Allergy and Clinical Immunology,

Neonatal Thymectomy in Children - Accelerating the Immunological Clock?

The thymus is critical for central tolerance and diverse T-lymphocyte repertoire development, to provide lifelong defence against pathogens, whilst maintaining self-tolerance. Peak thymic output occurs in-utero, infancy and early childhood, diminishing throughout life. Infants with congenital heart disease requiring sternotomy, often undergo thymectomy to clear the surgical field. Longterm effects of early thymectomy are just being appreciated. Many patients remain asymptomatic, despite immunological...

Allergy and Clinical Immunology

8h

Exhausted phenotype of follicular CD8 T cells in CVID

Follicular CD8 T cells are expanded in germinal centers of CVID patients with lymphadenopathy, show increased proliferation, an exhaustion-associated phenotype and IL-10 production and may thus potentially contribute to germinal center dysregulation in some CVID patients.

Allergy and Clinical Immunology

8h

Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Randomized Trial Comparing Clinical and Biological Responses to Cat Allergen

Comparing NAC and EEC allergen challenges revealed differences in kinetics and magnitude of clinical responses, but notable correlations in immunological responses, indicating similarity in the biological pathways elicited by both challenges.

Allergy and Clinical Immunology

8h

Long term follow-up of 168 patients with X-linked agammaglobulinemia reveals increased morbidity and mortality

This is the first real-life study involving patients with X-linked agammaglobulinemia revealing important co-morbidities and significantly reduced overall survival during long-term follow-up, suggesting that patients’ current clinical management may necessitate of additional measures.

Allergy and Clinical Immunology

8h

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