Κυριακή 6 Σεπτεμβρίου 2020

 


Elevated miR-29a Contributes to Axonal Outgrowth and Neurological Recovery After Intracerebral Hemorrhage via Targeting PTEN/PI3K/Akt Pathway.
Related Articles Elevated miR-29a Contributes to Axonal Outgrowth and Neurological Recovery After Intracerebral Hemorrhage via Targeting PTEN/PI3K/Akt Pathway. Cell Mol Neurobiol. 2020 Sep 05;: Authors: Zhao M, Gao J, Zhang Y, Jiang X, Tian Y, Zheng X, Wang K, Cui J Abstract Spontaneous intracerebral hemorrhage (ICH) is a clinical challenge with high disability and lacks an effective treatment. miR-29a strongly expressed in the brain has been...
pubmed: basal ganglia stroke...
Sun Sep 06, 2020 15:37
Haemodynamic analysis of adult patients with moyamoya disease: CT perfusion and DSA gradings.
Related Articles Haemodynamic analysis of adult patients with moyamoya disease: CT perfusion and DSA gradings. Stroke Vasc Neurol. 2020 Sep 03;: Authors: Shi Z, Ma G, Zhang D Abstract OBJECT: Moyamoya disease (MMD) is a common and chronic progressive stenotic-occlusive cerebrovascular disease in Eastern Asia. To evaluate the hemispheric haemodynamic status of adult patients with MMD, we explored the potential risk factors of hemispheric perfusion...
pubmed: basal ganglia stroke...
Sat Sep 05, 2020 15:38
Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM).
Related Articles Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM). Bioorg Chem. 2020 Aug 26;103:104189 Authors: Li XY, Li S, Lu GQ, Wang DP, Liu KL, Qian XH, Xue WH, Meng FH Abstract A series of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives were designed, synthesized, and evaluated...
pubmed: cell cycle arrest
Sun Sep 06, 2020 13:41
Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication.
Related Articles Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication. Virology. 2020 Aug 27;550:78-88 Authors: Trujillo-Uscanga A, Gutiérrez-Escolano AL Abstract p53 is implicated in several cellular pathways such as induction of cell-cycle arrest, differentiation, senescence, and apoptosis. p53 is activated by...
pubmed: cell cycle arrest
Sun Sep 06, 2020 13:41
Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling.
Related Articles Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Aug 26;103:104222 Authors: AbdelHaleem A, Mansour AO, AbdelKader M, Arafa RK Abstract VEGFR-2 is a key regulator in cancer angiogenesis. This research displays the design and synthesis of novel 3-cyano-6-naphthylpyridine scaffold-based derivatives as selective VEGFR-2 inhibitors and cytotoxic...
pubmed: cell cycle arrest
Sun Sep 06, 2020 13:41
Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion.
Related Articles Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion. J Cell Mol Med. 2020 Sep 05;: Authors: Rizeq B, Sif S, Nasrallah GK, Ouhtit A Abstract Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the contribution of other...
pubmed: cell cycle arrest
Sun Sep 06, 2020 13:41
Induction of Cell Cycle Arrest in MKN45 Cells after Schiff Base Oxovanadium Complex Treatment Using Changes in Gene Expression of CdC25 and P53.
Related Articles Induction of Cell Cycle Arrest in MKN45 Cells after Schiff Base Oxovanadium Complex Treatment Using Changes in Gene Expression of CdC25 and P53. Drug Res (Stuttg). 2020 Sep 04;: Authors: Mirjalili S, Dejamfekr M, Moshtaghian A, Salehi M, Behzad M, Khaleghian A Abstract Compounds containing heavy metals such as vanadium, nickel, and cobalt may be useful for the treatment of various diseases. Multiple studies have been carried...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
Long-Term Response to Intermittent Binimetinib in Patients with NRAS-Mutant Melanoma.
Related Articles Long-Term Response to Intermittent Binimetinib in Patients with NRAS-Mutant Melanoma. Oncologist. 2020 Sep 04;: Authors: Matter AV, Micaletto S, Urner-Bloch U, Dummer R, Goldinger SM Abstract Melanoma can be classified based on the detection of relevant oncogenic driver mutations. These mutations partially determine a patient's treatment options. MEK inhibitors have demonstrated little efficacy in patients with NRAS-mutated...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
Polo-like Kinase 1 as an emerging drug target: Structure, function and therapeutic implications.
Related Articles Polo-like Kinase 1 as an emerging drug target: Structure, function and therapeutic implications. J Drug Target. 2020 Sep 04;:1-43 Authors: Shakeel I, Basheer N, Hasan GM, Afzal M, Hassan MI Abstract Polo-like kinase 1 (PLK1) is a conserved mitotic serine-threonine protein kinase, functions as a regulatory protein, and is involved in the progression of the mitotic cycle. It plays important roles in the regulation of cell...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
Good or not good: Role of miR-18a in cancer biology.
Related Articles Good or not good: Role of miR-18a in cancer biology. Rep Pract Oncol Radiother. 2020 Sep-Oct;25(5):808-819 Authors: Kolenda T, Guglas K, Kopczyńska M, Sobocińska J, Teresiak A, Bliźniak R, Lamperska K Abstract miR-18a is a member of primary transcript called miR-17-92a (C13orf25 or MIR17HG) which also contains five other miRNAs: miR-17, miR-19a, miR-20a, miR-19b and miR-92a. This cluster as a whole shows specific characteristics,...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
Circ_0015756 Aggravates Hepatocellular Carcinoma Development by Regulating FGFR1 via Sponging miR-610.
Related Articles Circ_0015756 Aggravates Hepatocellular Carcinoma Development by Regulating FGFR1 via Sponging miR-610. Cancer Manag Res. 2020;12:7383-7394 Authors: Guo W, Zhao L, Wei G, Liu P, Zhang Y, Fu L Abstract Background: Hepatocellular carcinoma (HCC) is the leading threat of cancer-related death in humans. Increasing studies show that circular RNAs (circRNAs) are important indicators in cancer diagnosis and prognosis. This study...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway.
Related Articles The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway. Cancer Manag Res. 2020;12:6195-6207 Authors: Liu S, Yang J, Peng X, Li J, Zhu C Abstract Objective: Ovarian cancer (OC) is the leading cause of death among gynecological tumors; however, no effective treatment is currently available. Fucoidan, which is extracted from marine algae,...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors.
Related Articles Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors. Eur J Med Chem. 2020 Aug 30;208:112780 Authors: Xu Y, Zhang XJ, Li WB, Wang XR, Wang S, Qiao XP, Chen SW Abstract Bromodomain protein 4 (BRD4) plays a crucial role in transcriptional regulation and is considered to be a viable drug target for cancer treatment. Herein, we designed and synthesized a series of indole-2-one derivatives...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
Discovery of potent small molecule PROTACs targeting mutant EGFR.
Related Articles Discovery of potent small molecule PROTACs targeting mutant EGFR. Eur J Med Chem. 2020 Aug 26;208:112781 Authors: Zhao HY, Yang XY, Lei H, Xi XX, Lu SM, Zhang JJ, Xin M, Zhang SQ Abstract Epidermal growth factor receptor (EGFR) is an important therapeutic target for the treatment of non-small cell lung cancer. A number of efficacious EGFR tyrosine kinase inhibitors have been developed. However, acquired drug resistance...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
The efficacy of etanercept as anti-breast cancer treatment is attenuated by residing macrophages.
Related Articles The efficacy of etanercept as anti-breast cancer treatment is attenuated by residing macrophages. BMC Cancer. 2020 Sep 03;20(1):836 Authors: Shirmohammadi E, Ebrahimi SS, Farshchi A, Salimi M Abstract BACKGROUND: Interaction between microenvironment and breast cancer cells often is not considered at the early stages of drug development leading to failure of many drugs at later clinical stages. Etanercept is a TNF-alpha...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5.
Related Articles WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5. BMC Cancer. 2020 Sep 03;20(1):840 Authors: Zhou Y, Pei F, Ji M, Zhang F, Sun Y, Zhao Q, Wang X, Hong Y, Tian J, Wang Y, Chen JJ Abstract BACKGROUND: Genomic instability is a hallmark of cancer. The G1 checkpoint allows cells to repair damaged DNA that may lead to genomic instability. The high-risk human papillomavirus (HPV) E7 gene...
pubmed: cell cycle arrest
Sat Sep 05, 2020 13:58
Methylsulfonylmethane Induces Cell Cycle Arrest and Apoptosis, and Suppresses the Stemness Potential of HT-29 Cells.
Related Articles Methylsulfonylmethane Induces Cell Cycle Arrest and Apoptosis, and Suppresses the Stemness Potential of HT-29 Cells. Anticancer Res. 2020 Sep;40(9):5191-5200 Authors: Kim DH, Kang DY, Sp N, Jo ES, Rugamba A, Jang KJ, Yang YM Abstract BACKGROUND/AIM: Colorectal cancer is one of the most common malignancies worldwide. Small molecule-based chemotherapy is an attractive approach for the chemoprevention and treatment of colorectal...
pubmed: cell cycle arrest
Fri Sep 04, 2020 23:06
Effects of Sclareol Against Small Cell Lung Carcinoma and the Related Mechanism: In Vitro and In Vivo Studies.
Related Articles Effects of Sclareol Against Small Cell Lung Carcinoma and the Related Mechanism: In Vitro and In Vivo Studies. Anticancer Res. 2020 Sep;40(9):4947-4960 Authors: Chen HL, Gong JY, Lin SC, Li S, Chiang YC, Hung JH, Yen CC, Lin CC Abstract BACKGROUND/AIM: This study aimed to investigate the anticancer effects and potential mechanisms of sclareol in a human small cell lung carcinoma (SCLC) cell line. MATERIALS AND METHODS:...
pubmed: cell cycle arrest
Fri Sep 04, 2020 23:06
MSCs attenuate hypoxia induced pulmonary hypertension by activating P53 and NF-kB signaling pathway through TNFα secretion.
Related Articles MSCs attenuate hypoxia induced pulmonary hypertension by activating P53 and NF-kB signaling pathway through TNFα secretion. Biochem Biophys Res Commun. 2020 Aug 30;: Authors: Liu J, Li J, Xie C, Xuan L, Tang B Abstract Hypoxia could cause vascular smooth muscle hypertrophy, leading to high pulmonary circulation resistance, pulmonary artery (PA) pressure, even pulmonary arterial hypertension (PAH). Recent studies have demonstrated...
pubmed: cell cycle arrest
Fri Sep 04, 2020 23:06
FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway.
Related Articles FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway. Genome Med. 2020 Sep 02;12(1):77 Authors: Sun CC, Zhu W, Li SJ, Hu W, Zhang J, Zhuo Y, Zhang H, Wang J, Zhang Y, Huang SX, He QQ, Li DJ Abstract BACKGROUND: Long non-coding RNAs (lncRNAs) are extensively intricate in the tumorigenesis and metastasis of various...
pubmed: cell cycle arrest
Fri Sep 04, 2020 23:06
Anti-proliferation and anti-migration effects of an aqueous extract of Cinnamomi ramulus on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through induction of apoptosis, cell arrest and suppression of matrix metalloproteinase.
Related Articles Anti-proliferation and anti-migration effects of an aqueous extract of Cinnamomi ramulus on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through induction of apoptosis, cell arrest and suppression of matrix metalloproteinase. Pharm Biol. 2020 Dec;58(1):863-877 Authors: Liu J, Zhang Q, Li RL, Wei SJ, Gao YX, Ai L, Wu CJ, Pu XF Abstract CONTEXT: Cinnamomi ramulus, the dry twig of Cinnamomum cassia Presl. (Lauraceae),...
pubmed: cell cycle arrest
Fri Sep 04, 2020 23:06
Obacunone reduces inflammatory signalling and tumour occurrence in mice with chronic inflammation-induced colorectal cancer.
Related Articles Obacunone reduces inflammatory signalling and tumour occurrence in mice with chronic inflammation-induced colorectal cancer. Pharm Biol. 2020 Dec;58(1):886-897 Authors: Luo X, Yu Z, Yue B, Ren J, Zhang J, Mani S, Wang Z, Dou W Abstract CONTEXT: Obacunone, a limonoid abundantly found in Citrus fruits, exhibits a variety of bioactivities. OBJECTIVE: To investigate the effects of obacunone on a colorectal cancer (CRC)...
pubmed: cell cycle arrest
Fri Sep 04, 2020 23:06
Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells.
Related Articles Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells. Biomolecules. 2020 Aug 31;10(9): Authors: Dey P, Kundu A, Han SH, Kim KS, Park JH, Yoon S, Kim IS, Kim HS Abstract Renal cell carcinoma has emerged as one of the leading causes of cancer-related deaths in the USA. Here, we examined the anticancer profile of oxindole derivatives (SH-859) in human renal cancer cells....
pubmed: cell cycle arrest
Fri Sep 04, 2020 13:17
Responsive neurostimulation for refractory epilepsy in the pediatric population: A single-center experience.
Related Articles Responsive neurostimulation for refractory epilepsy in the pediatric population: A single-center experience. Epilepsy Behav. 2020 Sep 01;112:107389 Authors: Bercu MM, Friedman D, Silverberg A, Drees C, Geller EB, Dugan PC, Devinsky O, Doyle WH Abstract Drug-resistant focal epilepsy (DRFE) in children can impair cognition and behavior, and lead to premature death. Increased pediatric epilepsy surgery numbers reflect the improvements...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.
Related Articles Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex. Neuropharmacology. 2020 Sep 02;:108297 Authors: Theilmann W, Gericke B, Schidlitzki A, Muneeb Anjum SM, Borsdorf S, Harries T, Roberds SL, Aguiar DJ, Brunner D, Leiser SC, Song D, Fabbro D, Hillmann P, Wymann MP, Löscher W Abstract Mechanistic target of rapamycin...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
Trans-auricular Vagus Nerve Stimulation in the Treatment of Recovered Patients Affected by Eating and Feeding Disorders and Their Comorbidities.
Related Articles Trans-auricular Vagus Nerve Stimulation in the Treatment of Recovered Patients Affected by Eating and Feeding Disorders and Their Comorbidities. Psychiatr Danub. 2020 Sep;32(Suppl 1):42-46 Authors: Melis Y, Apicella E, Macario M, Dozio E, Bentivoglio G, Mendolicchio L Abstract INTRODUCTION: Eating and feeding disorders (EFD's) represent the psychiatric pathology with the highest mortality rate and one of the major disorders...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
Impact of ABCB1 Polymorphism on Levetiracetam Serum Concentrations in Epileptic Uygur Children in China.
Related Articles Impact of ABCB1 Polymorphism on Levetiracetam Serum Concentrations in Epileptic Uygur Children in China. Ther Drug Monit. 2020 Sep 01;: Authors: Zhao T, Yu J, Wang TT, Feng J, Zhao WB, Sun L, Yu LH, Li HJ, Sun Y Abstract BACKGROUND: Interindividual variations in the efficacy of antiseizure medications make epilepsy treatment challenging. This is due to genetic factors such as gene polymorphisms in ATP-Binding Cassette sub-family...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
When and How to Treat Status Epilepticus: The Tortoise or the Hare?
Related Articles When and How to Treat Status Epilepticus: The Tortoise or the Hare? J Clin Neurophysiol. 2020 Sep;37(5):393-398 Authors: Fong MWK, Hirsch LJ Abstract Status epilepticus (SE) is a collective term that is used to describe a variety of subtypes. Forgetting this point can be perilous, even resulting in exposing patients to unnecessary harms. This review revisits the foundations of many of our current treatment guidelines, providing...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
Initial treatment of seizures in children in an emergency department in rural Japan.
Related Articles Initial treatment of seizures in children in an emergency department in rural Japan. Brain Dev. 2020 Sep 01;: Authors: Shiraki A, Yasui M, Kidokoro H, Kido S, Ando H, Takahashi Y, Natsume J Abstract OBJECTIVE: Although the initial treatment of childhood seizures is important, treatment within an appropriate time window is often difficult in resource-limited areas. This study examined childhood seizure treatment in a rural area...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
Repetitive transcranial photobiomodulation but not long-term omega-3 intake reduces epileptiform discharges in rats with stroke-induced epilepsy.
Related Articles Repetitive transcranial photobiomodulation but not long-term omega-3 intake reduces epileptiform discharges in rats with stroke-induced epilepsy. J Biophotonics. 2020 Sep 05;:e202000287 Authors: Vogel DDS, Ortiz-Villatoro NN, de Freitas L, Aimbire F, Scorza FA, Albertini R, Scorza CA Abstract Epilepsy is a yet under-recognized consequence after a stroke and nearly 30% of cases are pharmacoresistant. There is an unmet need for...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase (PNPO) deficiency: a scoping review of 87 cases of PNPO deficiency.
Related Articles Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase (PNPO) deficiency: a scoping review of 87 cases of PNPO deficiency. Clin Genet. 2020 Sep 04;: Authors: Alghamdi M, Bashiri FA, Abdelhakim M, Adly N, Jamjoom DZ, Sumaily KM, Alghanem B, Arold ST Abstract Pyridoxamine-5'-phosphate oxidase (PNPO) deficiency is an autosomal recessive PLP-vitamin-responsive epileptic encephalopathy. The emerging feature of PNPO...
pubmed: epilepsy treatment
Sun Sep 06, 2020 14:05
Process and Outcome Evaluation of a Mindfulness-Based Cognitive Therapy Intervention for Cisgender and Transgender African American Women Living with HIV/AIDS.
Related Articles Process and Outcome Evaluation of a Mindfulness-Based Cognitive Therapy Intervention for Cisgender and Transgender African American Women Living with HIV/AIDS. AIDS Behav. 2020 Sep 04;: Authors: Hunter-Jones J, Gilliam S, Davis C, Brown D, Green D, Hunter C, Carswell A, Hansen N Abstract There is a need for evidence-based contextualized mental health interventions for persons living with HIV/AIDS. In the current study, the primary...
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Polycystic-Ovarian-Syndrome in Nigerian women with epilepsy on carbamazepine/ levetiracetam Monotherapy.
Related Articles Polycystic-Ovarian-Syndrome in Nigerian women with epilepsy on carbamazepine/ levetiracetam Monotherapy. Acta Neurol Scand. 2020 Sep 03;: Authors: Ogunjimi L, Yaria J, Makanjuola A, Alabi A, Osalusi B, Oboh D, Olusola-Bello M, Olawale O, Ogunniyi A Abstract OBJECTIVES: The study is aimed at comparing effects of older drugs like carbamazepine(CBZ) and newer agent like Levetiracetam (LEV) on Polycystic Ovarian Syndrome (PCOS)...
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Cutis verticis gyrata: Two cases associated with drug-resistant epilepsy.
Related Articles Cutis verticis gyrata: Two cases associated with drug-resistant epilepsy. Clin Case Rep. 2020 Aug;8(8):1365-1368 Authors: Rattagan M, De Francesco M, Kriebaum A, Ferraro F, Major C, Sharma D, Ojeda A, Martinez O, Musto AE Abstract Cutis verticis gyrata (CVG) is a neurocutaneous syndrome characterized by the formation of folds in the scalp that resembles the cerebral cortex. We present two cases of CVG and intellectual disability...
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Variability and change over time of weight and BMI among adolescents and adults with Prader-Willi syndrome: a 6-month text-based observational study.
Related Articles Variability and change over time of weight and BMI among adolescents and adults with Prader-Willi syndrome: a 6-month text-based observational study. Orphanet J Rare Dis. 2020 Sep 03;15(1):233 Authors: Vrana-Diaz CJ, Balasubramanian P, Kayadjanian N, Bohonowych J, Strong TV Abstract BACKGROUND: Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder in which hyperphagia (excessive appetite) is a hallmark feature. Understanding...
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Pitolisant and Other Histamine-3 Receptor Antagonists-An Update on Therapeutic Potentials and Clinical Prospects.
Related Articles Pitolisant and Other Histamine-3 Receptor Antagonists-An Update on Therapeutic Potentials and Clinical Prospects. Medicines (Basel). 2020 Sep 01;7(9): Authors: Harwell V, Fasinu PS Abstract Background: Besides its well-known role as a peripheral chemical mediator of immune, vascular, and cellular responses, histamine plays major roles in the central nervous system, particularly in the mediation of arousal and cognition-enhancement....
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Serum endocan and preoperative systemic inflammatory markers in patients with epilepsy.
Related Articles Serum endocan and preoperative systemic inflammatory markers in patients with epilepsy. Neurochirurgie. 2020 Feb;66(1):29-35 Authors: Faruk Ozdemir A, Kemerdere R, Orhan B, Ozturk Emre H, Bercik Inal B, Kayhan A, Naz Yeni S, Tanriverdi T Abstract OBJECTIVE: The mechanisms underlying epileptogenesis are still a focus of experimental and clinical research. Inflammation and angiogenesis are the two main topics that have been an...
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Mechanical considerations for design and implementation of peripheral intraneural devices.
Related Articles Mechanical considerations for design and implementation of peripheral intraneural devices. J Neural Eng. 2019 10 23;16(6):064001 Authors: Stiller AM, González-González MA, Boothby JM, Sherman SE, Benavides J, Romero-Ortega M, Pancrazio JJ, Black BJ Abstract OBJECTIVE: Neural interfaces designed to stimulate or record electrical activity from peripheral nerves have applications ranging from the electrical modulation of nerve...
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Brainstem Functional Connectivity Disturbances in Epilepsy may Recover After Successful Surgery.
Related Articles Brainstem Functional Connectivity Disturbances in Epilepsy may Recover After Successful Surgery. Neurosurgery. 2020 03 01;86(3):417-428 Authors: González HFJ, Goodale SE, Jacobs ML, Haas KF, Landman BA, Morgan VL, Englot DJ Abstract BACKGROUND: Focal seizures in temporal lobe epilepsy (TLE) are associated with widespread brain network perturbations and neurocognitive problems. OBJECTIVE: To determine whether brainstem...
pubmed: epilepsy treatment
Sat Sep 05, 2020 14:17
Abdominal Epilepsy: A Rare Cause of Unexplained Abdominal Pain.
Related Articles Abdominal Epilepsy: A Rare Cause of Unexplained Abdominal Pain. Cureus. 2020 Aug 29;12(8):e10120 Authors: Balabhadra A, Malipeddi A, Ali N, Balabhadra R Abstract Abdominal epilepsy (AE) is a very rare diagnosis; it is considered to be a category of temporal lobe epilepsies and is more commonly a diagnosis of exclusion. Demographic presentation of AE is usually in the pediatric age group. However, there is recorded documentation...
pubmed: epilepsy treatment
Fri Sep 04, 2020 23:22
Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy.
Related Articles Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jul 28;45(7):782-789 Authors: Yang X, Wang P, Pan J, Wang C, Luo J, Ma H Abstract OBJECTIVES: Due to the narrow therapeutic window of valproic acid (VPA), grievous adverse reactions such as hepatotoxicity, nephrotoxicity may occur in patients with epilepsy for a long...
pubmed: epilepsy treatment
Fri Sep 04, 2020 23:22
Immunization stress-related responses presenting as psychogenic non-epileptic seizures following HPV vaccination in Rio Branco, Brazil.
Related Articles Immunization stress-related responses presenting as psychogenic non-epileptic seizures following HPV vaccination in Rio Branco, Brazil. Vaccine. 2020 Aug 30;: Authors: Marchetti RL, Gallucci-Neto J, Kurcgant D, Proença ICGF, Valiengo LDCL, Fiore LA, Pinto LF, Maranhão AGK, Oliveira MTDC, de Oliveira LH Abstract IMPORTANCE: The absence of a positive diagnosis of psychogenic non-epileptic seizures (PNES) in immunization stress-related...
pubmed: epilepsy treatment
Fri Sep 04, 2020 23:22
Cerebral Microdialysis as a Tool for Assessing the Delivery of Chemotherapy in Brain Tumor Patients.
Related Articles Cerebral Microdialysis as a Tool for Assessing the Delivery of Chemotherapy in Brain Tumor Patients. World Neurosurg. 2020 Sep 02;: Authors: Pierce CF, Kwasnicki A, Lakka SS, Engelhard HH Abstract The development of curative treatment for glioblastoma is extremely challenging. Chemotherapeutic agents that have seemed promising have failed in clinical trials. Drugs that successfully target cancer cells within the brain must...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Do Coordinated Knowledge Translation Campaigns Persuade Radiation Oncologists to Utilize Single Fraction Radiotherapy over Multiple Fraction Radiotherapy for Bone Metastases?
Related Articles Do Coordinated Knowledge Translation Campaigns Persuade Radiation Oncologists to Utilize Single Fraction Radiotherapy over Multiple Fraction Radiotherapy for Bone Metastases? Int J Radiat Oncol Biol Phys. 2020 Sep 02;: Authors: Shahhat S, Hanumanthappa N, Chung YT, Beck J, Koul R, Bashir B, Cooke A, Dubey A, Butler J, Nashed M, Hunter W, Rathod S, Ong A, Tran K, Kim JO Abstract BACKGROUND: Although level 1 evidence supports...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Flap Delineation Guidelines in Postoperative Head and Neck Radiation Therapy for head and neck cancers.
Related Articles Flap Delineation Guidelines in Postoperative Head and Neck Radiation Therapy for head and neck cancers. Radiother Oncol. 2020 Sep 02;: Authors: Le Guevelou J, Bastit V, Marcy PY, Lasne-Cardon A, Guzene L, Gerard M, Larnaudie A, Coutte A, Beddok A, Calugaru V, Johnson A, Gery B, Liem X, Pointreau Y, Bourhis J, Thariat J, GORTEC Abstract INTRODUCTION: Reconstructive surgery in head and neck cancers frequently involves the...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Scholarly Publishing in the Wake of COVID-19.
Related Articles Scholarly Publishing in the Wake of COVID-19. Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):491-495 Authors: Miller RC, Tsai CJ Abstract The speed at which the COVID-19 pandemic spread across the globe and the accompanying need to rapidly disseminate knowledge have highlighted the inadequacies of the traditional research/publication cycle, particularly the slowness and the fragmentary access globally to manuscripts and...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Opportunities in Telemedicine, Lessons Learned After COVID-19 and the Way Into the Future.
Related Articles Opportunities in Telemedicine, Lessons Learned After COVID-19 and the Way Into the Future. Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):438-443 Authors: Abdel-Wahab M, Rosenblatt E, Prajogi B, Zubizarretta E, Mikhail M PMID: 32890528 [PubMed - as supplied by publisher]
pubmed: future oncology
Sun Sep 06, 2020 13:48
Radiation Oncologist Perceptions of Telemedicine from Consultation to Treatment Planning: A Mixed-Methods Study.
Related Articles Radiation Oncologist Perceptions of Telemedicine from Consultation to Treatment Planning: A Mixed-Methods Study. Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):421-429 Authors: Zhang H, Cha EE, Lynch K, Cahlon O, Gomez DR, Shaverdian N, Gillespie EF Abstract PURPOSE: Telemedicine was rapidly implemented for initial consultations and radiation treatment planning in the wake of the coronavirus disease 2019 (COVID-19) pandemic....
pubmed: future oncology
Sun Sep 06, 2020 13:48
The Importance of Temporary Telehealth Parity Laws to Improve Public Health During COVID-19 and Future Pandemics.
Related Articles The Importance of Temporary Telehealth Parity Laws to Improve Public Health During COVID-19 and Future Pandemics. Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):362-363 Authors: Baumann BC, MacArthur KM, Michalski JM PMID: 32890513 [PubMed - as supplied by publisher]
pubmed: future oncology
Sun Sep 06, 2020 13:48
Future of Alternative Payment Models and Big Data Analytics in the Post-COVID-19 Era: Implications for Radiation Oncology.
Related Articles Future of Alternative Payment Models and Big Data Analytics in the Post-COVID-19 Era: Implications for Radiation Oncology. Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):353-355 Authors: Thaker NG, Rewari A, Hubbard A PMID: 32890511 [PubMed - as supplied by publisher]
pubmed: future oncology
Sun Sep 06, 2020 13:48
Will the COVID Pandemic Lead to Uncounted Cancer Deaths in the Future?
Related Articles Will the COVID Pandemic Lead to Uncounted Cancer Deaths in the Future? Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):351-352 Authors: Chan JW, Lee VHF PMID: 32890510 [PubMed - as supplied by publisher]
pubmed: future oncology
Sun Sep 06, 2020 13:48
Quantitative Pectoralis Muscle Area is Associated with the Development of Lung Cancer in a Large Lung Cancer Screening Cohort.
Related Articles Quantitative Pectoralis Muscle Area is Associated with the Development of Lung Cancer in a Large Lung Cancer Screening Cohort. Lung. 2020 Sep 05;: Authors: Gazourian L, Durgana CS, Huntley D, Rizzo GS, Thedinger WB, Regis SM, Price LL, Pagura EJ, Lamb C, Rieger-Christ K, Thomson CC, Stefanescu CF, Sanayei A, Long WP, McKee AB, Washko GR, Estépar RSJ, Wald C, Liesching TN, McKee BJ Abstract BACKGROUND: Studies have demonstrated...
pubmed: future oncology
Sun Sep 06, 2020 13:48
"Looking at future cancer survivors, give them a roadmap": addressing fertility and family-building topics in post-treatment cancer survivorship care.
Related Articles "Looking at future cancer survivors, give them a roadmap": addressing fertility and family-building topics in post-treatment cancer survivorship care. Support Care Cancer. 2020 Sep 05;: Authors: Benedict C, Nieh JL, Hahn AL, McCready A, Diefenbach M, Ford JS Abstract PURPOSE: Fertility is an important issue among adolescent and young adult female (AYA-F) cancer survivors. This study examined AYA-F survivors' unmet needs...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Role of the gut microbiome for cancer patients receiving immunotherapy: Dietary and treatment implications.
Related Articles Role of the gut microbiome for cancer patients receiving immunotherapy: Dietary and treatment implications. Eur J Cancer. 2020 Sep 01;138:149-155 Authors: Lee KA, Shaw HM, Bataille V, Nathan P, Spector TD Abstract Immune-checkpoint inhibitors (ICIs) have revolutionised the therapeutic landscape for multiple malignancies and the health of the gut microbiome (GM) is strongly linked with therapeutic responses to ICI. This...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Cellular immunotherapy in breast cancer: The quest for consistent biomarkers.
Related Articles Cellular immunotherapy in breast cancer: The quest for consistent biomarkers. Cancer Treat Rev. 2020 Aug 14;90:102089 Authors: Venetis K, Invernizzi M, Sajjadi E, Curigliano G, Fusco N Abstract Breast cancer is the most common malignancy in women worldwide, with a relatively high proportion of patients experiencing resistance to standard treatments. Cellular immunotherapy (CI), which is based on the extraction, modification,...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Frequency and specificity of Red blood cell alloantibodies in multitransfused Egyptian patients with hematological and nonhematological malignancies.
Related Articles Frequency and specificity of Red blood cell alloantibodies in multitransfused Egyptian patients with hematological and nonhematological malignancies. Transfus Apher Sci. 2020 Aug 22;:102909 Authors: El Fetouh RMA, Elmoniem GMA, Allam RM, Sobeih ME, Kamel MM, Radwan SM Abstract BACKGROUND: Repeated blood transfusions can result in the production of alloantibodies against one or more red blood cell (RBC) antigens, which can...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Stress and coping strategies among allogeneic haematopoietic stem cell transplantation survivors: A qualitative study.
Related Articles Stress and coping strategies among allogeneic haematopoietic stem cell transplantation survivors: A qualitative study. Eur J Cancer Care (Engl). 2020 Sep 05;:e13307 Authors: Kusaka K, Inoguchi H, Nakahara R, Kurosawa S, Fukuda T, Satomura K, Shimizu K Abstract OBJECTIVE: The aim of this qualitative study was to explore allogeneic haematopoietic stem cell transplantation (allo-HSCT) survivors' perspectives of stresses and...
pubmed: future oncology
Sun Sep 06, 2020 13:48
The psychosocial impact of flu influenza pandemics on healthcare workers and lessons learnt for the COVID-19 emergency: a rapid review.
Related Articles The psychosocial impact of flu influenza pandemics on healthcare workers and lessons learnt for the COVID-19 emergency: a rapid review. Int J Public Health. 2020 Sep 04;: Authors: Barello S, Falcó-Pegueroles A, Rosa D, Tolotti A, Graffigna G, Bonetti L Abstract OBJECTIVES: During a pandemic, healthcare workers (HCWs) are essential to the health system response. Based on our knowledge, little information is available regarding...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Administration of label and off-label drugs by the subcutaneous route in palliative care: an observational cohort study.
Related Articles Administration of label and off-label drugs by the subcutaneous route in palliative care: an observational cohort study. BMJ Support Palliat Care. 2020 Sep 04;: Authors: Jensen JJ, Sjøgren P Abstract BACKGROUND: The marketing authorisation for many injectable drugs used in palliative care does not cover the frequently preferred subcutaneous route. Consequently, subcutaneous off-label drug administration is often practised....
pubmed: future oncology
Sun Sep 06, 2020 13:48
tRNA-derived RNA fragments in cancer: current status and future perspectives.
Related Articles tRNA-derived RNA fragments in cancer: current status and future perspectives. J Hematol Oncol. 2020 Sep 04;13(1):121 Authors: Yu M, Lu B, Zhang J, Ding J, Liu P, Lu Y Abstract Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekeeping ncRNAs that deliver amino acids to ribosomes during...
pubmed: future oncology
Sun Sep 06, 2020 13:48
The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts.
Related Articles The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts. Int J Mol Sci. 2020 Sep 02;21(17): Authors: Donaubauer AJ, Deloch L, Becker I, Fietkau R, Frey B, Gaipl US Abstract The bone is a complex organ that is dependent on a tight regulation between bone formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes can be influenced by environmental...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Peripheral cytokine levels as predictive biomarkers of benefit from immune checkpoint inhibitors in cancer therapy.
Related Articles Peripheral cytokine levels as predictive biomarkers of benefit from immune checkpoint inhibitors in cancer therapy. Biomed Pharmacother. 2020 Sep;129:110457 Authors: Ji S, Chen H, Yang K, Zhang G, Mao B, Hu Y, Zhang H, Xu J Abstract Currently, only a small subset of cancer patients can benefit from anti-PD-1/PD-L1 monotherapy, indicating that further predictive biomarkers are needed. In the retrospective study, plasma samples...
pubmed: future oncology
Sun Sep 06, 2020 13:48
Future Oncology; +25 new citations
25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
pubmed: future oncology
Sat Sep 05, 2020 14:53
The Accuracy of Imminent Death Diagnosis in a Palliative Care Setting.
Related Articles The Accuracy of Imminent Death Diagnosis in a Palliative Care Setting. Cureus. 2020 Aug 01;12(8):e9503 Authors: Alsuhail AI, Punalvasal Duraisamy B, Alkhudhair A, Alshammary SA, AlRehaili A Abstract Background Prognostication is important for patients and their family members as they need this information for the preparation and planning of their future. It is important for physicians as they desire to be accurate in their...
pubmed: future oncology
Fri Sep 04, 2020 23:01
Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions.
Related Articles Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions. World J Gastrointest Oncol. 2020 Aug 15;12(8):808-832 Authors: Chakrabarti S, Peterson CY, Sriram D, Mahipal A Abstract Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies. The majority of patients with...
pubmed: future oncology
Fri Sep 04, 2020 23:01
Older adults with cancer and their caregivers - current landscape and future directions for clinical care.
Related Articles Older adults with cancer and their caregivers - current landscape and future directions for clinical care. Nat Rev Clin Oncol. 2020 Sep 02;: Authors: Kadambi S, Loh KP, Dunne R, Magnuson A, Maggiore R, Zittel J, Flannery M, Inglis J, Gilmore N, Mohamed M, Ramsdale E, Mohile S Abstract Despite substantial improvements in the outcomes of patients with cancer over the past two decades, older adults (aged ≥65 years) with cancer...
pubmed: future oncology
Fri Sep 04, 2020 23:01
Dose-response assessment by quantitative MRI in a phase 1 clinical study of the anti-cancer vascular disrupting agent crolibulin.
Related Articles Dose-response assessment by quantitative MRI in a phase 1 clinical study of the anti-cancer vascular disrupting agent crolibulin. Sci Rep. 2020 Sep 02;10(1):14449 Authors: Lorza AMA, Ravi H, Philip RC, Galons JP, Trouard TP, Parra NA, Von Hoff DD, Read WL, Tibes R, Korn RL, Raghunand N Abstract The vascular disrupting agent crolibulin binds to the colchicine binding site and produces anti-vascular and apoptotic effects. In...
pubmed: future oncology
Fri Sep 04, 2020 23:01
Human herpes virus 8-positive germinotropic lymphoproliferative disorder: first case diagnosed in the UK, literature review and discussion of treatment options.
Related Articles Human herpes virus 8-positive germinotropic lymphoproliferative disorder: first case diagnosed in the UK, literature review and discussion of treatment options. BMJ Case Rep. 2020 Sep 02;13(9): Authors: Ghoneima A, Cooke J, Shaw E, Agrawal A Abstract We present this case of human herpes virus 8-positive germinotropic lymphoproliferative disorder in a 20-year-old woman seen in the surgical oncology clinic for localised lymphadenopathy....
pubmed: future oncology
Fri Sep 04, 2020 23:01
Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview.
Related Articles Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview. Anticancer Res. 2020 Sep;40(9):5319-5325 Authors: VAN Beeck A, VAN DE Sande M, VAN Praag V, Dammerer D, Michielsen J, Schubert T, Kapanci B, Shumelinsky F, Somville J, Dijkstra S Abstract AIM: This study was interested in extremity leiomyosarcoma with focus on clinical outcome after surgery with or without adjuvant therapy. ...
pubmed: future oncology
Fri Sep 04, 2020 23:01
The Future of ER+/HER2- Metastatic Breast Cancer Therapy: Beyond PI3K Inhibitors.
Related Articles The Future of ER+/HER2- Metastatic Breast Cancer Therapy: Beyond PI3K Inhibitors. Anticancer Res. 2020 Sep;40(9):4829-4841 Authors: Stravodimou A, Voutsadakis IA Abstract Most breast cancers express the estrogen receptor (ER) receptor and are negative for the human epidermal growth factor receptor 2 (HER2) receptor. ER+/HER2- cancers are treated with hormone-based therapies in the adjuvant setting and derive significant survival...
pubmed: future oncology
Fri Sep 04, 2020 23:01
Theory-driven development of a medication adherence intervention delivered by eHealth and transplant team in allogeneic stem cell transplantation: the SMILe implementation science project.
Related Articles Theory-driven development of a medication adherence intervention delivered by eHealth and transplant team in allogeneic stem cell transplantation: the SMILe implementation science project. BMC Health Serv Res. 2020 Sep 02;20(1):827 Authors: Ribaut J, Leppla L, Teynor A, Valenta S, Dobbels F, Zullig LL, De Geest S, SMILe study team Abstract BACKGROUND: Medication adherence to immunosuppressants in allogeneic stem cell transplantation...
pubmed: future oncology
Fri Sep 04, 2020 23:01
Patient and Medical Oncologists' Perspectives on Prescribed Lifestyle Intervention-Experiences of Women with Breast Cancer and Providers.
Related Articles Patient and Medical Oncologists' Perspectives on Prescribed Lifestyle Intervention-Experiences of Women with Breast Cancer and Providers. J Clin Med. 2020 Aug 31;9(9): Authors: Balneaves LG, Truant TLO, Van Patten C, Kirkham AA, Waters E, Campbell KL Abstract This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at...
pubmed: future oncology
Fri Sep 04, 2020 13:06

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