Mechano‐adaptive Responses of Alveolar Bone to Implant Hyper‐loading in a pre‐clinical in vivo model
Abstract Objectives Oral implants transmit biting forces to peri‐implant bone. In turn, those forces subject peri‐implant bone to mechanical stresses and strains. Here, our objective was to understand how peri‐implant bone responded to conditions of normal vs. hyper‐loading in a mouse model. Material and Methods Sixty‐six mice were randomly assigned to 2 groups; both groups underwent bilateral maxillary first molar extraction followed by complete healing. Titanium alloy implants were placed...
Abstract Objectives The aim of this prospective, clinical study was to evaluate the clinical performance and histological outcome of a new equine hydroxyapatite collagenated bone block (eHAC) for horizontal bone grafting prior to implant placement. Material and Methods Five patients (two male/ three female) with a mean age of 51.6 years (range 22 ‐ 66 years) and a reduced horizontal bone width of the alveolar ridge (mean 3.5 mm) underwent horizontal bone grafting using eHAC at 10 grafting...
Abstract Objectives To evaluate the survival rate, the orobuccal bone resorption and stability of periimplant hard and soft tissues following immediate implant placement of wide diameter implants in molar extraction sites and periimplant defect grafting with autogenous bone (AB) or biphasic bone graft material (BBGM) with 1‐ to 3‐year follow‐up examinations. Material and Methods Fifty wide diameter implants were placed in 50 patients immediately into molar extraction sockets by a flapless...
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Abstract Objectives To immunohistochemically characterize and correlate macrophage M1/M2 polarization status with disease severity at peri-implantitis sites. Materials and methods A total of twenty patients (n = 20 implants) diagnosed with peri-implantitis (i.e., bleeding on probing with or without suppuration, probing depths ≥ 6 mm, and radiographic marginal...
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Publication date: Available online 3 September 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Jaideep Singh Chauhan, Sarwpriya Sharma, Disha Jain, Jagrati Junval
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This study evaluated the effect on enamel demineralization of 10% hydrogen peroxide (H2O2) gels containing different concentrations of sodium trimetaphosphate (TMP) and sodium fluoride (NaF) combined with the daily use of fluoridated or placebo dentifrice. Bovine enamel blocks were selected by surface hardness (n = 72) and randomly assigned to one of the following experimental treatments: 10% H2O2; 10% H2O2 + 3% TMP + 0.1% NaF; and 10% H2O2 + 0.3% TMP + 0.05% NaF, each with or without fluoridated...
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The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinomas has been rising.1,2 Clinicians treating patients with oropharyngeal cancer strongly support the Joint Committee on Vaccination and Immunisation recommendation3 on gender-neutral vaccination to prevent anal, cervical, oropharyngeal, and penile cancer. However, although the HPV vaccines were initially tested and approved in triple-dose regimens,4 there is evidence to support a single-dose vaccination schedule...
We read the paper by Thambar et al with great interest.1 This is a very extensive review regarding botulinum toxin injection for temporomandibular joint disorders and we commend the authors.
The success of implant osseointegration is clearly impacted by the heat produced throughout the implant osteotomy site preparation. Bone necrosis of the implant bed should be prevented to maintain a stable osseointegration process. The objective of this experiment was to validate the impact of implant drill speed on the bone from the point of view of heat generation; a second objective was to evaluate viability of the osteotomised implant sites in rabbits histologically. Twenty healthy adult rabbits,...
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Publication date: Available online 3 September 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Bulat, S. Butsan, K. Salikhov, S. Abramian, A. Arsenidze
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Publication date: Available online 4 September 2020Source: Archives of Oral BiologyAuthor(s): Smriti Aryal AC, Sofiqul Islam, A.R. Samsudin
Publication date: Available online 3 September 2020Source: Archives of Oral BiologyAuthor(s): Yang Li, Ji-Na Zheng, En-Hao Wang, Keng-Fu Lan, Chan-Juan Gong, XiaoJun Ding
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Abstract Objectives Placement of a denture results in the application of mechanical stress (MS), such as occlusal force, onto the oral mucosa beneath the denture. To better understand the molecular mechanism underlying MS‐induced inflammation in the oral mucosa, we examined the impact of MS on human oral epithelial cells (HO‐1‐N‐1) and human fibroblasts (HGFs) in this study. Materials and Methods MS was applied on HO‐1‐N‐1and HGFs using a hydrostatic pressure apparatus. The expression and...
Abstract Objective This study aimed to investigate how mechanical force affects the proliferation of human periodontal ligament stem cells (hPDLSCs). Methods CCK‐8 assays and staining of ki67 were performed to evaluate hPDLSCs proliferation. qRT‐PCR, elisa, or western blot analysis were used to measure the expression levels of interleukin (IL)‐6, miR‐31 host gene (MIR31HG), DNA methyltransferase 1 (DNMT1), and DNA methyltransferase 3B (DNMT3B). Dual luciferase reporter assays and chromatin...
Abstract Objectives Although tooth transplantation is a useful treatment option as a substitute for a missing tooth, transplantation to a narrow alveolar ridge is not feasible. In this study, we tested a tissue engineering approach simultaneously with tooth transplantation using a scaffold or a combination with cells to accelerate bone formation and periodontal tissue regeneration. Materials and methods Bone marrow mononuclear cells (BM‐MNCs) were harvested from C57BL/6J mice. The upper...
Occupational COVID‐19 risk to dental staff working in a public dental unit in the outbreak epicentre
Abstract Objective The management of the COVID‐19 outbreak occurred in Lombardy (Italy) implied that non‐COVID‐19 healthcare was remodelled, limiting adequate resources in non‐hospital public dental healthcare settings. This situation offered the opportunity to investigate the occupational COVID‐19 risk to dental staff in public non‐hospital dental units. Methods An infection‐control protocol was designed for dental healthcare in the Territorial Health and Social Services Authority (ASST)...
Abstract Objectives In case of surgical removal of oral squamous cell carcinomas, a resection of mandibular bone is frequently part of the treatment. Nowadays, such resections frequently include the application of 3D virtual surgical planning (VSP) and guided surgery techniques. In this paper current methods for 3D VSP, leads for optimisation of the workflow, and patient specific application of guides and implants are reviewed. Recent findings Current methods for 3D VSP enable multi‐modality...
Abstract Objectives To evaluate whether salivary lactate dehydrogenase (LDH) levels are increased in patients with oral cancer (OC) or oral potentially malignant disorders (OPMD) when compared to a healthy control group (CG). Material and methods We conducted a comprehensive search of specialized databases (PubMed/MEDLINE, The Cochrane Library, Web of Science, Scopus and OpenGrey), including observational analytical studies evaluating the salivary LDH levels (in UI/L or μ/L) in OC or OPMD...
ABSTRACT Objective To assess the association of preoperative lymphocyte‐to‐monocyte ratio (LMR) and overall survival (OS) in oral cancer patients and develop a dynamic nomogram for individualized survival prediction. Method The prognostic value of LMR was evaluated in a large‐scale cohort with 651 postoperative oral cancer patients between January 2010 and December 2017. Propensity score‐matched (PSM) analysis and inverse probability of treatment weighting (IPTW) analysis were performed...
Abstract Objectives Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with high incidence. Numerous reports have elucidated that long non‐coding RNAs (lncRNAs) serve as crucial regulatory factors in various diseases including cancer. Nonetheless, the role of lncRNA JPX in OSCC is still not elaborated. Subjects and Methods In our research, we detected the expression of lncRNA JPX through qRT‐PCR. Colony formation, EdU staining, Transwell, TUNEL and caspase‐3 activity assays...
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Publication date: Available online 4 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): Perihan Oyar, Rukiye Durkan, Gonca Deste
Publication date: Available online 4 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): Ana Maria Estivalete Marchionatti, Iana Lamadrid Aurélio, Vinícius Felipe Wandscher
Publication date: Available online 4 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): John M. Aarts, Joanne Jung Eun Choi, Steven Metcalfe, Vincent Bennani
Publication date: Available online 4 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): Eun-Jeong Bae, Hyun-Soo Kim, Joong Yeon Lim
Publication date: Available online 4 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): Amal A. Swelem, Mohamed H. Abdelnabi
Publication date: September 2020Source: The Journal of Prosthetic Dentistry, Volume 124, Issue 3Author(s):
Publication date: September 2020Source: The Journal of Prosthetic Dentistry, Volume 124, Issue 3Author(s):
Publication date: September 2020Source: The Journal of Prosthetic Dentistry, Volume 124, Issue 3Author(s):
Publication date: September 2020Source: The Journal of Prosthetic Dentistry, Volume 124, Issue 3Author(s):
Publication date: September 2020Source: The Journal of Prosthetic Dentistry, Volume 124, Issue 3Author(s):
Publication date: Available online 4 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): Francisco X. Azpiazu-Flores, Damian J. Lee, Lisa A. Lang
Publication date: Available online 3 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): Arndt Guentsch, Laxmi Sukhtankar, Hongseok An, Paul G. Luepke
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