Background: The omission of surgery via nonoperative management (NOM) for rectal cancer may be increasing, and this strategy could be particularly attractive for younger patients, whose incidence of rectal cancer has been rising. We sought to assess trends in NOM in young (younger than 55 y) versus older adult (55 y and older) rectal cancer cohorts. Methods: The National Cancer Database was used to identify patients diagnosed with stage II to III rectal cancer between 2010 and 2015....
Fri Jun 19, 2020 03:00
Global, regional, and national burden of lung cancer and its attributable risk factors, 1990 to 2017
Background China's lung cancer (LC) burden plays a pivotal role in the global cancer epidemic. Comparing LC burden and population attributable fractions (PAFs) of risk factors between China and other countries/regions is essential to inform effective intervention. The Global Burden of Disease (GBD) study provides a unique opportunity for such comparisons. Methods We extracted the number of LC deaths, age‐standardized death rates (ASDRs), age‐standardized disability‐adjusted life‐year (DALY)...
Fri Jul 10, 2020 22:00
Background Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID‐19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS A 34‐item survey focusing on barriers to pediatric oncology management during the COVID‐19 pandemic was distributed to heads of pediatric oncology units within the Pediatric Oncology East and Mediterranean (POEM) collaborative...
Fri Jul 10, 2020 17:39
Background Although the American Joint Committee on Cancer TNM classification has been amended to include human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC) as an independent entity, to the authors' knowledge the optimized de‐escalating treatment modality has not been established to date. Methods The authors conducted a retrospective, nationwide, observational study in patients with HPV‐related OPSCC who were treated from 2011 to 2014 in Japan to determine the...
Fri Jul 10, 2020 17:39
Background The objective of the current study was to estimate productivity costs due to metastatic breast cancer (mBC) via productive time lost among survivors and potential life‐years lost from premature mortality among 3 age groups: younger (aged 18‐44 years), midlife (aged 45‐64 years), and older (aged ≥65 years) women. Methods The authors estimated the number of work and home productivity days missed due to mBC by age group using data from the 2000 to 2016 National Health Interview Survey....
Fri Jul 10, 2020 17:38
Thu Jul 09, 2020 22:00
Thu Jul 09, 2020 17:32
Thu Jul 09, 2020 17:32
The US Food and Drug Administration granted acalabrutinib approval as the second Bruton tyrosine kinase (BTK) inhibitor to treat patients with chronic lymphocytic leukemia and small lymphocytic lymphoma as monotherapy or in combination with obinutuzumab. This approval was based on 2 phase 3 trials: ELEVATE‐TN and ASCEND. There are several concerns with the design of these trials, including suboptimal treatment of patients in the control arm, expansion of the trial population, and lack of data regarding...
Thu Jul 09, 2020 17:29
Tue Jul 07, 2020 18:03
In diagnostic cytology, the known site‐specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exact nature of the specimen received, the staining method(s) used, and the use of additional laboratory techniques including molecular profiling; furthermore, they often differ to some...
Fri Jul 10, 2020 17:39
Abstract EphA10 (erythropoietin‐producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family. Although EphA10 is involved in the malignancy of some types of cancer, its role as an oncogene has not been extensively studied. Here, we investigated the influence of EphA10 on the tumorigenic potential of pancreatic cancer cells. Analysis of expression profiles from The Cancer Genome Atlas confirmed that EphA10 was elevated...
Thu Jul 09, 2020 18:04
Abstract Ovarian cancer has a high recurrence rate after platinum‐based chemotherapy. To improve the treatment of ovarian cancer and identify ovarian cancer‐specific antibodies, we immunized mice with the human ovarian carcinoma cell line, SKOV‐3, and generated hybridoma clones. Several rounds of screening yielded 30 monoclonal antibodies (mAbs) with no cross‐reactivity to normal cells. Among these mAbs, OV‐Ab 30‐7 was found to target integrin α3 and upregulate p53 and p21, while stimulating apoptosis...
Thu Jul 09, 2020 16:08
Publication date: August 2020Source: Cancer/Radiothérapie, Volume 24, Issue 5Author(s):
Sat Jul 11, 2020 17:59
Publication date: August 2020Source: Cancer/Radiothérapie, Volume 24, Issue 5Author(s):
Sat Jul 11, 2020 17:59
Therapeutic drug monitoring (TDM) is mandatory for the immunosuppressive drug tacrolimus (Tac). For clinical applicability, TDM is performed using morning trough concentrations. With recent developments making tacrolimus concentration determination possible in capillary microsamples and Bayesian estimator predicted area under the concentration curve (AUC), AUC‐guided TDM may now be clinically applicable. Tac circadian variation has, however, been reported, with lower systemic exposure following the...
Sat Jul 11, 2020 11:10
Purpose:African American (AFR) men have the highest mortality rate from prostate cancer (PCa) compared with men of other racial/ancestral groups. Differences in the spectrum of somatic genome alterations in tumors between AFR men and other populations have not been well-characterized due to a lack of inclusion of significant numbers in genomic studies.Experimental Design:To identify genomic alterations associated with race, we compared the frequencies of somatic alterations in PCa obtained from four...
Fri Jul 10, 2020 16:47
Publication date: Available online 12 July 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): F. Bozzetti, Z. Stanga
Sun Jul 12, 2020 15:51
Publication date: Available online 11 July 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Waisse Waissi, Adrien Paix, Anaïs Nicol, Georges Noël, Hélène Burckel
Sun Jul 12, 2020 15:51
Publication date: Available online 10 July 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): S.N. Amini, V.S. Nelson, A. Sobels, J.W. Schoones, J.J. Zwaginga, M.R Schipperus
Sat Jul 11, 2020 19:02
Publication date: Available online 9 July 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Alice Indini, Erika Rijavec, Michele Ghidini, Claudia Bareggi, Monica Cattaneo, Barbara Galassi, Donatella Gambini, Francesco Grossi
Fri Jul 10, 2020 14:04
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Frédéric Millot, Meinolf Suttorp, Anne B. Versluys, Krzysztof Kalwak, Brigitte Nelken, Stephane Ducassou, Yves Bertrand, André Baruchel
Sun Jul 12, 2020 17:17
Publication date: Available online 11 July 2020Source: European Journal of CancerAuthor(s): Sacha J. Howell, Brian Keevil, Claire Higham, Laura J. Owen, Phillip J. Monaghan
Sun Jul 12, 2020 17:17
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Ning Gu, Wei Dai, Hongliang Liu, Jie Ge, Sheng Luo, Eunyoung Cho, Christopher I. Amos, Jeffrey E. Lee, Xin Li, Hongmei Nan, Hua Yuan, Qingyi Wei
Fri Jul 10, 2020 19:58
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Gary Rodin, Camilla Zimmermann, Danielle Rodin, Ahmed al-Awamer, Richard Sullivan, Charlotte Chamberlain
Fri Jul 10, 2020 19:58
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Manon de Vries-Brilland, Marine Gross-Goupil, Valérie Seegers, Elouen Boughalem, Benoit Beuselinck, Constance Thibault, Christine Chevreau, Sylvain Ladoire, Philippe Barthélémy, Sylvie Negrier, Delphine Borchiellini, Olivier Huillard, Lionnel Geoffrois, Gwenaelle Gravis, Carolina Saldana, Antoine Thiery-Vuillemin, Bernard Escudier, Alain Ravaud, Laurence Albiges
Fri Jul 10, 2020 19:58
Publication date: Available online 11 July 2020Source: European Journal of Surgical OncologyAuthor(s): Hon Lyn Tan, Guowei Kim, Christopher John Charles, Renee R. Li, Clarisse JM. Jang, Asim Shabbir, Koy Min Chue, Chia Hui Tai, Raghav Sundar, Boon Cher Goh, Glenn Kunnath Bonney, Wen Donq Looi, Esther Sok Hwee Cheow, Jimmy BY. So, Ling Zhi Wang, Wei Peng Yong
Sun Jul 12, 2020 15:38
Publication date: Available online 11 July 2020Source: European Journal of Surgical OncologyAuthor(s): Xin Chen, Xingyu Feng, Muqing Wang, Xueqing Yao
Sat Jul 11, 2020 13:36
Publication date: Available online 10 July 2020Source: European Journal of Surgical OncologyAuthor(s): Philip H. Pucher, Saqib A. Rahman, Robert C. Walker, Ben L. Grace, Andrew Bateman, Tim Iveson, Andrew Jackson, Charlotte Rees, James P. Byrne, Jamie J. Kelly, Fergus Noble, Timothy J. Underwood
Fri Jul 10, 2020 17:40
Publication date: Available online 9 July 2020Source: European Journal of Surgical OncologyAuthor(s): Rami Rhaiem, Tullio Piardi, Ahmad Tashkandi, Reza Kianmanesh
Fri Jul 10, 2020 17:40
To tailor a surveillance system to its objectives and to evaluate its fitness for purpose, an accurate description of its structural elements is essential. Existing recommendations for setting up a system seldom offer a comprehensive list of all surveillance elements to be considered. Moreover, there is sometimes confusion in the way terms describing these elements are interpreted. The objective of this paper is to propose a comprehensive set of surveillance system descriptors that can delineate...
Thu Jul 09, 2020 03:00
Laboratory preparedness with quality-assured diagnostic assays is essential for controlling the current coronavirus disease (COVID-19) outbreak. We conducted an external quality assessment study with inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) samples to support clinical laboratories with a proficiency testing option for molecular assays. To analyse SARS-CoV-2 testing performance, we used an online questionnaire developed for the European Union project RECOVER to assess...
Thu Jul 09, 2020 03:00
Background In most countries, including France, data on clinical indications for outpatient antibiotic prescriptions are not available, making it impossible to assess appropriateness of antibiotic use at prescription level. Aim Our objectives were to: (i) propose proxy indicators (PIs) to estimate appropriateness of antibiotic use at general practitioner (GP) level based on routine reimbursement data; and (ii) assess PIs’ performance scores and their clinimetric properties using...
Thu Jul 09, 2020 03:00
Abstract Peptidylarginine deiminases (PADs) catalyze the conversion of arginine residues to citrulline residues on target proteins in the presence of calcium ions. This elaborate type of posttranslational modification (PTM) is termed citrullination. PADs may regulate gene transcriptional activity via histone citrullination. There has been an increasing appreciation for the roles of PADs in a wide variety of biological processes. In this review article, we summarize recent evidence indicating that...
Fri Jul 10, 2020 20:19
Abstract Despite efforts to increase the diversity of cancer clinical trial participants, African Americans are still underrepresented. While perceptions of participation have been studied, the objective of this study was to compare perceptions and decisional conflict towards clinical trials among African American cancer patients who have and have not participated in clinical trials to identify key areas for intervention. Post hoc analysis also looked at whether they had been...
Sat Jul 11, 2020 03:00
Abstract The purpose of this project was to develop and test the feasibility and preliminary efficacy of a video about cancer clinical trials (CCTs) developed for breast cancer patients. We developed 2 brief 7-min videos that focused on breast cancer patients describing their experiences participating in CCTs, supplemented with doctors and research staff explaining key research concepts. One video was culturally tailored to Black patients and the other to White patients. To assess...
Sat Jul 11, 2020 03:00
Abstract Genital human papillomavirus (HPV) is the most common sexually transmitted virus in the United States and etiologically linked to several types of cancers including the cervix, vulva, vagina, penis, anus, and oropharynges. Evidence indicates certain types of HPV-associated cancers disproportionally affect Latinos in the United States. This qualitative study sought to explore Latina mothers’ perceptions and understanding of HPV infection, HPV-associated cancers, and the...
Sat Jul 11, 2020 03:00
Abstract To address rural cancer disparities, the University of Wisconsin Carbone Cancer Center launched a rural cancer project through its Cancer Health Disparities Initiative (CHDI) in 2010. With support from the National Cancer Institute’s (NCI) National Outreach Network, CHDI conducted an assessment of rural counties and partnered with Adams County to implement a collaborative cancer education project. Together CHDI and Adams County partners selected an evidence-based educational...
Fri Jul 10, 2020 03:00
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality. Circular RNAs (CircRNAs) have become a research hotspot in recent years for their vital...
Sat Jul 11, 2020 03:00
Crosstalk between cancer cells and tumor-associated macrophages (TAMs) mediates tumor progression in colorectal cancer (CRC). Cytoplasmic polyadenylation element binding protein 3 (CPEB3) has been shown to exh...
Sat Jul 11, 2020 03:00
Esophageal cancer (EC) represents one of the most aggressive digestive neoplasms globally, with marked geographical variations in morbidity and mortality. Chemoprevention is a promising approach for cancer the...
Sat Jul 11, 2020 03:00
Trastuzumab and the related antibody-drug conjugate (ADC), ado-trastuzumab emtansine (T-DM1), both target HER2-overexpressing cells. Together, these drugs have treatment indications in both early-stage and metastatic settings for HER2+ breast cancer. T-DM1 retains the antibody functionalities of trastuzumab and adds the potency of a cytotoxic maytansine payload. Interestingly, in the clinic, T-DM1 cannot always replace the use of trastuzumab plus chemotherapy administered together as single agents....
Fri Jul 10, 2020 17:48
Abstract Introduction Surgical outcomes and healthcare utilization have been shown to vary based on patient insurance status. We analyzed whether patients’ insurance affects case urgency for and readmission after craniotomy for meningioma resection, using benign meningioma as a model system to minimize confounding from the disease-related characteristics of other neurosurgical pathologies. ...
Sat Jul 11, 2020 03:00
Abstract The unique character of selenium compounds, including sodium selenite and Se-methylselenocysteine (MSC), is that they exert cytotoxic effects on neoplastic cells, providing a great potential for treating cancer cells being highly resistant to cytostatic drugs. However, selenium treatment may affect microRNA (miRNA) expression as the pattern of circulating miRNAs changed in a placebo-controlled selenium supplement study. This necessitates exploring possible changes in...
Sun Jul 12, 2020 03:00
Abstract Colorectal cancer remains one of most common cancer types with poor prognosis globally. Recent years, numerous studies depicted pivotal roles of lncRNAs in colorectal cancer progression. This study aimed to investigate the role of FGF14-AS2 in colorectal cancer development. FGF14-AS2 was found as a significantly downregulated lncRNA in TCGA dataset. Via RT-qPCR, we confirmed the downregulation of FGF14-AS2 in collected colorectal carcinoma samples. Transfection of plasmid...
Sat Jul 11, 2020 03:00
Fri Jul 10, 2020 13:56
Fri Jul 10, 2020 13:52
To date, only limited magnetic resonance imaging (MRI) data are available concerning tumor regression during neoadjuvant radiochemotherapy (RCT) of rectal cancer patients, which is a prerequisite for adaptive ...
Sat Jul 11, 2020 03:00
Surface-guided radiation therapy (SGRT) employs a non-invasive real-time optical surface imaging (OSI) technique for patient surface motion monitoring during radiotherapy. The main purpose of this study is to ...
Fri Jul 10, 2020 03:00
Many dose calculation algorithms for radiotherapy planning need to be configured for each clinical beam using pre-defined measurements. An optimization process adjusts the physical parameters able to estimate ...
Fri Jul 10, 2020 03:00
The purpose was to evaluate the dosimetric effects in prostate cancer treatment caused by anatomical changes occurring during the time frame of adaptive replanning in a magnetic resonance linear accelerator (M...
Fri Jul 10, 2020 03:00
The daily new confirmed Coronavirus disease 2019 (COVID-19) cases have decreased in some European and Asian countries. Many countries and areas have started to ease public restrictions. Here, we share our expe...
Thu Jul 09, 2020 03:00
Immune-checkpoint inhibitors (ICI) have dramatically changed the landscape of lung cancer treatment. Preclinical studies investigating combination of ICI with radiation show a synergistic improvement of tumor ...
Thu Jul 09, 2020 03:00
Starting in December 2019, the current pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confronts the world with an unprecedented challenge. With no vaccine or drug being cur...
Thu Jul 09, 2020 03:00
The standard treatment of breast cancer includes a combination of treatment modalities, such as surgery, radiotherapy (RT), chemotherapy and endocrine therapy. RT is administered after breast conserving surgery (BCS) to reduce the risk of locoregional recurrences and improve overall survival[1–3]. However, RT can cause acute and late toxicity, resulting in a negative impact on health-related quality of life (HRQoL)[4–7]. Breast pain after RT has an important impact on different items of HRQoL[8].
Sat Jul 11, 2020 03:00
Radiotherapy plays a pivotal role in the curative treatment of oesophageal cancer patients [1]. However, thoracic radiotherapy is accompanied by serious risks of complications caused by dose to organs-at-risk (OARs), particularly to the heart and lungs [2–5]. Despite the development of new photon-based technologies, such as intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT), radiation dose to normal tissues is still substantial [6].
Sat Jul 11, 2020 03:00
Radiation therapy (RT) is part of definitive treatment for patients with unresectable non-small cell lung cancer (NSCLC). Despite major technological advances in imaging and conformal delivery techniques, the tolerances of adjacent normal tissues continue to limit target volume doses [1,2]. In patients receiving RT for thoracic malignancies, the most frequent toxicities occur in the lungs and/or heart. Radiation-induced cardiac toxicity (RICT) may present as multiple pathologies including myocardial...
Sat Jul 11, 2020 03:00
Multiple forms of definitive radiotherapy are acceptable alternatives to more prolonged radiotherapy regimens for men with intermediate-risk prostate cancer (PCa) and can be considered for men with low-risk disease who decline active surveillance.[1] Stereotactic body radiotherapy (SBRT) is an external beam radiotherapy modality in which large radiation doses are delivered over five or fewer fractions. Two forms of brachytherapy -- permanent seed implant low dose rate brachytherapy (LDR-BT) and temporary...
Sat Jul 11, 2020 03:00
We would like to thank Sandra Kos for her letter [1], giving us the opportunity to clarify some statements made in our review [2].
Fri Jul 10, 2020 03:00
Global Oncology capacity in Radiation Oncology (RO) needs development. We report on early outcomes of a Canadian Global Oncology elective scholarship program for trainees (2014-2019). The number of global oncology electives increased. Academic deliverables and collaborations were observed. There was evidence of personal and professional development.
Fri Jul 10, 2020 03:00
A gimbaled–head radiotherapy device was developed by industry-academic collaborations, with a concept of robust structures whilst maintaining high flexibilities, and its clinical application started in 2008. The unique structures with multi-image guidance functions initiated 2 new treatment modalities. One is dynamic tumor tracking radiotherapy with real time monitoring (DTTRM), which enables 4-D radiotherapy without prolongation of radiotherapy treatment time. This treatment has become clinically...
Fri Jul 10, 2020 03:00
Publication date: Available online 11 July 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Manasa Veluvolu, Mausam Patel, Ganesh Narayanasamy, Thomas Kim
Sun Jul 12, 2020 17:43
Publication date: September–October 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 5Author(s): Eduardo Netto, Hugo Santos, Luís Carvalho, José Luis Capelo-Martínez, Miguel Rito, José Cabeçadas, Margarida Roldão
Sat Jul 11, 2020 14:28
Publication date: September–October 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 5Author(s): Lukkana Apipunyasopon, Chalitpon Chaloeiparp, Thanayut Wiriyatharakij, Nakorn Phaisangittisakul
Sat Jul 11, 2020 14:28
Publication date: September–October 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 5Author(s): Felipe Amstalden Trevisan, Andressa Romualdo Rodrigues, Fermino Sanches Lizarte Neto, Fernanda Maris Peria, Múcio Luiz de Assis Cirino, Daniela Pretti da Cunha Tirapelli, Carlos Gilberto Carlotti Júnior
Sat Jul 11, 2020 14:28
Publication date: September–October 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 5Author(s): Fawzi Abuhijla, Samer Salah, Maysa Al-Hussaini, Issa Mohamed, Imad Jaradat, Abdulmajeed Dayyat, Hanan Almasri, Alaa Allozi, Ayah Arjan, Abdelatif Almousa, Ramiz Abu-Hijlih
Sat Jul 11, 2020 14:28
Publication date: September–October 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 5Author(s): Niloofar Yousefi Moteghaed, Ahmad Mostaar, Keivan Maghooli, Mohammad Houshyari, Ahmad Ameri
Sat Jul 11, 2020 14:28
Publication date: Available online 10 July 2020Source: Cancer EpidemiologyAuthor(s): K. Waddell, M. Matua, C. Bidwell, R. Atwine, J. Onyango, S.V. Picton, I. Simmons, J. Stahlschmidt, W.T. Johnston, R. Newton
Sat Jul 11, 2020 14:01
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Adam C. Olson, Franco Afyusisye, Joe Egger, David Noyd, Beda Likonda, Nestory Masalu, Gita Suneja, Nelson Chao, Leah L. Zullig, Kristin Schroeder
Sat Jul 11, 2020 00:11
Publication date: August 2020Source: Seminars in Oncology, Volume 47, Issue 4Author(s):
Sat Jul 11, 2020 14:41
Publication date: August 2020Source: Seminars in Oncology, Volume 47, Issue 4Author(s):
Sat Jul 11, 2020 14:41
Publication date: August 2020Source: Seminars in Oncology, Volume 47, Issue 4Author(s):
Sat Jul 11, 2020 14:41
Publication date: August 2020Source: Seminars in Oncology, Volume 47, Issue 4Author(s):
Sat Jul 11, 2020 14:41
Abstract Purpose Biodosimetric assessment and comparison of radiation-induced deoxyribonucleic acid (DNA) double-strand breaks (DSBs) by γH2AX immunostaining in peripheral leukocytes of patients with painful heel spur after radiation therapy (RT) with orthovoltage X‑rays or a 6-MV linear accelerator (linac). The treatment response for each RT technique was monitored as a secondary endpoint. ...
Fri Jul 10, 2020 03:00
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