Metabolites, Vol. 10, Pages 285: The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH Metabolites doi: 10.3390/metabo10070285 Authors: Khalid O. Alfarouk Samrein B. M. Ahmed Robert L. Elliott Amanda Benoit Saad S. Alqahtani Muntaser E. Ibrahim Adil H. H. Bashir Sari T. S. Alhoufie Gamal O. Elhassan Christian C. Wales Laurent H. Schwartz Heyam S. Ali Ahmed Ahmed Patrick F. Forde Jesus Devesa Rosa A. Cardone Stefano...
Sat Jul 11, 2020 03:00
Metabolites, Vol. 10, Pages 284: Changes in Metabolites During an Oral Glucose Tolerance Test in Early and Mid-Pregnancy: Findings from the PEARLS Randomized, Controlled Lifestyle Trial Metabolites doi: 10.3390/metabo10070284 Authors: Danielle E. Haslam Jun Li Liming Liang Marijulie Martinez Cristina Palacios Maria A. Trak-Fellermeier Paul W. Franks Kaumudi Joshipura Shilpa N. Bhupathiraju The oral glucose tolerance test (OGTT) is used to diagnose gestational...
Fri Jul 10, 2020 03:00
Microorganisms, Vol. 8, Pages 1031: Immune Transcriptome of Cells Infected with Enterovirus Strains Obtained from Cases of Type 1 Diabetes Microorganisms doi: 10.3390/microorganisms8071031 Authors: Anello Marcello Poma Angelo Genoni Francesco Broccolo Maria Denaro Alberto Pugliese Fulvio Basolo Antonio Toniolo Enterovirus (EV) infection of insulin-producing pancreatic beta cells is associated with type 1 diabetes (T1D), but little is known about the mechanisms that...
Sun Jul 12, 2020 03:00
Microorganisms, Vol. 8, Pages 1030: Construction of a High-Expression System in Bacillus through Transcriptomic Profiling and Promoter Engineering Microorganisms doi: 10.3390/microorganisms8071030 Authors: Cui-Cui Miao Lin-Li Han Yan-Bing Lu Hong Feng Bacillus subtilis is an ideal host for secretion and expression of foreign proteins. The promoter is one of the most important elements to facilitate the high-level production of recombinant protein. To expand the repertoire of...
Sun Jul 12, 2020 03:00
Microorganisms, Vol. 8, Pages 1032: Structures of the Skin Microbiome and Mycobiome Depending on Skin Sensitivity Microorganisms doi: 10.3390/microorganisms8071032 Authors: Hye Lim Keum Hanbyul Kim Hye-Jin Kim Taehun Park Seoyung Kim Susun An Woo Jun Sul Sensitive skin (SS) syndrome is a globally widespread, self-diagnosed discomfort characterized by subjective complaints. Although the skin microbiome is considered important in skin health, the relationship between...
Sun Jul 12, 2020 03:00
Microorganisms, Vol. 8, Pages 1029: Metschnikowia pulcherrima and Related Pulcherrimin-Producing Yeasts: Fuzzy Species Boundaries and Complex Antimicrobial Antagonism Microorganisms doi: 10.3390/microorganisms8071029 Authors: Matthias Sipiczki Yeasts affiliated with the Metschnikowia pulcherrima clade (subclade) of the large ascomycetous genus Metschnikowia frequently turn out to produce the characteristic maroon-red pulcherrimin when tested for pigment production and prove to exert...
Sun Jul 12, 2020 03:00
Microorganisms, Vol. 8, Pages 1028: Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in An M-SHIME® Model Microorganisms doi: 10.3390/microorganisms8071028 Authors: Massimo Marzorati Pieter Van den Abbeele Sarah S. Bubeck Thomas Bayne Kiran Krishnan Aicacia Young Dilip Mehta Anselm DeSouza Benefits associated with probiotic use have been reported; however, the mechanisms behind these...
Sat Jul 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1027: Impact of Probiotic Combination in InR[E19]/TM2 Drosophila melanogaster on Longevity, Related Gene Expression, and Intestinal Microbiota: A Preliminary Study Microorganisms doi: 10.3390/microorganisms8071027 Authors: Ma Sun Yang Gao Xu The insulin receptor (InR) pertains to the insulin receptor family, which plays a key role in the insulin/insulin-like growth factor (IGF)-like signaling (IIS) pathway. Insulin signaling defects may...
Sat Jul 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1026: Lactobacillus reuteri DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis Microorganisms doi: 10.3390/microorganisms8071026 Authors: Butler Lundqvist Axelsson Atopic Dermatitis (AD) is a chronically relapsing skin condition characterized by dry, itchy, and inflamed skin where sufferers can frequently be subject to infections. Probiotics are known to be potent immune-modulators,...
Sat Jul 11, 2020 03:00
Microorganisms, Vol. 8, Pages 1025: Low-Fat and High-Quality Fermented Sausages Microorganisms doi: 10.3390/microorganisms8071025 Authors: Patrizio Tremonte Gianfranco Pannella Silvia Jane Lombardi Massimo Iorizzo Franca Vergalito Autilia Cozzolino Lucia Maiuro Mariantonietta Succi Elena Sorrentino Raffaele Coppola The present study, considering for the first time microbiological concerns due to the use of lemon albedo as a fat replacer, aimed at the selection...
Fri Jul 10, 2020 03:00
Microorganisms, Vol. 8, Pages 1024: Bio‐ and Nanotechnology as the Key for Clinical Application of Salivary Peptide Histatin: A Necessary Advance Microorganisms doi: 10.3390/microorganisms8071024 Authors: Carolina Reis Reis Zambom Fauller Henrique da Henrique da Fonseca Saulo Santesso Garrido Candida albicans is a common microorganism of human’s microbiota and can be easily found in both respiratory and gastrointestinal tracts as well as in the genitourinary tract. Approximately...
Fri Jul 10, 2020 03:00
Microorganisms, Vol. 8, Pages 1023: Extrinsic Factors Shaping the Skin Microbiome Microorganisms doi: 10.3390/microorganisms8071023 Authors: Veronica Moskovicz Adi Gross Boaz Mizrahi Human skin, our most environmentally exposed organ, is colonized by a vast array of microorganisms constituting its microbiome. These bacterial communities are crucial for the fulfillment of human physiological functions such as immune system modulation and epidermal development and differentiation....
Fri Jul 10, 2020 03:00
Microorganisms, Vol. 8, Pages 1022: Antimicrobial Photodynamic Therapy in the Control of Pseudomonas syringae pv. actinidiae Transmission by Kiwifruit Pollen Microorganisms doi: 10.3390/microorganisms8071022 Authors: Margarida M. Lopes Maria Bartolomeu Ana T. P. C. Gomes Etelvina Figueira Ricardo Pinto Luís Reis Victor M. Balcão M. Amparo F. Faustino M. Graça P. M. S. Neves Adelaide Almeida Pseudomonas syringae pv. actinidiae (Psa) is a phytopathogen responsible...
Fri Jul 10, 2020 03:00
Molbank, Vol. 2020, Article M1147: Synthesis of γ-Glutamyl Derivatives of Sulfur-Containing Amino Acids in a Multigram Scale via a Two-Step, One-Pot Procedure Molbank doi: 10.3390/M1147 Authors: Giovanna Speranza Marco Rabuffetti Nikolina Vidović Carlo F. Morelli γ-Glutamyl derivatives of sulfur amino acids have been prepared in multigram scale starting from readily available starting materials. The synthesis comprises two one-pot operations, both consisting of two...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3181: Preferential Orientation of Photochromic Gadolinium Oxyhydride Films
Molecules, Vol. 25, Pages 3181: Preferential Orientation of Photochromic Gadolinium Oxyhydride Films Molecules doi: 10.3390/molecules25143181 Authors: Baba Montero Moldarev Moro Wolff Primetzhofer Sartori Zayim Karazhanov We report preferential orientation control in photochromic gadolinium oxyhydride (GdHO) thin films deposited by a two-step process. Gadolinium hydride (GdH2-x) films were grown by reactive magnetron sputtering, followed by oxidation...
Sun Jul 12, 2020 03:00
Molecules, Vol. 25, Pages 3180: Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors Molecules doi: 10.3390/molecules25143180 Authors: Wei Zhou Wenjin Zhang Yi Peng Zhi-Hong Jiang Lanyue Zhang Zhiyun Du Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein,...
Sun Jul 12, 2020 03:00
Molecules, Vol. 25, Pages 3179: Polyhedral [M2B5] Metallaborane Clusters and Derivatives: An Overview of Their Structural Features and Chemical Bonding Molecules doi: 10.3390/molecules25143179 Authors: Rini Prakash Jean-François Halet Sundargopal Ghosh A large number of metallaborane clusters and their derivatives with various structural arrangements are known. Among them, M2B5 clusters and derivatives constitute a significant class. Transition metals present in these species span...
Sun Jul 12, 2020 03:00
Molecules, Vol. 25, Pages 3177: LC-MS and Spectrophotometric Approaches for Evaluation of Bioactive Compounds from Peru Cocoa By-Products for Commercial Applications Molecules doi: 10.3390/molecules25143177 Authors: María de la Luz Cádiz-Gurrea Álvaro Fernández-Ochoa Francisco Javier Leyva-Jiménez Noelia Guerrero-Muñoz María del Carmen Villegas-Aguilar Sandra Pimentel-Moral Fernando Ramos-Escudero Antonio Segura-Carretero Peru is one of the main areas where there...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3178: Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum Molecules doi: 10.3390/molecules25143178 Authors: Susiany P. Lopes Lina M. Yepes Yunierkis Pérez-Castillo Sara M. Robledo Damião P. de de Sousa In low-income populations, neglected diseases are the principal cause of mortality. Of these, leishmaniasis and malaria, being parasitic, protozoan infections,...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3176: Fabrication and Plasma Surface Activation of Aligned Electrospun PLGA Fiber Fleeces with Improved Adhesion and Infiltration of Amniotic Epithelial Stem Cells Maintaining their Teno-inductive Potential Molecules doi: 10.3390/molecules25143176 Authors: Mohammad El Khatib Annunziata Mauro Ralf Wyrwa Miriam Di Mattia Maura Turriani Oriana Di Giacinto Björn Kretzschmar Thomas Seemann Luca Valbonetti Paolo Berardinelli Matthias Schnabelrauch...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3173: 5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules Molecules doi: 10.3390/molecules25143173 Authors: Mavridis Bermperoglou Pontiki Hadjipavlou-Litina The five membered heterocyclic oxazole group plays an important role in drug discovery. Oxazolones present a wide range of biological activities. In this article the synthesis of 4-substituted-2-phenyloxazol-5(4H)-ones from the appropriate substituted aldehydes via...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3174: Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels Molecules doi: 10.3390/molecules25143174 Authors: Agnese Gagliardi Silvia Voci Donatella Paolino Massimo Fresta Donato Cosco The controlled release of a compound entrapped in a biocompatible formulation is a sought-after goal in modern pharmaceutical technology. Zein is a hydrophobic protein which has several advantageous properties that make it suitable for...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3172: The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes Molecules doi: 10.3390/molecules25143172 Authors: Case Zubieta Doyle The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease—predominantly due to magnesium deficiency...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3175: The Effect of Nitrogen Fertigation and Harvesting Time on Plant Growth and Chemical Composition of Centaurea raphanina subsp. mixta (DC.) Runemark Molecules doi: 10.3390/molecules25143175 Authors: Spyridon A. Petropoulos Ângela Fernandes Maria Inês Dias Carla Pereira Ricardo C. Calhelha Marija Ivanov Marina D. Sokovic Isabel C.F.R. Ferreira Lillian Barros The aim of the present study was to evaluate the effect of nitrogen fertigation...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3171: Discovery of Novel Tankyrase Inhibitors through Molecular Docking-Based Virtual Screening and Molecular Dynamics Simulation Studies Molecules doi: 10.3390/molecules25143171 Authors: Vladimir P. Berishvili Alexander N. Kuimov Andrew E. Voronkov Eugene V. Radchenko Pradeep Kumar Yahya E. Choonara Viness Pillay Ahmed Kamal Vladimir A. Palyulin Tankyrase enzymes (TNKS), a core part of the canonical Wnt pathway, are a promising target...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3170: Characterization of Fatty Acid Composition Underlying Hypothalamic Inflammation in Aged Mice Molecules doi: 10.3390/molecules25143170 Authors: Ye Jin Kim Thai Hien Tu Sunggu Yang Jae Kwang Kim Jae Geun Kim Degenerative diseases, which can develop during aging, are underlined by inflammatory processes. Hypothalamic inflammation triggered by elevation in circulating fatty acid levels is directly coupled to metabolic disorders. The present study...
Sat Jul 11, 2020 03:00
Molecules, Vol. 25, Pages 3169: A Study on the Biodiversity of Pigmented Andean Potatoes: Nutritional Profile and Phenolic Composition Molecules doi: 10.3390/molecules25143169 Authors: Maria Bellumori Nancy A. Chasquibol Silva Laida Vilca Luisa Andrenelli Lorenzo Cecchi Marzia Innocenti Diletta Balli Nadia Mulinacci The characterization of six varieties of native Andean potatoes with a wide biodiversity in tuber shape, flesh, and skin color was performed, through...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3168: Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods Molecules doi: 10.3390/molecules25143168 Authors: Alexander Tamashevski Yuliya Harmaza Ekaterina Slobozhanina Roman Viter Igor Iatsunskyi The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3166: Study on Lavender Essential Oil Chemical Compositions by GC-MS and Improved pGC Molecules doi: 10.3390/molecules25143166 Authors: Guangyao Dong Xiaohui Bai Aoken Aimila Haji Akber Aisa Maitinuer Maiwulanjiang Lavender essential oil from the aerial parts of Lavandula angustifolia Mill. was analyzed by GC-MS equipped with three capillary columns of different polarities, which were HP-1, HP-5 ms and HP-INNOWax. A total of 40 compounds were identified...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3165: Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease Molecules doi: 10.3390/molecules25143165 Authors: Matheus de Freitas Silva Ellen Tardelli Lima Letizia Pruccoli Newton Castro Marcos Guimarães Fernanda M. R. da Silva Nathalia Fonseca Nadur Luciana de Azevedo Arthur Kümmerle Isabella Guedes Laurent Dardenne Vanessa Gontijo Andrea Tarozzi Claudio Viegas Alzheimer’s...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3167: Application Research of Biochar for the Remediation of Soil Heavy Metals Contamination: A Review Molecules doi: 10.3390/molecules25143167 Authors: Cheng Chen Xu Huang Jiang Yan Soil contamination by heavy metals threatens the quality of agricultural products and human health, so it is necessary to choose certain economic and effective remediation techniques to control the continuous deterioration of land quality. This paper is intended...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3163: Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity Molecules doi: 10.3390/molecules25143163 Authors: Misic Tadic Korzeniowska Nisavic Aksentijevic Kuzmanovic Zizovic Supercritical fluid extraction as an environmentally friendly technology was applied to isolate biologically active extracts from celery and parsley fruits for potential applications in the food industry. The...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3162: Switching the Conformation of 3,2′:6′,3′′-tpy Domains in 4′-(4-n-alkyloxyphenyl)-3,2′:6′,3′′-Terpyridines Molecules doi: 10.3390/molecules25143162 Authors: Rocco Prescimone Constable Housecroft The preparation and characterization of 4′-(4-n-octyloxyphenyl)-3,2′:6′,3′′-terpyridine (8) and 4′-(4-n-octyloxyphenyl)-3,2′:6′,3′′-terpyridine (9) are...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3164: 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells Molecules doi: 10.3390/molecules25143164 Authors: Ediriweera Moon Nguyen Cho 10-gingerol is a major phenolic lipid found in the rhizomes of ginger (Zingiber officinale). Being amphiphilic in nature, phenolic lipids have the ability to incorporate into cell membranes and modulate membrane properties. The purpose of the present...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3160: Vasodilatory Effect of Phellinus linteus Extract in Rat Mesenteric Arteries Molecules doi: 10.3390/molecules25143160 Authors: Kwon Haam Byeon Choi Shin Choi Lee : Phellinus linteus is a well-known medicinal mushroom that is widely used in Asian countries. In several experimental models, Phellinus linteus extracts were reported to have various biological effects, including anti-inflammatory, anti-cancer, hepatoprotective, anti-diabetic,...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3159: Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review Molecules doi: 10.3390/molecules25143159 Authors: Nemi Malhotra Jiann-Shing Lee Rhenz Alfred D. Liman Johnsy Margotte S. Ruallo Oliver B. Villaflores Tzong-Rong Ger Chung-Der Hsiao The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3158: The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies Molecules doi: 10.3390/molecules25143158 Authors: Miriam Rossi Sandjida Aktar Marissa Davis Emily Hefter Feuss Samara Roman-Holba Kelly Wen Christopher Gahn Francesco Caruso Coumarins are plant-derived secondary metabolites. The crystal structure of three coumarins—bergamottin,...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3161: Study on a Three-Step Rapid Assembly of Zolpidem and Its Fluorinated Analogues Employing Microwave-Assisted Chemistry Molecules doi: 10.3390/molecules25143161 Authors: Fajkis Marcinkowska Gryzło Krupa Kolaczkowski We developed an efficient microwave-assisted three-step synthesis of zolpidem and its fluorinated analogues 1–3. The procedure relays on the utilization of easily accessible and inexpensive starting materials. Our protocol...
Fri Jul 10, 2020 03:00
Molecules, Vol. 25, Pages 3156: Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery Molecules doi: 10.3390/molecules25143156 Authors: Auriemma Russo Pasquale Del Gaudio García-González Landín Aquino Polysaccharide-based hydrogel particles (PbHPs) are very promising carriers aiming to control and target the release of drugs with different physico-chemical properties. Such delivery systems can offer benefits through the proper encapsulation...
Fri Jul 10, 2020 03:00
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