Related Articles Alcohol increases exosome release from microglia to promote complement C1q induced cellular death of proopiomelanocortin neurons in the hypothalamus in a rat model of fetal alcohol spectrum disorders. J Neurosci. 2020 Sep 04;: Authors: Mukherjee S, Cabrera MA, Boyadjieva NI, Berger G, Rousseau B, Sarkar DK Abstract Microglia, a type of CNS immune cell, have been shown to contribute to ethanol-activated neuronal death of the...
Sun Sep 06, 2020 13:00
Abstract The present study was aimed at determining which combination of demographic, genetic, cognitive, neurophysiological, and neuroanatomical factors may predict differences in time to progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). To this end, a sample of 121 MCIs was followed up during a 5-year period. According to their clinical outcome, MCIs were divided into two subgroups: (i) the “progressive” MCI group (n = 46; mean time to progression...
Fri Sep 04, 2020 03:00
Related Articles Endoplasmic reticulum stress induces growth retardation by inhibiting growth hormone IGF-I axis. Growth Horm IGF Res. 2020 Aug 28;55:101341 Authors: Xia W, Wang Y, Zhang Y, Ge X, Lv P, Cheng J, Wei J Abstract OBJECTIVE: Insulin-like growth factor 1 (IGFI) is one of several growth factors which is induced by growth hormone (GH), which activates the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5)...
Sun Sep 06, 2020 14:58
Related Articles Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts. J Surg Res. 2020 Sep 02;257:306-316 Authors: Lv W, Liu S, Zhang Q, Yi Z, Bao X, Feng Y, Ren Y Abstract BACKGROUND: A keloid is a type of pathological scar often caused by abnormal tissue repair after a skin injury and is more common in genetically susceptible individuals. cAMP is a universal second messenger and regulates...
Sun Sep 06, 2020 14:58
Related Articles Paternal bisphenol A exposure in mice impairs glucose tolerance in female offspring. Food Chem Toxicol. 2020 Sep 02;:111716 Authors: Rashid CS, Bansal A, Mesaros C, Bartolomei MS, Simmons RA Abstract Humans are ubiquitously exposed bisphenol A (BPA), and epidemiological studies show a positive association between BPA exposure and diabetes risk, but the impact of parental exposure on offspring diabetes risk in humans is unknown....
Sun Sep 06, 2020 14:58
Related Articles Immunoglobulin A and the microbiome. Curr Opin Microbiol. 2020 Sep 01;56:89-96 Authors: Yang Y, Palm NW Abstract The trillions of microbes that constitutively colonize the intestine (the gut microbiota) impact diverse aspects of human physiology in health and disease. Immunoglobulin A (IgA) is the most abundant antibody isotype produced at mucosal surfaces, and nearly two grams of IgA is secreted into the intestine every day....
Sun Sep 06, 2020 14:58
Related Articles Protein Arginine Methyltransferase 5 in T Lymphocyte Biology. Trends Immunol. 2020 Sep 01;: Authors: Sengupta S, Kennemer A, Patrick K, Tsichlis P, Guerau-de-Arellano M Abstract Protein arginine methyltransferase 5 (PRMT5) is the major methyltransferase (MT) catalyzing symmetric dimethylation (SDM). PRMT5 regulates developmental, homeostatic and disease processes in vertebrates and invertebrates, and a carcinogenic role has...
Sun Sep 06, 2020 14:58
Related Articles Stealth Killing by Uterine NK Cells for Tolerance and Tissue Homeostasis. Cell. 2020 Sep 03;182(5):1074-1076 Authors: Dogra P, Farber DL Abstract Human natural killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of infected cells and are the predominant immune cell at the maternal-fetal interface. In this issue of Cell, Crespo et al. show that human NK cells in the decidual region...
Sun Sep 06, 2020 14:58
Related Articles Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis. Cell. 2020 Aug 31;: Authors: Neupane AS, Willson M, Chojnacki AK, Vargas E Silva Castanheira F, Morehouse C, Carestia A, Keller AE, Peiseler M, DiGiandomenico A, Kelly MM, Amrein M, Jenne C, Thanabalasuriar A, Kubes P Abstract During respiration, humans breathe in more than 10,000 liters of non-sterile air daily, allowing some pathogens...
Sun Sep 06, 2020 14:58
Related Articles Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men. Diabetes Care. 2020 Sep 04;: Authors: Xiao Q, Qian J, Evans DS, Redline S, Lane NE, Ancoli-Israel S, Scheer FAJL, Stone K, Osteoporotic Fractures in Men (MrOS) Study Group Abstract OBJECTIVE: Disruption of rest-activity rhythms is cross-sectionally associated with metabolic disorders, including type...
Sun Sep 06, 2020 14:58
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 05, 2020 14:58
Related Articles Association between body size phenotypes and subclinical atherosclerosis. J Clin Endocrinol Metab. 2020 Sep 03;: Authors: Rossello X, Fuster V, Oliva B, Sanz J, Fernández Friera LA, López-Melgar B, Mendiguren JM, Lara-Pezzi E, Bueno H, Fernández-Ortiz A, Ibanez B, Ordovás JM Abstract CONTEXT: The underlying relationship between body mass index (BMI), cardiometabolic disorders and subclinical atherosclerosis (SA) is poorly understood....
Fri Sep 04, 2020 22:56
Related Articles Miniaturized Piezo Force Sensor for a Medical Catheter and Implantable Device. ACS Appl Electron Mater. 2020 Aug 25;2(8):2669-2677 Authors: Gil B, Li B, Gao A, Yang GZ Abstract Real-time monitoring of intrabody pressures can benefit from the use of miniaturized force sensors during surgical interventions or for the recovery period thereafter. Herein, we present a force sensor made of poly(vinylidene fluoride)-co-trifluoroethylene...
Fri Sep 04, 2020 22:56
Related Articles Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms. Transl Vis Sci Technol. 2020 Aug;9(9):13 Authors: Justis BM, Coburn CE, Tyler EM, Showalter RS, Dissler BJ, Li M, McNamara NA, Laurie GW, McKown RL Abstract Purpose: Lacritin is a tear glycoprotein with pro-tearing and pro-ocular surface homeostasis activities that is selectively deficient in most dry eye tears. Proteoforms include an active monomer, inactive...
Fri Sep 04, 2020 22:56
Related Articles Hyperglycemia Augments Endothelin-1-Induced Constriction of Human Retinal Venules. Transl Vis Sci Technol. 2020 Aug;9(9):1 Authors: Chen YL, Rosa RH, Kuo L, Hein TW Abstract Purpose: Endothelin-1 (ET-1) is a potent vasoactive factor implicated in development of diabetic retinopathy, which is commonly associated with retinal edema and hyperglycemia. Although the vasomotor activity of venules contributes to the regulation of...
Fri Sep 04, 2020 22:56
Related Articles Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut. Commun Biol. 2020 Sep 02;3(1):483 Authors: Qi H, Wei J, Gao Y, Yang Y, Li Y, Zhu H, Su L, Su X, Zhang Y, Yang R Abstract The expansion of Enterobacteriaceae, such as E. coli is a main characteristic of gut inflammation and is related to multiple human diseases. However, how to control these E. coli overgrowth is not well understood. Here, we demonstrate...
Fri Sep 04, 2020 22:56
Related Articles Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract. Sci Rep. 2020 Sep 02;10(1):14496 Authors: Ghaddar B, Veeren B, Rondeau P, Bringart M, Lefebvre d'Hellencourt C, Meilhac O, Bascands JL, Diotel N Abstract Overweight and obesity are worldwide health concerns leading to many physiological disorders. Recent data highlighted their deleterious effects on...
Fri Sep 04, 2020 22:56
Related Articles SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control. Sci Transl Med. 2020 Sep 02;12(559): Authors: Montgomery MK, Bayliss J, Devereux C, Bezawork-Geleta A, Roberts D, Huang C, Schittenhelm RB, Ryan A, Townley SL, Selth LA, Biden TJ, Steinberg GR, Samocha-Bonet D, Meex RCR, Watt MJ Abstract Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to...
Fri Sep 04, 2020 22:56
Related Articles Human Cytomegalovirus-Induced Autophagy Prevents Necroptosis Of Infected Monocytes. J Virol. 2020 Sep 02;: Authors: Altman AM, Miller MJ, Mahmud J, Smith NA, Chan GC Abstract Key to the viral dissemination strategy of human cytomegalovirus (HCMV) is the induction of monocyte survival, which are normally short-lived cells. Autophagy is a cellular process that preserves cellular homeostasis and promotes cellular survival during...
Fri Sep 04, 2020 22:56
Related Articles Deoxynivalenol Exposure Suppresses Adipogenesis by Inhibiting the Expression of Peroxisome Proliferator-Activated Receptor Gamma 2 (PPARγ2) in 3T3-L1 Cells. Int J Mol Sci. 2020 Aug 31;21(17): Authors: Zhao Y, Tang S, Lin R, Zheng T, Li D, Chen X, Zhu J, Wen J, Deng Y Abstract Deoxynivalenol (DON)-a type B trichothecene mycotoxin, mainly produced by the secondary metabolism of Fusarium-has toxic effects on animals and humans....
Fri Sep 04, 2020 22:56
29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/09/06PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Sep 06, 2020 17:49
106 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 05, 2020 18:02
Related Articles Repeatability and reproducibility of post-mortem central corneal thickness measurements using a portable optical coherence tomography system in humans: a prospective multicenter study. Sci Rep. 2020 Sep 02;10(1):14508 Authors: Napoli PE, Nioi M, Gabiati L, Laurenzo M, De-Giorgio F, Scorcia V, Grassi S, d'Aloja E, Fossarello M Abstract To assess the repeatability and reproducibility of post-mortem central corneal thickness (CCT)...
Fri Sep 04, 2020 22:15
Related Articles Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations. Nat Commun. 2020 Sep 02;11(1):4410 Authors: Todd WD, Venner A, Anaclet C, Broadhurst RY, De Luca R, Bandaru SS, Issokson L, Hablitz LM, Cravetchi O, Arrigoni E, Campbell JN, Allen CN, Olson DP, Fuller PM Abstract The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined...
Fri Sep 04, 2020 22:15
Related Articles Lead exposure induces cell autophagy via blocking the Akt/mTOR signaling in rat astrocytes. J Toxicol Sci. 2020;45(9):559-567 Authors: Huang Y, Liao Y, Zhang H, Li S Abstract Lead is a main threat to human health due to its neurotoxicity and the astrocyte is known to be a common deposit site of lead in vivo. However, the detailed mechanisms related to lead exposure in the astrocytes were unclear. In order to deeply investigate...
Fri Sep 04, 2020 22:15
Related Articles Unique morphological characteristics in the ovary of cotton rat (Sigmodon hispidus). J Reprod Dev. 2020 Sep 03;: Authors: Islam MR, Ichii O, Nakamura T, Irie T, Masum MA, Hosotani M, Otani Y, Elewa YHA, Kon Y Abstract Cotton rats (Sigmodon hispidus, CRs) are commonly used as animal models in biomedical research. However, the reproductive characteristics and ovarian development in the CRs has not been widely investigated. We...
Fri Sep 04, 2020 22:15
Related Articles Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice. J Atheroscler Thromb. 2020 Sep 02;: Authors: Ganbaatar B, Fukuda D, Shinohara M, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M Abstract AIM: The bioactive lipid, sphingosine-1-phosphate (S1P), has various roles in the physiology and pathophysiology of many diseases. There are five S1P receptors;...
Fri Sep 04, 2020 22:15
Related Articles LILRB4-Targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia. Mol Cancer Ther. 2020 Sep 02;: Authors: Anami Y, Deng M, Gui X, Yamaguchi A, Yamazaki CM, Zhang N, Zhang C, An Z, Tsuchikama K Abstract Acute myeloid leukemia (AML) is the most common and aggressive blood cancer in adults. In particular, significant unmet medical needs exist for effective treatment strategies for M4 and M5 AML subtypes. Antibody-drug...
Fri Sep 04, 2020 22:15
Related Articles Ephemeranthol A Suppresses Epithelial to Mesenchymal Transition and FAK-Akt Signaling in Lung Cancer Cells. Anticancer Res. 2020 Sep;40(9):4989-4999 Authors: Nonpanya N, Prakhongcheep O, Petsri K, Jitjaicham C, Tungsukruthai S, Sritularak B, Chanvorachote P Abstract BACKGROUND/AIM: Epithelial to mesenchymal transition (EMT) is a cellular process that facilitates cancer metastasis. Therefore, therapeutic approaches that target...
Fri Sep 04, 2020 22:15
Related Articles Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases. Int J Mol Sci. 2020 Aug 31;21(17): Authors: Arrazola Sastre A, Luque Montoro M, Gálvez-Martín P, Lacerda HM, Lucia AM, Llavero F, Zugaza JL Abstract Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation,...
Fri Sep 04, 2020 22:15
Related Articles A Simplified Iohexol-Based Method to Measure Renal Function in Sheep Models of Renal Disease. Biology (Basel). 2020 Aug 31;9(9): Authors: Luis-Lima S, Mas-Sanmartin C, Rodríguez-Rodríguez AE, Porrini E, Ortiz A, Gaspari F, Diaz-Martin L, Åsberg A, Jenssen T, Jiménez-Sosa A, Martinez-Ros P, Gonzalez-Bulnes A Abstract Sheep are highly adequate models for human renal diseases because of their many similarities in the histology...
Fri Sep 04, 2020 22:15
Related Articles Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer's Disease and the Blood-Brain Barrier. Int J Mol Sci. 2020 Aug 31;21(17): Authors: Semyachkina-Glushkovskaya O, Postnov D, Penzel T, Kurths J Abstract Cerebral small vessel disease (CSVD) is a leading cause of cognitive decline in elderly people and development of Alzheimer's disease (AD). Blood-brain...
Fri Sep 04, 2020 22:15
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