Publication date: Available online 30 March 2020Source: GeneAuthor(s): Tural Sengul, Yuce Melek, Polat Ayfer Kamali, Tekcan Esra, Celik Betul, Karabacak Ufuk, Kara Nurten
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Abstract Deep invasive gastrointestinal endometriosis (DIGIE) is a frequent and severe presentation of endometriosis. Although most cases invade the rectosigmoid colon, DIGIE can involve any portion of the gastrointestinal tract from the stomach to the rectum, and is commonly multifocal and multicentric. Although histopathologic confirmation with surgery remains the gold standard for diagnosis, ultrasound (US) and magnetic resonance imaging (MRI) are the key non-invasive imaging...
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Publication date: Available online 30 March 2020Source: Journal of Controlled ReleaseAuthor(s): Yining Zhu, Jiao Xue, Wenfei Chen, Shuting Bai, Tao Zheng, Chunting He, Zhaofei Guo, Min Jiang, Guangsheng Du, Xun Sun
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Abstract Rabies is the most critical zoonotic disease in Iran, which imposes many extra costs on health care system in each country. The present study aimed to determine the molecular characteristics of the wild circulating strains of the rabies virus (RABV) collected in Iran during 2015–2017. Rabies-suspected samples were collected from different regions of Iran and identified for RABV antigen confirmation using fluorescent antibody tests. Polymerase chain reaction (PCR) was performed...
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IntroductionElectronic palliative care coordination systems (EPaCCS) aim to support people approaching the end of life (EOL) to receive consistent care, according to their wishes, that is coordinated effectively across multiple care sectors. They are in use across the UK although empirical evidence into their effectiveness is poor. This paper presents a protocol of a mixed-methods study, to understand how, and by whom, EPaCCS are being used and whether EPaCCS are enabling Healthcare Professionals...
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IntroductionHospital admission in older adults with multiple chronic conditions is associated with unwanted outcomes like readmission, institutionalisation, functional decline and mortality. Providing acute care in the community and integrating effective components of care models might lead to a reduction in negative outcomes. Recently, the first geriatrician-led Acute Geriatric Community Hospital (AGCH) was introduced in the Netherlands. Care at the AGCH is focused on the treatment of acute diseases,...
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ObjectiveZambia is among the world’s top 10 countries with higher fertility rate (5.5 births/woman); unmet family planning need for births spacing (14%) and limiting births (7%). Women in rural Zambia (24%) are reported to have unmet need for family planning than those in urban areas (17%). This study was conducted to ascertain factors associated with modern contraceptive use among rural Zambian women. DesignCross-sectional study. SettingRural Zambia. ParticipantsSecondary data of 4903 married...
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ObjectivesLiver disease is a major cause of morbidity and mortality in sub-Saharan Africa, but its prevalence, distribution and aetiology have not been well characterised. We therefore set out to examine liver function tests (LFTs) and liver fibrosis scores in a rural African population. DesignWe undertook a cross-sectional survey of LFTs. We classified abnormal LFTs based on reference ranges set in America and in Africa. We derived fibrosis scores (aspartate aminotransferase (AST) to Platelet...
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IntroductionExisting literature on attitudes toward end-of-life care (EoLC) covers the general public but has little information on the frail elderly population. The aim of the current study is to investigate the preferences of Chinese frail elderly home residents with respect to EoLC by conducting cross-sectional surveys. Methods and analysisSurveys, including resident and family versions, were developed based on the existing literature and our pilot interviews. The targeted participants were...
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IntroductionInsufficient physical activity is one of the most important risk factors for non-communicable diseases. Physical activity should therefore be intensively promoted in all age groups. Several trials suggest that it can be effectively increased through smartphone interventions. However, few of the smartphone-interventions available on the market have been scientifically evaluated. Therefore, the described study aims to assess the short-term and long-term effects of the smartphone intervention...
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ObjectiveTo explore why transplant patients experience unexpected mild-to-moderate distress and what support they may need. DesignQualitative study using individual in-depth interviews. SettingFour National Health Service (NHS) Trusts in the Midlands, UK. ParticipantsFifteen renal transplant patients meeting the criteria for mild-to-moderate distress from their responses to emotion thermometers. Main outcome measuresIdentification of the reasons for distress and support options acceptable...
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IntroductionRates of mental health illnesses and burnout are increasing internationally. Therapeutic yoga is increasingly used to improve and maintain physical, mental and emotional well-being and general health. This protocol describes a study to evaluate the effectiveness of an existing primary care group-based therapeutic yoga programme, the Yoga of Stress Resilience programme, which combines yoga and psychotherapeutic techniques, in improving mental health and decreasing burnout. Implementation...
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IntroductionAntimicrobial resistance (AMR) is a growing problem globally especially in Sub-Saharan Africa including Kenya. Without any intervention, lower/middle-income countries (LMICs) will be most affected due to already higher AMR levels compared with higher income countries and due to the far higher burden of diseases in the LMICs. Studies have consistently shown that inappropriate use of antimicrobials is the major driver of AMR. To address this challenge, hospitals are now implementing antibiotic...
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Si svolgerà domenica 30 agosto in Prato della Valle la Pink Run, la corsa non competitiva riservata alle donne più frequentata di Padova. L’ultima edizione ha visto infatti oltre 7500 iscritte: grazie alla loro partecipazione...
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Publication date: Available online 30 March 2020Source: Experimental Cell ResearchAuthor(s): Jihao Liu, Zhuo Chen, Mingdong Huang, Shuzhi Tang, Qianchao Wang, Ping Hu, Pranav Gupta, Charles R. Ashby, Zhe-Sheng Chen, Lei Zhang
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Publication date: Available online 30 March 2020Source: Experimental Cell ResearchAuthor(s): Michael C. Rahe, Cheryl M.T. Dvorak, Barry Wiseman, Daniel Martin, Michael P. Murtaugh
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Photochem. Photobiol. Sci., 2020, Accepted ManuscriptDOI: 10.1039/C9PP00489K, PaperThomas Wallner, Laura Pedroza, Karsten Voigt, Volkhard Kaever, Annegret WildeThe cyanobacterial phytochrome Cph2 is a light-dependent diguanylate cyclase. Under blue light, the Cph2-dependent increase in the cellular c-di-GMP concentration leads to inhibition of surface motility and a higher rate...The content of this RSS Feed (c) The Royal Society of Chemistry
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Post-transplantation lymphoproliferative disorder (PTLD) is uncommon following solid organ transplantation. We present a case of PTLD presenting as hematochezia and abdominal pain in a 66-year-old man, who had undergone bilateral lung transplantation with alemtuzumab induction 7 months prior to presentation. The transplant serologic status was "high-risk" for the presence of both Epstein-Barr virus (EBV) serologies in the donor and negative serologies in the recipient. Biopsies taken during colonoscopy...
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We present a case of a 52-year-old man with previous mitral valve replacement who presented to an outside hospital for planned cardiac ablation for atrial fibrillation. During the procedure, while advancing the microcatheter across the mitral valve, the microcatheter was sheared embolising into the right middle cerebral artery. This retained cardiac microcatheter tip was successfully retrieved with the monorail microsnare technique. The patient made a complete recovery without any neurological deficits...
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Management of sore throat requires robust decision-making to balance successfully the conflicting risks of unnecessary antibiotic use against those of untreated bacterial infection. We present a case of fulminant sepsis caused by Streptococcus constellatus, presenting as a sore throat, initially managed conservatively. Despite subsequent appropriate anti-microbial therapy and surgical drainage, contiguous spread ultimately involved the deep neck spaces, mediastinum and thoracic wall, and was complicated...
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A 65-year-old comorbid female patient presented to our urology department with a history of multiple interventions to treat severe overactive bladder symptoms. She had a history of clam ileocystoplasty, which was then converted to an ileal conduit due to failure to resolve her symptoms. She subsequently developed multiple complications, most significantly ureteroileal stenosis, managed with bilateral ureteric stents. She later decided on bilateral nephrostomies and subsequent antegrade stent insertion....
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Type B lactic acidosis is a rare metabolic complication of malignancy, more commonly in haematological malignancies. Due to the lack of formal prospective trials, treatment of lactic acidosis associated with malignancy is based on case reports. Given the poor prognosis, early recognition of type B lactic acidosis and prompt treatment are crucial. We report the first case of type B lactic acidosis in metastatic melanoma, followed by a brief literature review on the proposed pathophysiology and treatment.
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We report two cases of cerebral venous thrombosis associated with the use of compounded preparations containing several active substances prescribed for weight loss. In both cases there is suspicion of additive/synergic interaction with oral contraceptives. The adverse drug reactions were considered serious, being life-threatening and causing hospitalisation for days.
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A 64-year-old woman with refractory cellulitis in the lower legs was referred for inadequate glycaemic control. Physical examination revealed cushingoid features including central obesity. CT of the abdomen revealed a right adrenal mass that was positive on 131I-adosterol imaging. Findings on endocrine evaluation confirmed a diagnosis of Cushing’s syndrome, which was cured with a right adrenalectomy. Two months after surgery, the patient complained of pain and marked swelling of the hands during...
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A 69-year-old woman with a remote history of Graves’ disease treated with radioactive iodine ablation, who was maintained on a stable dose of levothyroxine for 15 years, presented with abnormal and fluctuating thyroid function tests which were confusing. After extensive evaluation, no diagnosis could be made, and it became difficult to optimise the levothyroxine dose, until we became aware of the recently recognised biotin-induced lab interference. It was then noticed that her medication list included...
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By: Leanne Armstrong If you’re like us, you’re probably painfully aware of everything that can go wrong on route to achieving your project objectives. You may even be intimately familiar with any number of methods for planning, executing, and monitoring your way from conception to closure. But did you know that common project management techniques can be made significantly more effective when you hitch them to a visual framework? ...
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Antibiotics, Vol. 9, Pages 152: Antibiotic Resistance and Virulence Traits in Vancomycin-Resistant Enterococci (VRE) and Extended-Spectrum -Lactamase/AmpC-producing (ESBL/AmpC) Enterobacteriaceae from Humans and Pets Antibiotics doi: 10.3390/antibiotics9040152 Authors: Iseppi Di Cerbo Messi Sabia Background: We investigated the virulence factors, genes, antibiotic resistance patterns, and genotypes (VRE and ESBL/AmpC) production in Enterococci and Enterobacteriaceae...
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Antibiotics, Vol. 9, Pages 151: Bacteriology and Antimicrobial Resistance in Vanuatu: January 2017 to December 2019 Antibiotics doi: 10.3390/antibiotics9040151 Authors: Foxlee Townell Tosul McIver Lau Keywords: drug resistance; antimicrobial; public health surveillance; Pacific Islands; bacteriology; epidemiology
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Antibiotics, Vol. 9, Pages 150: Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery Antibiotics doi: 10.3390/antibiotics9040150 Authors: Lewis Marquez Cassandra L. Quave Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of Candida auris and azole-resistant Aspergillus fumigatus were highlighted in the Centers...
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Antibiotics, Vol. 9, Pages 149: Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence Antibiotics doi: 10.3390/antibiotics9040149 Authors: Seitaro Nakagawa Greg G. Hillebrand Gabriel Nunez Staphylococcus aureus is an opportunistic pathogen and a common cause of skin infection. S. aureus also plays a role in the pathogenesis of the chronic inflammatory skin disease, atopic...
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Publication date: Available online 30 March 2020Source: Biological PsychologyAuthor(s): Sara C. Verosky, Katja A. Zoner, Corinne W. Marble, Margaret M. Sammon, Charlotte O. Babarinsa
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