IJMS, Vol. 21, Pages 2521: Nanostructured Materials for Artificial Tissue Replacements International Journal of Molecular Sciences doi: 10.3390/ijms21072521 Authors: Pryjmaková Kaimlová Hubáček Švorčík Siegel This paper review current trends in applications of nanomaterials in tissue engineering. Nanomaterials applicable in this area can be divided into two groups: organic and inorganic. Organic nanomaterials are especially used for the preparation of highly porous scaffolds...
Sun Apr 05, 2020 03:00
IJMS, Vol. 21, Pages 2520: The Cbs Locus Affects the Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21072520 Authors: Utyro Perła-Kaján Jakubowski Cystathionine β-synthase (CBS) is a housekeeping enzyme that catalyzes the first step of the homocysteine to cysteine transsulfuration pathway. Homozygous deletion of the Cbs gene in mice causes severe hyperhomocysteinemia...
Sun Apr 05, 2020 03:00
IJMS, Vol. 21, Pages 2519: Protective Effects of Recombinant Human Soluble Thrombomodulin on Lipopolysaccharide-Induced Acute Kidney Injury International Journal of Molecular Sciences doi: 10.3390/ijms21072519 Authors: Yuji Nozaki Jinhai Ri Kenji Sakai Kaoru Niki Masanori Funauchi Itaru Matsumura Thrombomodulin (TM) is a single transmembrane, multidomain glycoprotein receptor for thrombin, and is best known for its role as a cofactor in a clinically important natural anticoagulant...
Sun Apr 05, 2020 03:00
IJMS, Vol. 21, Pages 2517: A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMETTM Plus Platform International Journal of Molecular Sciences doi: 10.3390/ijms21072517 Authors: Jeong-An Gim Yonghan Kwon Hyun A Lee Kyeong-Ryoon Lee Soohyun Kim Yoonjung Choi Yu Kyong Kim Howard Lee Tacrolimus is an immunosuppressive drug with a narrow therapeutic index and larger interindividual variability. We identified genetic...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2518: Dysbacteriosis-Derived Lipopolysaccharide Causes Embryonic Osteopenia through Retinoic-Acid-Regulated DLX5 Expression International Journal of Molecular Sciences doi: 10.3390/ijms21072518 Authors: You Zhu Li Wang Cai Song Long Berman Lin Cheng Yang Growing evidence suggests an adverse impact of gut microbiota dysbiosis on human health. However, it remains unclear whether embryonic osteogenesis is affected by maternal...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2516: Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability International Journal of Molecular Sciences doi: 10.3390/ijms21072516 Authors: Koeneke Ponce Troya-Balseca Palomo Hoenicka The TaqIA single nucleotide variant (SNV) has been tested for association with addictions in a huge number of studies. TaqIA is located in the ankyrin repeat and kinase domain containing 1 gene (ANKK1) that codes for a receptor interacting protein...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2515: Pathogenesis of Mucopolysaccharidoses, an Update International Journal of Molecular Sciences doi: 10.3390/ijms21072515 Authors: Simona Fecarotta Antonietta Tarallo Carla Damiano Nadia Minopoli Giancarlo Parenti The recent advancements in the knowledge of lysosomal biology and function have translated into an improved understanding of the pathophysiology of mucopolysaccharidoses (MPSs). The concept that MPS manifestations are direct consequences...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2513: Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH International Journal of Molecular Sciences doi: 10.3390/ijms21072513 Authors: Julia C. Berkmann Aaron X. Herrera Martin Agnes Ellinghaus Claudia Schlundt Hanna Schell Evi Lippens Georg N. Duda Serafeim Tsitsilonis Katharina Schmidt-Bleek Local pH is stated to acidify after bone fracture. However,...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2514: Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers International Journal of Molecular Sciences doi: 10.3390/ijms21072514 Authors: Pasquale Simeone Giuseppina Bologna Paola Lanuti Laura Pierdomenico Maria Teresa Guagnano Damiana Pieragostino Piero Del Boccio Daniele Vergara Marco Marchisio Sebastiano Miscia Renato Mariani-Costantini Extracellular vesicles act as shuttle vectors or signal...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2511: The Role of Bcl-xL Protein Research in Veterinary Oncology International Journal of Molecular Sciences doi: 10.3390/ijms21072511 Authors: Aleksandra Pawlak Marta Henklewska Due to their significant impact on human and animal health, cancer diseases are an area of considerable concern for both human and veterinary medicine. Research on the cancer pathogenesis in companion animals, such as dogs, allows not only for improving canine cancer treatment, but also...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2510: Anemarrhenae asphodeloides rhizoma Extract Enriched in Mangiferin Protects PC12 Cells against a Neurotoxic Agent-3-Nitropropionic Acid International Journal of Molecular Sciences doi: 10.3390/ijms21072510 Authors: Agnieszka Piwowar Nina Rembiałkowska Anna Rorbach-Dolata Arnold Garbiec Sylwester Ślusarczyk Agnieszka Dobosz Anna Długosz Zofia Marchewka Adam Matkowski Jolanta Saczko The rhizome of Anemarrhena asphodeloides Bunge, used...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2512: Molecular Dynamics Simulation and Kinetic Study of Fluoride Binding to V21C/V66C Myoglobin with a Cytoglobin-like Disulfide Bond International Journal of Molecular Sciences doi: 10.3390/ijms21072512 Authors: Lu-Lu Yin Jia-Kun Xu Xiao-Juan Wang Shu-Qin Gao Ying-Wu Lin Protein design is able to create artificial proteins with advanced functions, and computer simulation plays a key role in guiding the rational design. In the absence of structural evidence...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2509: Potential Molecular Pathways Related to Pulmonary Artery Aneurysm Development: Lessons to Learn from the Aorta International Journal of Molecular Sciences doi: 10.3390/ijms21072509 Authors: Jorge Nuche Julián Palomino-Doza Fernando Arribas Ynsaurriaga Juan F. Delgado Borja Ibáñez Eduardo Oliver Pilar Escribano Subías Pulmonary arterial hypertension (PAH) is a rare disease caused by pulmonary vascular remodeling. Current vasodilator treatments...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2508: The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions International Journal of Molecular Sciences doi: 10.3390/ijms21072508 Authors: Jörn Heuer Franziska Heuer René Stürmer Sönke Harder Hartmut Schlüter Nayara Braga Emidio Markus Muttenthaler Dörthe Jechorek Frank Meyer Werner Hoffmann TFF1 is a protective peptide of...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2507: Modulation of Sensory Nerve Function by Insulin: Possible Relevance to Pain, Inflammation and Axon Growth International Journal of Molecular Sciences doi: 10.3390/ijms21072507 Authors: Bence András Lázár Gábor Jancsó Péter Sántha Insulin, besides its pivotal role in energy metabolism, may also modulate neuronal processes through acting on insulin receptors (InsRs) expressed by neurons of both the central and the peripheral nervous system. Recently, the...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2506: Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid Dispersion International Journal of Molecular Sciences doi: 10.3390/ijms21072506 Authors: Ching-Chi Yen Yu-Kai Liang Chao-Pei Cheng Mei-Chich Hsu Yu-Tse Wu Andrographolide (AG), a major diterpene lactone isolated from Andrographis paniculata (Burm. f.) Nees (Acanthaceae), possesses a wide spectrum of biological activities. However, its poor water solubility...
Sat Apr 04, 2020 03:00
IJMS, Vol. 21, Pages 2503: HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function International Journal of Molecular Sciences doi: 10.3390/ijms21072503 Authors: Rosario Gajardo-Gómez Cristian A. Santibañez Valeria C. Labra Gonzalo I. Gómez Eliseo A. Eugenin Juan A. Orellana At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive,...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2504: Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia International Journal of Molecular Sciences doi: 10.3390/ijms21072504 Authors: Rahana Abd Rahman Padma Murthi Harmeet Singh Seshini Gurungsinghe Bryan Leaw Joanne C. Mockler Rebecca Lim Euan M. Wallace In preeclampsia, widespread maternal endothelial dysfunction is often secondary to excessive generation...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2502: Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade International Journal of Molecular Sciences doi: 10.3390/ijms21072502 Authors: Oyindamola Vivian Ojulari Seul Gi Lee Ju-Ock Nam Present-day lifestyles associated with high calorie-fat intake and accumulation, as well as energy imbalance, have led to the development of obesity and its comorbidities, which have emerged as some of the major health...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2501: Lipids Nutrients in Parkinson and Alzheimer’s Diseases: Cell Death and Cytoprotection International Journal of Molecular Sciences doi: 10.3390/ijms21072501 Authors: Thomas Nury Gérard Lizard Anne Vejux Neurodegenerative diseases, particularly Parkinson's and Alzheimer's, have common features: protein accumulation, cell death with mitochondrial involvement and oxidative stress. Patients are treated to cure the symptoms, but the treatments do not target...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2505: Mitochondrial Damage and Necroptosis in Aging Cochlea International Journal of Molecular Sciences doi: 10.3390/ijms21072505 Authors: Ah-Ra Lyu Tae Hwan Kim Sung Jae Park Sun-Ae Shin Seong-Hun Jeong Yang Yu Yang Hoon Huh A Reum Je Min Jung Park Yong-Ho Park Age-related hearing loss (ARHL) is an irreversible, progressive neurodegenerative disorder and is presently untreatable. Previous studies using animal models have suggested mitochondrial...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2500: Male sterile 305 Mutation Leads the Misregulation of Anther Cuticle Formation by Disrupting Lipid Metabolism in Maize International Journal of Molecular Sciences doi: 10.3390/ijms21072500 Authors: Haichun Shi Yang Yu Ronghuan Gu Chenxi Feng Yu Fu Xuejie Yu Jichao Yuan Qun Sun Yongpei Ke The anther cuticle, which is mainly composed of lipid polymers, functions as physical barriers to protect genetic material intact; however, the mechanism...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2499: Advances on Chelation and Chelator Metal Complexes in Medicine International Journal of Molecular Sciences doi: 10.3390/ijms21072499 Authors: Kontoghiorghes Metal ions such as iron, copper and zinc are essential for life. Chelators (Chele, greek χειλή-claw of a crab) are organic molecules possessing specific ligands which have high affinity and can bind/carry metal ions and play very important roles in living systems...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2497: Detecting the Effects of the Glucocorticoid Dexamethasone on Primary Human Skeletal Muscle Cells—Differences to the Murine Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21072497 Authors: Eva K. Langendorf Pol M. Rommens Philipp Drees Stefan G. Mattyasovszky Ulrike Ritz Skeletal muscle atrophy is characterized by a decrease in muscle fiber size as a result of a decreased protein synthesis, which leads to degradation of contractile...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2498: Mapping the Gene Expression Spectrum of Mediator Subunits in Response to Viroid Infection in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21072498 Authors: Vishnu Sukumari Nath Ankita Shrestha Praveen Awasthi Ajay Kumar Mishra Tomáš Kocábek Jaroslav Matoušek Andrej Sečnik Jernej Jakše Sebastjan Radišek Vipin Hallan The mediator (MED) represents a large, conserved, multi-subunit protein complex that regulates...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2496: Quantitative Proteomic Analyses Identify STO/BBX24 -Related Proteins Induced by UV-B International Journal of Molecular Sciences doi: 10.3390/ijms21072496 Authors: Guizhen Lyu Dongbing Li Hui Xiong Langtao Xiao Jianhua Tong Chanjuan Ning Ping Wang Shaoshan Li Plants use solar radiation for photosynthesis and are inevitably exposed to UV-B. To adapt to UV-B radiation, plants have evolved a sophisticated strategy, but the mechanism is not...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2494: The Optogenetic Revolution in Cerebellar Investigations International Journal of Molecular Sciences doi: 10.3390/ijms21072494 Authors: Francesca Prestori Ileana Montagna Egidio D’Angelo Lisa Mapelli The cerebellum is most renowned for its role in sensorimotor control and coordination, but a growing number of anatomical and physiological studies are demonstrating its deep involvement in cognitive and emotional functions. Recently, the development and...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2493: A Precision Strategy to Cure Renal Cell Carcinoma by Targeting Transglutaminase 2 International Journal of Molecular Sciences doi: 10.3390/ijms21072493 Authors: Soo-Youl Kim Jeffrey W. Keillor In a recent report, no significance of transglutaminase 2 (TGase 2) was noted in the analyses of expression differences between normal and clear cell renal cell carcinoma (ccRCC), although we found that knock down of TGase 2 induced significant p53-mediated cell death...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2495: Peptidylarginine Deiminase of Porphyromonas gingivalis Modulates the Interactions between Candida albicans Biofilm and Human Plasminogen and High-Molecular-Mass Kininogen International Journal of Molecular Sciences doi: 10.3390/ijms21072495 Authors: Justyna Karkowska-Kuleta Magdalena Surowiec Mariusz Gogol Joanna Koziel Barbara Potempa Jan Potempa Andrzej Kozik Maria Rapala-Kozik Microorganisms that create mixed-species biofilms in the...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2492: Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish International Journal of Molecular Sciences doi: 10.3390/ijms21072492 Authors: Yam Nath Paudel Yatinesh Kumari Syafiq Asnawi Zainal Abidin Iekhsan Othman Mohd. Farooq Shaikh Epilepsy is a devastating neurological condition exhibited by repeated spontaneous and unpredictable seizures afflicting around 70 million people globally. The basic...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2491: Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model International Journal of Molecular Sciences doi: 10.3390/ijms21072491 Authors: Yuki Narita Koichi Fukumoto Masaki Fukunaga Yuki Kondo Yoichi Ishitsuka Hirofumi Jono Tetsumi Irie Hideyuki Saito Daisuke Kadowaki Sumio Hirata Patients on dialysis are frequently administered high doses of potassium binders such as calcium...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2489: Fifteen Years of Airborne Particulates in Vitro Toxicology in Milano: Lessons and Perspectives Learned International Journal of Molecular Sciences doi: 10.3390/ijms21072489 Authors: Eleonora Marta Longhin Paride Mantecca Maurizio Gualtieri Air pollution is one of the world’s leading environmental causes of death. The epidemiological relationship between outdoor air pollution and the onset of health diseases associated with death is now well...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2490: 2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa International Journal of Molecular Sciences doi: 10.3390/ijms21072490 Authors: Alyssa C. McVey Sean Bartlett Mahmud Kajbaf Annalisa Pellacani Viviana Gatta Päivi Tammela David R. Spring Martin Welch Pseudomonas aeruginosa is an opportunistic pathogen responsible for many hospital-acquired infections. P. aeruginosa can thrive in diverse infection...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2487: Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy International Journal of Molecular Sciences doi: 10.3390/ijms21072487 Authors: Miguel A Ortega Miguel A Saez Oscar Fraile-Martínez Ángel Asúnsolo Leonel Pekarek Coral Bravo Santiago Coca Felipe Sainz Melchor Álvarez- Mon Julia Buján Natalio García-Honduvilla Pregnancy is a period in a woman’s life...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2488: The Cell Wall PAC (Proline-Rich, Arabinogalactan Proteins, Conserved Cysteines) Domain-Proteins Are Conserved in the Green Lineage International Journal of Molecular Sciences doi: 10.3390/ijms21072488 Authors: Huan Nguyen-Kim Hélène San Clemente Josef Laimer Peter Lackner Gabriele Gadermaier Christophe Dunand Elisabeth Jamet Plant cell wall proteins play major roles during plant development and in response to environmental cues. A bioinformatic...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2481: Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms21072481 Authors: Alexandra Lipus Ewa Janosz Mania Ackermann Miriam Hetzel Julia Dahlke Theresa Buchegger Stephanie Wunderlich Ulrich Martin Toni Cathomen Axel Schambach Thomas Moritz Nico Lachmann Induced pluripotent stem cells (iPSCs) offer...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2484: Effects of Mindfulness-Based Interventions on Biomarkers and Low-Grade Inflammation in Patients with Psychiatric Disorders: A Meta-Analytic Review International Journal of Molecular Sciences doi: 10.3390/ijms21072484 Authors: Kenji Sanada Jesus Montero-Marin Alberto Barceló-Soler Daisuke Ikuse Marie Ota Akihito Hirata Akira Yoshizawa Rieko Hatanaka Montserrat Salas Valero Marcelo Demarzo Javier García Campayo Akira Iwanami Mindfulness-Based...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2485: Antibodies, Nanobodies, or Aptamers—Which Is Best for Deciphering the Proteomes of Non-Model Species? International Journal of Molecular Sciences doi: 10.3390/ijms21072485 Authors: Poshmaal Dhar Rasika M. Samarasinghe Sarah Shigdar This planet is home to countless species, some more well-known than the others. While we have developed many techniques to be able to interrogate some of the “omics”, proteomics is becoming recognized as...
Fri Apr 03, 2020 03:00
IJMS, Vol. 21, Pages 2486: Development and Assessment of Duplex and Triplex Laminated Edible Films Using Whey Protein Isolate, Gelatin and Sodium Alginate International Journal of Molecular Sciences doi: 10.3390/ijms21072486 Authors: Andrey A. Tyuftin Lizhe Wang Mark A.E. Auty Joe P. Kerry The objective of this study was to assess the ability of producing laminated edible films manufactured using the following proteins; gelatin (G), whey protein isolate (WPI) and polysaccharide...
Fri Apr 03, 2020 03:00
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