzymatic Deposition of Pseudo-Polydopamine (ψ-PDA) Thin Films from Tyramine International Journal of Molecular Sciences doi: 10.3390/ijms21144873 Authors: Maria Laura Alfieri Lucia Panzella Youri Arntz Alessandra Napolitano Vincent Ball Marco d’Ischia The tyrosinase-catalyzed oxidation of tyramine, leading to the deposition of pseudo-polydopamine (ψ-PDA) thin films, is disclosed...
Fri Jul 10, 2020 03:00
JCM, Vol. 9, Pages 2204: A Retrospective Comparison of DLI and gDLI for Post-Transplant Treatment Journal of Clinical Medicine doi: 10.3390/jcm9072204 Authors: Sylvain Lamure Franciane Paul Anne-Laure Gagez Jérémy Delage Laure Vincent Nathalie Fegueux Anne Sirvent Eve Gehlkopf Jean Luc Veyrune Lu Zhao Yang Tarik Kanouni Valère Cacheux Jérôme Moreaux Beatrice Bonafoux Guillaume Cartron John De Vos Patrice Ceballos Donor lymphocyte infusion...
Sun Jul 12, 2020 03:00
JCM, Vol. 9, Pages 2203: Prevention and Management of Hormonal Crisis during Theragnosis with LU-DOTA-TATE in Neuroendocrine Tumors. A Systematic Review and Approach Proposal Journal of Clinical Medicine doi: 10.3390/jcm9072203 Authors: Maria Isabel del Olmo-García Maria Angustias Muros Martín López-de-la-Torre Marc Agudelo Pilar Bello Jose M. Soriano Juan-Francisco Merino-Torres Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTR) on their...
Sun Jul 12, 2020 03:00
JCM, Vol. 9, Pages 2205: Advancing Digital Workflows for Refractive Error Measurements Journal of Clinical Medicine doi: 10.3390/jcm9072205 Authors: Arne Ohlendorf Alexander Leube Siegfried Wahl Advancements in clinical measurement of refractive errors should lead to faster and more reliable measurements of such errors. The study investigated different aspects of advancements and the agreement of the spherocylindrical prescriptions obtained with an objective method of measurement...
Sun Jul 12, 2020 03:00
JCM, Vol. 9, Pages 2201: Accuracy of a Symptom-Based Approach to Identify Hypertensive Emergencies in the Emergency Department Journal of Clinical Medicine doi: 10.3390/jcm9072201 Authors: Fabrizio Vallelonga Federica Carbone Francesco Benedetto Lorenzo Airale Silvia Totaro Dario Leone Anna Astarita Eleonora Avenatti Simona Maule Franco Veglio Enrico Lupia Alberto Milan Background: A hierarchical symptoms-based diagnostic strategy relying on the presence...
Sun Jul 12, 2020 03:00
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