Abstract The world’s number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contributes to the underlying pathology. Therefore, therapeutic targeting of inflammatory pathways in patients with cardiovascular...
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Abstract Dexmedetomidine inhibits the release of inflammatory cytokines and exerts a systemic anti-inflammatory effect and has potential protective effects on vital organs such as lung, heart, and kidneys. The aim of this study was to investigate the effect of dexmedetomidine on LPS-treated HK-2 cells in vitro and explore the potential mechanisms. The HK-2 cells were pretreated with dexmedetomidine before LPS induction. CCK-8, flow cytometry,...
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Fri Jul 10, 2020 03:00
The Journal of Antibiotics, Published online: 10 July 2020; doi:10.1038/s41429-020-0346-xSpiropiperidyl rifabutins: expanded in vitro testing against ESKAPE pathogens and select bacterial biofilms
Fri Jul 10, 2020 03:00
The Journal of Antibiotics, Published online: 10 July 2020; doi:10.1038/s41429-020-0348-8Highly oxygenated angucycline from Streptomyces sp. KCB15JA014
Fri Jul 10, 2020 03:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01011A, PaperXiaonan Gao, Congcong Zhao, Keyan Wei, Bo Hu, Yu-Qin Chen, Kehua Xu, Bo TangThe anticancer mechanism for reduced/oxidized ascorbic acid (AA/DHA) is of great significance for clinical cancer therapies. A pH controlled fluorescent nanocarrier was designed to targetable deliver AA and DHA into...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00967A, PaperHye Jin Jeong, Sein Min, Keunhong JeongSignal amplification by reversible exchange (SABRE), a parahydrogen-based hyperpolarization technique, is valuable in detecting low concentrations of chemical compounds, which facilitates the understanding of their functions at molecular level as...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jul 10, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00676A, PaperJesper Uhd, Laura Miotke, Hanlee P. Ji, Marina Dunaeva, Ger J. M. Pruijn, Christian Damsgaard Jørgensen, Emil Laust Kristoffersen, Victoria Birkedal, Christina Westmose Yde, Finn Cilius Nielsen, Jonas Hansen, Kira AstakhovaFast and reliable assay for amplification-free absolute quantification of DNA and RNA in biofluids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed...
Fri Jul 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01280G, PaperMaryam Tabatabaei-Anraki , Daniel H. Lysak, Ronald Soong, Myrna Simpson, Manfred Spraul, Wolfgang Bermel, Hermann Heumann, Marcel Gundy, Holger Boenisch, Andre SimpsonDaphnia (freshwater fleas) are among the most widely used organisms in regulatory aquatic toxicology/ecology, while their recent listing as an NIH model organism is stimulating research for understanding human diseases...The content of this RSS Feed (c) The Royal Society...
Fri Jul 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01203C, PaperYingqi Pei, Jing Zhang, Kang Wu, Anping Deng, Jianguo LiA rapid and highly-sensitive flow injection chemiluminescence immunoassay was developed to detect ractopamine residues in pork products. Palladium nanocubes with excellent catalytic performance for traditional luminol-PIP-H2O2 chemiluminescence system was used...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jul 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01199A, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yi Wen, Yundi Chen, Guosheng Wang, Komal Abhange, Fei Xue, Zachary Quinn, Wenjun Mao, Yuan WanExtracellular vesicles (EVs) are cell-derived vesicles which encapsulate a variety of molecules. Numerous studies demonstrated EVs as signaling mediators of intercellular communication are heavily involved in physiological and pathological...
Fri Jul 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00759E, PaperGuanglu Zhang, Tong Ding, Qian Shi, Zhongyao Jiang, Yaxin Niu, Minmin Zhang, Lili Tong, Zhenzhen Chen, Bo TangHow to further improve the sensitivity of paper spray mass spectrometry (PS-MS) is very important for its application of low content substances detection. Covalent organic frameworks (COFs) are a kind...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jul 10, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00984A, PaperMarjan Dolatmoradi, Jarod A. Fincher, Andrew R. Korte, Nicholas J. Morris, Akos VertesLaser ablation electrospray ionization (LAESI) driven by mid-infrared laser pulses, allows the direct analysis of biological tissues with minimal sample preparation. Dedicated remote ablation chambers have been developed to eliminate...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Jul 10, 2020 02:00
Abstract Selenium (Se) is an essential trace element with important functions in animals and whose deficiency is associated with reproductive failures. The aim of this study was to investigate the effect of Se concentrations during in vitro maturation (IVM) of Bos taurus oocyte within the reference ranges for Se status in cattle. For this purpose, Aberdeen Angus cumulus–oocyte complexes (COCs) were matured in IVM medium supplemented with 0, 10, 50, and 100 ng/mL Se (control,...
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Abstract Concentrations of toxic elements (lead, cadmium, mercury, and arsenic) were measured in water, sediment, and four commercial fish species (Cyprinus carpio, Hypophthalmichthys molitrix, Silurus glanis, and Esox lucius) and their tissues (muscle, liver, and kidney) from Saničani Lake, Bosnia and Herzegovina. The concentration of toxic elements was measured by atomic absorption spectrometry. Toxic element concentrations were significantly affected by the fish species and...
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Abstract We report here a simple microwave irradiation method (850 W, 3 min) for the synthesis of palladium nanoparticles (Pd NPs) using ascorbic acid (as reducing agent) and sodium alginate (as stabilizer agent). The synthesized nanoparticles were characterized using transmission electron microscopy (TEM), energy dispersive X-ray (EDX), X-ray diffraction spectroscopy (XRD), UV-Visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. Antioxidant properties...
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Abstract The aim of this study was to determine the levels of 8 microelements (Zn, Fe, Cu, Ca, Mn, Mg, Cd, Pb) and the health status test of 184 female nursing students at a college in Zhaoqing, China, and to get the relevant data of nursing students in a Zhaoqing University. The relationship between microelements and physical health status was investigated. There were significant differences in the levels of Ca, Mg, Mn, and Pb between grade 1 and grade 2 students (all, P < 0.01)....
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Abstract Changes in the macro and trace element composition of saliva might be indicative for pathological changes in periodontal tissues. However, there is a lack of evidence in the literature showing associations between mineral elements and periodontal status. The aim of this study was to determine whether such associations occur. Totally, 190 systemically healthy non-smoker participants (mean age 32.2 ± 6.02; 50 periodontally healthy, 50 gingivitis, 50 chronic periodontitis,...
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Abstract Fish is important in the traditional diet of Jamaicans, and the fishing industry contributes to social and economic development, as well as food security in Jamaica. However, there are associated health risks from contaminant exposure. The aim of this paper was to use risk-benefit analysis methods to determine the best fish species for consumption. Composite samples consisting of 14 fish species were collected from major fishing villages in 2016 and measured for total...
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Abstract Manganese (Mn) pollution is an important environmental problem because of the potential toxicity to human and animal health. However, the effects of Mn on energy metabolism and autophagy are not clear. Consequently, we examined the effects of excessive and chronic exposure to Mn on liver function, oxidative stress, respiratory chain complex activity, and autophagy in chicken liver. Our results indicated that the accumulation of Mn in the liver and levels of AST and ALT...
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Abstract Bioaccessibility study is of great significance to the health risk assessment of trace elements in the seafood. In this work, the most consumed crab (Portunus trituberculatus) in coastal area of Shandong, China was analyzed to study the distribution and the bioaccessibility of cadmium (Cd) in the edible tissues of crab, and the dietary risk from consumption of crab was also evaluated. Results showed that the content of Cd in the whole edible tissues of 109 crab specimens...
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Abstract In order to explore the characteristics of the rare earth elements (REEs) and selenium (Se) among the Chinese centenarians, the concentrations of REE and Se were detected in the hair of healthy centenarians living in typical Chinese longevity region, and the influences of physiological conditions and behavior on the concentrations of REE and Se were assessed. The average values of light RE (LRE) and heavy RE (HRE) are 31.87 and 11.12 ng/g. Female centenarians had higher...
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Abstract Arsenic and fluoride are two of the major groundwater pollutants. To better understand the liver damage induced during development, 24 male rats exposed to fluoride (F), arsenic (As), and their combination (As + F) from the prenatal stage to 90 days after birth were selected for analysis. Histopathological results showed vacuolar degeneration in the As and As + F groups. Compared to those in the control group, aspartate aminotransferase and alanine aminotransferase levels...
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Abstract Studies on the ingredients of energy drinks and isotonic drinks focus mainly on the evaluation of their content in terms of substances modulating the body’s metabolism or those regarded as food additives. Having regard to the widespread availability of these beverages, their diversity and the limited number of studies in this area, the aim of this study was to analyse the contents of F, Al, Cd, Cr, Mn, V, Co, Ni, Zn, Bi and Na in the energy drinks and isotonic drinks...
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Abstract This study evaluates the effect of three calcium levels in the diet (normal, moderate, and severe calcium depletion) on bone metabolism of male Wistar rats during their growth period. Bone mineral density (BMD) and femur length were determined in vivo during the growth stage using a single X-ray transmission system. The apparent calcium absorption was calculated in the rat adolescent and adulthood stages. At the end of the experiment, calcium concentrations in serum...
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Abstract Autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are two developmental disorders that affect children worldwide, and are linked to both genetic and environmental factors. This study aims to investigate the levels of lead, manganese, and zinc in each of ASD, ADHD, and ASD with comorbid ADHD in Syrian children born or grown during the Syrian crisis. Lead and manganese were measured in the whole blood, and zinc was measured in the serum...
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Abstract The objective of this study was to determine the effects of selenium (Se) on antioxidative function and the synthesis of milk protein in bovine mammary epithelial cells (BMECs). Two experiments were conducted using a single-factor completely randomized design study. In part I, BMECs were randomly divided into seven groups: control (without Se) and six Se treatments (10, 20, 50, 100, 150, and 200 nmol/L). In part II, based on the results of part I, we used lipopolysaccharide...
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Determination of markers of systemic inflammation is one of the important directions in the study of pathogenesis and improvement of diagnosis of chronic obstructive pulmonary disease (COPD), asthma-COPD overlap (ACO), and bronchial asthma (BA). The aim of our work was a comparative study of the features of changes in serum levels of IL-17, IL-18, and TNF-α in patients with COPD, ACO, and BA with various severity of the disease, as well as evaluation of the relationship between the level of these...
Sun Jul 12, 2020 20:35
Spontaneous preterm birth (sPTB), defined as delivery before 37 weeks of gestation, is thought to be a multifactorial syndrome. However, the inflammatory imbalance at the maternal-fetal interface promotes excessive secretion of inflammatory factors and induces apoptosis and degradation of the extracellular matrix (ECM), which can subsequently lead to preterm birth. As an anti-inflammatory molecule in the IL-1 family, interleukin-37 (IL-37) mainly plays an inhibiting role in a variety of inflammatory...
Sat Jul 11, 2020 13:20
Objective. Atherosclerosis is a chronic inflammatory disease which is responsible for many clinical manifestations. The present study was to investigate the anti-inflammatory functions and mechanisms of TNK1 in atherosclerosis. Methods. The ApoE(-/-) mice and human carotid endarterectomy (CEA) atherosclerotic plaques were used to investigate the differential expression of TNK1. The ApoE(-/-) mice were fed with high-fat diet (HFD) or normal-fat diet (NFD) for 8 weeks; the aorta was separated and stained...
Fri Jul 10, 2020 11:35
Sun Jul 12, 2020 23:55
Ovarian edema, ovarian leiomyoma, and double inferior vena cava are all rare clinical entities. The coexistence of all these entities has not been yet reported in the literature.
Sun Jul 12, 2020 03:00
Chronic calcified subdural empyema is an exceedingly rare central nervous system infection with a handful of cases published to date. Reported cases presented with nonspecific clinical signs and symptoms. The ...
Sat Jul 11, 2020 03:00
Anomalous coronary arteries occur in less than 1% of the population and have been implicated in sudden cardiac and exercise-related death. The most common variant involves the left circumflex artery arising fr...
Fri Jul 10, 2020 03:00
To assess correlations between auditory-perceptual and self-reported speech evaluation methods for substitution voicing (SV) and to investigate the robustness of these methods in a clinical setting.
Sun Jul 12, 2020 03:00
To verify the immediate effects of voiced gargling on the electrical activity of extrinsic laryngeal muscles and vocal self-assessment.
Sat Jul 11, 2020 03:00
This study aimed to assess the feasibility of a neck-surface accelerometer (ACC) for estimating the amount of acoustic output produced during phonation regardless of individual differences or the mouth configuration.
Fri Jul 10, 2020 03:00
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