Objective Considering the demonstrated implication of the retina in PD pathology and the importance of dopaminergic cells in this tissue, we aimed to analyze the state of the dopaminergic amacrine cells and some of their main post‐synaptic neurons in the retina of PD. Methods Using immunohistochemistry and confocal microscopy, we evaluated morphology, number, and synaptic connections of dopaminergic cells and their post‐synaptic cells, AII amacrine and melanopsin‐containing retinal ganglion...
Thu Sep 03, 2020 16:11
Objective To examine the association of plasma neuroaxonal injury markers neurofilament light (NfL), total tau, glial fibrillary acid protein and ubiquitin carboxyl‐terminal esterase l1 and delirium, delirium severity, and cognitive performance. Methods Delirium case‐no delirium control (n=108) pairs were matched by age, sex, surgery type, cognition, and vascular comorbidities. Biomarkers were measured in plasma collected preoperative(PREOP), 2 days(POD2) and 30 days postoperative(PO1MO) using...
Thu Sep 03, 2020 16:09
Publication date: Available online 4 September 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Wen-qiang Xin, Peng-ju Sun, Fan Li, Ming-xun Cheng, Shi-xue Yang, Bao-long Cui, Zeng-guang Wang, Xin-yu Yang
Sat Sep 05, 2020 16:08
Publication date: Available online 4 September 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Seckin Aydin, Baris Ozoner, Serdar Sahin, Orkhan Alizada, Nil Comunoglu, Buge Oz, Nurperi Gazioglu, Pinar Kadioglu, Necmettin Tanriover
Sat Sep 05, 2020 16:08
Publication date: Available online 3 September 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Bernd-Otto Hütter, Beate Huffmann, Joachim-Michael Gilsbach
Fri Sep 04, 2020 22:01
Publication date: April 2021Source: Current Opinion in Neurobiology, Volume 67Author(s): Iva B Zovkic
Sun Sep 06, 2020 15:22
Abstract Adaptively changing between different tasks while in locomotion is a fundamental prerequisite of modern daily life. The cognitive processes underlying dual tasking have been investigated extensively using EEG. Due to technological restrictions, however, this was not possible for dual task scenarios including locomotion. With new technological opportunities, this became possible and cognitive‐motor interference can be studied, even in outside‐the‐lab environments. In the present study, participants...
Sat Sep 05, 2020 15:36
Abstract Arc (activity‐regulated cytoskeleton‐associated protein) is posited as a critical regulator of long‐term synaptic plasticity at excitatory synapses, including long‐term potentiation, long‐term depression, inverse synaptic tagging, and homeostatic scaling, with pivotal roles in memory and postnatal cortical development. However, the mechanisms underlying the bidirectional regulation of synaptic strength are poorly understood. Here we review evidence from different plasticity paradigms, highlight...
Sat Sep 05, 2020 12:28
Abstract Evidence suggests that brain network dynamics are a key determinant of brain function and dysfunction. Here we propose a new framework to assess the dynamics of brain networks based on recurrence analysis. Our framework uses recurrence plots and recurrence quantification analysis to characterize dynamic networks. For resting‐state magnetoencephalographic dynamic functional networks (dFNs), we have found that functional networks recur more quickly in people with epilepsy than healthy controls....
Fri Sep 04, 2020 21:26
ABSTRACT When walking in our natural environment, we often solve additional cognitive tasks. This increases the demand of resources needed for both the cognitive and motor systems, resulting in Cognitive‐Motor Interference (CMI). A large portion of neurophysiological investigations on CMI took place in static settings, emphasizing the experimental rigor but overshadowing the ecological validity. As a more ecologically valid alternative to treadmill and desktop‐based set‐ups to investigate CMI, we...
Thu Sep 03, 2020 15:10
Abstract Neuronal dysfunction and loss are thought to be one of the causes of cognitive impairment in Alzheimer's disease (AD), but the specific mechanism of neuronal loss in the pathogenesis of AD remains controversial. This study explored the role of NLRP3 inflammasome-induced neuronal pyroptosis in neuronal loss of AD, and pioneered the use of NLRP3 inhibitor MCC950 to intervene in the treatment of senescence-accelerated mouse prone 8 (SAMP8) mice. In vitro, human primary neurons...
Sun Sep 06, 2020 03:00
Abstract Binocular disparity, a primary cue for stereoscopic depth perception, is widely represented in visual cortex. However, the functional specialization in the disparity processing network remains unclear. Using magnetic resonance imaging-guided transcranial magnetic stimulation, we studied the causal contributions of V3A and MT+ to stereoscopic depth perception. Subjects viewed random-dot stereograms forming transparent planes with various interplane disparities. Their smallest...
Fri Sep 04, 2020 03:00
Abstract Systemic treatments for ischemic stroke as a disease with high disability and death have been yet unsuccessful. Combined treatments can potentially cause better results in treatment of patients with Stroke. In this study we assessed the neuroprotective effect of modafinil-coated gold nanoparticles (AuNPs) and mesenchymal stem cell (MSC) in ischemic stroke rats. Stem cells and AuNPs offer great promise for new medical treatments. 60 male Wistar rats were randomly divided...
Fri Sep 04, 2020 03:00
Neuromuscular Electrical Stimulation (NMES) has been utilized for many years in cerebral palsy (CP) with limited success despite its inherent potential for improving muscle size and/or strength, inhibiting or ...
Thu Sep 03, 2020 03:00
Publication date: Available online 6 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Zhijian Weng, Liyi Ma, Junjie Li, Qiang Zhou, Lin Peng, Hong Li, Lei Chen, Zong Xin, Linyong Shi, Songtao Qi, Yuntao Lu
Sun Sep 06, 2020 18:27
Publication date: Available online 6 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Yunyuan Gao, Xiangkun Wang, Thomas Potter, Jianhai Zhang, Yingchun Zhang
Sun Sep 06, 2020 18:27
Publication date: Available online 5 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Zhenxiong Wang, Mehran Shaghaghi, Shun Zhang, Guiling Zhang, Yiran Zhou, Di Wu, Zhuoli Zhang, Wenzhen Zhu, Kejia Cai
Sun Sep 06, 2020 18:27
Publication date: Available online 4 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Massimo De Agrò
Sat Sep 05, 2020 16:47
The original version of this article unfortunately contained an error. Tables and Supplementary are incorrectly processed during production. Given in this article are the correct tables.
Sat Sep 05, 2020 03:00
Abstract Purpose To identify the independent risk factors for developing morbid hypothalamic obesity, to propose a predictive scoring system for morbid hypothalamic obesity, and to propose an algorithm for management in order to minimize the risk of developing morbid hypothalamic obesity in patients with pediatric craniopharyngioma. Methods A retrospective...
Fri Sep 04, 2020 03:00
Related Articles Outcome improvement in cerebral ventriculitis after ventricular irrigation: a prospective controlled study. J Neurosurg Pediatr. 2020 Sep 04;:1-9 Authors: Al Menabbawy A, El Refaee E, Soliman MAR, Elborady MA, Katri MA, Fleck S, Schroeder HWS, Zohdi A Abstract OBJECTIVE: Cerebral ventriculitis remains one of the most challenging neurosurgical conditions, with poor outcome and a long course of treatment and duration of hospital...
Sat Sep 05, 2020 15:29
Publication date: Available online 6 September 2020Source: Brain Research BulletinAuthor(s): Si Tang, Jing Zhu, Dong Zhao, Huaheng Mo, Zhaofu Zeng, Mengqing Xiong, Minglin Dong, Ke Hu
Sun Sep 06, 2020 18:23
Publication date: Available online 5 September 2020Source: Brain Research BulletinAuthor(s): Jian Wen, Yan Ding, Le Wang, Ying Xiao
Sun Sep 06, 2020 18:23
Active surveillance for patients with esophageal cancer with a clinically complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT) is being studied. Active surveillance requires accurate clinical response evaluations (CREs). 18F-FDG PET/CT might be able to detect local tumor recurrence after nCRT as soon as the esophagus recovers from radiation-induced esophagitis. The aims of this study were to assess the value of serial 18F-FDG PET/CT to detect local recurrence in patients beyond 3 months...
Fri Sep 04, 2020 23:10
Purpose: We investigated the value of O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET for treatment monitoring of immune checkpoint inhibition (ICI) or targeted therapy (TT) alone or in combination with radiotherapy in patients with brain metastases (BM) since contrast-enhanced MRI often remains inconclusive. Methods: We retrospectively identified 40 patients with 107 BM secondary to melanoma (n = 29 with 75 BM) or non-small cell lung cancer (n = 11 with 32 BM) treated with ICI or TT who had 18F-FET...
Fri Sep 04, 2020 23:10
Non-invasive methods to study glucocorticoid receptor (GR) signaling are urgently needed to reveal the complexity of GR signaling in normal physiology and human disorders, as well as to identify selective GR modulators to treat diseases. Here, we report evidence supporting translational studies with (±)-[11C]-5-(4-fluorobenzyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f ]-quinoline (named as (±)-[11C]YJH08), a radioligand for positron emission tomography (PET) that engages the ligand...
Fri Sep 04, 2020 23:10
While FDG PET/CT is widely available and is being increasingly used to monitor response to immunotherapy and simultaneously identify immune-related adverse events, there are several challenges in interpreting the results of this investigation, especially early in the course of treatment. It also has limited utility in selecting the optimal type of immunotherapy. As knowledge about immune contexture increases, new targets that may be amenable to imaging are being defined. These exciting advances,...
Fri Sep 04, 2020 23:10
Rationale: The primary aims of this study were to determine the correlation between absolute quantitative 99mTc-pyrophosphate (99mTc-PYP) metrics and traditional measures of cardiac amyloid burden and to measure intra-observer repeatability of the quantitative metrics. Methods: We studied 72 patients who underwent 99mTc-PYP SPECT/CT using a novel general purpose CZT-based SPECT/CT system (Veriton, Spectrum Dynamics Inc). The clinical standard for these studies is visual grading (0-3: myocardial...
Fri Sep 04, 2020 23:10
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Russell J. Andrews
Sun Sep 06, 2020 13:48
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Taichiro Imahori, Takashi Mizobe, Toshiyuki Fujinaka, Shinichi Miura, Masahiro Sugihara, Hideo Aihara, Eiji Kohmura
Sun Sep 06, 2020 13:48
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Kasra Khatibi, Lucido Luciano Ponce Mejia, Naoki Kaneko, Yinn Ooi, Tania Kaprealian, Nestor R. Gonzalez, Nader Pouratian, Viktor Szeder
Sun Sep 06, 2020 13:48
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Alessandro Bertuccio, Angela Elia, Chiara Robba, Giorgio Scaglione, Gian Paolo Longo, Donatella Sgubin, Matteo Vitali, Andrea Barbanera
Sun Sep 06, 2020 13:48
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