Background: The revised fourth edition of the World Health Organization Classification of Tumors of the Central Nervous System—published in 2016—established 1p19q codeletion as the molecular hallmark for the diagnosis of oligodendrogliomas. Fluorescence in situ hybridization (FISH) is currently the most commonly used modality for 1p19q testing. However, as with most laboratory testing, 1p19q FISH testing has a false-positive rate, potentially resulting in an erroneous diagnosis of oligodendroglioma...
Tue Sep 01, 2020 03:00
Objective: Angiosarcoma of the breast is rare and has a poor prognosis. We reviewed our institution’s experience with this disease to characterize presentation, identify management patterns, and report outcomes. Methods: Fifty-eight patients with nonmetastatic angiosarcoma were identified from 1998 to 2019 and retrospectively reviewed. Overall survival (OS) and recurrence-free survival (RFS) were calculated using the Kaplan-Meier analysis and log-rank test. Results: The median...
Tue Sep 01, 2020 03:00
Aim: Conduct a systematic review of available evidence on food and beverage intake during cancer treatment. Objective: Determine what food or beverages consumed during cancer treatment might prevent recurrence, subsequent malignancies, treatment-related toxicity, or death. Background: Food and beverage intake, as well as weight status, can integrate with cancer treatment to mitigate treatment-related toxicities, support treatment success, and prevent recurrence. Yet, evidence-based...
Tue Sep 01, 2020 03:00
The hypoxic microenvironment is commonly found in various solid tumors including pancreatic ductal adenocarcinoma (PDAC). Saururus chinensis is a medicinal Chinese herb widely used because of documented anti-inflammatory and anti-angiogenic properties. Sauchinone is special active lignin extracted from S. chinensis and its biological functions have been extensively explored. Recent studies have found that sauchinone could affect tumor initiation, metastasis and progression of some cancers. However,...
Wed Sep 02, 2020 03:00
Since the introduction of antiepidermal growth factor receptor (anti-EGFR) monoclonal antibodies (moAbs), the treatment of metastatic colorectal cancer (mCRC) has become crucially dependent on the mutation profile of the tumour over the last two decades. Recently, rechallenge strategy with cetuximab-based chemotherapy has demonstrated to be active in a subgroup of patients whose tumour maintained wild-type RAS and RAF status. In this setting, liquid biopsy may replace tissue sample for the identification...
Wed Sep 02, 2020 03:00
Studies have confirmed that microRNAs play important roles in the development and progression of cancer. Therefore, to identify the differentially expressed microRNAs between the cancer and the normal tissues, microRNAs will provide new clues for exploring the molecular mechanisms of cancer development and potential targeted therapies. In the present study, we found that miR-338-3p was downregulated in hypopharyngeal carcinoma and inversely correlated with the pathological grade. When the miR-338-3p...
Wed Sep 02, 2020 03:00
After the failure of first-line epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy, some non-small cell lung cancer patients desire to receive switching with another EGFR-TKI (TKI-switching), although cytotoxic chemotherapy has been recommended as second-line therapy. It is unclear who should not receive TKI-switching in these patients. We retrospectively evaluated overall survival (OS) from the initiation of first EGFR-TKI (first-TKI) therapy in advanced lung adenocarcinoma...
Wed Sep 02, 2020 03:00
Colorectal cancer (CRC) is a frequently diagnosed cancer worldwide. Accumulating researches suggested that circular RNA 0007142 (circ_0007142) contributed to the progression and initiation of CRC. However, the molecular mechanism of circ_0007142 in CRC needs further research. Levels of circ_0007142, microRNA-455-5p (miR-455-5p), and serum- and glucocorticoid-induced protein kinase 1 (SGK1) were identified by quantitative real-time PCR. Cell proliferation was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium...
Wed Sep 02, 2020 03:00
Background In May 2012, the US Preventive Services Task Force (USPSTF) recommended against prostate‐specific antigen (PSA)–based screening for prostate cancer (PCa), assigning it a grade D. This decision then was modified in 2018 to a grade C for men aged 55 to 69 years. The authors hypothesized that changes in screening practices would reduce survival outcomes for both Black and White men but maintain racial discrepancies in outcomes. Methods Using the Surveillance, Epidemiology, and End...
Sat Sep 05, 2020 14:30
Background Anatomical site is strongly associated with head and neck cancer etiology, and etiology and patient sociodemographic characteristics are prognostic factors for survival. It is not known whether the effects of these predictors persist over the postdiagnosis period or are strongest proximal to the time of diagnosis. Methods Using survival times and causes of death for 180,434 patients with head and neck cancer in the Surveillance, Epidemiology, and End Results cancer registry (1973‐2015),...
Sat Sep 05, 2020 14:30
Over the years, there has been a continuous increase in clinically relevant driver mutations in patients with non–small cell lung cancer (NSCLC). Among these, dysregulated activation of the MET tyrosine kinase receptor has gained importance due to the recent development of quite effective treatments. MET dysregulation encompasses a heterogeneous array of alterations leading to the prolonged activation of the cellular MET (c‐MET or MET) receptor and downstream proliferation pathways. It can arise...
Sat Sep 05, 2020 14:29
Background Oral mucositis (OM) is a debilitating sequela for patients treated for squamous cell carcinoma of the head and neck (HNSCC). This study investigated whether oral microbial features before treatment or during treatment are associated with the time to onset of severe OM in patients with HNSCC. Methods This was a cohort study of newly diagnosed patients with locoregional HNSCC who received chemotherapy with or without radiotherapy from April 2016 to September 2017. OM was based on...
Sat Sep 05, 2020 14:25
Background In the current study, the authors assessed the risks and outcomes of immune checkpoint inhibitor (ICI) rechallenge in patients with resolved grade 3 to 4 ICI hepatitis because current guidelines recommend permanent ICI discontinuation in these patients. Methods The authors performed a retrospective cohort study from 2010 through 2019 of patients with melanoma who were treated with ≥1 ICIs and who recovered from grade 3 to 4 ICI hepatitis. The primary outcome was hepatitis recurrence...
Sat Sep 05, 2020 14:23
Background Despite being the standard of care for patients with locoregional cervical cancer, many patients do not complete all components of primary chemoradiotherapy (pCRT): external beam radiotherapy, chemosensitization, and brachytherapy. Incomplete or protracted pCRT is associated with worse survival. The authors implemented a socially determined cervical cancer care navigation program at a public safety‐net hospital to improve treatment adherence. Methods Patients with International...
Sat Sep 05, 2020 14:23
Background A majority of older adults with cancer develop malnutrition; however, the implications of malnutrition among this vulnerable population are poorly understood. The goal of this study was to quantify the prevalence of nutrition related‐symptoms and malnutrition among older adults with gastrointestinal (GI) malignancies and the association of malnutrition with geriatric assessment (GA) impairment, health‐related quality of life (HRQoL), and health care utilization. Methods We performed...
Fri Sep 04, 2020 15:27
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Sep 02, 2020 10:00
Abstract Advanced HBV‐related HCC with poor prognosis is often associated with chronic inflammation, immune tolerance and marked heterogeneity. IL‐6/JAK/STAT3 signal pathways play multiple regulatory roles in modulating inflammation and immunity in cancers. Polarisation of myeloid‐derived suppressor cells (MDSCs) is involved in HBV‐related immunosuppression and CD8+ T‐cell activation via ERK/IL‐6/STAT3. Icaritin is a small molecule that has displayed anticancer activities via IL‐6/JAK/STAT3 pathways...
Sat Sep 05, 2020 18:27
Abstract Ribosome assembly factor URB1 is essential for ribosome biogenesis. However, its latent role in cancer remains unclear. Cancer Genome Atlas database analysis and clinical tissue microarray staining showed that URB1 expression was upregulated in colorectal cancer (CRC) and prominently related to clinicopathological characteristics. URB1 silencing hampered human CRC cell proliferation and growth in vitro and in vivo. Microarray screening, ingenuity pathway analysis, and JASPAR assessment...
Sat Sep 05, 2020 13:08
Abstract Most cancers harbor a small population of highly tumorigenic cells, known as cancer stem cells (CSCs). Because of their stem cell‐like properties and resistance to conventional therapies, CSCs are considered to be a rational target for curable cancer treatment. However, despite recent advances in CSC research, CSC‐targeted therapies are not as successful as was initially hoped. The proliferative, invasive, and drug‐resistant properties of CSCs are regulated by the tumor microenvironment...
Fri Sep 04, 2020 16:39
In 1955, an outbreak of arsenic poisoning caused by the ingestion of arsenic‐contaminated Morinaga Dry Milk occurred in western Japan. This study aimed to assess the mortality and cancer incidence risk among Japanese individuals who were poisoned during this time as infants. Abstract In 1955, an outbreak of arsenic poisoning caused by the ingestion of arsenic‐contaminated Morinaga Dry Milk occurred in western Japan. This study aimed to assess the mortality and cancer incidence risk among Japanese...
Sat Sep 05, 2020 12:34
Cover of this issue. An image of extracellular vesicles isolated from 22Rv1 cells under transmission electron microscopy. See also Urabe et al. (pp. https://doi.org/10.1111/cas.145353258‐3267 of this issue).
Thu Sep 03, 2020 22:00
Abstract Notch signaling plays a pivotal role in many cancers, including glioblastoma (GBM). Recombination signal binding protein for immunoglobulin kappa J region (RBPJ) is a key transcription factor of the Notch signaling pathway. Here, we interrogated the function of RBPJ in GBM. Firstly, RBPJ expression of GBM samples was examined. Then, we knocked down RBPJ expression in two GBM cell lines (U251 and T98) and four GBM stem‐like cell (GSC) lines derived from surgical samples of GBM (KGS01, KGS07,...
Thu Sep 03, 2020 18:45
Abstract Cancer metastasis to lymph nodes (LNs) almost certainly contributes to distant metastasis. Elevation of LN internal pressure (intranodal pressure, INP) during tumor proliferation is associated with a poor prognosis for patients. We have previously demonstrated that a lymphatic drug delivery system (LDDS) allows the direct delivery of anti‐cancer drugs into the lymphatic system and is a promising treatment strategy for early‐stage LN metastasis. However, methods for evaluating the treatment...
Thu Sep 03, 2020 11:02
Abstract The risk‐benefit ratio associated with the use of repurposed drugs to treat 2019 SARS‐CoV‐2 related infectious disease (COVID‐19) is complicated since benefits are awaited, not proven. A thorough literature search was conducted to source information on the pharmacological properties of 5 drugs and 1 combination (azithromycin, chloroquine, favipiravir, hydroxychloroquine, remdesivir, and lopinavir/ritonavir) repurposed to treat COVID‐19. A risk assessment of drug‐induced Long QT Syndrome...
Sat Sep 05, 2020 15:09
Abstract T‐cell directing/engaging bispecifics (TDBs) enable a powerful mode of action by activating T‐cells through the creation of artificial immune synapses. Their pharmacological response involves the dynamic inter‐relationships between T‐cells, tumor cells, and TDBs. This results in complex and challenging issues in understanding pharmacokinetics (PK), tissue distribution, target engagement, and exposure‐response relationship. Dosing strategy plays a crucial role in determining the therapeutic...
Thu Sep 03, 2020 19:54
Abstract This open‐label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID‐19) and to explore its clinical efficacy and safety.Patients with mild or moderate COVID‐19 were randomly divided into the BRH group or the Control group at a 2:1 ratio. Routine treatment according to China’s Novel Coronavirus Pneumonia Diagnosis and Treatment Plan was performed in both groups,...
Thu Sep 03, 2020 17:16
Abstract On March 11, 2020, the World Health Organization declared its assessment of COVID‐19 as a global pandemic. However, specific anti SARS‐CoV‐2 drugs are still under development, and patients are managed by multiple complementary treatments. We performed a retrospective analysis to compare and evaluate the effect of low molecular weight heparin (LMWH) treatment on disease progression. For this purpose, the clinical records and laboratory indicators were extracted from electronic medical records...
Thu Sep 03, 2020 17:14
Purpose: The safety and preliminary efficacy of MEDI1873, an agonistic IgG1 fusion protein targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR), were evaluated in an open-label, first-time-in-human, Phase 1, dose-escalation study in previously treated patients with advanced solid tumors. Experimental Design: Two single-patient cohorts at 1.5 and 3 mg IV were followed by 3+3 dose escalation in six cohorts at 7.5, 25, 75, 250, 500, and 750 mg, all Q2W for up to...
Fri Sep 04, 2020 14:58
Purpose: Advanced thyroid cancers, including poorly differentiated and anaplastic thyroid cancer (ATC), are lethal malignancies with limited treatment options. The majority of ATC patients have responded poorly to programmed death 1 (PD1) blockade in early clinical trials. There is a need to explore new treatment options. Experimental Design: We examined the expression of PD-L1 (a ligand of PD1) and intercellular adhesion molecule 1 (ICAM1) in thyroid tumors and ATC cell lines, and investigated the...
Fri Sep 04, 2020 14:58
Purpose: CD28, CD57 and KLRG1 have been previously identified as markers of T-cell immunosenescence. The impact of immunosenescence on anti-PD(L)-1 (ICI) or platinum-based chemotherapy (PCT) in advanced NSCLC (aNSCLC) patients is unknown. Experimental Design: The percentage of CD28-, CD57+, KLRG1+ among CD8+ T-cells (SIP) was assessed by flow cytometry on blood from aNSCLC patients before single-agent ICI (discovery cohort). A SIP cut-off was identified by log-rank maximization method and aNSCLC...
Fri Sep 04, 2020 14:58
Purpose: Resistance to treatment with endocrine therapy in patients with HR+, HER2- advanced breast cancer (ABC) is common and dual inhibition of CDK4/6 and PI3K pathways may delay the development of resistance. This phase Ib trial evaluates the safety and tolerability of triple and double regimens containing the CDK4/6 inhibitor ribociclib. Experimental Design: In this open-label, multicenter, phase Ib study, 70 postmenopausal women with HR+, HER2- ABC were enrolled into one of four treatment combinations:...
Fri Sep 04, 2020 14:58
Statins are widely prescribed cholesterol-lowering drugs that inhibit HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate (MVA) metabolic pathway. Multiple lines of evidence indicate that certain cancers depend on the MVA pathway for growth and survival, and therefore are vulnerable to statin therapy. However, these immediately available, well tolerated and inexpensive drugs have yet to be successfully repurposed and integrated into cancer patient care. In this Review, we highlight...
Fri Sep 04, 2020 14:58
Publication date: Available online 5 September 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Sara M. Elgendy, Shatha K. Alyammahi, Dima W. Alhamad, Shifaa M. Abdin, Hany A. Omar
Sun Sep 06, 2020 16:15
Publication date: October 2020Source: European Journal of Cancer, Volume 138Author(s): Elisabeth Quoix, Clarisse Audigier-Valette, Armelle Lavolé, Olivier Molinier, Virginie Westeel, Fabrice Barlesi, Jacques Le Treut, Eric Pichon, Jérôme Dauba, Josiane Otto, Lionel Moreau, Jeannick Madelaine, Patrick Dumont, Jacques Margery, Didier Debieuvre, Patrick Aldo Renault, Jean-Louis Pujol, Alexandra Langlais, Franck Morin, Denis Moro-Sibilot
Sun Sep 06, 2020 21:04
Publication date: Available online 6 September 2020Source: European Journal of CancerAuthor(s): Rebecca Auer, Duvaraga Sivajohanathan, Jim Biagi, James Conner, Erin Kennedy, Taymaa May
Sun Sep 06, 2020 21:04
Publication date: October 2020Source: European Journal of Cancer, Volume 138Author(s): Loïc Vasseur, Sophie Prevot, Nicolas Mounier, Dominique Costagliola, Caroline Besson
Sat Sep 05, 2020 12:53
Publication date: October 2020Source: European Journal of Cancer, Volume 138Author(s): Alberto F. Sobrero, Alberto Puccini, Qian Shi, Axel Grothey, Thierry Andrè, Anthony F. Shields, Ioannis Souglakos, Takayuki Yoshino, Timothy Iveson, Marcello Ceppi, Paolo Bruzzi
Fri Sep 04, 2020 18:39
Publication date: Available online 3 September 2020Source: European Journal of CancerAuthor(s): Arielle Elkrief, Antoine Desilets, Neha Papneja, Lena Cvetkovic, Catherine Groleau, Yahia Abdelali Lakehal, Layla Shbat, Corentin Richard, Julie Malo CCRP, Wiam Belkaid, Erin Cook, Stéphane Doucet, Thai Hoa Tran, Kevin Jao, Nathalie Daaboul, Eric Bhang, Jonathan M. Loree, Wilson H. Miller, Donald C. Vinh, Nathaniel Bouganim
Fri Sep 04, 2020 18:39
Publication date: Available online 6 September 2020Source: European Journal of Surgical OncologyAuthor(s): Mikael L. Soucisse, Oliver Fisher, Winston Liauw, Lana Ghanipour, Peter Cashin
Sun Sep 06, 2020 16:14
Publication date: Available online 6 September 2020Source: European Journal of Surgical OncologyAuthor(s): Liming Deng, Yi Wang, Jungang Zhao, Yifan Tong, Sina Zhang, Chen Jin, Kaiyu Chen, Wenming Bao, Zhengping Yu, Gang Chen
Sun Sep 06, 2020 16:14
Publication date: Available online 5 September 2020Source: European Journal of Surgical OncologyAuthor(s): Leopoldo Costarelli, Antonio Rizzo, Bortul Marina, Francesca Pietribiasi, Mario Taffurelli, Corrado Tinterri, Luigi Cataliotti, Burlizzi Stefano, Lavinia Bargiacchi, Lucio Fortunato, Senonetwork Italia Breast Centres Responders
Sun Sep 06, 2020 16:14
Background Vancomycin-resistant enterococci (VRE), mostly Enterococcus faecium, are multidrug-resistant microorganisms that can cause nosocomial infections. VRE has increased throughout many European countries, but data from Switzerland are scarce. Aim The aim of this work was to characterise the epidemiology of enterococcal bacteraemias in Switzerland with a focus on VRE. Methods In this observational study, we retrospectively investigated bacteraemias from 81 healthcare...
Thu Sep 03, 2020 03:00
On 6 June 2019, the Norwegian Institute of Public Health was notified of more than 50 cases of gastroenteritis in Askøy. A reservoir in a water supply system was suspected as the source of the outbreak because of the acute onset and geographical distribution of cases. We investigated the outbreak to confirm the source, extent of the outbreak and effect of control measures. A case was defined as a person in a household served by Water Supply System A (WSS-A) who had gastroenteritis for more than 24...
Thu Sep 03, 2020 03:00
Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings....
Thu Sep 03, 2020 03:00
Future Oncology, Ahead of Print.
Sat Sep 05, 2020 07:31
Future Oncology, Ahead of Print.
Sat Sep 05, 2020 07:19
Future Oncology, Ahead of Print.
Sat Sep 05, 2020 06:56
Future Oncology, Ahead of Print.
Fri Sep 04, 2020 15:24
Future Oncology, Ahead of Print.
Fri Sep 04, 2020 12:57
Future Oncology, Ahead of Print.
Fri Sep 04, 2020 11:03
Future Oncology, Ahead of Print.
Fri Sep 04, 2020 06:15
Future Oncology, Ahead of Print.
Thu Sep 03, 2020 13:40
Related Articles Apalutamide for the treatment of metastatic castration-sensitive prostate cancer. Future Oncol. 2020 Sep 04;: Authors: Dror CM, Chi KN Abstract Prostate cancer is the fifth leading cause of cancer related death among men with the majority of deaths linked to metastatic disease. Accumulating clinical data have confirmed the substantial survival benefit of the addition of docetaxel or - androgen signaling inhibitors to androgen...
Sat Sep 05, 2020 14:38
Related Articles Identification of key factors associated with early- and late-onset ovarian serous cystadenocarcinoma. Future Oncol. 2020 Sep 04;: Authors: Ma S, Zheng Y, Fei C Abstract Aim: To uncover the molecular mechanisms of early-onset ovarian serous cystadenocarcinoma (EOOSC; patients <50 years old) and late-onset ovarian serous cystadenocarcinoma (LOOSC; patients ≥50 years old). Materials & methods: Bioinformatics was utilized...
Sat Sep 05, 2020 14:38
Related Articles Treatment patterns, outcomes and clinical characteristics in advanced renal cell carcinoma: a real-world US study. Future Oncol. 2020 Sep 04;: Authors: Hall JP, Zanotti G, Kim R, Krulewicz SP, Leith A, Bailey A, Liu FX, Kearney M Abstract Aim: Assessing treatment patterns, outcomes and clinical characteristics in advanced renal cell carcinoma clinical practice. Materials & methods: A US cross-sectional physician survey conducted...
Sat Sep 05, 2020 14:38
Related Articles Real-world outcomes among US Merkel cell carcinoma patients initiating immune checkpoint inhibitors or chemotherapy. Future Oncol. 2020 Sep 04;: Authors: Chandra S, Zheng Y, Pandya S, Yu T, Kearney M, Wang L, Kim R, Phatak H Abstract Aim: Retrospectively assessed treatment patterns and clinical and economic outcomes in Merkel cell carcinoma (MCC) patients receiving recommended first-line regimens. Materials & methods: MCC...
Sat Sep 05, 2020 14:38
Abstract Research across the cancer care continuum indicates peer support can improve patient outcomes, yet little is known about how cancer peer support programs are implemented in practice. This study aimed to describe cancer peer support programs in “real world” (i.e., non-research) settings. A web search identified 100 programs in a wide variety of settings and locations; 48 published contact information on their website and were invited to participate in semi-structured interviews....
Sat Sep 05, 2020 03:00
Abstract In response to the COVID-19 social distancing guidelines, residency and fellowship programs transitioned to virtual instruction to deliver didactics and continue with medical education. The efficacy of such a fully online learning environment, however, remains unknown. To investigate its impact on medical education, this study surveyed hematology/oncology fellows at The University of Texas MD Anderson Cancer Center on their attitudes regarding the online-based lecture...
Sat Sep 05, 2020 03:00
Abstract The aim of this study was to analyse knowledge on colon cancer prevention among patients of primary care and identify their sources of information. The questionnaire study was conducted among patients of 36 primary healthcare clinics in Poland between September 2018 and February 2019. Patients were interviewed separately by trained researchers. Over 39% of the primary health patients declared that their knowledge about colon cancer prevention is unsatisfactory. Information...
Fri Sep 04, 2020 03:00
Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-A...
Sat Sep 05, 2020 03:00
Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...
Fri Sep 04, 2020 03:00
Abstract TNF‐related apoptosis‐inducing ligand (TRAIL) induces apoptosis selectively in cancer cells. For melanoma, the targeting of TRAIL signaling appears highly attractive, due to pronounced TRAIL receptor expression in tumor tissue. However, mechanisms of TRAIL resistance observed in melanoma cells may limit its clinical use. The Bcl‐2 family members are critical regulators of cell‐intrinsic apoptotic pathways. Thus, the antiapoptotic Bcl‐2 protein myeloid cell leukemia 1 (Mcl‐1) is overexpressed...
Fri Sep 04, 2020 12:48
Abstract ObjectiveWe investigated the patterns of tobacco treatment utilization among US adult smokers with cancer and the role of negative affect as potential individual‐level psychosocial barriers and facilitators influencing quit attempts and tobacco treatment utilization.MethodsWe analyzed data from the adult sample in Wave 1 (2013‐2014) of the Population Assessment of Tobacco and Health (PATH) Study. Using structural equation modeling (SEM), we examined (1) the association between cancer diagnosis...
Fri Sep 04, 2020 15:13
Abstract ObjectivesFamily conflict and family functioning were regarded as changeable factors associated with complicated grief (CG) and major depressive disorder (MDD) in the bereaved families of patients with advanced cancer, although the evidence is limited. We explored the family functioning associated with CG and MDD developing either independently or co‐morbidly in the bereaved families of patients with advanced cancer who died in palliative care units (PCUs).MethodsThis study comprised a...
Thu Sep 03, 2020 14:55
To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy.
Fri Sep 04, 2020 03:00
The goal of radiotherapy treatment plan robust optimization is to create a deliverable treatment plan which adequately covers the target volume with the lowest dose possible to the most relevant organs at risk. Treatment preparation and execution uncertainties need to be accounted for to avoid undertreating the target.[1] Composite minimax robust optimization (CMRO) is known to be advantageous for pencil beam scanning (PBS) proton therapy as compared to PTV-based treatment planning which is more...
Sat Sep 05, 2020 03:00
Carbon-ion radiotherapy (C-ion RT) has become a treatment option for several types of malignant disease in recent years [1]. Compared with photon beams, C-ion beams are advantageous with respect to dose localisation and biological effectiveness [2]. C-ion beams show high linear energy transfer (LET) and therefore provide high-density energy deposition per unit length [3]. Thus, the cell-killing effect of C-ion beams is thought to be 2–3 times greater than that of X-ray beams [4]. This LET-related...
Sat Sep 05, 2020 03:00
In Canada, as of July 25, 2020, over 115,000 cases of COVID-19 have been diagnosed. That number is anticipated to grow until between 30% and 70% of the population have been infected (11-26 million people) [1]. This is despite advantages to disease control of having a small population (37 million) spread over a large geographic area (10 million square km with varying population densities) and governments having implemented nationwide social distancing early in the spread of disease.
Sat Sep 05, 2020 03:00
Merlotti and colleagues wrote a letter [1] on our manuscript in which we described the multiple measures for patient and staff COVID-19 protection and prevention at the Hubei Cancer Hospital in Wuhan, China in early 2020 at the start of the COVID-19 pandemic. We concluded that they raised three questions and discussion points: Firstly, Merlotti et al. thought that the main reason that a large proportion of cancer patients did not receive necessary radiation treatment was the two-team staff schedule...
Sat Sep 05, 2020 03:00
Resolution of polycistronic RNA by SL2 trans-splicing is a widely-conserved nematode trait [Article]
Spliced leader trans-splicing is essential for the processing and translation of polycistronic RNAs generated by eukaryotic operons. In C. elegans, a specialised spliced leader, SL2, provides the 5’ end for uncapped pre-mRNAs derived from polycistronic RNAs. Studies of other nematodes suggested that SL2-type trans-splicing is a relatively recent innovation, confined to Rhabditina, the clade containing C. elegans and its close relatives. Here we conduct a survey of transcriptome-wide spliced leader...
Fri Sep 04, 2020 19:55
Publication date: October 2020Source: Cancer Epidemiology, Volume 68Author(s): Barbara Nemesure, Denise Albano, Thomas Bilfinger
Sat Sep 05, 2020 13:20
Publication date: Available online 4 September 2020Source: Seminars in OncologyAuthor(s): Casavilca-Zambrano Sandro, Custodio Nilton, Liendo-Picoaga Ruddy, Cancino-Maldonado Karina, Esenarro Loida, Montesinos Rosa, Bertani Stéphane, Fejerman Laura, Guerchet Maëlenn, Vidaurre Tatiana
Sat Sep 05, 2020 18:11
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