Hereditary angioedema is a rare autosomal dominant disease characterized by recurrent and unpredictable episodes of swelling, particularly of the skin and the gastric, oropharyngeal, and laryngeal mucosa, which can be life threatening. The majority of cases of hereditary angioedema are caused by…
Wed Sep 02, 2020 03:00
For patients with high-risk resected melanoma, immune checkpoint inhibitors and BRAF plus MEK inhibitors (dabrafenib plus trametinib) are well-established adjuvant therapies. In such patients, the side-effect profile and long-term benefit of the drugs are important criteria for selecting the…
Wed Sep 02, 2020 03:00
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
Thu Sep 03, 2020 03:00
Antibodies are immune proteins that mark the evolution of the host immune response to infection. Antibodies can be measured in a sensitive and specific manner, providing an archive that reflects recent or previous infection. If maintained at sufficiently high levels, antibodies can rapidly block…
Tue Sep 01, 2020 03:00
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (Covid-19), emerged in December 2019. Seroconversion of most patients with Covid-19 occurs between 7 and 14 days after diagnosis. A study of 61,000 persons in Spain showed that 5% of the population had…
Tue Sep 01, 2020 03:00
Familial hypercholesterolemia is a genetic condition characterized by an elevated plasma concentration of low-density lipoprotein (LDL) cholesterol starting at birth and an increased risk of premature atherosclerotic cardiovascular disease. With an estimated prevalence of 1 in 250 in the general…
Sat Aug 29, 2020 03:00
To the Editor: The Aicardi–Goutières syndrome is a genetic interferonopathy that is associated with severe disability and death. Most children with this syndrome are unable to walk or talk and have multisystemic complications, including skin inflammation (Figure 1A). Janus kinase (JAK) inhibitors…
Thu Sep 03, 2020 03:00
R. was a teenager when his osteosarcoma came roaring back, with vertebral metastases that left him paralyzed and bed-bound. He’d been told he was going to die, but his mother, a tower of strength, was determined to keep things positive. During home visits, she stood guard, making sure my team and I…
Tue Sep 01, 2020 03:00
Many countries have been recruiting Covid-19 contact tracers as part of a "test, track, and trace" strategy. In the United Kingdom and the United States, for example, large corps of volunteers have signed up for online classes on the concepts and methods that have served South Korea, Singapore, and…
Wed Sep 02, 2020 03:00
The merciless killing of George Floyd by Minneapolis police officer Derek Chauvin and the more recent shooting of Jacob Blake by Kenosha police officer Rusten Sheskey have catalyzed the most widespread protests in American history, calling not only for an end to police brutality but also for a…
Tue Sep 01, 2020 03:00
Transcatheter aortic-valve implantation (TAVI) is an established treatment in patients with symptomatic severe aortic stenosis. Ischemic and bleeding complications that frequently occur after TAVI can be life-threatening. Practice guidelines recommend clopidogrel in addition to aspirin for the…
Sun Aug 30, 2020 03:00
Coronavirus disease 2019 (Covid-19) has spread globally at a rapid pace since the novel coronavirus was first reported in late December 2019 in Wuhan, China, and was declared a pandemic by the World Health Organization on March 11, 2020. As of August 1, 2020, more than 17 million cases and over…
Wed Sep 02, 2020 03:00
To the Editor: Rapid and accurate diagnostic tests are essential for controlling the ongoing Covid-19 pandemic. Although the current standard involves testing of nasopharyngeal swab specimens by quantitative reverse-transcriptase polymerase chain reaction (RT-qPCR) to detect SARS-CoV-2, saliva…
Fri Aug 28, 2020 03:00
Treatment approaches for atrial fibrillation are characterized broadly into two categories: "rhythm control," attempting to maintain sinus rhythm, and "rate control," to slow ventricular rate. In the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM), in which rhythm control…
Sat Aug 29, 2020 03:00
Even with current guideline-based management, patients with atrial fibrillation have stroke, acute coronary syndrome, heart failure, and cardiovascular death at a rate of approximately 5% of patients per year, and 35 to 50% of patients with atrial fibrillation who receive adequate anticoagulation…
Sat Aug 29, 2020 03:00
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