IJMS, Vol. 21, Pages 6473: Agent-Based Modeling of T Cell Receptor Cooperativity International Journal of Molecular Sciences doi: 10.3390/ijms21186473 Authors: Anastasios Siokis Philippe A. Robert Michael Meyer-Hermann Immunological synapse (IS) formation is a key event during antigen recognition by T cells. Recent experimental evidence suggests that the affinity between T cell receptors (TCRs) and antigen is actively modulated during the early steps of TCR signaling. In this work,...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6475: Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep International Journal of Molecular Sciences doi: 10.3390/ijms21186475 Authors: Panzao Yang Joanne O. Davidson Tania M. Fowke Robert Galinsky Guido Wassink Rashika N. Karunasinghe Jaya D. Prasad Sumudu Ranasinghe Colin R. Green Laura Bennet Alistair J. Gunn Justin M. Dean ...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6466: A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option? International Journal of Molecular Sciences doi: 10.3390/ijms21186466 Authors: Karim Sidhom Patience O. Obi Ayesha Saleem Extracellular vesicles (EVs) are membranous vesicles secreted by both prokaryotic and eukaryotic cells and play a vital role in intercellular communication. EVs are classified into several subtypes based on their origin, physical characteristics,...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6471: Cardiovascular Damage in COVID-19: Therapeutic Approaches Targeting the Renin-Angiotensin-Aldosterone System International Journal of Molecular Sciences doi: 10.3390/ijms21186471 Authors: Jairo Lumpuy-Castillo Ana Lorenzo-Almorós Ana María Pello-Lázaro Carlos Sánchez-Ferrer Jesús Egido José Tuñón Concepción Peiró Óscar Lorenzo Coronavirus disease 2019 (COVID-19) is usually more severe and associated with worst outcomes in individuals with...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6465: A Mechanosensitive Channel, Mouse Transmembrane Channel-Like Protein 1 (Mtmc1) Is Translated from a Splice Variant mTmc1ex1 but Not from the Other Variant mTmc1ex2 International Journal of Molecular Sciences doi: 10.3390/ijms21186465 Authors: Soichiro Yamaguchi Maho Hamamura Ken-ichi Otsuguro Mechanical stimuli caused by sound waves are detected by hair cells in the cochlea through the opening of mechanoelectrical transduction (MET) channels. Transmembrane...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6467: Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21186467 Authors: Chao Lien Liu Ying Jen Chen Ming Huei Fan Yi Jen Liao Tsui Lien Mao Cancer stem cells (CSCs) are considered to be the origin of ovarian cancer (OC) development, recurrence, and chemoresistance. We investigated changes in expression levels of the CSC biomarker, cluster of...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6468: HTK-N: Modified Histidine-Tryptophan-Ketoglutarate Solution—A Promising New Tool in Solid Organ Preservation International Journal of Molecular Sciences doi: 10.3390/ijms21186468 Authors: Annika Mohr Jens G. Brockmann Felix Becker To ameliorate ischemia-induced graft injury, optimal organ preservation remains a critical hallmark event in solid organ transplantation. Although numerous preservation solutions are in use, they still have functional limitations....
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6470: Novel ANO1 Inhibitor from Mallotus apelta Extract Exerts Anticancer Activity through Downregulation of ANO1 International Journal of Molecular Sciences doi: 10.3390/ijms21186470 Authors: Yohan Seo Nguyen Hoang Anh Yunkyung Heo So-Hyeon Park Phan Van Kiem Yechan Lee Duong Thi Hai Yen Sungwoo Jo Dongkyu Jeon Bui Huu Tai Nguyen Hoai Nam Chau Van Minh Seung Hyun Kim Nguyen Xuan Nhiem Wan Namkung Anoctamin1 (ANO1), a calcium-activated...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6463: Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis International Journal of Molecular Sciences doi: 10.3390/ijms21186463 Authors: Bisera Stepanovska Aleksandra Zivkovic Gaby Enzmann Silvia Tietz Thomas Homann Burkhard Kleuser Britta Engelhardt Holger Stark Andrea Huwiler Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6462: Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies International Journal of Molecular Sciences doi: 10.3390/ijms21186462 Authors: Emanuele Monda Giuseppe Palmiero Marta Rubino Federica Verrillo Federica Amodio Francesco Di Fraia Roberta Pacileo Fabio Fimiani Augusto Esposito Annapaola Cirillo Adelaide Fusco Elisabetta Moscarella Giulia Frisso Maria Giovanna Russo Giuseppe Pacileo Paolo Calabrò Olga...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6464: Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21186464 Authors: Qingkang Lyu Magdalena Wawrzyniuk Victor P. M. G. Rutten Willem van Eden Alice J. A. M. Sijts Femke Broere The pathogenesis of many inflammatory diseases is associated with the uncontrolled activation of nuclear factor kappa B (NF-κB) in macrophages. Previous...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6459: Role of miR-30a-3p Regulation of Oncogenic Targets in Pancreatic Ductal Adenocarcinoma Pathogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21186459 Authors: Hiroki Shimomura Reona Okada Takako Tanaka Yuto Hozaka Masumi Wada Shogo Moriya Tetsuya Idichi Yoshiaki Kita Hiroshi Kurahara Takao Ohtsuka Naohiko Seki Our recent studies have implicated some passenger strands of miRNAs in the molecular pathogenesis of...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6460: Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA International Journal of Molecular Sciences doi: 10.3390/ijms21186460 Authors: Takayuki Ikeda Hidehito Saito-Takatsuji Yasuo Yoshitomi Hideto Yonekura Mature mRNA is generated by the 3ʹ end cleavage and polyadenylation of its precursor pre-mRNA. Eukaryotic genes frequently have multiple polyadenylation sites, resulting in mRNA isoforms with different 3ʹ-UTR lengths...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6461: Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks International Journal of Molecular Sciences doi: 10.3390/ijms21186461 Authors: Han Yang Shuling Ren Siyuan Yu Haifeng Pan Tingdong Li Shengxiang Ge Jun Zhang Ningshao Xia Precise gene editing is—or will soon be—in clinical use for several diseases, and more applications are under development. The programmable nuclease...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6458: Interleukin-36 Cytokine/Receptor Signaling: A New Target for Tissue Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21186458 Authors: Elaina Melton Hongyu Qiu Tissue fibrosis is a major unresolved medical problem, which impairs the function of various systems. The molecular mechanisms involved are poorly understood, which hinders the development of effective therapeutic strategies. Emerging evidence from recent studies indicates that...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6457: The Lactate Receptor HCA1 Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle International Journal of Molecular Sciences doi: 10.3390/ijms21186457 Authors: Alena Hadzic Teresa D. Nguyen Makoto Hosoyamada Naoko H. Tomioka Linda H. Bergersen Jon Storm-Mathisen Cecilie Morland The volume, composition, and movement of the cerebrospinal fluid (CSF) are important for brain...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6455: Adipose-Derived Mesenchymal Stem Cells do not Affect the Invasion and Migration Potential of Oral Squamous Carcinoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21186455 Authors: Snehadri Sinha Matilda Narjus-Sterba Katja Tuomainen Sippy Kaur Riitta Seppänen-Kaijansinkko Tuula Salo Bettina Mannerström Ahmed Al-Samadi Mesenchymal stem cells (MSCs) are commonly isolated from bone marrow and adipose tissue. Depending...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6456: Neuroprotection by Neurotropin through Crosstalk of Neurotrophic and Innate Immune Receptors in PC12 Cells International Journal of Molecular Sciences doi: 10.3390/ijms21186456 Authors: Yu Fukuda Kazuki Nakajima Tatsuro Mutoh Infected or damaged tissues release multiple “alert” molecules such as alarmins and damage-associated molecular patterns (DAMPs) that are recognized by innate immune receptors, and induce tissue inflammation,...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6454: Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches International Journal of Molecular Sciences doi: 10.3390/ijms21186454 Authors: Carlo Domenico Maida Rosario Luca Norrito Mario Daidone Antonino Tuttolomondo Antonio Pinto One of the most important causes of neurological morbidity and mortality in the world is ischemic stroke. It can be a result of multiple events such as embolism...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6453: Elucidating the Role of Ezh2 in Tolerogenic Function of NOD Bone Marrow-Derived Dendritic Cells Expressing Constitutively Active Stat5b International Journal of Molecular Sciences doi: 10.3390/ijms21186453 Authors: Echarki Zerif Farhan Ullah Khan Ahmed Aziz Raki Véronique Lullier Denis Gris Gilles Dupuis Abdelaziz Amrani Tolerogenic dendritic cells (toDCs) are crucial to controlling the development of autoreactive T cell responses and the...
Fri Sep 04, 2020 03:00
IJMS, Vol. 21, Pages 6452: Global Analysis of the Human RNA Degradome Reveals Widespread Decapped and Endonucleolytic Cleaved Transcripts International Journal of Molecular Sciences doi: 10.3390/ijms21186452 Authors: Jung-Im Won JaeMoon Shin So Young Park JeeHee Yoon Dong-Hoon Jeong RNA decay is an important regulatory mechanism for gene expression at the posttranscriptional level. Although the main pathways and major enzymes that facilitate this process are well defined,...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2881: Analysis of miR-29 Serum Levels in Patients with Neuroendocrine Tumors—Results from an Exploratory Study Journal of Clinical Medicine doi: 10.3390/jcm9092881 Authors: Burcin Özdirik Anna K. Stueven Raphael Mohr Lukas Geisler Alexander Wree Jana Knorr Münevver Demir Mihael Vucur Sven H. Loosen Fabian Benz Markus Reiss Bertram Wiedenmann Frank Tacke Henning Jann Teresa Hellberg Christoph Roderburg Background and aims:...
Sun Sep 06, 2020 03:00
JCM, Vol. 9, Pages 2879: Feasibility and Acceptability Findings of an Energy Balance Data Repository of Children, Adolescents, and Young Adults with Cancer Journal of Clinical Medicine doi: 10.3390/jcm9092879 Authors: Maria C. Swartz Alaina K. Teague Stephanie J. Wells Theresa Honey Min Fu Kris M. Mahadeo Laura S. Kabiri Joya Chandra Karen Moody Keri Schadler Cancer patients suffer changes in energy balance (EB), the combination of energy intake (nutrition)...
Sun Sep 06, 2020 03:00
JCM, Vol. 9, Pages 2880: Coronary Microvascular Dysfunction Journal of Clinical Medicine doi: 10.3390/jcm9092880 Authors: Vancheri Longo Vancheri Henein Many patients with chest pain undergoing coronary angiography do not show significant obstructive coronary lesions. A substantial proportion of these patients have abnormalities in the function and structure of coronary microcirculation due to endothelial and smooth muscle cell dysfunction. The coronary microcirculation...
Sun Sep 06, 2020 03:00
JCM, Vol. 9, Pages 2878: Challenges in Antifungal Therapy in Diabetes Mellitus Journal of Clinical Medicine doi: 10.3390/jcm9092878 Authors: Sazlyna Mohd Sazlly Lim Mahipal Sinnollareddy Fekade Bruck Sime Diabetic patients have an increased propensity to Candida sp. infections due to disease-related immunosuppression and various other physiological alterations. The incidence of candidiasis has increased in number over the years and is linked to significant morbidity and mortality...
Sun Sep 06, 2020 03:00
JCM, Vol. 9, Pages 2877: Peripheral Blood Lymphocyte Subpopulations in Patients Following Small Diameter Metal-On-Metal Total Hip Replacement at Long-Term Follow-Up Journal of Clinical Medicine doi: 10.3390/jcm9092877 Authors: Tobias Reiner Hester Haubenreisser Elena Tripel Nils Rosshirt Reza Sorbi Timo Albert Nees Tobias Gotterbarm Christian Merle Babak Moradi Sébastien Hagmann (1) Background: The objective of the present study was to investigate peripheral...
Sun Sep 06, 2020 03:00
JCM, Vol. 9, Pages 2876: A Real-Life Survey of Venous Thromboembolic Events Occurring in Myeloma Patients Treated in Third Line with Second-Generation Novel Agents Journal of Clinical Medicine doi: 10.3390/jcm9092876 Authors: Valeria Calafiore Silvia Giamporcaro Concetta Conticello Alessandra Romano Marina Parisi Gaetano Giuffrida Daniele Tibullo Francesco Di Raimondo Salvatore Santo Signorelli Compared to the general population, patients with multiple myeloma...
Sat Sep 05, 2020 03:00
JCM, Vol. 9, Pages 2875: Hematological Phenotype of COVID-19-Induced Coagulopathy: Far from Typical Sepsis-Induced Coagulopathy Journal of Clinical Medicine doi: 10.3390/jcm9092875 Authors: Yutaka Umemura Kazuma Yamakawa Takeyuki Kiguchi Takeshi Nishida Masahiro Kawada Satoshi Fujimi Background: Blood coagulation disorders commonly occur with severe coronavirus disease 2019 (COVID-19). However, there is only limited evidence on differentiating the pattern of the hemostatic...
Sat Sep 05, 2020 03:00
JCM, Vol. 9, Pages 2874: Safety and Tolerability of Plasma Exchange and Immunoadsorption in Neuroinflammatory Diseases Journal of Clinical Medicine doi: 10.3390/jcm9092874 Authors: Johannes Dorst Frank Fillies Jens Dreyhaupt Makbule Senel Hayrettin Tumani Plasma exchange (PE) and immunoadsorption (IA) are frequently used for treatment of various autoimmune-mediated neurological diseases, including multiple sclerosis (MS), chronic inflammatory demyelinating polyneuropathy...
Sat Sep 05, 2020 03:00
JCM, Vol. 9, Pages 2872: Evaluation of Mental Health Factors among People with Systemic Lupus Erythematosus during the SARS-CoV-2 Pandemic Journal of Clinical Medicine doi: 10.3390/jcm9092872 Authors: Paweł Wańkowicz Aleksandra Szylińska Iwona Rotter There are considerable psychological and psychiatric consequences of the pandemic. Researchers have started to take into account the real or perceived sense of social threats that may be expressed, such as anxiety, depression, and...
Sat Sep 05, 2020 03:00
JCM, Vol. 9, Pages 2873: Triage of Amyotrophic Lateral Sclerosis Patients during the COVID-19 Pandemic: An Application of the D50 Model Journal of Clinical Medicine doi: 10.3390/jcm9092873 Authors: Robert Steinbach Tino Prell Nayana Gaur Beatrice Stubendorff Annekathrin Roediger Benjamin Ilse Otto W. Witte Julian Grosskreutz Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease, the management of which requires the continuous provision of multidisciplinary...
Sat Sep 05, 2020 03:00
JCM, Vol. 9, Pages 2869: Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration Journal of Clinical Medicine doi: 10.3390/jcm9092869 Authors: Sander De Bruyne Caroline Vandenbroecke Henk Vrielinck Samira Khelifi Olivier De Wever Ken Bracke Manon Huizing Nezahat Boston Jonas Himpe Marijn Speeckaert Anne Vral Jo Van Dorpe Elisabeth Van Aken Joris R. Delanghe Age-related macular degeneration is the leading cause...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2871: Late Diagnosis of Infants with PCD and Neonatal Respiratory Distress Journal of Clinical Medicine doi: 10.3390/jcm9092871 Authors: Myrofora Goutaki Florian S. Halbeisen Angelo Barbato Suzanne Crowley Amanda Harris Robert A. Hirst Bülent Karadag Vendula Martinu Lucy Morgan Christopher O’Callaghan Ugur Ozçelik Sergio Scigliano Santiago Ucros Panayiotis Yiallouros Sven M. Schulzke Claudia E. Kuehni Neonatal respiratory...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2867: Is There an Association between Diabetes and Neck and Back Pain? Results of a Case-Control Study Journal of Clinical Medicine doi: 10.3390/jcm9092867 Authors: Lidiane Lima Florencio Ana Lopez-de-Andres Valentin Hernández-Barrera Domingo Palacios-Ceña César Fernández-de-las-Peñas Rodrigo Jimenez-Garcia Napoleon Perez-Farinos David Carabantes-Alarcon David Martinez-Hernandez Romana Albaladejo-Vicente We aimed to assess if subjects with...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2868: Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer Journal of Clinical Medicine doi: 10.3390/jcm9092868 Authors: Taxiarchis Konstantinos Nikolouzakis Luca Falzone Konstantinos Lasithiotakis Sabine Krüger-Krasagakis Alexandra Kalogeraki Maria Sifaki Demetrios A. Spandidos Emmanuel Chrysos Aristidis Tsatsakis John Tsiaoussis Skin cancer represents the most...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2870: Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study Journal of Clinical Medicine doi: 10.3390/jcm9092870 Authors: Giuseppe La Torre Anna Paola Massetti Guido Antonelli Caterina Fimiani Mauro Fantini Mattia Marte Augusto Faticoni Carlo Maria Previte Ombretta Turriziani Francesco Pugliese Paolo Villari Ferdinando Romano Claudio Maria Mastroianni Covid-19 Sapienza...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2862: The Relevance of Dual Diagnoses among Drug-Dependent Patients with Sleep Disorders Journal of Clinical Medicine doi: 10.3390/jcm9092862 Authors: Carlos Roncero Llanyra García-Ullán Alberto Bullón Diego Remón-Gallo Begoña Vicente-Hernández Ana Álvarez Amaya Caldero Andrea Flores Lourdes Aguilar Background: Sleep disorders are often associated with drug use. Nearly 70% of patients admitted for detoxification report sleep problems. Dual disorder...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2865: Ascitic Interleukin 6 Is Associated with Poor Outcome and Spontaneous Bacterial Peritonitis: A Validation in Critically Ill Patients with Decompensated Cirrhosis Journal of Clinical Medicine doi: 10.3390/jcm9092865 Authors: Ulrich Mayr Marina Lukas Mayada Elnegouly Christine Vogt Ulrike Bauer Joerg Ulrich Roland M. Schmid Wolfgang Huber Tobias Lahmer Decompensated cirrhosis predisposes to infectious diseases and acute-on-chronic liver...
Fri Sep 04, 2020 03:00
JCM, Vol. 9, Pages 2863: Foetal Sonographic Anogenital Distance Is Longer in Polycystic Ovary Syndrome Mothers Journal of Clinical Medicine doi: 10.3390/jcm9092863 Authors: Sharon Perlman Yoel Toledano Zvi Kivilevitch Nufar Halevy Elena Rubin Yinon Gilboa Anogenital distance (AGD) is a biomarker for the prenatal hormonal environment. Androgen excess is a key element in polycystic ovary syndrome (PCOS). The aim of this study was to assess the sonographic foetal AGD in a...
Fri Sep 04, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου