Cancers, Vol. 12, Pages 871: Establishment and Characterisation of Heterotopic Patient-Derived Xenografts for Glioblastoma Cancers doi: 10.3390/cancers12040871 Authors: Sarah Meneceur Annett Linge Matthias Meinhardt Sandra Hering Steffen Löck Rebecca Bütof Dietmar Krex Gabriele Schackert Achim Temme Michael Baumann Mechthild Krause Cläre von Neubeck Glioblastoma is an aggressive brain tumour with a patient median survival of approximately 14 months. The...
Fri Apr 03, 2020 03:00
Cancers, Vol. 12, Pages 870: Urine Endocannabinoids as Novel Non-Invasive Biomarkers for Bladder Cancer at Early Stage Cancers doi: 10.3390/cancers12040870 Authors: Riccardo Vago Alessandro Ravelli Arianna Bettiga Silvana Casati Giovanni Lavorgna Fabio Benigni Andrea Salonia Francesco Montorsi Marica Orioli Pierangela Ciuffreda Roberta Ottria Due to the involvement of the endocannabinoid system (ECS) in cancer onset and progression and the less studied connection...
Fri Apr 03, 2020 03:00
Cancers, Vol. 12, Pages 868: TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases Cancers doi: 10.3390/cancers12040868 Authors: Florian Drescher Patricia Juárez Danna L. Arellano Nicolás Serafín-Higuera Felipe Olvera-Rodriguez Samanta Jiménez Alexei F. Licea-Navarro Pierrick GJ. Fournier Breast cancer (BCa) cells disseminating to the bone can remain dormant and resistant to treatments for many years until relapsing as...
Fri Apr 03, 2020 03:00
Cancers, Vol. 12, Pages 867: The Role of Circulating Tumor Cells in the Metastatic Cascade: Biology, Technical Challenges, and Clinical Relevance Cancers doi: 10.3390/cancers12040867 Authors: Hassan Dianat-Moghadam Mehdi Azizi Zahra Eslami-S Luis Enrique Cortés-Hernández Maryam Heidarifard Mohammad Nouri Catherine Alix-Panabières Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor Cells (CTCs) and disseminated tumor cells are the...
Fri Apr 03, 2020 03:00
Cancers, Vol. 12, Pages 869: Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma Cancers doi: 10.3390/cancers12040869 Authors: Tashbib Khan Yaowu He Thomas Kryza Brittney S. Harrington Jennifer H. Gunter Mitchell A. Sullivan Tahleesa Cuda Rebecca Rogers Claire M. Davies Amy Broomfield Madeline Gough Andy C. Wu Thomas McGann S. John Weroha Paul Haluska Josephine...
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 888: Detection of Circulating Tumor Cells (CTCs) in Malignant Pleural Mesothelioma (MPM) with the “Universal” CTC-Chip and An Anti-Podoplanin Antibody NZ-1.2 Cells doi: 10.3390/cells9040888 Authors: Kuwata Yoneda Mori Kanayama Kuroda Kaneko Kato Tanaka Circulating tumor cell (CTC) is a potentially useful surrogate of micro-metastasis, but detection of rare tumor cells contaminated in a vast majority of normal hematologic cells remains...
Sun Apr 05, 2020 03:00
Cells, Vol. 9, Pages 889: Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining Cells doi: 10.3390/cells9040889 Authors: Szymonowicz Krysztofiak Linden Kern Deycmar Oeck Squire Koska Hlouschek Vüllings Neander Siveke Matschke Pruschy Timmermann Jendrossek Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the...
Sun Apr 05, 2020 03:00
Cells, Vol. 9, Pages 886: Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1 Cells doi: 10.3390/cells9040886 Authors: Hii Chung Mai Yee Chan Raja Dephoure Pyne Pyne Leong Cancer stem cells (CSCs) represent rare tumor cell populations capable of self-renewal, differentiation, and tumor initiation and are highly resistant to chemotherapy and radiotherapy. Thus, therapeutic...
Sat Apr 04, 2020 03:00
Cells, Vol. 9, Pages 887: Microautophagy in Plants: Consideration of Its Molecular Mechanism Cells doi: 10.3390/cells9040887 Authors: Sieńko Poormassalehgoo Yamada Goto-Yamada Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved...
Sat Apr 04, 2020 03:00
Cells, Vol. 9, Pages 885: Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma Cells doi: 10.3390/cells9040885 Authors: Antonina Germano Daniela Rossin Valerio Leoni Noemi Iaia Laura Saba Vittoria Basile Soraya Puglisi Claudio Caccia Giuseppe Poli Fiorella Biasi Massimo Terzolo Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis...
Sat Apr 04, 2020 03:00
Cells, Vol. 9, Pages 883: Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc Cells doi: 10.3390/cells9040883 Authors: Daniel Massó-Vallés Laura Soucek First designed and published in 1998 as a laboratory tool to study Myc perturbation, Omomyc has come a long way in the past 22 years. This dominant negative has contributed to our understanding of Myc biology when expressed, first, in normal and cancer cells, and later in genetically-engineered mice, and has shown remarkable...
Sat Apr 04, 2020 03:00
Cells, Vol. 9, Pages 884: Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts Cells doi: 10.3390/cells9040884 Authors: Kerstin Kuffner Julian Triebelhorn Katrin Meindl Christoph Benner André Manook Daniel Sudria-Lopez Ramona Siebert Caroline Nothdurfter Thomas C. Baghai Konstantin Drexler Mark Berneburg Rainer Rupprecht Vladimir M. Milenkovic Christian H. Wetzel Mitochondrial malfunction is supposed to...
Sat Apr 04, 2020 03:00
Cells, Vol. 9, Pages 880: Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis Cells doi: 10.3390/cells9040880 Authors: Yen-Ju Lin Martina Anzaghe Stefan Schülke Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally. It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage destruction and bone erosion. While until the 1990s RA frequently resulted in disability, inability...
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 881: Improved Prediction of miRNA-Disease Associations Based on Matrix Completion with Network Regularization Cells doi: 10.3390/cells9040881 Authors: Jihwan Ha Chihyun Park Chanyoung Park Sanghyun Park The identification of potential microRNA (miRNA)-disease associations enables the elucidation of the pathogenesis of complex human diseases owing to the crucial role of miRNAs in various biologic processes and it yields insights into novel prognostic markers....
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 882: Large Animal Models of Inherited Retinal Degenerations: A Review Cells doi: 10.3390/cells9040882 Authors: Paige A. Winkler Laurence M. Occelli Simon M. Petersen-Jones Studies utilizing large animal models of inherited retinal degeneration (IRD) have proven important in not only the development of translational therapeutic approaches, but also in improving our understanding of disease mechanisms. The dog is the predominant species utilized because spontaneous...
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 879: Human AlphoidtetO Artificial Chromosome as a Gene Therapy Vector for the Developing Hemophilia A Model in Mice Cells doi: 10.3390/cells9040879 Authors: Sergey V. Ponomartsev Sergey A. Sinenko Elena V. Skvortsova Mikhail A. Liskovykh Ivan N. Voropaev Maria M. Savina Andrey A. Kuzmin Elena Yu. Kuzmina Alexandra M. Kondrashkina Vladimir Larionov Natalay Kouprina Alexey N. Tomilin Human artificial chromosomes (HACs), including the...
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 878: MeCP2 and Chromatin Compartmentalization Cells doi: 10.3390/cells9040878 Authors: Annika Schmidt Hui Zhang M. Cristina Cardoso Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address...
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 876: Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature Cells doi: 10.3390/cells9040876 Authors: Anton G. Kutikhin Alexey E. Tupikin Vera G. Matveeva Daria K. Shishkova Larisa V. Antonova Marsel R. Kabilov Elena A. Velikanova Endothelial colony-forming cells (ECFC) are currently considered as a promising cell population for...
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 877: Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells Cells doi: 10.3390/cells9040877 Authors: Jui-Hung Yen Ching-Yen Lin Chin-Hsien Chuang Hsien-Kuo Chin Ming-Jiuan Wu Pei-Yi Chen Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor...
Fri Apr 03, 2020 03:00
Cells, Vol. 9, Pages 875: Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives Cells doi: 10.3390/cells9040875 Authors: Natascha Roehlen Emilie Crouchet Thomas F. Baumert Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. Correlating with liver disease progression, fibrosis is a key factor for liver disease outcome and risk of hepatocellular carcinoma (HCC). Despite different mechanism of primary liver injury and...
Fri Apr 03, 2020 03:00
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