New Findings What is the central question of this study? Obesity is associated with complex perturbations to iron homeostasis. We examined if plasma ferritin concentration (a biomarker of whole‐body iron stores) is related to the abundance of ferritin (the key tissue iron storage protein) in skeletal muscle in adults with obesity. What is the main finding and its importance? Plasma ferritin concentration was tightly correlated with the abundance of ferritin in skeletal muscle, and...
Sat Sep 05, 2020 13:04
New Findings What is the central question of this study? To compare H‐reflex and V‐wave excitability between men and women engaging in similar levels of physical activity. What is the main finding and its importance? H‐reflex excitability is lower in women than in men because of their greater level of antagonist co‐activation during sustained plantar flexion isometric exercise. In addition, supraspinal drive is similar between men and women independently of their differences in...
Fri Sep 04, 2020 19:54
Publication date: Available online 6 September 2020Source: International Journal of PsychophysiologyAuthor(s): Zhiyuan Liu, Xuemei Cheng, Sijia Liu, Zhenyu Zhang, Shuang Li, Lin Li, Xiuyan Guo
Sun Sep 06, 2020 13:39
Abstract Sepsis-induced acute kidney injury (SAKI) is a common complication of hospitalized patients, often leading to unacceptable mortality. Limited effective treatment or diagnosis biomarkers are available and the underlying mechanism remains unclear. The miR-30c-5p is considered as a critical mediator of kidney diseases and aberrantly decreased in patients with SAKI, while the mechanism is still unclear. For this purpose, the role of miR-30c-5p in SAKI has been investigated...
Sat Sep 05, 2020 03:00
Abstract Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies demonstrate reduced pGSN concentrations in several disease states, including severe trauma, burns, and sepsis. Markedly decreased pGSN concentrations in these conditions precede and predict adverse clinical outcomes. In this study, we measured pGSN in patients with chronic...
Fri Sep 04, 2020 03:00
Key points Heart failure patients with reduced ejection fraction (HFrEF) exhibit severe limitations in exercise capacity (V̇O2peak). One of the primary peripheral mechanisms suggested to underlie exercise intolerance in HFrEF is excessive locomotor muscle group III/IV afferent feedback; however, this has never been investigated in human HF. HFrEF patients and controls performed an incremental exercise test to volitional exhaustion to determine V̇O2peak with lumbar intrathecal fentanyl or placebo....
Fri Sep 04, 2020 19:58
Key points Placental pathological abnormalities are more frequently observed in complicated pregnancies than in healthy pregnancies Infiltration of CD8+ T‐cells into the placental villous tissue occurred in both fetal growth restriction and pre‐eclampsia, whereas CD79α+ B‐cell infiltration was only apparent with reduced fetal growth. Vascularisation, fibrin depositions, macrophage and neutrophil infiltration in the placenta did not differ between healthy and complicated pregnancies. Abstract...
Fri Sep 04, 2020 19:56
Key points Rod and cone photoreceptors convert light into electrochemical signals that are transferred to second order cells, initiating image‐forming visual processing. Electroretinograms (ERGs) can detect the associated light‐induced extracellular transretinal events, allowing for physiological assessment of cellular activity from morphologically intact retinas. We outline a method for economically configuring a traditional patch‐clamp rig for performing high signal‐to‐noise ex‐vivo ERGs....
Fri Sep 04, 2020 19:55
Key points Small mammals native to high altitude must sustain high rates of thermogenesis to cope with cold. Skeletal muscle is a key site of shivering and non‐shivering thermogenesis, but the importance of mitochondrial plasticity in cold hypoxic environments remains unresolved. We examined high‐altitude deer mice, which have evolved a high capacity for aerobic thermogenesis, to examine the mechanisms of mitochondrial plasticity during chronic exposure to cold and hypoxia, alone and in combination....
Fri Sep 04, 2020 19:55
Key points Fasting can increases motivation for food and can energize reward‐seeking. Ventral tegmental area (VTA) dopamine neurons respond to motivationally relevant information and fasting can influence mesolimbic dopamine concentration. An acute overnight fast differentially alters food approach behaviours and excitatory synaptic transmission onto VTA dopamine neurons of male or female mice. While inhibitory synapses onto VTA dopamine neurons are not altered by fasting in male or female...
Fri Sep 04, 2020 19:55
Key points Neurons of the enteric submucous plexus are challenged by osmolar fluctuations during digestion and absorption of nutrients. Central neurons are very sensitive to changes in osmolality but knowledge on that issue related to enteric neurons is sparse. The present study focuses on investigation of osmosensitivity of submucosal neurons including potential molecular mediating mechanisms. Results show that submucosal neurons respond to hypoosmolar stimuli with increased activity which...
Thu Sep 03, 2020 11:25
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