Related Articles Identifying oncogenic drivers associated with increased risk of late distant recurrence in post-menopausal, estrogen receptor-positive, HER2-negative early breast cancer: results from the BIG 1-98 study. Ann Oncol. 2020 Jul 08;: Authors: Luen SJ, Asher R, Lee CK, Savas P, Kammler R, Dell'Orto P, Biasi M, Demanse D, Hackl W, Thuerlimann B, Viale G, Di Leo A, Colleoni M, Regan MM, Loi S Abstract BACKGROUND: In postmenopausal,...
Sun Jul 12, 2020 14:22
Related Articles Tumor Organoids to Study Gastroesophageal Cancer: A Primer. J Mol Cell Biol. 2020 Jul 11;: Authors: Jin RU, Mills JC Abstract Gastroesophageal cancers are leading causes of cancer death. Our attempts at adopting molecularly based treatment approaches have been slow and ineffective even though we begin to identify specific targetable gene mutations and pathways. It is clear that we should no longer treat all gastroesophageal...
Sun Jul 12, 2020 14:22
Related Articles Genome instability in multiple myeloma. Leukemia. 2020 Jul 10;: Authors: Neuse CJ, Lomas OC, Schliemann C, Shen YJ, Manier S, Bustoros M, Ghobrial IM Abstract Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal proliferation of plasma cells and a heterogenous genomic landscape. Copy number and structural changes due to chromosomal instability (CIN) are common features of MM. In this review, we...
Sun Jul 12, 2020 14:22
Related Articles Utilizing SEER cancer registries for population-based cancer survivor epidemiologic studies: a feasibility study. Cancer Epidemiol Biomarkers Prev. 2020 Jul 10;: Authors: Gallicchio L, Elena JW, Fagan S, Carter M, Hamilton AS, Hastert TA, Hunter LL, Li J, Lynch CF, Milam J, Millar MM, Modjeski D, Paddock LE, Reed AR, Moses LB, Stroup AM, Sweeney C, Trapido EJ, West MM, Wu XC, Helzlsouer KJ Abstract BACKGROUND: While the primary...
Sun Jul 12, 2020 14:22
Related Articles Role of the Bone Marrow Milieu in Multiple Myeloma Progression and Therapeutic Resistance. Clin Lymphoma Myeloma Leuk. 2020 Jun 07;: Authors: Ho M, Goh CY, Patel A, Staunton S, O'Connor R, Godeau M, Bianchi G Abstract Multiple myeloma (MM) is a cancer of the plasma cells within the bone marrow (BM). Studies have shown that the cellular and noncellular components of the BM milieu, such as cytokines and exosomes, play an integral...
Sun Jul 12, 2020 14:22
Related Articles Challenges for cancer patients returning home during SARS-COV-19 pandemic after medical tourism - a consensus report by the emirates oncology task force. BMC Cancer. 2020 Jul 10;20(1):641 Authors: Al-Shamsi HO, Abu-Gheida I, Rana SK, Nijhawan N, Abdulsamad AS, Alrawi S, Abuhaleeqa M, Almansoori TM, Alkasab T, Aleassa EM, McManus MC Abstract BACKGROUND: The COVID-19 pandemic has caused a global health crisis. Numerous cancer...
Sun Jul 12, 2020 14:22
Related Articles The NLRP3 Inflammasome Role in the Pathogenesis of Pregnancy Induced Hypertension and Preeclampsia. Cells. 2020 Jul 08;9(7): Authors: Socha MW, Malinowski B, Puk O, Dubiel M, Wiciński M Abstract Pregnancy-induced hypertension and preeclampsia are associated with significant maternal and fetal mortality. A better understanding of these diseases, delineation of molecular pathomechanism, and efficient treatment development are...
Sun Jul 12, 2020 14:22
Related Articles Past, present and future of proton therapy for head and neck cancer. Oral Oncol. 2020 Jul 07;110:104879 Authors: Li X, Lee A, Cohen MA, Sherman EJ, Lee NY Abstract Proton therapy has recently gained substantial momentum worldwide due to improved accessibility to the technology and sustained interests in its advantage of better tissue sparing compared to traditional photon radiation. Proton therapy in head and neck cancer has...
Sat Jul 11, 2020 14:48
Related Articles Pattern and prognosis of distant metastases in nasopharyngeal carcinoma: A large-population retrospective analysis. Cancer Med. 2020 Jul 10;: Authors: Qu W, Li S, Zhang M, Qiao Q Abstract Currently, the features and prognosis of nasopharyngeal carcinoma (NPC) with distant metastases are still rarely reported. Thus, the main purpose of our study was to investigate the metastasis patterns of different histological types of NPC...
Sat Jul 11, 2020 14:48
Related Articles Childhood cancer survivorship and late effects: The landscape in India in 2020. Pediatr Blood Cancer. 2020 Jul 10;:e28556 Authors: Arora RS, Arora PR, Seth R, Sharma S, Kumar C, Dhamankar V, Kurkure P, Prasad M Abstract Survivorship care is a major area of focus in the holistic management of childhood cancer with current knowledge and information almost exclusively from high-income countries. In this review, we summarize the...
Sat Jul 11, 2020 14:48
Related Articles Topological Transformation-Based Nanobarcoding for Detection and Enumeration of MicroRNAs and Single Nucleotide Polymorphism. Adv Biosyst. 2019 Jul;3(7):e1900013 Authors: Yuk JS, Shin SW, Chun SH, Ku BM, Choi YJ, Lim YT, Luo D, Ahn MJ, Um SH Abstract RNA biomarkers have been recently reported to be associated tightly with the diagnosis and prognosis of many diseases. Particularly, cancers considered to be a serious threat to...
Sat Jul 11, 2020 14:48
Related Articles Augmenting engineered T-cell strategies in solid cancers through epigenetic priming. Cancer Immunol Immunother. 2020 Jul 10;: Authors: Nielsen AY, Ormhøj M, Traynor S, Gjerstorff MF Abstract T-cell receptor (TCR)- and chimeric antigen receptor (CAR)-based adoptive cell transfer (ACT) has shown promising results in hematological malignancies, but remains immature in solid cancers. The challenges associated with identification...
Sat Jul 11, 2020 13:21
Related Articles High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul 09;82(7):91 Authors: Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA Abstract Modern cancer research, and the wealth of data across multiple spatial and temporal scales, has created the need for researchers that are...
Sat Jul 11, 2020 13:21
Related Articles Exploratory Analysis to Identify Candidates Benefitting from Combination Therapy of Transarterial Chemoembolization and Sorafenib for First-Line Treatment of Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Observational Study. Liver Cancer. 2020 Jun;9(3):308-325 Authors: Wang Z, Wang E, Bai W, Xia D, Ding R, Li J, Wang Q, Liu L, Sun J, Mu W, Zhao H, Pan X, Shao G, Zhu X, Yin G, Shi H, Wu J, Lin Z, Yang S, Liu J, Wang W, Zhu...
Sat Jul 11, 2020 13:21
Related Articles The future of liver transplantation: an interview with Pierre-Alain Clavien. Hepat Oncol. 2020 Jun 22;7(2):HEP23 Authors: Clavien PA Abstract In this interview, we catch up with Hepatic Oncology board member Pierre-Alain Clavien to discuss his involvement in the development of an integrated perfusion machine capable of preserving livers outside of the body for up to 1 week. The development could have huge implications for the...
Sat Jul 11, 2020 13:21
Related Articles A Study on Association Between Protein Carbonyl and Anti-cyclic Citrullinated Peptide Antibody in Rheumatoid Arthritis: Introducing a New Supplementary Biomarker. Indian J Clin Biochem. 2020 Jul;35(3):347-352 Authors: Khorasani S, Boroumand N, Ghaeni Pasavei A, Sahebari M, Hashemy SI Abstract Redox state and immune mechanisms are two major factors implicated in rheumatoid arthritis (RA). Regarding some limitations of anti-cyclic...
Sat Jul 11, 2020 13:21
Related Articles Chinese perspective on end-of-life communication: a systematic review. BMJ Support Palliat Care. 2020 Jul 09;: Authors: Pun JKH, Cheung KM, Chow JCH, Chan WL Abstract BACKGROUND: Palliative care providers serving Chinese patients lack a culture-specific model of communication, a strong evidence base for this and clear guidance on its application. Thus, providers find it challenging to address patients' dignity, and determine...
Sat Jul 11, 2020 13:21
Related Articles Challenges in platelet inventory management at a tertiary care oncology center during the novel coronavirus disease (COVID-19) pandemic lockdown in India. Transfus Apher Sci. 2020 Jul 01;:102868 Authors: Ojha S, Gupta AM, Nagaraju P, Poojary M, S H S Abstract The novel coronavirus disease (COVID-19) has been declared a pandemic by the world health organization and to limit the spread of the disease, many countries in the world,...
Sat Jul 11, 2020 13:21
Related Articles Interprofessional Education for Cancer Care. Clin Teach. 2019 10;16(5):519-524 Authors: McKinlay E, White K, McChesney P, Hardie C, Higgs R, Hilder J, Gallagher P Abstract BACKGROUND: Cancer care is typically delivered by a range of health professionals, and is frequently a uniprofessional pre-registration clinical placement. A workplace-based, 6-hour interprofessional education (IPE) pilot on cancer care, led by clinical tutors,...
Sat Jul 11, 2020 13:21
Related Articles Development and validation of the HNC-LL score for predicting the severity of coronavirus disease 2019. EBioMedicine. 2020 Jul 06;57:102880 Authors: Xiao LS, Zhang WF, Gong MC, Zhang YP, Chen LY, Zhu HB, Hu CY, Kang P, Liu L, Zhu H Abstract BACKGROUND: Information regarding risk factors associated with severe coronavirus disease (COVID-19) is limited. This study aimed to develop a model for predicting COVID-19 severity. ...
Fri Jul 10, 2020 15:27
Related Articles Mandibular canal vs. inferior alveolar canal: Evidence-based terminology analysis. Clin Anat. 2020 Jul 09;: Authors: Iwanaga J, Matsushita Y, Decater T, Ibaragi S, Tubbs RS Abstract INTRODUCTION: The mandibular canal, as it was formerly named in Terminologia Anatomica (TA), has also been called the inferior alveolar (nerve) canal in many scientific publications. This study was conducted to investigate how these terms have been...
Fri Jul 10, 2020 15:27
Related Articles Systematic Optimization of the iMALDI Workflow for the Robust and Straightforward Quantification of Signalling Proteins in Cancer Cells. Proteomics Clin Appl. 2020 Jul 08;:e2000034 Authors: Froehlich BC, Popp R, Sobsey CA, Ibrahim S, LeBlanc AM, Mohammed Y, Aguilar-Mahecha A, Poetz O, Chen MX, Spatz A, Basik M, Batist G, Zahedi RP, Borchers CH Abstract PURPOSE: Immuno-MALDI (iMALDI) combines immuno-enrichment of biomarkers with...
Fri Jul 10, 2020 15:27
Related Articles Clinical recommendations in the management of advanced prostate cancer: International Gastrointestinal, Liver and Uro-oncology (IGILUC 2019) experts. World J Urol. 2020 Jul 08;: Authors: Elghazaly H, Mottet N, Garcia J, Oudard S, Roach M, Abbou C, Merseburger A, Emara A, Shehata S, Tawfik H, Khorshid O, Selim A, Assem A, Abdelkarim K, Ezz El-Arab L, Bazarbashi S, Omar A, Elwakil H, Elashry M, Abou ElFotouh M, Osman T, Ezz El Din M Abstract...
Fri Jul 10, 2020 15:27
Related Articles Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Disease. Curr Oncol Rep. 2020 Jul 09;22(9):87 Authors: Kumar P, Kopecky SL, Yang EH, Oren O Abstract PURPOSE OF REVIEW: The purpose of this review article is to summarize the preclinical and clinical evidence supporting the notion of clonal hematopoiesis of indeterminate potential (CHIP), highlight current knowledge gap, and provide future directions. ...
Fri Jul 10, 2020 15:27
Related Articles CT based quantitative measures of the stability of fractured metastatically involved vertebrae treated with spine stereotactic body radiotherapy. Clin Exp Metastasis. 2020 Jul 08;: Authors: Hardisty M, Wright T, Campbell M, Burke M, Atenafu E, Cawricz M, Caldwell C, Yee A, Sahgal A, Whyne C Abstract Mechanical instability secondary to vertebral metastases can lead to pathologic vertebral compression fracture (VCF) mechanical...
Fri Jul 10, 2020 15:27
Related Articles Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis? Osteoporos Int. 2020 Jul 08;: Authors: Rozenberg S, Al-Daghri N, Aubertin-Leheudre M, Brandi ML, Cano A, Collins P, Cooper C, Genazzani AR, Hillard T, Kanis JA, Kaufman JM, Lambrinoudaki I, Laslop A, McCloskey E, Palacios S, Prieto-Alhambra D, Reginster JY, Rizzoli R, Rosano G, Trémollieres F, Harvey NC Abstract We provide an evidence...
Fri Jul 10, 2020 15:27
Related Articles Clinical trial design in neurofibromatosis type 1 as a model for other tumor predisposition syndromes. Neurooncol Adv. 2020 Jul;2(Suppl 1):i134-i140 Authors: Gross AM, Widemann BC Abstract Up to 10% of all pediatric cancer patients may have an underlying germline mutation which predisposed them to develop a malignancy. With more patients being tested for and diagnosed with genetic tumor predisposition syndromes, there has been...
Fri Jul 10, 2020 15:27
Related Articles Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1. Neurooncol Adv. 2020 Jul;2(Suppl 1):i75-i84 Authors: Godec A, Jayasinghe R, Chrisinger JSA, Prudner B, Ball T, Wang Y, Srihari D, Kaushal M, Dietz H, Zhang X, Pekmezci M, Dahiya S, Tao Y, Luo J, Van Tine BA, Ding L, Gutmann DH, Hirbe AC Abstract Background: Malignant peripheral...
Fri Jul 10, 2020 15:27
Related Articles Diagnosis and management of malignant peripheral nerve sheath tumors: Current practice and future perspectives. Neurooncol Adv. 2020 Jul;2(Suppl 1):i40-i49 Authors: Prudner BC, Ball T, Rathore R, Hirbe AC Abstract One of the most common malignancies affecting adults with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the malignant peripheral nerve sheath tumor (MPNST), a highly aggressive sarcoma that typically...
Fri Jul 10, 2020 15:27
Related Articles Identification of functionally distinct and interacting cancer cell subpopulations from glioblastoma with intratumoral genetic heterogeneity. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa061 Authors: Guo M, van Vliet M, Zhao J, de Ståhl TD, Lindström MS, Cheng H, Heller S, Nistér M, Hägerstrand D Abstract Background: Glioblastomas display a high level of intratumoral heterogeneity with regard to both genetic and histological features....
Fri Jul 10, 2020 15:27
Related Articles Effect of radiation therapy on cerebral cortical thickness in glioma patients: Treatment-induced thinning of the healthy cortex. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa060 Authors: Nagtegaal SHJ, David S, Snijders TJ, Philippens MEP, Leemans A, Verhoeff JJC Abstract Background: With overall survival of brain tumors improving, radiation induced brain injury is becoming an increasing issue. One of the effects of radiation therapy...
Fri Jul 10, 2020 15:27
Related Articles Clinical utility of circulating miR-371a-3p for the management of patients with intracranial malignant germ cell tumors. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa048 Authors: Murray MJ, Ajithkumar T, Harris F, Williams RM, Jalloh I, Cross J, Ronghe M, Ward D, Scarpini CG, Nicholson JC, Coleman N Abstract Background: The current biomarkers alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) have limited sensitivity/specificity...
Fri Jul 10, 2020 15:27
Related Articles Interferon-β exposure induces a fragile glioblastoma stem cell phenotype with a transcriptional profile of reduced migratory and MAPK pathway activity. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa043 Authors: Lohmann B, Silginer M, Picard D, Schneider H, Remke M, Roth P, Reifenberger G, Weller M Abstract Background: Type I interferons (IFN-α/β) are cytokines that are typically expressed in response to double-stranded RNA associated...
Fri Jul 10, 2020 15:27
Related Articles NCI-CONNECT rare CNS tumor initiative: current progress and anticipated future impact. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa022 Authors: Mansouri A, Zadeh G PMID: 32642683 [PubMed]
Fri Jul 10, 2020 15:27
Related Articles Suicide gene therapy for the treatment of high-grade glioma: past lessons, present trends, and future prospects. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa013 Authors: Hossain JA, Marchini A, Fehse B, Bjerkvig R, Miletic H Abstract Suicide gene therapy has represented an experimental cancer treatment modality for nearly 40 years. Among the various cancers experimentally treated by suicide gene therapy, high-grade gliomas have been...
Fri Jul 10, 2020 15:27
Related Articles NCI-CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors-Histone Mutated Midline Glioma Workshop Proceedings. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa007 Authors: Theeler BJ, Dalal Y, Monje M, Shilatifard A, Suvà ML, Aboud O, Camphausen K, Cordova C, Finch E, Heiss JD, Packer RJ, Romo CG, Aldape K, Penas-Prado M, Armstrong T, Gilbert MR Abstract Histone mutations occur in approximately 4% of different cancer types....
Fri Jul 10, 2020 15:27
Related Articles T2/FLAIR-mismatch sign for noninvasive detection of IDH-mutant 1p/19q non-codeleted gliomas: validity and pathophysiology. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa004 Authors: Foltyn M, Nieto Taborda KN, Neuberger U, Brugnara G, Reinhardt A, Stichel D, Heiland S, Herold-Mende C, Unterberg A, Debus J, von Deimling A, Wick W, Bendszus M, Kickingereder P Abstract Background: This study aimed to assess the validity and pathophysiology...
Fri Jul 10, 2020 15:27
Related Articles The effect of brain metastasis location on clinical outcomes: A review of the literature. Neurooncol Adv. 2019 May-Dec;1(1):vdz017 Authors: Kancharla P, Ivanov A, Chan S, Ashamalla H, Huang RY, Yanagihara TK Abstract It is common clinical practice to consider the location of a brain metastasis when making decisions regarding local therapies and, in some scenarios, estimating clinical outcomes, such as local disease control and...
Fri Jul 10, 2020 15:27
Related Articles Biomarkers and smart intracranial devices for the diagnosis, treatment, and monitoring of high-grade gliomas: a review of the literature and future prospects. Neurooncol Adv. 2019 May-Dec;1(1):vdz013 Authors: Hafeez U, Cher LM Abstract Glioblastoma (GBM) is the most common primary brain neoplasm with median overall survival (OS) around 15 months. There is a dearth of effective monitoring strategies for patients with high-grade...
Fri Jul 10, 2020 15:27
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