IJMS, Vol. 21, Pages 6511: Human Natural Antibodies Recognizing Glycan Galβ1-3GlcNAc (LeC) International Journal of Molecular Sciences doi: 10.3390/ijms21186511 Authors: Kira Dobrochaeva Nailya Khasbiullina Nadezhda Shilova Nadezhda Antipova Polina Obukhova Oxana Galanina Mikhail Gorbach Inna Popova Sergey Khaidukov Natalia Grishchenko Nikolai Tupitsyn Jacques Le Pendu Nicolai Bovin The level of human natural antibodies of immunoglobulin M isotype...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6510: Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects International Journal of Molecular Sciences doi: 10.3390/ijms21186510 Authors: Alexandre A. de de Castro Daniel A. Polisel Bruna T. L. Pereira Elaine F. F. da da Cunha Kamil Kuca Eugenie Nepovimova Teodorico C. Ramalho Organophosphorus (OP) compounds are used as both chemical weapons and pesticides....
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6509: Altered Phosphorylation of Cytoskeleton Proteins in Peripheral Blood Mononuclear Cells Characterizes Chronic Antibody-Mediated Rejection in Kidney Transplantation International Journal of Molecular Sciences doi: 10.3390/ijms21186509 Authors: Maria Teresa Rocchetti Federica Rascio Giuseppe Castellano Marco Fiorentino Giuseppe Stefano Netti Federica Spadaccino Elena Ranieri Anna Gallone Loreto Gesualdo Giovanni Stallone Paola Pontrelli...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6508: High Resolution Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Visualization of Choroidal Vascular Occlusion International Journal of Molecular Sciences doi: 10.3390/ijms21186508 Authors: Van Phuc Nguyen Yanxiu Li Jessica Henry Wei Zhang Xueding Wang Yannis M. Paulus Photoacoustic microscopy is a novel, non-ionizing, non-invasive imaging technology that evaluates tissue absorption of short-pulsed light through the sound...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6507: Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem (iPS) Cells Suppress or Activate T Cells via Costimulatory Signals International Journal of Molecular Sciences doi: 10.3390/ijms21186507 Authors: Sunao Sugita Yoko Futatsugi Masaaki Ishida Ayaka Edo Masayo Takahashi Human retinal pigment epithelial (RPE) cells derived from induced pluripotent stem (iPS) cells have immunosuppressive properties. However, RPE cells are also known...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6506: An Iatrogenic Model of Brain Small-Vessel Disease: Post-Radiation Encephalopathy International Journal of Molecular Sciences doi: 10.3390/ijms21186506 Authors: Rita Moretti Paola Caruso We studied 114 primitive cerebral neoplasia, that were surgically treated, and underwent radiotherapy (RT), and compared their results to those obtained by 190 patients diagnosed with subcortical vascular dementia (sVAD). Patients with any form of primitive cerebral neoplasia...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6505: Construction of Gossypium barbadense Mutant Library Provides Genetic Resources for Cotton Germplasm Improvement International Journal of Molecular Sciences doi: 10.3390/ijms21186505 Authors: Muhammad Ali Abid Peilin Wang Tao Zhu Chengzhen Liang Zhigang Meng Waqas Malik Sandui Guo Rui Zhang Allotetraploid cotton (Gossypium hirsutum and Gossypium barbadense) are cultivated worldwide for its white fiber. For centuries, conventional breeding...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6504: Cataract-Associated New Mutants S175G/H181Q of βΒ2-Crystallin and P24S/S31G of γD-Crystallin Are Involved in Protein Aggregation by Structural Changes International Journal of Molecular Sciences doi: 10.3390/ijms21186504 Authors: In-Kang Song Seungjin Na Eunok Paek Kong-Joo Lee β/γ-Crystallins, the main structural protein in human lenses, have highly stable structure for keeping the lens transparent. Their mutations have been linked...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6502: New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21186502 Authors: Adrian H. Teruel Isabel Gonzalez-Alvarez Marival Bermejo Virginia Merino Maria Dolores Marcos Felix Sancenon Marta Gonzalez-Alvarez Ramon Martinez-Mañez Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD)....
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6503: Functional Grading of a Transversely Isotropic Hyperelastic Model with Applications in Modeling Tricuspid and Mitral Valve Transition Regions International Journal of Molecular Sciences doi: 10.3390/ijms21186503 Authors: Rajarshi Roy Eric Warren Yaoyao Xu Caleb Yow Rama S. Madhurapantula Joseph P. R. O. Orgel Kevin Lister Surgical simulators and injury-prediction human models require a combination of representative tissue geometry and accurate...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6501: Chemoenzymatic Synthesis of the New 3-((2,3-Diacetoxypropanoyl)oxy)propane-1,2-diyl Diacetate Using Immobilized Lipase B from Candida antarctica and Pyridinium Chlorochromate as an Oxidizing Agent International Journal of Molecular Sciences doi: 10.3390/ijms21186501 Authors: Esteban Plata Mónica Ruiz Jennifer Ruiz Claudia Ortiz John J. Castillo Roberto Fernández-Lafuente To exploit the hydrolytic activity and high selectivity of immobilized lipase...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6500: Lasso Peptide Microcin J25 Effectively Enhances Gut Barrier Function and Modulates Inflammatory Response in an Enterotoxigenic Escherichia coli-Challenged Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21186500 Authors: Xiuliang Ding Haitao Yu Shiyan Qiao Bacterial resistance leads to severe public health and safety issues worldwide. Alternatives to antibiotics are currently needed. A promising lasso peptide, microcin J25 (MccJ25),...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6498: Insight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21186498 Authors: Chen Xie Wenjuan Jiang Jerome J. Lacroix Yun Luo Jijun Hao Activins transduce the TGF-β pathway through a heteromeric signaling complex consisting of type I and type II receptors, and activins also inhibit bone morphogenetic protein (BMP) signaling mediated by type I receptor...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6499: MiR-581/SMAD7 Axis Contributes to Colorectal Cancer Metastasis: A Bioinformatic and Experimental Validation-Based Study International Journal of Molecular Sciences doi: 10.3390/ijms21186499 Authors: Xiaojuan Zhao Shuzhen Liu Bianbian Yan Jin Yang Erfei Chen Metastasis is a well-known poor prognostic factor and primary cause of mortality in patients with colorectal cancer (CRC). Recently, with the progress of high through-put sequencing, aberrantly...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6497: The Transcription Factor TCF1 in T Cell Differentiation and Aging International Journal of Molecular Sciences doi: 10.3390/ijms21186497 Authors: Chulwoo Kim Jun Jin Cornelia M. Weyand Jörg J. Goronzy The transcription factor T cell factor 1 (TCF1), a pioneer transcription factor as well as a downstream effector of WNT/β-catenin signaling, is indispensable for T cell development in the thymus. Recent studies have highlighted the additional...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6496: The Role of Losartan as a Potential Neuroregenerative Pharmacological Agent after Aneurysmal Subarachnoid Haemorrhage International Journal of Molecular Sciences doi: 10.3390/ijms21186496 Authors: Stefan Wanderer Lukas Andereggen Jan Mrosek Sepide Kashefiolasl Serge Marbacher Jürgen Konczalla Background: Cerebral vasospasm (CVS) remains a major cause of delayed cerebral ischaemia following aneurysmal subarachnoid haemorrhage (SAH), making it...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6494: Definition of a Novel Plasmid-Based Gene Transfection Protocol of Mammalian Skeletal Muscles by Means of In Vivo Electroporation International Journal of Molecular Sciences doi: 10.3390/ijms21186494 Authors: Enrico P. Spugnini Manuel Scimeca Bruno Amadio Giancarlo Cortese Maurizio Fanciulli Bruno Vincenzi Antonio De Luca Alfonso Baldi We describe an original electroporation protocol for in vivo plasmid DNA transfection. The right hind limbs...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6493: Transcriptome Analysis of Testis from HFD-Induced Obese Rats (Rattus norvigicus) Indicated Predisposition for Male Infertility International Journal of Molecular Sciences doi: 10.3390/ijms21186493 Authors: Ahmed M. El-Shehawi Samir El-Shazly Mohamed Ahmed Mohamed Alkafafy Samy Sayed Samy Farouk Saqer S. Alotaibi Mona M. Elseehy Obesity is a worldwide life-threatening metabolic disorder, associated with various chronic diseases, including...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6495: Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review International Journal of Molecular Sciences doi: 10.3390/ijms21186495 Authors: Susanne Naumann Dirk Haller Peter Eisner Ute Schweiggert-Weisz Plant compounds are described to interact with bile acids during small intestinal digestion. This review will summarise mechanisms of interaction between bile acids and plant compounds, challenges in in vivo and in vitro analyses, and...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6492: FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21186492 Authors: Jonathan R. Hughes Jason L. Parsons FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of magnitude higher than what is currently used in conventional clinical radiotherapy, and has the potential to revolutionize the future of cancer treatment. FLASH radiotherapy...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6491: SCH23390 Reduces Methamphetamine Self-Administration and Prevents Methamphetamine-Induced Striatal LTD International Journal of Molecular Sciences doi: 10.3390/ijms21186491 Authors: Yosef Avchalumov Wulfran Trenet Juan Piña-Crespo Chitra Mandyam Extended-access methamphetamine self-administration results in unregulated intake of the drug; however, the role of dorsal striatal dopamine D1-like receptors (D1Rs) in the reinforcing properties of methamphetamine...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6490: G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21186490 Authors: Chuang Chen Chou Ho Chang Estrogen is an important hormone to regulate skeletal physiology via estrogen receptors. The traditional estrogen receptors are ascribed to two nuclear estrogen receptors (ERs), ERα and...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6488: Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovine Parthenogenetic Embryos Revealed by Fluorescent Staining and RNA-seq International Journal of Molecular Sciences doi: 10.3390/ijms21186488 Authors: Arkadiusz Kajdasz Ewelina Warzych Natalia Derebecka Zofia E. Madeja Dorota Lechniak Joanna Wesoly Piotr Pawlak Compared to other mammalian species, porcine oocytes and embryos are characterized by large amounts of...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6489: The Role of Epac in Cancer Progression International Journal of Molecular Sciences doi: 10.3390/ijms21186489 Authors: Nadine Wehbe Hasan Slika Joelle Mesmar Suzanne A. Nasser Gianfranco Pintus Serine Baydoun Adnan Badran Firas Kobeissy Ali H. Eid Elias Baydoun Cancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6487: Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21186487 Authors: Jéssica Mariane Ferreira Mendes Ludmila de Faro Valverde Manuela Torres Andion Vidal Bruno Diaz Paredes Paulo Coelho Kyan James Allahdadi Ricardo Della Coletta Bruno Solano de Freitas Souza Clarissa Araújo Gurgel...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6472: Episodic Ataxias: Faux or Real? International Journal of Molecular Sciences doi: 10.3390/ijms21186472 Authors: Paola Giunti Elide Mantuano Marina Frontali The term Episodic Ataxias (EA) was originally used for a few autosomal dominant diseases, characterized by attacks of cerebellar dysfunction of variable duration and frequency, often accompanied by other ictal and interictal signs. The original group subsequently grew to include other very rare EAs,...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6477: Endothelial Jagged1 Antagonizes Dll4/Notch Signaling in Decidual Angiogenesis during Early Mouse Pregnancy International Journal of Molecular Sciences doi: 10.3390/ijms21186477 Authors: Nicole M. Marchetto Salma Begum Tracy Wu Valerie O’Besso Christina C. Yarborough Nuriban Valero-Pacheco Aimee M. Beaulieu Jan K. Kitajewski Carrie J. Shawber Nataki C. Douglas Maternal spiral arteries and newly formed decidual capillaries support embryonic...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6469: Exercise Training and Vitamin C Supplementation Affects Ferritin mRNA in Leukocytes without Affecting Prooxidative/Antioxidative Balance in Elderly Women International Journal of Molecular Sciences doi: 10.3390/ijms21186469 Authors: Małgorzata Żychowska Agata Grzybkowska Monika Wiech Robert Urbański Wanda Pilch Anna Piotrowska Olga Czerwińska-Ledwig Jędrzej Antosiewicz Physical training and antioxidant supplementation may influence iron...
Sat Sep 05, 2020 03:00
IJMS, Vol. 21, Pages 6486: Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy? International Journal of Molecular Sciences doi: 10.3390/ijms21186486 Authors: Stefano Martellucci Nicola Salvatore Orefice Adriano Angelucci Amalia Luce Michele Caraglia Silvia Zappavigna Extracellular Vesicles (EVs) represent a heterogeneous population of membranous cell-derived structures, including cargo-oriented exosomes and microvesicles. EVs are...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6484: Genetic and Epigenetic Aspects of Atopic Dermatitis International Journal of Molecular Sciences doi: 10.3390/ijms21186484 Authors: Bogusław Nedoszytko Edyta Reszka Danuta Gutowska-Owsiak Magdalena Trzeciak Magdalena Lange Justyna Jarczak Marek Niedoszytko Ewa Jablonska Jan Romantowski Dominik Strapagiel Jarosław Skokowski Anna Siekierzycka Roman J. Nowicki Iwona T. Dobrucki Anna Zaryczańska Leszek Kalinowski Atopic...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6485: Biological Responses to Cadmium Stress in Liverwort Conocephalum Conicum (Marchantiales) International Journal of Molecular Sciences doi: 10.3390/ijms21186485 Authors: Viviana Maresca Gennaro Lettieri Sergio Sorbo Marina Piscopo Adriana Basile Oxidative damage (production and localization of reactive oxygen species) and related response mechanisms (activity of antioxidant enzymes), and induction of Heat Shock Protein 70 expression, have been studied...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6483: Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure International Journal of Molecular Sciences doi: 10.3390/ijms21186483 Authors: Nejla Latic Reinhold G. Erben Vitamin D deficiency is the most common nutritional deficiency, affecting almost one billion people worldwide. Vitamin D is mostly known for its role in intestinal calcium absorption and bone mineralization. However, the observation of seasonal...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6481: Structure-Function Relationship of TRPM2: Recent Advances, Contradictions, and Open Questions International Journal of Molecular Sciences doi: 10.3390/ijms21186481 Authors: Frank J.P. Kühn When in a particular scientific field, major progress is rapidly reached after a long period of relative stand-still, this is often achieved by the development or exploitation of new techniques and methods. A striking example is the new insights brought into the understanding...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6480: p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?
IJMS, Vol. 21, Pages 6480: p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful? International Journal of Molecular Sciences doi: 10.3390/ijms21186480 Authors: Eyal Bengal Sharon Aviram Tony Hayek Skeletal muscles respond to environmental and physiological changes by varying their size, fiber type, and metabolic properties. P38 mitogen-activated protein kinase (MAPK) is one of several signaling pathways that drive the metabolic adaptation of skeletal muscle...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6482: The Role of Transforming Growth Factor-Beta in Retinal Ganglion Cells with Hyperglycemia and Oxidative Stress International Journal of Molecular Sciences doi: 10.3390/ijms21186482 Authors: Hsin-Yi Chen Yi-Jung Ho Hsiu-Chuan Chou En-Chi Liao Yi-Ting Tsai Yu-Shan Wei Li-Hsun Lin Meng-Wei Lin Yi-Shiuan Wang Mei-Lan Ko Hong-Lin Chan A characteristic of diabetes mellitus is hyperglycemia, which is considered with an emphasis on the...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6478: Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment International Journal of Molecular Sciences doi: 10.3390/ijms21186478 Authors: Daniel T. Doty Julia Schueler Vienna L. Mott Cassie M. Bryan Nathan F. Moore John C. Ho Jeffrey T. Borenstein The immune checkpoint blockade represents a revolution in cancer therapy, with the potential to increase survival for many patients...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6476: P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures International Journal of Molecular Sciences doi: 10.3390/ijms21186476 Authors: Duk-Shin Lee Ji-Eun Kim Recently, we have reported that blockade/deletion of P2X7 receptor (P2X7R), an ATP-gated ion channel, exacerbates heat shock protein 25 (HSP25)-mediated astroglial autophagy (clasmatodendrosis) following...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6479: Targeting Cell Cycle in Breast Cancer: CDK4/6 Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms21186479 Authors: Michela Piezzo Stefania Cocco Roberta Caputo Daniela Cianniello Germira Di Gioia Vincenzo Di Lauro Giuseppina Fusco Claudia Martinelli Francesco Nuzzo Matilde Pensabene Michelino De Laurentiis Deregulation of cell cycle, via cyclin D/CDK/pRb pathway, is frequently observed in breast cancer lending...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6474: Tolerance of Stored Boar Spermatozoa to Autologous Seminal Plasma: A Proteomic and Lipidomic Approach International Journal of Molecular Sciences doi: 10.3390/ijms21186474 Authors: Lisa Höfner Anne-Marie Luther Alessandra Palladini Thomas Fröhlich Dagmar Waberski Long-term exposure of liquid preserved boar spermatozoa to seminal plasma (SP) can cause dramatic sperm injury. This study examined whether boar specificity exists in the sensitivity of...
Fri Sep 04, 2020 03:00
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