Κυριακή 5 Απριλίου 2020


Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews
Dear editor,We read with great interest the review entitled ‘Paracetamol vs other analgesia in adult patients with minor musculoskeletal injuries: a systematic review’,1 published in the Emergency Medicine Journal. Although the authors have stated that they followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, there is a methodological issue regarding the study discussed in this letter, which need to be addressed by the authors.Selection of eligible studies is the...
Emergency Medicine Journal Online First
32m
Retrospective chart review of minor tibial fractures in preschoolers: immobilisation and complications
ObjectiveTo compare the treatment practices (immobilisation vs non-immobilisation) of toddler fractures and other minor tibial fractures (both proven and suspected) in preschoolers, aged 9 months–4 years, and examine rates of ED re-presentations and complications.MethodsRetrospective chart review of presentations of minor tibial fractures, both proven (radiologically confirmed) or suspected (negative X-ray but clinical evidence of bony injury), in children aged 9 months–4 years presenting to a single...
Emergency Medicine Journal Online First
2d
Use of prehospital emergency medical services according to income of residential area
BackgroundThe increasing usage of emergency medical services (EMS) missions is a challenge in modern practice. This study was designed to examine the association of the income level of residential areas on the rate of EMS missions and the frequency of EMS use in these areas.MethodsAll EMS missions for adult patients (>18 years) encountered by one rescue department in Northern Finland between June 2015 and May 2017 were analysed. The area served was categorised into four categories, according to...
Emergency Medicine Journal Online First
2d
Neonatal incubator or artificial womb? Distinguishing ectogestation and ectogenesis using the metaphysics of pregnancy
Abstract A 2017 Nature report was widely touted as hailing the arrival of the artificial womb. But the scientists involved claim their technology is merely an improvement in neonatal care. This raises an under‐considered question: what differentiates neonatal incubation from artificial womb technology? Considering the nature of gestation—or metaphysics of pregnancy—(a) identifies more profound differences between fetuses and neonates/babies than their location (in or outside the maternal body)...
Bioethics
36m
More than a statistic [Humanities]
Canadian Medical Association Journal current issue
39m
Management of the neurologically deceased organ donor: A Canadian clinical practice guideline [Guideline]
Canadian Medical Association Journal current issue
39m
Use of sodium-glucose cotransporter-2 inhibitors and risk of acute kidney injury in older adults with diabetes: a population-based cohort study [Research]
BACKGROUND:Regulatory agencies warn about the risk of acute kidney injury (AKI) after the initiation of sodium-glucose cotransporter-2 (SGLT2) inhibitors. Our objective was to quantify the 90-day risk of AKI in older adults after initiation of SGLT2 inhibitors in routine clinical practice. METHODS:We conducted a population-based retrospective cohort study in Ontario, Canada, involving adults with diabetes who were aged 66 years or older and who were newly dispensed either an SGLT2 inhibitor or...
Canadian Medical Association Journal current issue
39m
Microscopic hematuria [Practice]
Canadian Medical Association Journal current issue
39m
How long will social distancing take to work? Experts weigh in on Canadas COVID-19 response [News]
Canadian Medical Association Journal current issue
39m
Hypertensive retinopathy and choroidopathy [Practice]
Canadian Medical Association Journal current issue
39m
Use of fecal immunochemical testing in patients presenting in primary care with lower GI symptoms [Letters]
Canadian Medical Association Journal current issue
39m
Optimizing provision of extracorporeal life support during the COVID-19 pandemic: practical considerations for Canadian jurisdictions [Commentary]
Canadian Medical Association Journal current issue
39m
Canadian primary care doctors face shortage of protective equipment [News]
Canadian Medical Association Journal current issue
39m
Should sodium-glucose cotransporter-2 inhibitors be first-line treatment for patients with type 2 diabetes? [Commentary]
Canadian Medical Association Journal current issue
39m
COVID-19 outbreak measures may indirectly lead to greater burden on hospitals [Letters]
Canadian Medical Association Journal current issue
39m
Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells
Abstract Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are man-made chemicals that are used for the fabrication of many products with water- and dirt-repellent properties. The toxicological potential of both substances is currently under debate. In a recent Scientific Opinion, the European Food Safety Authority (EFSA) has identified increased serum total cholesterol levels in humans as one major critical effect being associated with exposure to PFOA or...
Latest Results for Archives of Toxicology
1h
Designer drugs: mechanism of action and adverse effects
Abstract Psychoactive substances with chemical structures or pharmacological profiles that are similar to traditional drugs of abuse continue to emerge on the recreational drug market. Internet vendors may at least temporarily sell these so-called designer drugs without adhering to legal statutes or facing legal consequences. Overall, the mechanism of action and adverse effects of designer drugs are similar to traditional drugs of abuse. Stimulants, such as amphetamines and cathinones,...
Latest Results for Archives of Toxicology
1h
Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine
Abstract The two fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine (4F-Cy-BAP) and furanoyl-1-benzyl-4-anilinopiperidine (Fu-BAP) have recently been seized as new psychoactive substances (NPS) on the drugs of abuse market. As their toxicokinetic and toxicodynamic characteristics are completely unknown, this study focused on elucidating their in vitro metabolic stability in pooled human liver S9 fraction (pHLS9), their qualitative in vitro (pHLS9), and in...
Latest Results for Archives of Toxicology
21h
Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects
Abstract Depressive disorders are amongst the greatest mental health challenges, with an increasing number of patients being diagnosed each year. Though it has not yet been fully elucidated, redox metabolism imbalances and oxidative stress seem to play a major role in the pathogenesis of depressive disorders. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressants, considered to have a better tolerability. However, several adverse effects have been...
Latest Results for Archives of Toxicology
2d
Reducing time to treatment of bacterial sexually transmitted infections in an HIV cohort
Sexually transmitted infections (STIs) are known to increase the risk of transmission of HIV and care of sexual health needs should form part of routine HIV care. Delayed treatment of STIs can lead to complications and avoidable onward transmission. Management of acute STIs in UK specialist sexual health services usually involves a multidisciplinary approach to ensure patient recall, antimicrobial treatment and partner notification. While this works well in dedicated sexual health clinics, we found...
BMJ QIR Current Issue
1h
MRI/TRUS fusion vs. systematic biopsy: intra-patient comparison of diagnostic accuracy for prostate cancer using PI-RADS v2
Abstract Objective To evaluate the efficacy of multiparametric magnetic resonance/transrectal ultrasound fusion (MRI/TRUS fusion) biopsy versus systematic biopsy and its association with PI-RADS v2 categories in patients with suspected prostate cancer. Materials and methods 122 patients undergoing both MRI/TRUS fusion and systematic biopsy, with suspicion...
Latest Results for Abdominal Imaging
1h
Deep learning reconstruction of drip-infusion cholangiography acquired with ultra-high-resolution computed tomography
Abstract Purpose Deep learning reconstruction (DLR) introduces deep convolutional neural networks into the reconstruction flow. We examined the clinical applicability of drip-infusion cholangiography (DIC) acquired on an ultra-high-resolution CT (U-HRCT) scanner reconstructed with DLR in comparison to hybrid and model-based iterative reconstruction (hybrid-IR, MBIR). Methods...
Latest Results for Abdominal Imaging
1d
Detection of pancreatic ductal adenocarcinoma and liver metastases: comparison of Gd-EOB-DTPA-enhanced MR imaging vs. extracellular contrast materials
Abstract Purpose To compare the detectability of pancreatic ductal adenocarcinoma (PDAC) and liver metastases between Gd-EOB-DTPA- and extracellular contrast materials (ECCMs) contrast-enhanced MR imaging contrast. Methods Two hundred seventy-two patients with suspected pancreatic disease underwent Gd-EOB-DTPA-enhanced MR imaging (EOB group, n = 79) or ECCMs-enhanced...
Latest Results for Abdominal Imaging
1d
New prostate MRI techniques and sequences
Abstract Prostate MRI has seen increasing interest in recent years and has led to the development of new MRI techniques and sequences to improve prostate cancer (PCa) diagnosis which are reviewed in this article. Numerous studies have focused on improving image quality (segmented DWI) and faster acquisition (compressed sensing, k-t-SENSE, PROPELLER). An increasing number of studies have developed new quantitative and computer-aided diagnosis methods including artificial intelligence...
Latest Results for Abdominal Imaging
1d
Imaging assessment of local recurrence of prostate cancer after radical prostatectomy
Abstract Definitive therapy for prostate cancer includes radical prostatectomy and radiation therapy. Treatment is elected based on patient preference, biological tumor factors, and underlying health. Post prostatectomy, men are surveyed for disease recurrence with serial PSA measurements, digital rectal exam, and imaging studies depending on nomogram predicted risk of local disease recurrence and distant metastasis. In men with rising PSA levels, pathologically incomplete surgical...
Latest Results for Abdominal Imaging
1d
Mucinous cystic neoplasm of the liver communicated with intrahepatic duct exhibiting peculiar chronological change in MR imaging appearances: a case report
Abstract A 70-year-old woman has been followed up for chronic hepatitis C and hepatocellular carcinoma which had been successfully controlled by several sessions of radiofrequency ablation. A small cystic lesion in segment IV associated with adjacent intrahepatic duct dilatation was firstly noted 4 years before on MR imaging, which showed gradual increase in size and significant interval change in the MRI signal intensity of the cystic content on the follow-up examinations. The...
Latest Results for Abdominal Imaging
2d
Computed tomography-guided radiofrequency ablation combined with transarterial embolization assisted by a three-dimensional visualization ablation planning system for hepatocellular carcinoma in challenging locations: a preliminary study
Abstract Objective To assess the clinical efficacy and safety of computed tomography-guided radiofrequency ablation(CT-RFA) combined with transarterial embolization(TAE) assisted by a three-dimensional visualization ablation planning system(3DVAPS) for hepatocellular carcinoma(HCC) in challenging locations. Methods Data from 62 treatment-naive...
Latest Results for Abdominal Imaging
2d
Health-Related Quality of Life evaluation in “left” versus “right” access for percutaneous transhepatic biliary drainage using EORTC QLQBIL-21 questionnaire: a randomized controlled trial
Abstract Purpose To investigate the impact of the different access for percutaneous transhepatic biliary drainage (PTBD) in terms of “Quality of Life” (QoL) in the management of malignant obstructive jaundice. Methods In this IRB-approved study, 64 consecutive patients with malignant obstructive jaundice were prospectively randomized to the...
Latest Results for Abdominal Imaging
2d
Correction to: Incidence of clinically significant perforation at low dose non‑contrast CT and its value prior to same day CT colonography following incomplete colonoscopy
The original version of this article has an error in the order of authors name. The order of author names should read as “Aileen O’Shea, Timothy Murray, Eavan Thornton, Michael J. Lee and Martina M. Morrin” in the authors group.
Latest Results for Abdominal Imaging
2d
Computed tomography and magnetic resonance enterography protocols and techniques: survey of the Society of Abdominal Radiology Crohn’s Disease Disease-Focused Panel
Abstract Purpose To survey Society of Abdominal Radiology Crohn’s Disease (CD) Disease-Focused Panel (DFP) members to understand state-of-the-art CT/MR enterography (CTE/MRE) protocols and variability between institutions. Methods This study was determined by an institutional review board to be “exempt” research. The survey consisted of 70 questions...
Latest Results for Abdominal Imaging
2d
Staging MRI of uterine malignant mixed Müllerian tumors versus endometrial carcinomas with emphasis on dynamic enhancement characteristics
Abstract Purpose To determine whether staging pelvic magnetic resonance imaging (MRI) can distinguish malignant mixed Müllerian tumor (MMMT) from EC. Methods Thirty-seven treatment-naïve patients with histologically proven uterine MMMT and 42 treatment-naïve patients with EC, treated at our institution, were included in our retrospective study....
Latest Results for Abdominal Imaging
2d
Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG from Cupriavidus necator [Molecular Biophysics]
Formate oxidation to carbon dioxide is a key reaction in one-carbon compound metabolism, and its reverse reaction represents the first step in carbon assimilation in the acetogenic and methanogenic branches of many anaerobic organisms. The molybdenum-containing dehydrogenase FdsABG is a soluble NAD+-dependent formate dehydrogenase and a member of the NADH dehydrogenase superfamily. Here, we present the first structure of the FdsBG subcomplex of the cytosolic FdsABG formate dehydrogenase from the...
JBC Papers in Press
2h
SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9 and PIAS2 and enhances its stability and function in cell proliferation [Protein Synthesis and Degradation]
SUMOylation is a posttranslational modification (PTM) at a lysine residue and is crucial for the proper functions of many proteins, particularly of transcription factors, in various biological processes. Zinc finger homeobox 3 (ZFHX3), also known as AT motif–binding factor 1 (ATBF1), is a large transcription factor that is active in multiple pathological processes, including atrial fibrillation and carcinogenesis, and in circadian regulation and development. We have previously demonstrated that ZFHX3...
JBC Papers in Press
2h
One proline deletion in the fusion peptide of neurotropic mouse hepatitis virus (MHV) restricts retrograde axonal transport and neurodegeneration [Microbiology]
Mouse hepatitis virus (MHV; murine coronavirus [M-CoV]) causes meningoencephalitis, myelitis, and optic neuritis followed by axonal loss and demyelination. This murine virus is used as a common model to study both acute and chronic virus-induced demyelination in the central nervous system. Studies with recombinant MHV strains that differ in the gene encoding the spike protein have demonstrated that the spike has a role in both MHV pathogenesis and retrograde axonal transport. Fusion peptides (FPs)...
JBC Papers in Press
2h
The histone H4 basic patch regulates SAGA-mediated H2B deubiquitylation and histone acetylation [DNA and Chromosomes]
Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that establish and remove H2Bub1, we have only an incomplete understanding of how H2Bub1 is regulated. We report here that the histone H4 basic patch regulates H2Bub1. Yeast cells with arginine-to-alanine...
JBC Papers in Press
2d
The polymorphism rs975484 in the protein arginine methyltransferase-1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma [Immunology]
Protein arginine methyltransferase 1 (PRMT1) is a key regulator of hepatic immune responses. Recently, we reported that PRMT1 regulates the tumor immune response in hepatocellular carcinoma (HCC). Here, we found that PRMT1 expression in human HCC correlates with that of programmed cell death 1 ligand 1 (PD-L1), PD-L2, and other checkpoint genes. PRMT1 deletion in mice reduced PD-L1 and PD-L2 expression in tumors and reduced the efficiency of PD-1 antibody treatment in a diethylnitrosamine-induced...
JBC Papers in Press
2d
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress [Bioenergetics]
Optic atrophy 1 (OPA1) is a dynamin protein that mediates mitochondrial fusion at the inner membrane. OPA1 is also necessary for maintaining the cristae, and thus essential for supporting cellular energetics. OPA1 exists as membrane-anchored long form (L-OPA1) and short form (S-OPA1) that lacks the transmembrane region and is generated by cleavage of L-OPA1. Mitochondrial dysfunction and cellular stresses activate the inner membrane–associated zinc metallopeptidase OMA1 that cleaves L-OPA1, causing...
JBC Papers in Press
2d
Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors [Neurobiology]
Glial-cell line-derived neurotrophic Factor (GDNF) is a growth factor that regulates the health and function of neurons and other cells. GDNF binds to GDNF family receptor alpha 1 (GFRa1), and the resulting complex activates the RET receptor tyrosine kinase and subsequent downstream signals. This feature restricts GDNF activity to systems in which GFRa1 and RET are both present, a scenario that may constrain GDNF breadth of action. Furthermore, this co-dependence precludes the use of GDNF as a tool...
JBC Papers in Press
2d
The Levels of Monoamines and Their Metabolites in the Brain Structures of Rats Subjected to Two- and Three-Month-Long Social Isolation
The levels of monoamines and their metabolites in the brain structures of adult Wistar rats subjected to post-weaning social isolation for 2 and 3 months were analyzed by HPLC with electrochemical detection. We have previously shown that these rats consistently demonstrate increased aggressiveness and, as a rule, impairment of short-term habituation. Two-monthlong social isolation was accompanied by a reduction in serotonin content and its increased turnover judging from the 5-HIAA/5-HT ratio in...
Latest Results for Bulletin of Experimental Biology and Medicine
2h

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