Abstract Background Psychodermatology is an interdisciplinary field in dermatology which involves the interaction between mind and skin. Studies from various parts of the world demonstrate generalized lack of knowledge regarding psychocutaneous disorders among dermatologists. We provide this survey to evaluate the knowledge, awareness, and practice patterns of Iranian dermatologists about psychodermatology. Methods A survey questionnaire on the topic of this study was randomly distributed...
Abstract Background Continuously updated information is helpful for evaluating the safety of long‐term systemic drug use in psoriasis patients with concomitant hepatitis B virus (HBV) infection. Objective To investigate the impact of long‐term systemic treatment for psoriasis on liver disease in psoriasis patients with HBV infection. Methods Data of patients during 10‐year period were recorded and analyzed. Results Sixty‐six patients (46 males, 20 females) with a mean age of...
Abstract Vascular malformations of soft tissue are a consequence of abnormal development of vascular elements during embryogenesis. They are named after the vessel responsible. Their presence at birth raises the hypothesis of an intra‐uterine etiology of vascular malformations, but the influence of other factors may play an important role in their appearance, localization and size. The literature suggests that treatment of vascular malformations is, rarely surgical. Surgery is applied in cases...
Abstract Background Photoaging is closely related to UV‐induced oxidative stress. Ferulic acid is a plant‐based antioxidant with anti‐aging activity. Combining ferulic acid peel with microneedling enhances it's transdermal penetration. This study was designed to evaluate the efficacy of 14% ferulic acid peel combined with microneedling for facial photoaging. Materials and methods 16 women aged 45‐60 with Fitzpatrick skin type II and III, were enrolled in this trial. All patients received...
ABSTRACT INTRODUCTION Lasers are considered the most efficient methods for hair reduction. The goal of these devices is to provide long‐term effects without adverse reactions. OBJECTIVES This is a randomised split‐body controlled study on body hair removal and pseudofolliculitis (PFC) treatment, comparing the standard Single Pass (SP) emission with the MultiPass emission (Moveo handpiece) with 755 alexandrite laser. MATERIAL AND METHODS Patients with Fitzpatrick skin types I‐VI underwent...
Abstract Photodynamic therapy (PDT) has long been used in Dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious...
Abstract Premature graying of hair (PGH) being a very common entity for which pharmacotherapy and reversibility are not properly addressed. Therefore, this systematic review was conducted to address these issues. For this relevant study were selected from various databases including PubMed, EMBASE, OVID, Web of science, Scopus and Google Scholar till January 20, 2019. Studies which reported risk factors, co‐morbid conditions associated with PGH, its pharmacotherapy and reversal were included in...
Abstract Background and Objectives Dermatochalasis (DC) is part of the aging process of the eyelids, characterized by lax, redundant, overhanging excess eyelid skin. Mostly it is treated by surgical blepharoplasty. Lately alternative alternative non‐surgical blepharoplasty technologies have been introduced. In this study we evaluated the efficacy and safety of a novel non‐invasive RF microplasma technology for upper eyelid DC. A prospective single center study included 17 patients with moderate...
Abstract Vitiligo is an autoimmune disease characterized by patches of depigmentation. Zinc is an antiapoptotic molecule that exhibits antioxidant properties. The study aimed to investigate the serum levels of zinc in vitiligo patients compared to healthy controls and to whether exists a correlation between disease severity and serum levels of zinc. Fifty patients with vitilgo (Group A) and fifty age and sex matched healthy controls (Group B) were recruited and serum zinc level was measured using...
Abstract In‐depth analysis on the rambling genes of psoriasis may help to identify the pathologic mechanism of this disease. However, this has seldom been performed. Using bioinformatic approaches, we analyzed four gene expression profiles in gene expression omnibus (GEO) database, identified the differentially expressed genes (DEGs), and found out the overlapping DEGs (common DEGs, CDEGs) in the above 4 profiles. The CDEGs were further subjected to Gene Ontology (GO) enrichment analysis, Kyoto...
Abstract Purpose To reach a consensus, among experts, on the management of patients with actinic keratosis (AK). Methods Two round tables involving experts were organized: in the first, seven clinical questions were selected and analyzed by a systematic literature review, using a Population, Intervention, Control, and Outcomes (PICO) framework; in the second, the experts discussed relevant evidences and a consensus statement for each question was developed. Results Lesion‐directed...
Abstract Skin‐centered body dysmorphic disorder (BDD) and excoriation disorder (ED) are categorized under Obsessive Compulsive and Related Disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5) and are characterized by excessive or inappropriate skin picking. Patients with skin‐centered BDD and ED often first present to dermatology. These conditions are important to recognize and appropriately diagnose, as perpetuation of the disorder is inevitable without appropriate psychiatric...
Abstract Background The optimal surgical management of sebaceous carcinoma (SC) has yet to be determined between Mohs micrographic surgery (MMS) and wide local excision (WLE). Objective To investigate overall survival (OS) differences for SC undergoing WLE or MMS Methods The National Cancer Database (NCDB) was queried for all SC from 2004 to 2015 (n = 2863). Cases missing staging data, undergoing palliative care, showing lymph node extension, or of AJCC Stage III/IV were omitted....
Abstract COVID‐19 is an outbreak of viral pneumonia which became a global health crisis, and the risk of morbidity and mortality of people with obesity are higher. SARS‐CoV‐2, the pathogen of COVID‐19, enters into cells through binding to the Angiotensin Converting Enzyme (ACE) homolog‐2 (ACE2). ACE2 is a regulator of two contrary pathways in renin angiotensin system (RAS): ACE‐Ang‐II‐AT1R axis and ACE2‐Ang 1‐7‐Mas axis. Viral entry process eventuate in downregulation of ACE2 and subsequent activation...
Abstract Sphingolipids (SLs), are structural components of the skin that contribute to the regulation of the proliferation and differentiation of keratinocytes as well as regulation of the skin epidermal barrier. A prospective cross sectional comparative controlled study was designed to evaluate the serum level of sphingosine 1 phosphate(S1P) and ceramide(CER) before and after narrow band ultraviolet B (NBUVB) in psoriatic patients. The study included 32 patients presented with psoriasis and 32...
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