Purpose: Fulvestrant, the first-in-class selective estrogen receptor (ER) degrader (SERD), is clinically effective in patients with ER+ breast cancer, but it has administration and pharmacokinetic (PK) limitations. Pharmacodynamic (PD) data suggests complete ER degradation is not achieved at fulvestrant's clinically feasible dose. This pre-surgical study (NCT03236974) compared the PD effects of fulvestrant with AZD9496, a novel, orally bioavailable, non-steroidal, potent SERD, in treatment-naive...
Tue Mar 31, 2020 16:00
Poly-ADP-ribose-polymerase inhibitors (PARPi) are promising in BRCA2-altered prostate cancer. Data were presented on PARPi efficacy in prostate cancers with alterations in other DNA damage repair genes which suggest low response rates in ATM-, CHEK2-, CDK12-altered tumors and promising results in PALB2-, RAD51B-, FANCA-, and BRIP1-altered tumors.
Tue Mar 31, 2020 16:00
PURPOSE: We performed next-generation sequencing (NGS) in the CONKO-001 phase-3 trial to identify clinically relevant prognostic and predictive mutations and conducted a functional validation in TCGA sequencing data. PATIENTS AND METHODS: Patients of the CONKO-001 trial received curatively intended surgery for pancreatic adenocarcinoma (PDAC) followed by adjuvant chemotherapy with gemcitabine (Gem) or observation only (Obs). Tissue samples of 101 patients were evaluated by NGS of 37 genes. Cox proportional...
Tue Mar 31, 2020 16:00
British Journal of Cancer, Published online: 01 April 2020; doi:10.1038/s41416-020-0796-8Molecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response
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Reconstructive surgery of the conductive hearing mechanism is collectively called as tympanoplasty, which has gradually evolved over time with the contributions from all over the word. The aim of the present historical review is to summarize the Indian contributions in the development of the technique of tympanoplasty. The literature review was conducted using only the “Medline” search using keywords “tympanoplasty” and “ossiculoplasty” in “India” on 15th June 2016. A total of 195 articles and abstracts...
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Chronic cough is a frequently encountered condition with multiple etiologies. In patients with neurogenic chronic cough, peripheral laryngopharyngeal hypersensitivity of the vagus nerve stimulates the cough reflex. We present three cases of “Oto-tricho-tussia,” describing hair within the ear canal stimulating Arnold’s branch of the vagus nerve and triggering the urge-to-cough. All three patients experienced significant improvement or complete resolution of their cough symptoms after removal of the...
Tue Mar 31, 2020 15:35
Laryngo-Rhino-OtolDOI: 10.1055/a-1148-3553© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Mar 31, 2020 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01022
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05466
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00513
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01316
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00114
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00298
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00004
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05111
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00172
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05278
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04806
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05299
Tue Mar 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00093
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13551
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00954
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01605
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03398
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01313
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02684
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13080
Tue Mar 31, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01430
Tue Mar 31, 2020 07:00
Teach your little ones some new survival tips to fill up free time. (Christine Peterson/)This story originally featured on Outdoor Life.Unless you’re an engineer or calculus teacher, you probably aren’t going to be able to help your high school senior with math homework. Nor will you likely teach a 5-year-old to speak a foreign language fluently. Let’s face it, few of us are teachers and even fewer are trained to teach whatever grade level and subject matter your suddenly homeschooled student is...
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The yellow-rumped leaf-eared mouse might only be a tiny critter, but it can live in some dire conditions. (Marcial Quiroga-Carmona/)The peak of Llullaillaco, the world’s highest active volcano, stretches some 22,000 feet above sea level and is almost like another planet. The peak straddling Chile and Argentina is one of the driest places on earth, making it the perfect place for mummies to remain intact for thousands of years and not much else. Temperatures regularly drop below freezing, and vegetation...
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A rocket carrying a BeiDou-3 satellite lifts off in November, 2018. (Deposit Photos/)On March 9, China moved into the end run of a decades-long project to build its own global navigation satellite system, a project that will make it independent of foreign rivals when it comes to a network that undergirds modern tech, business, and the military. It’s called BeiDou.The latest satellite in the navigation system, a third-gen craft (known as BeiDou-3) now in a geostationary orbit, lifted off earlier this...
Tue Mar 31, 2020 21:42
It might be time to put down your iPad. (Amirali Mirhashemian via Unsplash/)Board games are analog solutions for a very digital problem: too much screen time. Convert your kitchen table into a tournament hall with a board game, and revisit classic games generations have enjoyed as kids and adults. With tangible pieces, colorful designs, and fanciful escapes from everyday life, what’s not to like? These four favorites for all ages will remind you that people were actually able to have fun before the...
Tue Mar 31, 2020 20:29
Wired and wireless options that give you an edge. (Alex Haney via Unsplash/)If you want to battle zombies on a console like Xbox or PlayStation, you need a gaming controller to get started. When you play on your computer, nothing’s stopping you from using the mouse that came with it or (shudder) your laptop’s trackpad. Mice designed just for gaming help you scroll quickly through your environment, zero in on targets, and even program favorite actions for speed and efficiency. With these four choices,...
Tue Mar 31, 2020 20:24
Turning everyone vegan to prevent zoonotic diseases is nonsensical. (Pexels/)While the precise origin of the SARS-CoV-2 virus that causes COVID-19 is still murky epidemiologists are at least sure it came from animals. This connection has triggered a number of internet folks to draw connections between animal consumption and the arrival of COVID-19 and other zoonotic disease outbreaks. They include vegan influencer Earthling Ed, whose real name is Ed Winters. In an interview with USA Today, Winters,...
Tue Mar 31, 2020 19:00
We all love free stuff. But some free stuff comes with a cost. (Jacob Boavista/Unsplash/)Free trials are fantastic—you get to learn if you actually like or need an app or service before you hand over any money. That said, you should never sign up for something without knowing what you’re actually agreeing to—free trial or not.Some platforms will automatically start charging you after your trial expires, and others will collect your personal data in exchange for their service. But fret not: With just...
Tue Mar 31, 2020 16:12
There are still many communities around the country where COVID-19 is not yet spreading widely. Its important those communities practice social distancing, too. (Pexels/)New York City has become the epicenter of the COVID-19 pandemic in the United States. As of March 30, the city had recorded over 36,000 cases—more than anyplace else in the nation—and 790 deaths. Officials have projected that the state of New York still needs 30,000 ventilators for critically ill people, with only several thousand...
Tue Mar 31, 2020 18:38
J Neurol Surg Rep 2020; 81: e20-e27DOI: 10.1055/s-0039-1695795 Objective Atlantoaxial fixation is technically demanding and challenging, especially in cases with anatomical abnormality. The purpose of this study is to report the effectiveness of the three-dimensional (3D)-customized guiding template for placement of C1 and C2 screws in cases with abnormalities. Method Two patients with anatomical abnormality and one without were included. The preoperative computed tomography...
Tue Mar 31, 2020 02:00
J Neurol Surg Rep 2020; 81: e15-e19DOI: 10.1055/s-0039-3399569 Objective Stimulation of the subthalamic nucleus by implanted electrodes (deep brain stimulation [DBS]) is performed to suppress symptoms of Parkinson's disease. However, postoperative wound dehiscence and infection can require removal of the implanted electrode leads. This report describes treatment of intractable unilateral wound infection in two patients without removing the DBS device. Methods First, components...
Tue Mar 31, 2020 02:00
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