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Oral Dis. 2020 Mar 28;:
Authors: Liu W, Wang Y, Du G, Zhou Z, Yang X, Shi L
Abstract
OBJECTIVES: To assess potential association between oral nevi (ON) and nevus-associated melanoma (NAM), in which melanoma cells coexist with nevus cells.
METHODS: A total of 74 ON patients and 7 NAM patients were retrospectively reviewed. Comparative and regression analyses of clinical and histologic data were performed between two groups.
RESULTS: The mean age of the patients with ON was 36.5 years compared with that of 54.7 years of the patients with NAM (P=0.008). Gender ratio was female predominance for ON (1.64:1 ratio) and male predominance for NAM (6:1 ratio). The most common location of ON and NAM was the palate (31.1%) and gingiva (71.4%), respectively. Univariate regression analysis revealed that elderly male patients (≥60 years) with junctional ON located on the gingiva correlate with higher risk of melanoma. Multivariate analysis revealed that junctional type of ON was an independent factor (adjusted OR, 38.32; 95% CI, 3.20-458.64; P=0.004) associated significantly with increased risk for melanoma.
CONCLUSIONS: The preliminary study for the first time elucidated the clinicopathologic features of a Chinese series of ON, and evaluated the potential association between ON and NAM with a limited sample size. Further large muticentre studies are needed to confirm the findings.
PMID: 32223052 [PubMed - as supplied by publisher]
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