: Patients with CKD are prone to develop sensorineural hearing loss, tinnitus, recurrent epistaxis, opportunistic infections including oropharyngeal candidiasis or rhino-cerebral mucormycosis, taste and smell changes, phonatory and vestibular dysfunctions, deep neck infections, mucosal abnormalities, gingival hyperplasia, halitosis or xerostomia. Immunosuppressive therapy after kidney transplantation increases the risk of carcinogenesis, both related and not-related to latent viral infection. The most commonly viral-related neoplasms observed in these patients are oral and oropharyngeal cancers, whereas the majority of not-related to viral infection tumors constitute lip and thyroid cancers. CKD-related otorhinolaryngological dysfunctions are often permanent, difficult to control, have a significant negative influence on patient's quality of life, and can be life threatening.

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages.:

Related Articles

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages.

Eur Arch Otorhinolaryngol. 2020 Mar 28;:

Authors: Krajewska Wojciechowska J, Krajewski W, Zatoński T

Abstract

PURPOSE: Otorhinolaryngological abnormalities are common complications of chronic kidney disease (CKD) and its treatment. The main aim of this study was to provide a brief and precise review of the current knowledge regarding CKD and its treatment-related influence on head and neck organs.

METHODS: The Medline and Web of Science databases were searched using the terms "chronic kidney disease", "kidney transplantation", "immunosuppression", "dialysis" in conjunction with "otorhinolaryngological manifestation". Articles that did not address the topics, low-quality studies, case reports, and studies based on nonsignificant cohorts were excluded, and the full text of remaining high-quality, novel articles were examined and elaborated on.

RESULTS: Patients with CKD are prone to develop sensorineural hearing loss, tinnitus, recurrent epistaxis, opportunistic infections including oropharyngeal candidiasis or rhino-cerebral mucormycosis, taste and smell changes, phonatory and vestibular dysfunctions, deep neck infections, mucosal abnormalities, gingival hyperplasia, halitosis or xerostomia. Immunosuppressive therapy after kidney transplantation increases the risk of carcinogenesis, both related and not-related to latent viral infection. The most commonly viral-related neoplasms observed in these patients are oral and oropharyngeal cancers, whereas the majority of not-related to viral infection tumors constitute lip and thyroid cancers. CKD-related otorhinolaryngological dysfunctions are often permanent, difficult to control, have a significant negative influence on patient's quality of life, and can be life threatening.

CONCLUSION: Patients with CKD suffer from a number of otorhinolaryngological CKD-induced complications. The relationship between several otorhinolaryngological complications and CKD was widely explained, whereas the correlation between the rest of them and CKD remains unclear. Further studies on this subject are necessary.

PMID: 32222803 [PubMed - as supplied by publisher]

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages.

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages.:

Related Articles

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages.

Eur Arch Otorhinolaryngol. 2020 Mar 28;:

Authors: Krajewska Wojciechowska J, Krajewski W, Zatoński T

Abstract

PURPOSE: Otorhinolaryngological abnormalities are common complications of chronic kidney disease (CKD) and its treatment. The main aim of this study was to provide a brief and precise review of the current knowledge regarding CKD and its treatment-related influence on head and neck organs.

METHODS: The Medline and Web of Science databases were searched using the terms "chronic kidney disease", "kidney transplantation", "immunosuppression", "dialysis" in conjunction with "otorhinolaryngological manifestation". Articles that did not address the topics, low-quality studies, case reports, and studies based on nonsignificant cohorts were excluded, and the full text of remaining high-quality, novel articles were examined and elaborated on.

RESULTS: Patients with CKD are prone to develop sensorineural hearing loss, tinnitus, recurrent epistaxis, opportunistic infections including oropharyngeal candidiasis or rhino-cerebral mucormycosis, taste and smell changes, phonatory and vestibular dysfunctions, deep neck infections, mucosal abnormalities, gingival hyperplasia, halitosis or xerostomia. Immunosuppressive therapy after kidney transplantation increases the risk of carcinogenesis, both related and not-related to latent viral infection. The most commonly viral-related neoplasms observed in these patients are oral and oropharyngeal cancers, whereas the majority of not-related to viral infection tumors constitute lip and thyroid cancers. CKD-related otorhinolaryngological dysfunctions are often permanent, difficult to control, have a significant negative influence on patient's quality of life, and can be life threatening.

CONCLUSION: Patients with CKD suffer from a number of otorhinolaryngological CKD-induced complications. The relationship between several otorhinolaryngological complications and CKD was widely explained, whereas the correlation between the rest of them and CKD remains unclear. Further studies on this subject are necessary.

PMID: 32222803 [PubMed - as supplied by publisher]

Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model.

Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model.:

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Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model.

Photochem Photobiol. 2020 Mar 29;:

Authors: Peng W, de Bruijn HS, Ten Hagen TLM, van Dam GM, Roodenburg JLN, Berg K, Witjes MJH, Robinson DJ

Abstract

Targeted photodynamic therapy (PDT) in head/neck cancer patients with a conjugate of the anti-epidermal growth factor receptor (EGFR) antibody, Cetuximab and a phthalocyanine photosensitizer IR700DX is under way, but the exact mechanisms of action are still not fully understood. In this study the EGFR over-expressing human head/neck OSC-19-luc2-cGFP tumour with transfected GFP gene was used in a skin-fold window-chamber model in BALB/c nude mice. The uptake and localization of the conjugate in the tumour and its surrounding normal tissues were studied by an intravital confocal laser scanning microscopy with image analyses. The tumour was also irradiated with 690 nm laser light 24 hours after conjugate administration. The vascular and tumour responses were examined by morphological evaluation and immunohistochemistry (IHC). The amount of conjugate in the tumour peaked at 24-48 hours after injection. Image analyses of colocalization correlation parameters demonstrated a high fraction of the conjugate IR700DX colocalised in the GFP-expressing tumour cells. PDT-treated tumours showed extensive necrotic/apoptotic destruction with little vascular damage; while IHC showed no HIF-1α expression and decreased EGFR and Ki67 expression with activated caspase-3 overexpression, indicating a direct killing of tumour cells through both necrotic and apoptotic cell death.

PMID: 32222965 [PubMed - as supplied by publisher]

Potential association between oral mucosal nevus and melanoma: a preliminary clinicopathologic study.

Potential association between oral mucosal nevus and melanoma: a preliminary clinicopathologic study.:

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Potential association between oral mucosal nevus and melanoma: a preliminary clinicopathologic study.

Oral Dis. 2020 Mar 28;:

Authors: Liu W, Wang Y, Du G, Zhou Z, Yang X, Shi L

Abstract

OBJECTIVES: To assess potential association between oral nevi (ON) and nevus-associated melanoma (NAM), in which melanoma cells coexist with nevus cells.

METHODS: A total of 74 ON patients and 7 NAM patients were retrospectively reviewed. Comparative and regression analyses of clinical and histologic data were performed between two groups.

RESULTS: The mean age of the patients with ON was 36.5 years compared with that of 54.7 years of the patients with NAM (P=0.008). Gender ratio was female predominance for ON (1.64:1 ratio) and male predominance for NAM (6:1 ratio). The most common location of ON and NAM was the palate (31.1%) and gingiva (71.4%), respectively. Univariate regression analysis revealed that elderly male patients (≥60 years) with junctional ON located on the gingiva correlate with higher risk of melanoma. Multivariate analysis revealed that junctional type of ON was an independent factor (adjusted OR, 38.32; 95% CI, 3.20-458.64; P=0.004) associated significantly with increased risk for melanoma.

CONCLUSIONS: The preliminary study for the first time elucidated the clinicopathologic features of a Chinese series of ON, and evaluated the potential association between ON and NAM with a limited sample size. Further large muticentre studies are needed to confirm the findings.

PMID: 32223052 [PubMed - as supplied by publisher]

The effect of the standard length of the first prescription on the adherence to sublingual immunotherapy for patients with allergic rhinitis.

The effect of the standard length of the first prescription on the adherence to sublingual immunotherapy for patients with allergic rhinitis.:

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The effect of the standard length of the first prescription on the adherence to sublingual immunotherapy for patients with allergic rhinitis.

Int Forum Allergy Rhinol. 2020 Mar 29;:

Authors: Jin M, Zhang L, Zhou G, Zhang S, Li X, Hu S

Abstract

BACKGROUND: Poor adherence to sublingual immunotherapy (SLIT) has become a major cause of unsatisfactory clinical efficacy for patients with allergic rhinitis (AR). This study was designed to identify the effect of different first prescription lengths on the adherence to SLIT.

METHODS: The clinical data of 306 patients with AR who started SLIT between January 2017 and June 2018 were retrospectively reviewed. Patients were divided into 3 groups according to the length of their first prescription (group A: less than 3 months, group B: 3 to 6 months, group C: more than 6 months). The numbers of adherent or nonadherent patients in each group and the main reasons of nonadherence were analyzed.

RESULTS: Groups A, B, and C included 102, 161, and 43 patients, respectively. The average lengths of the first prescription for group A, B, and C were 62.52 ± 17.63, 102.21 ± 9.22, and 189.07 ± 17.97 days. There were significance differences among the 3 groups (p < 0.05). There were 42 (41.18%), 112 (69.57%), and 37 (86.05%) adherent patients in group A, B, and C. There were 60 (58.82%), 49 (30.43%), and 6 (13.95%) nonadherent patients in group A, B, and C. There were significant differences in the proportions of adherent and nonadherent patients among the 3 groups (p < 0.05). The following reasons were cited for nonadherence to SLIT: the long course of SLIT; inconvenience of getting the prescription; ineffectiveness; side effects; and other reasons.

CONCLUSION: Under certain conditions, 6 months is recommended as the standard length for the first prescription, which can significantly improve adherence to SLIT in patients with AR.

PMID: 32223075 [PubMed - as supplied by publisher]

Laparoscopic management of pelvic organ prolapse recurrence after open sacrocervicopexy.

Related ArticlesLaparoscopic management of pelvic organ prolapse recurrence after open sacrocervicopexy. Int Urogynecol J. 2020 Mar 28;: Authors: Grinstein E, Gluck O, Veit-Rubin N, Deval B Abstract In this narrated video we present a case of pelvic organ prolapse (POP) recurrence 12 years after sacrocervicopexy, outline our management and suggest an optimal laparoscopic surgical technique that may reduce the risk of future recurrence. A 71-year-old...

Oncology

Tue Mar 31, 2020 13:37

Predictors of hospital readmission among older adults with cancer.

Related ArticlesPredictors of hospital readmission among older adults with cancer. J Geriatr Oncol. 2020 Mar 25;: Authors: Burhenn P, Sun CL, Scher KS, Hsu J, Pandya P, Chui CY, Arsenyan A, Mitani D, Morrison R, Katheria V, Hurria A Abstract OBJECTIVE: Older adults with cancer are at higher risk for costly and potentially dangerous hospital readmissions. Identifying risk factors for readmission in this population is important for future prevention of...

Oncology

Tue Mar 31, 2020 13:37

Small molecules, big impact: 20 years of targeted therapy in oncology.

Related ArticlesSmall molecules, big impact: 20 years of targeted therapy in oncology. Lancet. 2020 Mar 28;395(10229):1078-1088 Authors: Bedard PL, Hyman DM, Davids MS, Siu LL Abstract The identification of molecular targets and the growing knowledge of their cellular functions have led to the development of small molecule inhibitors as a major therapeutic class for cancer treatment. Both multitargeted and highly selective kinase inhibitors are used...

Oncology

Tue Mar 31, 2020 13:37

Is the Vision of Radioligand Therapy for Prostate Cancer Becoming a Reality? An Overview of the Phase III VISION Trial and Its Importance for the Future of Theranostics.

Related ArticlesIs the Vision of Radioligand Therapy for Prostate Cancer Becoming a Reality? An Overview of the Phase III VISION Trial and Its Importance for the Future of Theranostics. J Nucl Med. 2019 11;60(11):1504-1506 Authors: Rahbar K, Bodei L, Morris MJ Abstract Prostate-specific membrane antigen (PSMA) is of considerable interest as a target for diagnostics and therapy of prostate cancer patients. PSMA-targeted imaging has demonstrable value...

Oncology

Tue Mar 31, 2020 13:37

Growth and Characterization of Irradiated Organoids from Mammary Glands.

Related ArticlesGrowth and Characterization of Irradiated Organoids from Mammary Glands. J Vis Exp. 2019 05 03;(147): Authors: Hacker BC, Gomez JD, Batista CAS, Rafat M Abstract Organoids derived from the digested tissue are multicellular three-dimensional (3D) constructs that better recapitulate in vivo conditions than cell monolayers. Although they cannot completely model in vivo complexity, they retain some functionality of the original organ. In...

Oncology

Tue Mar 31, 2020 13:37

DOTA-MGS5, a New Cholecystokinin-2 Receptor-Targeting Peptide Analog with an Optimized Targeting Profile for Theranostic Use.

Related ArticlesDOTA-MGS5, a New Cholecystokinin-2 Receptor-Targeting Peptide Analog with an Optimized Targeting Profile for Theranostic Use. J Nucl Med. 2019 07;60(7):1010-1016 Authors: Klingler M, Summer D, Rangger C, Haubner R, Foster J, Sosabowski J, Decristoforo C, Virgolini I, von Guggenberg E Abstract Molecular imaging and targeted radiotherapy with radiolabeled cholecystokinin-2 receptor (CCK2R) targeting peptide probes holds high promise to...

Oncology

Tue Mar 31, 2020 13:37

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 European Journal of Surgical Oncology (EJSO)

Enhanced recovery after surgery programmes in older patients undergoing hepatopancreatobiliary surgery: What benefits might prehabilitation have?

Publication date: Available online 29 March 2020Source: European Journal of Surgical OncologyAuthor(s): Bart C. Bongers, Cornelis H.C. Dejong, Marcel den Dulk

European Journal of Surgical Oncology (EJSO)

Tue Mar 31, 2020 13:36

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 PeerJ Computer Science

Characterization of cold stress responses in different rapeseed ecotypes based on metabolomics and transcriptomics analyses

The winter oilseed ecotype is more tolerant to low temperature than the spring ecotype. Transcriptome and metabolome analyses of leaf samples of five spring Brassica napus L. (B. napus) ecotype lines and five winter B. napus ecotype lines treated at 4 °C and 28 °C were performed. A total of 25,460 differentially expressed genes (DEGs) of the spring oilseed ecotype and 28,512 DEGs of the winter oilseed ecotype were identified after cold stress; there were 41 differentially expressed metabolites (DEMs)...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

A new plesiosaurian from the Jurassic–Cretaceous transitional interval of the Slottsmøya Member (Volgian), with insights into the cranial anatomy of cryptoclidids using computed tomography

Cryptoclidids are a major clade of plesiosauromorph plesiosaurians best known from the Middle—Late Jurassic, but little is known regarding their turnover into the Early Cretaceous. Of the known cryptoclidid genera, most preserve only a limited amount of cranial material and of these Cryptoclidus eurymerus, displays the most complete, but compressed cranium. Thus, the lack of knowledge of the cranial anatomy of this group may hinder the understanding of phylogenetic interrelationships, which are currently...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

Overexpression of PheNAC3 from moso bamboo promotes leaf senescence and enhances abiotic stress tolerance in Arabidopsis

The NAC family is one of the largest transcription factor families unique to plants, which regulates the growth and development, biotic and abiotic stress responses, and maturation and senescence in plants. In this study, PheNAC3, a NAC gene, was isolated and characterized from moso bamboo (Phyllostachys edulis). PheNAC3 belong to the NAC1 subgroup and has a conserved NAC domain on the N-terminus, which with 88.74% similarity to ONAC011 protein. PheNAC3 localized in the nucleus and exhibited transactivation...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

Patterns of gene evolution following duplications and speciations in vertebrates

Background Eukaryotic genes typically form independent evolutionary lineages through either speciation or gene duplication events. Generally, gene copies resulting from speciation events (orthologs) are expected to maintain similarity over time with regard to sequence, structure and function. After a duplication event, however, resulting gene copies (paralogs) may experience a broader set of possible fates, including partial (subfunctionalization) or complete loss of function, as well as gain of...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases

Abstract The morbidity and mortality of prostate carcinoma has increased in recent years and has become the second most common ale malignant carcinoma worldwide. The interaction mechanisms between different genes and signaling pathways, however, are still unclear. Methods Variation analysis of GSE38241, GSE69223, GSE46602 and GSE104749 were realized by GEO2R in Gene Expression Omnibus database. Function enrichment was analyzed by DAVID.6.8. Furthermore, the PPI network and the significant...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

Food additive “lauric acid” possess non-toxic profile on biochemical, haematological and histopathological studies in female Sprague Dawley (SD) rats

Background Lauric acid (LA), a common constituent of coconut oil, is used as food additives and supplements in various formulations. Despite various potential pharmacological properties, no scientific evidence on its dose-related toxicity and safety is available till date. Objective The current study was conducted to evaluate acute oral toxicity of LA on normal rats. Methods...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

Diagnostic model of combined ceRNA and DNA methylation related genes in esophageal carcinoma

Esophageal cancer is a common malignant tumor in the world, and the aim of this study was to screen key genes related to the development of esophageal cancer using a variety of bioinformatics analysis tools and analyze their biological functions. The data of esophageal squamous cell carcinoma from the Gene Expression Omnibus (GEO) were selected as the research object, processed and analyzed to screen differentially expressed microRNAs (miRNAs) and differential methylation genes. The competing endogenous...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

Plantar support adaptations in healthy subjects after eight weeks of barefoot running training

Background Although the studies of barefoot running have intensified, it is still missing longitudinal work analyzing the effects of barefoot running on the phases of plantar support. The objective of this research was to analyze the modifications undergone by the Total Foot Contact (TFC) phase and its Flat Foot Phase (FFP) in subjects beginning the practice of barefoot running, in its acute and chronic effects. Methods A total of 28 subjects were divided into the Barefoot Group (BFGr)...

PeerJ Computer Science

Tue Mar 31, 2020 03:00

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