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Related Articles Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM). Bioorg Chem. 2020 Aug 26;103:104189 Authors: Li XY, Li S, Lu GQ, Wang DP, Liu KL, Qian XH, Xue WH, Meng FH Abstract A series of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives were designed, synthesized, and evaluated...
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Related Articles The efficacy of etanercept as anti-breast cancer treatment is attenuated by residing macrophages. BMC Cancer. 2020 Sep 03;20(1):836 Authors: Shirmohammadi E, Ebrahimi SS, Farshchi A, Salimi M Abstract BACKGROUND: Interaction between microenvironment and breast cancer cells often is not considered at the early stages of drug development leading to failure of many drugs at later clinical stages. Etanercept is a TNF-alpha...
Related Articles WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5. BMC Cancer. 2020 Sep 03;20(1):840 Authors: Zhou Y, Pei F, Ji M, Zhang F, Sun Y, Zhao Q, Wang X, Hong Y, Tian J, Wang Y, Chen JJ Abstract BACKGROUND: Genomic instability is a hallmark of cancer. The G1 checkpoint allows cells to repair damaged DNA that may lead to genomic instability. The high-risk human papillomavirus (HPV) E7 gene...
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Related Articles Obacunone reduces inflammatory signalling and tumour occurrence in mice with chronic inflammation-induced colorectal cancer. Pharm Biol. 2020 Dec;58(1):886-897 Authors: Luo X, Yu Z, Yue B, Ren J, Zhang J, Mani S, Wang Z, Dou W Abstract CONTEXT: Obacunone, a limonoid abundantly found in Citrus fruits, exhibits a variety of bioactivities. OBJECTIVE: To investigate the effects of obacunone on a colorectal cancer (CRC)...
Related Articles Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells. Biomolecules. 2020 Aug 31;10(9): Authors: Dey P, Kundu A, Han SH, Kim KS, Park JH, Yoon S, Kim IS, Kim HS Abstract Renal cell carcinoma has emerged as one of the leading causes of cancer-related deaths in the USA. Here, we examined the anticancer profile of oxindole derivatives (SH-859) in human renal cancer cells....
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Related Articles Responsive neurostimulation for refractory epilepsy in the pediatric population: A single-center experience. Epilepsy Behav. 2020 Sep 01;112:107389 Authors: Bercu MM, Friedman D, Silverberg A, Drees C, Geller EB, Dugan PC, Devinsky O, Doyle WH Abstract Drug-resistant focal epilepsy (DRFE) in children can impair cognition and behavior, and lead to premature death. Increased pediatric epilepsy surgery numbers reflect the improvements...
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Related Articles Impact of ABCB1 Polymorphism on Levetiracetam Serum Concentrations in Epileptic Uygur Children in China. Ther Drug Monit. 2020 Sep 01;: Authors: Zhao T, Yu J, Wang TT, Feng J, Zhao WB, Sun L, Yu LH, Li HJ, Sun Y Abstract BACKGROUND: Interindividual variations in the efficacy of antiseizure medications make epilepsy treatment challenging. This is due to genetic factors such as gene polymorphisms in ATP-Binding Cassette sub-family...
Related Articles When and How to Treat Status Epilepticus: The Tortoise or the Hare? J Clin Neurophysiol. 2020 Sep;37(5):393-398 Authors: Fong MWK, Hirsch LJ Abstract Status epilepticus (SE) is a collective term that is used to describe a variety of subtypes. Forgetting this point can be perilous, even resulting in exposing patients to unnecessary harms. This review revisits the foundations of many of our current treatment guidelines, providing...
Related Articles Initial treatment of seizures in children in an emergency department in rural Japan. Brain Dev. 2020 Sep 01;: Authors: Shiraki A, Yasui M, Kidokoro H, Kido S, Ando H, Takahashi Y, Natsume J Abstract OBJECTIVE: Although the initial treatment of childhood seizures is important, treatment within an appropriate time window is often difficult in resource-limited areas. This study examined childhood seizure treatment in a rural area...
Related Articles Repetitive transcranial photobiomodulation but not long-term omega-3 intake reduces epileptiform discharges in rats with stroke-induced epilepsy. J Biophotonics. 2020 Sep 05;:e202000287 Authors: Vogel DDS, Ortiz-Villatoro NN, de Freitas L, Aimbire F, Scorza FA, Albertini R, Scorza CA Abstract Epilepsy is a yet under-recognized consequence after a stroke and nearly 30% of cases are pharmacoresistant. There is an unmet need for...
Related Articles Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase (PNPO) deficiency: a scoping review of 87 cases of PNPO deficiency. Clin Genet. 2020 Sep 04;: Authors: Alghamdi M, Bashiri FA, Abdelhakim M, Adly N, Jamjoom DZ, Sumaily KM, Alghanem B, Arold ST Abstract Pyridoxamine-5'-phosphate oxidase (PNPO) deficiency is an autosomal recessive PLP-vitamin-responsive epileptic encephalopathy. The emerging feature of PNPO...
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Related Articles Cutis verticis gyrata: Two cases associated with drug-resistant epilepsy. Clin Case Rep. 2020 Aug;8(8):1365-1368 Authors: Rattagan M, De Francesco M, Kriebaum A, Ferraro F, Major C, Sharma D, Ojeda A, Martinez O, Musto AE Abstract Cutis verticis gyrata (CVG) is a neurocutaneous syndrome characterized by the formation of folds in the scalp that resembles the cerebral cortex. We present two cases of CVG and intellectual disability...
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Related Articles Pitolisant and Other Histamine-3 Receptor Antagonists-An Update on Therapeutic Potentials and Clinical Prospects. Medicines (Basel). 2020 Sep 01;7(9): Authors: Harwell V, Fasinu PS Abstract Background: Besides its well-known role as a peripheral chemical mediator of immune, vascular, and cellular responses, histamine plays major roles in the central nervous system, particularly in the mediation of arousal and cognition-enhancement....
Related Articles Serum endocan and preoperative systemic inflammatory markers in patients with epilepsy. Neurochirurgie. 2020 Feb;66(1):29-35 Authors: Faruk Ozdemir A, Kemerdere R, Orhan B, Ozturk Emre H, Bercik Inal B, Kayhan A, Naz Yeni S, Tanriverdi T Abstract OBJECTIVE: The mechanisms underlying epileptogenesis are still a focus of experimental and clinical research. Inflammation and angiogenesis are the two main topics that have been an...
Related Articles Mechanical considerations for design and implementation of peripheral intraneural devices. J Neural Eng. 2019 10 23;16(6):064001 Authors: Stiller AM, González-González MA, Boothby JM, Sherman SE, Benavides J, Romero-Ortega M, Pancrazio JJ, Black BJ Abstract OBJECTIVE: Neural interfaces designed to stimulate or record electrical activity from peripheral nerves have applications ranging from the electrical modulation of nerve...
Related Articles Brainstem Functional Connectivity Disturbances in Epilepsy may Recover After Successful Surgery. Neurosurgery. 2020 03 01;86(3):417-428 Authors: González HFJ, Goodale SE, Jacobs ML, Haas KF, Landman BA, Morgan VL, Englot DJ Abstract BACKGROUND: Focal seizures in temporal lobe epilepsy (TLE) are associated with widespread brain network perturbations and neurocognitive problems. OBJECTIVE: To determine whether brainstem...
Related Articles Abdominal Epilepsy: A Rare Cause of Unexplained Abdominal Pain. Cureus. 2020 Aug 29;12(8):e10120 Authors: Balabhadra A, Malipeddi A, Ali N, Balabhadra R Abstract Abdominal epilepsy (AE) is a very rare diagnosis; it is considered to be a category of temporal lobe epilepsies and is more commonly a diagnosis of exclusion. Demographic presentation of AE is usually in the pediatric age group. However, there is recorded documentation...
Related Articles Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jul 28;45(7):782-789 Authors: Yang X, Wang P, Pan J, Wang C, Luo J, Ma H Abstract OBJECTIVES: Due to the narrow therapeutic window of valproic acid (VPA), grievous adverse reactions such as hepatotoxicity, nephrotoxicity may occur in patients with epilepsy for a long...
Related Articles Immunization stress-related responses presenting as psychogenic non-epileptic seizures following HPV vaccination in Rio Branco, Brazil. Vaccine. 2020 Aug 30;: Authors: Marchetti RL, Gallucci-Neto J, Kurcgant D, Proença ICGF, Valiengo LDCL, Fiore LA, Pinto LF, Maranhão AGK, Oliveira MTDC, de Oliveira LH Abstract IMPORTANCE: The absence of a positive diagnosis of psychogenic non-epileptic seizures (PNES) in immunization stress-related...
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Cerebral Microdialysis as a Tool for Assessing the Delivery of Chemotherapy in Brain Tumor Patients.
Related Articles Cerebral Microdialysis as a Tool for Assessing the Delivery of Chemotherapy in Brain Tumor Patients. World Neurosurg. 2020 Sep 02;: Authors: Pierce CF, Kwasnicki A, Lakka SS, Engelhard HH Abstract The development of curative treatment for glioblastoma is extremely challenging. Chemotherapeutic agents that have seemed promising have failed in clinical trials. Drugs that successfully target cancer cells within the brain must...
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Related Articles Flap Delineation Guidelines in Postoperative Head and Neck Radiation Therapy for head and neck cancers. Radiother Oncol. 2020 Sep 02;: Authors: Le Guevelou J, Bastit V, Marcy PY, Lasne-Cardon A, Guzene L, Gerard M, Larnaudie A, Coutte A, Beddok A, Calugaru V, Johnson A, Gery B, Liem X, Pointreau Y, Bourhis J, Thariat J, GORTEC Abstract INTRODUCTION: Reconstructive surgery in head and neck cancers frequently involves the...
Related Articles Scholarly Publishing in the Wake of COVID-19. Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):491-495 Authors: Miller RC, Tsai CJ Abstract The speed at which the COVID-19 pandemic spread across the globe and the accompanying need to rapidly disseminate knowledge have highlighted the inadequacies of the traditional research/publication cycle, particularly the slowness and the fragmentary access globally to manuscripts and...
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Related Articles Radiation Oncologist Perceptions of Telemedicine from Consultation to Treatment Planning: A Mixed-Methods Study. Int J Radiat Oncol Biol Phys. 2020 Oct 01;108(2):421-429 Authors: Zhang H, Cha EE, Lynch K, Cahlon O, Gomez DR, Shaverdian N, Gillespie EF Abstract PURPOSE: Telemedicine was rapidly implemented for initial consultations and radiation treatment planning in the wake of the coronavirus disease 2019 (COVID-19) pandemic....
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Related Articles Quantitative Pectoralis Muscle Area is Associated with the Development of Lung Cancer in a Large Lung Cancer Screening Cohort. Lung. 2020 Sep 05;: Authors: Gazourian L, Durgana CS, Huntley D, Rizzo GS, Thedinger WB, Regis SM, Price LL, Pagura EJ, Lamb C, Rieger-Christ K, Thomson CC, Stefanescu CF, Sanayei A, Long WP, McKee AB, Washko GR, Estépar RSJ, Wald C, Liesching TN, McKee BJ Abstract BACKGROUND: Studies have demonstrated...
Related Articles "Looking at future cancer survivors, give them a roadmap": addressing fertility and family-building topics in post-treatment cancer survivorship care. Support Care Cancer. 2020 Sep 05;: Authors: Benedict C, Nieh JL, Hahn AL, McCready A, Diefenbach M, Ford JS Abstract PURPOSE: Fertility is an important issue among adolescent and young adult female (AYA-F) cancer survivors. This study examined AYA-F survivors' unmet needs...
Related Articles Role of the gut microbiome for cancer patients receiving immunotherapy: Dietary and treatment implications. Eur J Cancer. 2020 Sep 01;138:149-155 Authors: Lee KA, Shaw HM, Bataille V, Nathan P, Spector TD Abstract Immune-checkpoint inhibitors (ICIs) have revolutionised the therapeutic landscape for multiple malignancies and the health of the gut microbiome (GM) is strongly linked with therapeutic responses to ICI. This...
Related Articles Cellular immunotherapy in breast cancer: The quest for consistent biomarkers. Cancer Treat Rev. 2020 Aug 14;90:102089 Authors: Venetis K, Invernizzi M, Sajjadi E, Curigliano G, Fusco N Abstract Breast cancer is the most common malignancy in women worldwide, with a relatively high proportion of patients experiencing resistance to standard treatments. Cellular immunotherapy (CI), which is based on the extraction, modification,...
Related Articles Frequency and specificity of Red blood cell alloantibodies in multitransfused Egyptian patients with hematological and nonhematological malignancies. Transfus Apher Sci. 2020 Aug 22;:102909 Authors: El Fetouh RMA, Elmoniem GMA, Allam RM, Sobeih ME, Kamel MM, Radwan SM Abstract BACKGROUND: Repeated blood transfusions can result in the production of alloantibodies against one or more red blood cell (RBC) antigens, which can...
Related Articles Stress and coping strategies among allogeneic haematopoietic stem cell transplantation survivors: A qualitative study. Eur J Cancer Care (Engl). 2020 Sep 05;:e13307 Authors: Kusaka K, Inoguchi H, Nakahara R, Kurosawa S, Fukuda T, Satomura K, Shimizu K Abstract OBJECTIVE: The aim of this qualitative study was to explore allogeneic haematopoietic stem cell transplantation (allo-HSCT) survivors' perspectives of stresses and...
Related Articles The psychosocial impact of flu influenza pandemics on healthcare workers and lessons learnt for the COVID-19 emergency: a rapid review. Int J Public Health. 2020 Sep 04;: Authors: Barello S, Falcó-Pegueroles A, Rosa D, Tolotti A, Graffigna G, Bonetti L Abstract OBJECTIVES: During a pandemic, healthcare workers (HCWs) are essential to the health system response. Based on our knowledge, little information is available regarding...
Related Articles Administration of label and off-label drugs by the subcutaneous route in palliative care: an observational cohort study. BMJ Support Palliat Care. 2020 Sep 04;: Authors: Jensen JJ, Sjøgren P Abstract BACKGROUND: The marketing authorisation for many injectable drugs used in palliative care does not cover the frequently preferred subcutaneous route. Consequently, subcutaneous off-label drug administration is often practised....
Related Articles tRNA-derived RNA fragments in cancer: current status and future perspectives. J Hematol Oncol. 2020 Sep 04;13(1):121 Authors: Yu M, Lu B, Zhang J, Ding J, Liu P, Lu Y Abstract Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekeeping ncRNAs that deliver amino acids to ribosomes during...
Related Articles The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts. Int J Mol Sci. 2020 Sep 02;21(17): Authors: Donaubauer AJ, Deloch L, Becker I, Fietkau R, Frey B, Gaipl US Abstract The bone is a complex organ that is dependent on a tight regulation between bone formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes can be influenced by environmental...
Related Articles Peripheral cytokine levels as predictive biomarkers of benefit from immune checkpoint inhibitors in cancer therapy. Biomed Pharmacother. 2020 Sep;129:110457 Authors: Ji S, Chen H, Yang K, Zhang G, Mao B, Hu Y, Zhang H, Xu J Abstract Currently, only a small subset of cancer patients can benefit from anti-PD-1/PD-L1 monotherapy, indicating that further predictive biomarkers are needed. In the retrospective study, plasma samples...
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Related Articles The Accuracy of Imminent Death Diagnosis in a Palliative Care Setting. Cureus. 2020 Aug 01;12(8):e9503 Authors: Alsuhail AI, Punalvasal Duraisamy B, Alkhudhair A, Alshammary SA, AlRehaili A Abstract Background Prognostication is important for patients and their family members as they need this information for the preparation and planning of their future. It is important for physicians as they desire to be accurate in their...
Related Articles Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions. World J Gastrointest Oncol. 2020 Aug 15;12(8):808-832 Authors: Chakrabarti S, Peterson CY, Sriram D, Mahipal A Abstract Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies. The majority of patients with...
Related Articles Older adults with cancer and their caregivers - current landscape and future directions for clinical care. Nat Rev Clin Oncol. 2020 Sep 02;: Authors: Kadambi S, Loh KP, Dunne R, Magnuson A, Maggiore R, Zittel J, Flannery M, Inglis J, Gilmore N, Mohamed M, Ramsdale E, Mohile S Abstract Despite substantial improvements in the outcomes of patients with cancer over the past two decades, older adults (aged ≥65 years) with cancer...
Related Articles Dose-response assessment by quantitative MRI in a phase 1 clinical study of the anti-cancer vascular disrupting agent crolibulin. Sci Rep. 2020 Sep 02;10(1):14449 Authors: Lorza AMA, Ravi H, Philip RC, Galons JP, Trouard TP, Parra NA, Von Hoff DD, Read WL, Tibes R, Korn RL, Raghunand N Abstract The vascular disrupting agent crolibulin binds to the colchicine binding site and produces anti-vascular and apoptotic effects. In...
Related Articles Human herpes virus 8-positive germinotropic lymphoproliferative disorder: first case diagnosed in the UK, literature review and discussion of treatment options. BMJ Case Rep. 2020 Sep 02;13(9): Authors: Ghoneima A, Cooke J, Shaw E, Agrawal A Abstract We present this case of human herpes virus 8-positive germinotropic lymphoproliferative disorder in a 20-year-old woman seen in the surgical oncology clinic for localised lymphadenopathy....
Related Articles Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview. Anticancer Res. 2020 Sep;40(9):5319-5325 Authors: VAN Beeck A, VAN DE Sande M, VAN Praag V, Dammerer D, Michielsen J, Schubert T, Kapanci B, Shumelinsky F, Somville J, Dijkstra S Abstract AIM: This study was interested in extremity leiomyosarcoma with focus on clinical outcome after surgery with or without adjuvant therapy. ...
Related Articles The Future of ER+/HER2- Metastatic Breast Cancer Therapy: Beyond PI3K Inhibitors. Anticancer Res. 2020 Sep;40(9):4829-4841 Authors: Stravodimou A, Voutsadakis IA Abstract Most breast cancers express the estrogen receptor (ER) receptor and are negative for the human epidermal growth factor receptor 2 (HER2) receptor. ER+/HER2- cancers are treated with hormone-based therapies in the adjuvant setting and derive significant survival...
Related Articles Theory-driven development of a medication adherence intervention delivered by eHealth and transplant team in allogeneic stem cell transplantation: the SMILe implementation science project. BMC Health Serv Res. 2020 Sep 02;20(1):827 Authors: Ribaut J, Leppla L, Teynor A, Valenta S, Dobbels F, Zullig LL, De Geest S, SMILe study team Abstract BACKGROUND: Medication adherence to immunosuppressants in allogeneic stem cell transplantation...
Related Articles Patient and Medical Oncologists' Perspectives on Prescribed Lifestyle Intervention-Experiences of Women with Breast Cancer and Providers. J Clin Med. 2020 Aug 31;9(9): Authors: Balneaves LG, Truant TLO, Van Patten C, Kirkham AA, Waters E, Campbell KL Abstract This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at...
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