The relevance of formant-based measures has been noted across a spectrum of medical, technical, and linguistic applications. Therefore, the primary aim of the study was to evaluate the effect of ageing on vowel articulation, as the previous research revealed contradictory findings. The secondary aim was to provide normative acoustic data for all Czech monophthongs.
Tue Mar 31, 2020 03:00
Laryngopharyngeal reflux (LPR) is a prevalent condition in both general otolaryngology and laryngology. Scientists are faced with both the diagnostic and therapeutic controversies and the many “gray” areas related to LPR. Among those shades of gray are the poorly understood impact of diet and lifestyle, the lack of recognition/understanding of the variability in pH of the refluxate (acid, nonacid, and mixed and the impact this has on treatment options), and the nonspecific presenting signs and symptoms...
Tue Mar 31, 2020 03:00
Surgical Infections, Ahead of Print.
Tue Mar 31, 2020 10:00
Metastatic neuroendocrine carcinoma often presents as carcinoma of unknown primary. Although most cases display immunohistochemical positivity for neuroendocrine markers, subsets of cases display reduced or ne...
Tue Mar 31, 2020 03:00
Many cardiac arrhythmias are episodic and only detectable after continuously monitoring the heart’s rhythm for several days or weeks. In particular, atrial arrhythmias can be a diagnostic challenge due to the difficulty in clearly visualizing the P wave on an ECG. The two main monitoring options are either Holter monitors, which capture high-quality signals but are highly uncomfortable, or patch monitors, which can be worn more comfortably but that provide a lower-quality signal. Bardy...
Tue Mar 31, 2020 23:13
Nuvo Group announced that it has received 510(k) clearance from the FDA to market INVU, a wearable device that remotely monitors fetal and maternal heart rates. Fetal and maternal heart rates are important measurements late in pregnancy, and an elevated fetal heart rate can be one of the first signals of fetal distress. Currently, obtaining these vital signs requires regular office visits and use of an electronic fetal monitor. INVU allows patients and physicians to monitor these data...
Tue Mar 31, 2020 22:03
To help address the COVID-19 emergency that’s taking over emergency rooms and intensive care units in the United States, the FDA has cleared the RAPIDPoint 500e blood gas system from Siemens Healthineers. The device uses the company’s Integri-sense technology to provide results on blood gas, electrolyte, metabolite, CO-oximetry, and neonatal bilirubin. This is important during the crisis, as mechanically ventilated patients require regular blood gas testing to maintain proper ventilator...
Tue Mar 31, 2020 16:56
Researchers at UC Berkeley have set up a “pop-up” robotic COVID-19 testing lab that can process up to 1000 patient samples a day, and it could ramp up to as many as 3000 a day, if required. The initiative received donations of high-throughput robotic PCR systems from campus research labs within Berkeley, and the new facility can provide results as quickly as 4 hours from the receipt of patient swabs. One of the current bottle necks in assessing and stopping the COVID-19 pandemic is diagnostic...
Tue Mar 31, 2020 16:44
The present work aims to elaborate many juice formulas (F1 to F8) from two dried fruits (jujubes: Ziziphus lotus L. and dates: Phoenix dactylifera L.). Physicochemical and biochemical characterization of the formula juices shows that juices rich in dates fruits (F1, F3, F5, and F7) are loaded, on average, in total sugars (129.5 g/l), proteins (3.02 g/l), lipids (1.08 g/l), and carotenoid (0.02 mg/l), while juices rich in jujube fruits (F2, F4, F6, and F8) are overloaded, on average, in phenolic compounds...
Tue Mar 31, 2020 14:20
Objectives. Statin-induced myopathy is one of the major causes of poor adherence and discontinuation of this medication. There are contrary results regarding association of vitamin D insufficiency with statin-induced myopathy. This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats. Methodology. Animals were divided into six groups with 6 rats in each group. Groups I and II acted as controls, Group III and Group IV were administered...
Tue Mar 31, 2020 14:20
Publication date: Available online 30 March 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Min Jeong Cho, Kyunghwa Han, Ilah Shin, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y. Park, Jin Young Kwak
Tue Mar 31, 2020 22:21
Publication date: April 2020Source: Allergology International, Volume 69, Issue 2Author(s): Kenji Izuhara
Tue Mar 31, 2020 22:17
Abstract The aim of this study is to evaluate through computed tomography differences in cortical plate thickness of condyle in patients with a different facial vertical skeletal pattern. The final sample of this retrospective study included CBCT exams of 60 adult subjects (mean age 33.2 ± 5.6), selected from the digital archive of a private practice. The subjects were assigned to 3 different groups according to the values of the Frankfurt-mandibular plane angle: hyper-, normo-,...
Tue Mar 31, 2020 03:00
Researchers describe their discovery of a new mechanism that could contribute to the pathogenesis of inflammatory diseases. The scientists found that ZBP1, a protein best known for defending against incoming viruses, is activated by sensing an unusual form of cellular genetic material (Z-nucleic acids), leading to cell death and inflammation.
Tue Mar 31, 2020 20:00
Hypoxemia is a severe condition associated with high rates of mortality, particularly in low- and middle-income countries (LMICs) with poor access to oxygen therapy. Despite its clinical significance, there ha...
Mon Mar 30, 2020 03:00
Fatigue, sleep disturbance and altered mood are frequently reported in patients with primary antibody deficiency syndrome (PADS) on adequate immunoglobulin replacement therapy. This study aimed to determine th...
Mon Mar 30, 2020 03:00
Here, we describe a protocol to visualize and analyze the pharyngeal arch arteries 3, 4, and 6 of mouse embryos using whole-mount immunofluorescence, tissue clearing, confocal microscopy, and 3D reconstruction.
Tue Mar 31, 2020 21:48
This article presents methods for generating, purifying, and quantifying Caenorhabditis elegans extracellular vesicles.
Tue Mar 31, 2020 20:47
Publication date: Available online 30 March 2020Source: Practical Radiation OncologyAuthor(s): Shane Mesko, He Wang, Samuel Tung, Congjun Wang, Dario Pasalic, Matthew S. Ning, Todd A. Pezzi, Amy C. Moreno, Jay P. Reddy, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, Steven J. Frank, Clifton D. Fuller, William Morrison, Shirley Y. Su, Ehab Hanna, Jack Phan
Tue Mar 31, 2020 21:39
Publication date: Available online 29 March 2020Source: Practical Radiation OncologyAuthor(s): W. Robert Lee
Tue Mar 31, 2020 21:39
Publication date: Available online 30 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): B. Movahedian Attar, S.M. Razavi, M. Daneshmand, A. Davoudi
Tue Mar 31, 2020 21:38
Publication date: Available online 30 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Coopman, J. Fennis, H. Ghaeminia, G. Van de Vyvere, C. Politis, T.J.M. Hoppenreijs
Tue Mar 31, 2020 21:38
Radiation therapy is an integral part of the multidisciplinary management of breast cancer. Regional lymph node irradiation in younger trials seems to provide superior target coverage as well as a reduction in...
Mon Mar 30, 2020 03:00
Publication date: Available online 31 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Josip Tomic, Andre Alcon, Philipp Metzler, Norbert Jakse, Wolfgang Zemann, Monika Schanbacher, Tomislav A. Zrnc
Tue Mar 31, 2020 21:33
Publication date: Available online 30 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Jesper Jansen, Leander Dubois, Thomas J.J. Maal, Maarten P. Mourits, Hinke Marijke Jellema, Patricia Neomagus, Jan de Lange, Lidy J.C. Hartman, Peter J.J. Gooris, Alfred G. Becking
Tue Mar 31, 2020 21:33
Objective: We analyzed the long-term changes in speech perception ability of pediatric cochlear implants (CIs) to evaluate the effect of the age at the time of surgery. Study Design: Retrospective. Setting: Tertiary care academic center. Patients: One hundred fourteen prelingually deaf children with CI use duration >10 years. Main Outcome Measures: Categories of auditory performance (CAP) scores and monosyllabic word recognition scores using the Asan-Samsung Korean word...
Mon Mar 30, 2020 03:00
Objective: To evaluate the performance changes after sequential bilateral cochlear implantation in a pediatric population of bimodal cochlear implant (CI) users. To evaluate the factors which influence the parental and recipient decision to discontinue hearing aid use and seek a second implant. Study Design: Retrospective case review, within-subject comparison. Setting: Tertiary referral center. Patients: Thirty-one pediatric (
Mon Mar 30, 2020 03:00
Objective: To determine if Menière's disease is associated with fluctuations in afferent excitability in four human subjects previously implanted with vestibular stimulators. Study design: Longitudinal repeated measures. Setting: Tertiary referral center, human vestibular research laboratory. Patients: Four human subjects with previously uncontrolled Menière's disease unilaterally implanted in each semicircular canal with a vestibular stimulator. One subject had only two canals implanted. ...
Mon Mar 30, 2020 03:00
Publication date: June 2020Source: Brain and Language, Volume 205Author(s): Joanna C. Lee, Peggy C. Nopoulos, J. Bruce Tomblin
Tue Mar 31, 2020 21:11
Publication date: May 2020Source: Brain and Language, Volume 204Author(s):
Tue Mar 31, 2020 21:11
The outbreak of a novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) is currently ongoing in China. Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. However, the...
Mon Mar 30, 2020 03:00
Cancers, Vol. 12, Pages 846: Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis Cancers doi: 10.3390/cancers12040846 Authors: Entenberg Oktay D’Alfonso Ginter Robinson Xue Rohan Sparano Jones Condeelis Metastasis causes ~90% of breast cancer mortality. However, standard prognostic tests based mostly on proliferation genes do not measure metastatic potential. Tumor...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 848: Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer Cancers doi: 10.3390/cancers12040848 Authors: Kutasovic McCart Reed Sokolova Lakhani Simpson : Breast cancer is a remarkably complex and diverse disease. Subtyping based on morphology, genomics, biomarkers and/or clinical parameters seeks to stratify optimal approaches for management, but it is clear that every breast cancer is fundamentally unique....
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 843: Plasma and Tissue Specific miRNA Expression Pattern and Functional Analysis Associated to Colorectal Cancer Patients Cancers doi: 10.3390/cancers12040843 Authors: Cojocneanu Braicu Raduly Jurj Zanoaga Magdo Irimie Muresan Ionescu Grigorescu Berindan-Neagoe An increasing number of studies suggest the implication of microRNAs (miRNAs) in colorectal (CRC) carcinogenesis and disease progression. Nevertheless,...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 844: Safety of Aflibercept in Metastatic Colorectal Cancer: A Literature Review and Expert Perspective on Clinical and Real-World Data Cancers doi: 10.3390/cancers12040844 Authors: Muro Salinardi Singh Macarulla : Background: Metastatic colorectal cancer (mCRC) represents a substantial health burden globally and an increasing challenge in Asian countries. Treatment options include chemotherapy plus a vascular endothelial growth factor (VEGF)...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 845: Combination Treatment with Cold Physical Plasma and Pulsed Electric Fields Augments ROS Production and Cytotoxicity in Lymphoma Cancers doi: 10.3390/cancers12040845 Authors: Wolff Kolb Weltmann von Woedtke Bekeschus New approaches in oncotherapy rely on the combination of different treatments to enhance the efficacy of established monotherapies. Pulsed electric fields (PEFs) are an established method (electrochemotherapy) for enhancing...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 847: Lactotransferrin Downregulation Drives the Metastatic Progression in Clear Cell Renal Cell Carcinoma Cancers doi: 10.3390/cancers12040847 Authors: Chiu Hsu Chang Yang Chiu Lin : Clear cell renal cell carcinoma (ccRCC) is the main type of RCC, which is the most common type of malignant kidney tumor in adults. A subpopulation (>30%) of ccRCC patients develop metastasis; however, the molecular mechanism remains largely unknown....
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 841: Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer Cancers doi: 10.3390/cancers12040841 Authors: Chen Tsai Ko Lai Cheng Shiah Hsiao Chang Lin The discoidin domain receptor-1 (DDR1) is a non-integrin collagen receptor recently implicated in the collective cell migration of other cancer types. Previously, we identified an elevated expression of DDR1 in oral squamous cell carcinoma...
Tue Mar 31, 2020 03:00
Cancers, Vol. 12, Pages 842: Chimeric Antigen Receptor Cell Therapy: Overcoming Obstacles to Battle Cancer Cancers doi: 10.3390/cancers12040842 Authors: Petty Heyman Yang Chimeric antigen receptors (CAR) are fusion proteins engineered from antigen recognition, signaling, and costimulatory domains that can be used to reprogram T cells to specifically target tumor cells expressing specific antigens. Current CAR-T cell technology utilizes the patient’s own T cells...
Tue Mar 31, 2020 03:00
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