KCNQ1OT1 exerts an important role in various cancers, but its role in osteosarcoma (OS) and the potential mechanism remain to be clarified. In the present research, we aimed to explore the effect of KCNQ1OT1 on osteosarcoma and further explore the special molecular mechanism. The expression of KCNQ1OT1 was analyzed in tumor and adjacent tissues of 30 patients with osteosarcoma by RT-PCR. Cell proliferation and invasion were explored using MTT and transwell assay, respectively. Luciferase reporter...
Fri Sep 04, 2020 18:20
Ventricular action potential is well-known because of its plateau phase with a spike-notch-dome morphology. As such, the morphology of action potential is necessary for ensuring a correct heart functioning. Any distraction from normal notch-dome morphology may trigger a circus movement reentry in the form of lethal ventricular fibrillation. When the epicardial action potential dome propagates from a site where it is maintained to regions where it has been lost, it gives rise to the proposed mechanism...
Fri Sep 04, 2020 14:50
Background. Previous studies showed that recanalization and angiogenesis within the infarct region are of vital importance to the survival of myocardial cells during the treatment of acute myocardial infarction (AMI). Methods. In this study, EdU cell proliferation assay, Transwell assay, scratch wound assay, and tube formation assay were used. Twelve bioinformatics analysis packages were used to predict the target genes of miR-101. Target genes were verified by luciferase reporter generation and...
Fri Sep 04, 2020 08:05
Abstract Based on the principle of distraction osteogenesis, external fixators are widely used in deformity correction of the foot and ankle. In this study, a novel ankle external fixator is proposed to correct complex multiplane deformities, especially for supramalleolar osteotomy to correct distal tibia deformities. The relatively simple structure and fewer struts in the proposed fixator reduce the complexity of adjusting the external fixator. Based on two existing adjustment strategies, a new...
Sat Sep 05, 2020 15:49
Publication date: Available online 5 September 2020Source: Medical Image AnalysisAuthor(s): Haomin Chen, Shun Miao, Daguang Xu, Gregory D. Hager, Adam P. Harrison
Sun Sep 06, 2020 22:50
Publication date: Available online 5 September 2020Source: Medical Image AnalysisAuthor(s): Midas Meijs, Frederick J.A. Meijer, Mathias Prokop, Bram van Ginneken, Rashindra Manniesing
Sun Sep 06, 2020 22:50
The freshwater clam Corbicula fluminea s.l. is an edible freshwater bivalve of economic value in Asia. The species has been particularly well studied in the invaded range. However, there is a lack of knowledge in its native range where it supports an increasing commercial harvest pressure. Among Asiatic countries, China accounts for 70% of known commercial harvest and aquaculture production. We aim to characterize here wild C. fluminea s.l populations exposed to commercial harvest pressure in Poyang...
Fri Sep 04, 2020 03:00
Background Cratera is a genus of land planarians endemic to the Brazilian Atlantic forest. The species of this genus are distinguished from each other by a series of external and internal characters, nonetheless they represent a challenging taxonomic issue due to the extreme alikeness of the species analysed in the present work. To resolve these difficulties, we have performed morphological analyses and used three nuclear markers (ribosomal 18S and 28S, Elongation Factor, a new...
Fri Sep 04, 2020 03:00
Background Although the risk factors for diagnostic bronchoalveolar lavage (BAL)-induced acute exacerbations in patients with idiopathic pulmonary fibrosis (IPF) have been previously reported, no study has assessed these in patients with non-IPF. We aimed to identify the risk factors for BAL-induced disease deterioration (BAL-DD) in all types of diffuse lung disease. Methods Patients with diffuse lung disease who underwent...
Fri Sep 04, 2020 03:00
Platelet-rich plasma (PRP) has been reported recently as a potential therapeutic approach for alopecia, such as androgenetic alopecia, but the exact mechanisms and effects of specific components of this recipe remain largely unknown. In this study, we identified that platelet factor 4 (PF4), a component of PRP, significantly suppressed human hair follicle growth and restrained the proliferation of human dermal papilla cells (hDPCs). Furthermore, our results showed that PF4 upregulated androgen receptor...
Fri Sep 04, 2020 03:00
Allergic rhinitis (AR) is a common disease affecting 400 million of the population worldwide. Nasal epithelial cells form a barrier against the invasion of environmental pathogens. These nasal epithelial cells are connected together by tight junction (TJ) proteins including zonula occludens-1 (ZO-1), ZO-2 and ZO-3. Impairment of ZO proteins are observed in AR patients whereby dysfunction of ZOs allows allergens to pass the nasal passage into the subepithelium causing AR development. In this review,...
Fri Sep 04, 2020 03:00
Publication date: Available online 6 September 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jinsoo Uh, Thomas E. Merchant, Heather M. Conklin, Yousef Ismael, Yimei Li, Yuanyuan Han, Noah D. Sabin, Abbas Babajani-Feremi, Daniel J. Indelicato, Chia-ho Hua
Sun Sep 06, 2020 16:57
Publication date: Available online 6 September 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Cheng-Hsiang Lo, Hsin-Lun Lee, Chih-Weim Hsiang, Jeng-Fong Chiou, Meei-Shyuan Lee, Shang-Wen Chen, Po-Chien Shen, Chun-Shu Lin, Wei-Chou Chang, Jen-Fu Yang, Yang-Hong Dai, Chun-You Chen, Jason Chia-Hsien Cheng, Wen-Yen Huang
Sun Sep 06, 2020 16:57
Publication date: Available online 6 September 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Trevor J. Royce, Panayiotis Mavroidis, Kyle Wang, Aaron D. Falchook, Nathan C. Sheets, Donald B. Fuller, Sean P. Collins, Issam El Naqa, Daniel Y. Song, George X. Ding, Alan E. Nahum, Andrew Jackson, Jimm Grimm, Ellen Yorke, Ronald C. Chen
Sun Sep 06, 2020 16:57
Publication date: Available online 4 September 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Mudit Chowdhary, Simul Parikh, Anna Lee, Rahul Tendulkar, Trevor J. Royce
Sat Sep 05, 2020 15:29
Publication date: Available online 4 September 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Christopher D. Goodman, Justin D. Pautler, Christopher S. Balestrini, Santiago Cobos, Leah D’Souza, Paige Eansor, Jasbir Jaswal, Anthony Nichols, Madeleine Norris, Manas Sharma, Katherine Willmore, Andrew Warner, Donna H. Murrell, David A. Palma
Sat Sep 05, 2020 15:29
Publication date: Available online 4 September 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Joshua N. Herb, Rachael T. Wolff, Philip M. McDaniel, G. Mark Holmes, Trevor J. Royce, Karyn B. Stitzenberg
Sat Sep 05, 2020 15:29
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