Biomedicines, Vol. 8, Pages 328: SARS-CoV-2 Infection Induces a Dual Response in Liver Function Tests: Association with Mortality during Hospitalization Biomedicines doi: 10.3390/biomedicines8090328 Authors: Vanesa Bernal-Monterde Diego Casas-Deza Laura Letona-Giménez Natalia de la Llama-Celis Pilar Calmarza Olivia Sierra-Gabarda Elena Betoré-Glaria María Martínez-de Lagos Lucía Martínez-Barredo María Espinosa-Pérez Jose M. Arbones-Mainar Severe acute respiratory...
Fri Sep 04, 2020 03:00
Biomedicines, Vol. 8, Pages 329: An Overview of Methods for Cardiac Rhythm Detection in Zebrafish Biomedicines doi: 10.3390/biomedicines8090329 Authors: Santoso Farhan Castillo Malhotra Saputra Kurnia Chen Huang Chen Hsiao The heart is the most important muscular organ of the cardiovascular system, which pumps blood and circulates, supplying oxygen and nutrients to peripheral tissues. Zebrafish have been widely explored in cardiotoxicity research....
Fri Sep 04, 2020 03:00
Biomolecules, Vol. 10, Pages 1283: Tryptophanyl-tRNA Synthetase 1 Signals Activate TREM-1 via TLR2 and TLR4 Biomolecules doi: 10.3390/biom10091283 Authors: Tram T. T. Nguyen Hee Kyeong Yoon Yoon Tae Kim Yun Hui Choi Won-Kyu Lee Mirim Jin Tryptophanyl-tRNA synthetase 1 (WARS1) is an endogenous ligand of mammalian Toll-like receptors (TLR) 2 and TLR4. Microarray data, using mRNA from WARS1-treated human peripheral blood mononuclear cells (PBMCs), had indicated WARS1 to mainly...
Sun Sep 06, 2020 03:00
Biomolecules, Vol. 10, Pages 1282: Different Research Approaches in Unraveling the Venom Proteome of Naja ashei Biomolecules doi: 10.3390/biom10091282 Authors: Konrad Kamil Hus Łukasz Marczak Vladimír Petrilla Monika Petrillová Jaroslav Legáth Aleksandra Bocian The dynamic development of venomics in recent years has resulted in a significant increase in publicly available proteomic data. The information contained therein is often used for comparisons between different...
Sat Sep 05, 2020 03:00
Biomolecules, Vol. 10, Pages 1281: miR-361-5p Mediates SMAD4 to Promote Porcine Granulosa Cell Apoptosis through VEGFA Biomolecules doi: 10.3390/biom10091281 Authors: Mengnan Ma Jinbi Zhang Xiaomeng Gao Wang Yao Qifa Li Zengxiang Pan Follicular atresia is an inevitable degenerative process that occurs in mammalian ovarian follicles. The molecular events involved in atresia, particularly granulosa cell apoptosis, have long attracted researchers’ attention. Vascular...
Fri Sep 04, 2020 03:00
Biomolecules, Vol. 10, Pages 1279: An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic Biomolecules doi: 10.3390/biom10091279 Authors: Blaise Cozene Nadia Sadanandan Bella Gonzales-Portillo Madeline Saft Justin Cho You Jeong Park Cesar V. Borlongan Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates...
Fri Sep 04, 2020 03:00
Biomolecules, Vol. 10, Pages 1280: Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe? Biomolecules doi: 10.3390/biom10091280 Authors: Eleonora Panfili Roberto Gerli Ursula Grohmann Maria Teresa Pallotta In mammals, amino acid metabolism has evolved to act as a critical regulator of innate and adaptive immune responses. Rheumatoid arthritis (RA) is the most common form of inflammatory arthropathy sustained by autoimmune responses. We examine here the current knowledge...
Fri Sep 04, 2020 03:00
Biomolecules, Vol. 10, Pages 1278: Retinoids in Embryonic Development Biomolecules doi: 10.3390/biom10091278 Authors: Michael Schubert Yann Gibert Retinoids constitute a class of compounds chemically related to vitamin A [...]
Fri Sep 04, 2020 03:00
Biomolecules, Vol. 10, Pages 1277: Galectin-3: A Potential Prognostic and Diagnostic Marker for Heart Disease and Detection of Early Stage Pathology Biomolecules doi: 10.3390/biom10091277 Authors: Akira Hara Masayuki Niwa Tomohiro Kanayama Kei Noguchi Ayumi Niwa Mikiko Matsuo Takahiro Kuroda Yuichiro Hatano Hideshi Okada Hiroyuki Tomita The use of molecular biomarkers for the early detection of heart disease, before their onset of symptoms, is an attractive...
Fri Sep 04, 2020 03:00
Biomolecules, Vol. 10, Pages 1276: The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer’s Disease Biomolecules doi: 10.3390/biom10091276 Authors: Dustin Chernick Rui Zhong Ling Li The role of high-density lipoproteins (HDL) in the cardiovascular system has been extensively studied and the cardioprotective effects of HDL are well established. As HDL particles are formed both in the systemic circulation and in the central nervous system, the role of HDL...
Fri Sep 04, 2020 03:00
Brain Sciences, Vol. 10, Pages 614: The Effects of Hypocapnia on Brain Tissue Pulsations Brain Sciences doi: 10.3390/brainsci10090614 Authors: Meshal Alharbi Poppy Turner Jonathan Ince Mitsuhiro Oura Kelechi U. Ebirim Alanoud Almudayni Andrea Lecchini-Visintini Jatinder S. Minhas Emma M.L. Chung Hypocapnia is known to affect patients with acute stroke and plays a key role in governing cerebral autoregulation. However, the impact of hypocapnia on brain tissue pulsations...
Sun Sep 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 613: Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study Brain Sciences doi: 10.3390/brainsci10090613 Authors: Jacopo Lanzone Claudio Imperatori Giovanni Assenza Lorenzo Ricci Benedetto Farina Vincenzo Di Lazzaro Mario Tombini Transient epileptic amnesia (TEA) is a rare epileptic condition, often confused with transient global amnesia (TGA). In a real-life scenario, differential...
Sun Sep 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 615: Autism and Migraine: An Unexplored Association? Brain Sciences doi: 10.3390/brainsci10090615 Authors: Luigi Vetri Autism spectrum disorder is characterized by neurological, psychiatric and medical comorbidities—some conditions co-occur so frequently that comorbidity in autism is the rule rather than the exception. The most common autism co-occurring conditions are intellectual disability, language disorders, attention-deficit hyperactivity...
Sun Sep 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 612: Exercise for Older Adults Improves the Quality of Life in Parkinson’s Disease and Potentially Enhances the Immune Response to COVID-19 Brain Sciences doi: 10.3390/brainsci10090612 Authors: Mary-Frances E. Hall Frank C. Church Parkinson’s disease (PD) is a progressive neurodegenerative disorder brought about due to dopaminergic neuronal cell loss in the midbrain substantia nigra pars compacta region. PD presents most commonly in older adults...
Sun Sep 06, 2020 03:00
Brain Sciences, Vol. 10, Pages 611: Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes Brain Sciences doi: 10.3390/brainsci10090611 Authors: Kalaiselvi Sivalingam Thangavel Samikkannu Cocaine abuse is known to alter mitochondrial biogenesis and induce epigenetic modification linked with neuronal dysfunction. Cocaine-induced epigenetic modification of DNA methylation and the mitochondrial genome may affect mitochondrial...
Sat Sep 05, 2020 03:00
Brain Sciences, Vol. 10, Pages 610: Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls Brain Sciences doi: 10.3390/brainsci10090610 Authors: Mohamed B. Abou-Donia Elizabeth S. Lapadula Maxine H. Krengel Emily Quinn Jessica LeClair Joseph Massaro Lisa A. Conboy Efi Kokkotou Maria Abreu Nancy G. Klimas Daniel D. Nguyen Kimberly Sullivan For the past 30 years,...
Sat Sep 05, 2020 03:00
Brain Sciences, Vol. 10, Pages 609: Pathophysiology of Swallowing Dysfunction in Parkinson Disease and Lack of Dopaminergic Impact on the Swallow Function and on the Effect of Thickening Agents Brain Sciences doi: 10.3390/brainsci10090609 Authors: Weslania Viviane Nascimento Viridiana Arreola Pilar Sanz Ediz Necati Mireia Bolivar-Prados Emilia Michou Omar Ortega Pere Clavé (1) Background: The effect of dopaminergic treatment on swallowing response in patients with...
Fri Sep 04, 2020 03:00
Brain Sciences, Vol. 10, Pages 608: Short-Term Effects of Meditation on Sustained Attention as Measured by fNIRS Brain Sciences doi: 10.3390/brainsci10090608 Authors: Meltem Izzetoglu Patricia A. Shewokis Kathryn Tsai Phillip Dantoin Kathryn Sparango Katherine Min Cognitive abilities such as attention, memory, processing time, perception, and reasoning can be augmented using some type of intervention. Within the broad range of conventional and unconventional intervention...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2531: Gut Microbiome Associated with the Psychoneurological Symptom Cluster in Patients with Head and Neck Cancers Cancers doi: 10.3390/cancers12092531 Authors: Jinbing Bai Deborah Watkins Bruner Veronika Fedirko Jonathan J. Beitler Chao Zhou Jianlei Gu Hongyu Zhao I-Hsin Lin Cynthia E. Chico Kristin A. Higgins Dong M. Shin Nabil F. Saba Andrew H. Miller Canhua Xiao Cancer patients experience a cluster of co-occurring psychoneurological...
Sun Sep 06, 2020 03:00
Cancers, Vol. 12, Pages 2533: Potential Role of PDGFRβ-Associated THBS4 in Colorectal Cancer Development Cancers doi: 10.3390/cancers12092533 Authors: Min Seob Kim Hyun Seok Choi Moxin Wu JiYeon Myung Eui Joong Kim Yong Sung Kim Seungil Ro Se Eun Ha Allison Bartlett Lai Wei Han-Seung Ryu Suck Chei Choi Won Cheol Park Keun Young Kim Moon Young Lee Colorectal cancer is a significant cause of death since it frequently metastasizes to several organs...
Sun Sep 06, 2020 03:00
Cancers, Vol. 12, Pages 2532: Glucose Metabolism Quantified by SUVmax on Baseline FDG-PET/CT Predicts Survival in Newly Diagnosed Multiple Myeloma Patients: Combined Harmonized Analysis of Two Prospective Phase III Trials Cancers doi: 10.3390/cancers12092532 Authors: Anne-Victoire Michaud-Robert Elena Zamagni Thomas Carlier Clément Bailly Bastien Jamet Cyrille Touzeau Philippe Moreau Françoise Kraeber-Bodere Cristina Nanni Caroline Bodet-Milin Background: Multiple...
Sun Sep 06, 2020 03:00
Cancers, Vol. 12, Pages 2530: pT1 Colorectal Cancer Detected in a Colorectal Cancer Mass Screening Program: Treatment and Factors Associated with Residual and Extraluminal Disease Cancers doi: 10.3390/cancers12092530 Authors: Joaquín Cubiella Antía González Raquel Almazán Elena Rodríguez-Camacho Juana Fontenla Rodiles Carmen Domínguez Ferreiro Coral Tejido Sandoval Cristina Sánchez Gómez Natalia de Vicente Bielza Isabel Peña-Rey Lorenzo Raquel Zubizarreta ...
Sun Sep 06, 2020 03:00
Cancers, Vol. 12, Pages 2529: DNA FISH Diagnostic Assay on Cytological Samples of Thyroid Follicular Neoplasms Cancers doi: 10.3390/cancers12092529 Authors: Philippe Vielh Zsofia Balogh Voichita Suciu Catherine Richon Bastien Job Guillaume Meurice Alexander Valent Ludovic Lacroix Virginie Marty Nelly Motte Philippe Dessen Bernard Caillou Abir Al Ghuzlan Jean-Michel Bidart Vladimir Lazar Paul Hofman Jean-Yves Scoazec Adel K. El-Naggar Martin...
Sun Sep 06, 2020 03:00
Cancers, Vol. 12, Pages 2527: Prognosis of Early-Stage Hepatocellular Carcinoma: Comparison between Trans-Arterial Chemoembolization and Radiofrequency Ablation Cancers doi: 10.3390/cancers12092527 Authors: Byung-Yoon Yun Hye Won Lee In Kyung Min Seung Up Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Beom Kyung Kim Radiofrequency ablation (RFA) is a curative treatment for early-stage hepatocellular carcinoma (HCC) ineligible for surgery or liver transplantation. However,...
Sat Sep 05, 2020 03:00
Cancers, Vol. 12, Pages 2528: Immunomodulatory Drugs in Acute Myeloid Leukemia Treatment Cancers doi: 10.3390/cancers12092528 Authors: Antonio Piccolomo Claudia Pia Schifone Vanda Strafella Giorgina Specchia Pellegrino Musto Francesco Albano Immunomodulatory drugs (IMiDs) are analogs of thalidomide. They have immunomodulatory, antiangiogenic and proapoptotic properties and exert a role in regulating the tumor microenvironment. Recently IMiDs have been investigated for...
Sat Sep 05, 2020 03:00
Cancers, Vol. 12, Pages 2526: Genetic Testing and Surveillance of Young Breast Cancer Survivors and Blood Relatives: A Cluster Randomized Trial Cancers doi: 10.3390/cancers12092526 Authors: Maria C. Katapodi Chang Ming Laurel L. Northouse Sonia A. Duffy Debra Duquette Kari E. Mendelsohn-Victor Kara J. Milliron Sofia D. Merajver Ivo D. Dinov Nancy K. Janz We compared a tailored and a targeted intervention designed to increase genetic testing, clinical breast...
Sat Sep 05, 2020 03:00
Cancers, Vol. 12, Pages 2525: Relevant Cytokines in the B Cell Lymphoma Micro-Environment Cancers doi: 10.3390/cancers12092525 Authors: Günter Krause Floyd Hassenrück Michael Hallek Cytokines are soluble protein factors with importance in intercellular communication and, as such, play pivotal roles in the pathogenesis of B cell malignancies. Evidence from in vitro cultures permitted us to choose example cytokines that bind to different biochemical receptor types. Activated malignant...
Sat Sep 05, 2020 03:00
Cancers, Vol. 12, Pages 2524: Influence of Intratumor Microbiome on Clinical Outcome and Immune Processes in Prostate Cancer Cancers doi: 10.3390/cancers12092524 Authors: Jiayan Ma Aditi Gnanasekar Abby Lee Wei Tse Li Martin Haas Jessica Wang-Rodriguez Eric Y. Chang Mahadevan Rajasekaran Weg M. Ongkeko Although 1 in 9 American men will receive a diagnosis of prostate cancer (PC), most men with this diagnosis will not die from it, as most PCs are indolent. However,...
Sat Sep 05, 2020 03:00
Cancers, Vol. 12, Pages 2523: Bispecific Chimeric Antigen Receptor T Cell Therapy for B Cell Malignancies and Multiple Myeloma Cancers doi: 10.3390/cancers12092523 Authors: Robert J. Cronk Joanna Zurko Nirav N. Shah Chimeric antigen receptor (CAR) modified T cell therapy offers a targeted immunotherapeutic approach to patients with refractory hematological malignancies. This technology is most advanced in B cell malignancies and multiple myeloma and is rapidly evolving as more...
Sat Sep 05, 2020 03:00
Cancers, Vol. 12, Pages 2521: Incidences of Deep Molecular Responses and Treatment-Free Remission in de Novo CP-CML Patients Cancers doi: 10.3390/cancers12092521 Authors: Gabriel Etienne Stéphanie Dulucq Fréderic Bauduer Didier Adiko François Lifermann Corinne Dagada Caroline Lenoir Anna Schmitt Emilie Klein Samia Madene Marie-Pierre Fort Fontanet Bijou Marius Moldovan Beatrice Turcq Fanny Robbesyn Françoise Durrieu Laura Versmée Sandrine...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2522: Immunotherapy in Small Cell Lung Cancer Cancers doi: 10.3390/cancers12092522 Authors: Giovanna Esposito Giuliano Palumbo Guido Carillio Anna Manzo Agnese Montanino Vincenzo Sforza Raffaele Costanzo Claudia Sandomenico Carmine La Manna Nicola Martucci Antonello La Rocca Giuseppe De Luca Maria Carmela Piccirillo Rossella De Cecio Gerardo Botti Giuseppe Totaro Paolo Muto Carmine Picone Nicola Normanno Alessandro...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2520: Current Status and Perspectives of Patient-Derived Models for Ewing’s Sarcoma Cancers doi: 10.3390/cancers12092520 Authors: Tadashi Kondo Patient-derived cancer models, including cell lines, organoids, and xenografts, are indispensable tools in cancer research. These models, which recapitulate molecular features of original tumors, allow studies on the biological significance of cancer-associated genes, antitumor effects of novel agents, and molecular mechanisms...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2518: Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma Cancers doi: 10.3390/cancers12092518 Authors: Zili Zhai Jenny Mae Samson Takeshi Yamauchi Prasanna K. Vaddi Yuko Matsumoto Charles A. Dinarello Dinoop Ravindran Menon Mayumi Fujita Cancer cells gain drug resistance through a complex mechanism, in which nuclear factor-κB (NF-κB) and interleukin-1β (IL-1β)...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2517: Monitoring DNA Damage and Repair in Peripheral Blood Mononuclear Cells of Lung Cancer Radiotherapy Patients Cancers doi: 10.3390/cancers12092517 Authors: Pavel N. Lobachevsky Nicholas W. Bucknell Joel Mason Diane Russo Xiaoyu Yin Lisa Selbie David L. Ball Tomas Kron Michael Hofman Shankar Siva Olga A. Martin Thoracic radiotherapy (RT) is required for the curative management of inoperable lung cancer, however, treatment delivery...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2519: Definition and Independent Validation of a Proteomic-Classifier in Ovarian Cancer Cancers doi: 10.3390/cancers12092519 Authors: Sabine Kasimir-Bauer Joanna Roder Eva Obermayr Sven Mahner Ignace Vergote Liselore Loverix Elena Braicu Jalid Sehouli Nicole Concin Rainer Kimmig Lelia Net Heinrich Roder Robert Zeillinger Stefanie Aust on behalf of the OVCAD (Ovarian Cancer Diagnosis initiative) Mass-spectrometry-based...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2515: mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer Cancers doi: 10.3390/cancers12092515 Authors: Jiha Shin Jeongyun Bae Sumi Park Hyun-Goo Kang Seong Min Shin Gunho Won Jong-Seok Kim Ssang-Goo Cho Youngsok Choi Sang-Muk Oh Jongdae Shin Jeong Sig Kim Hwan-Woo Park Oncogenic activation of the mammalian target of rapamycin complex 1 (mTORC1) leads to endometrial cancer cell growth...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2514: Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53 Cancers doi: 10.3390/cancers12092514 Authors: Xinyu Zhou Sietske N. Zijlstra Abel Soto-Gamez Rita Setroikromo Wim J. Quax Artemisinin derivatives, widely known as commercial anti-malaria drugs, may also have huge potential in treating cancer cells. It has been reported that artemisinin derivatives can overcome resistance to tumor necrosis factor-related...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2516: Evaluation of PD-L1 Expression and HPV Genotyping in Anal Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12092516 Authors: Anja Wessely Markus V. Heppt Claudia Kammerbauer Theresa Steeb Thomas Kirchner Michael J. Flaig Lars E. French Carola Berking Elisa Schmoeckel Markus Reinholz Anal squamous cell carcinoma (SCC) is a rare cancer with increasing incidence. Infection with high-risk human papillomavirus (HPV) subtypes is the...
Fri Sep 04, 2020 03:00
Cancers, Vol. 12, Pages 2512: Immunotherapy and NSCLC: The Long and Winding Road Cancers doi: 10.3390/cancers12092512 Authors: Antonio Rossi Lung cancer is one of the most incident tumors worldwide, characterized by a very bad prognosis due to its high mortality even in early stages [...]
Fri Sep 04, 2020 03:00
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