Publication date: Available online 30 March 2020Source: Autoimmunity ReviewsAuthor(s): Cristina Belizna, Pier Luigi Meroni, Yehuda Shoenfeld, Katrien Devreese, Jaume Aliotaj-Reig, Enrique Esteve-Valverde, Cecilia Chighizola, Francesca Pregnolato, Hannah Cohen, Celine Fassot, Patrick Martin Mattera, Pascale Peretti, Alexandre Levy, Laurence Bernard, Mathilde Saiet, Laurence Lagarce, Marie Briet, Marianne Rivière, Isabelle Pellier, Géraldine Gascoin
Tue Mar 31, 2020 19:36
Publication date: Available online 30 March 2020Source: Autoimmunity ReviewsAuthor(s): Yanli Tong, Tony Marion, Georg Schett, Yubin Luo, Yi Liu
Tue Mar 31, 2020 19:36
Abstract Deep invasive gastrointestinal endometriosis (DIGIE) is a frequent and severe presentation of endometriosis. Although most cases invade the rectosigmoid colon, DIGIE can involve any portion of the gastrointestinal tract from the stomach to the rectum, and is commonly multifocal and multicentric. Although histopathologic confirmation with surgery remains the gold standard for diagnosis, ultrasound (US) and magnetic resonance imaging (MRI) are the key non-invasive imaging...
Tue Mar 31, 2020 03:00
This Special Communication provides safety recommendations for health care workers regarding otolaryngologic examinations and surgical procedures during the coronavirus disease 2019 (COVID-19) pandemic.
Tue Mar 31, 2020 03:00
This Viewpoint highlights important perioperative considerations when planning for open tracheostomy in an infected patient during the COVID-19 pandemic.
Tue Mar 31, 2020 03:00
Primary thyroid angiosarcoma is a rare malignant tumor and characterized by its prevalence in Alpine regions of Central Europe, close relation to longstanding goiter, and aggressive clinical course with dismal prognosis. We describe the case of an 83-year-old Chinese female who lives in the coastal area of Taiwan. She came to our hospital due to a progressively enlarged mass at her anterior neck. The sonography of the thyroid revealed a well-circumscribed mass in the left lobe. She underwent left...
Tue Mar 31, 2020 15:05
Πολλοί έχουν παρατηρήσει εμπειρικά ότι τα ψυχολογικά φαινόμενα καταλαγιάζουν το χειμώνα και γνωρίζουν έξαρση την άνοιξη, με την απότομη άνοδο της θερμοκρασίας. Τώρα, αυτό φαίνεται να μην αποτελεί μύθο. Καταρχάς να πούμε ότι, η ανθρώπινη υγεία αναγνωρίζεται πλέον ως ένας από τους σημαντικότερους τομείς που επηρεάζονται από την αλλαγή του κλίματος και την υπερθέρμανση του πλανήτη. Ειδικότερα, η ψυχική υγεία έχει προσελκύσει την προσοχή των παγκόσμιων ηγετών τα τελευταία χρόνια και έχει συμπεριληφθεί...
Tue Mar 31, 2020 15:11
Αμερικανοί και Βρετανοί επιστήμονες ανακοίνωσαν ότι ανέπτυξαν το πρώτο τεστ αίματος που μπορεί -με τη βοήθεια της τεχνητής νοημοσύνης- να ανιχνεύσει με ακρίβεια περισσότερους από 50 τύπους καρκίνου και επιπλέον να εντοπίσει σε ποιον ιστό ξεκίνησε η καρκινογένεση, συχνά προτού υπάρξει η παραμικρή κλινική ένδειξη ή σύμπτωμα της νόσου. Οι ερευνητές του Αντικαρκινικού Ινστιτούτου Dana-Faber και της Ιατρικής Σχολής του Πανεπιστημίου Χάρβαρντ των ΗΠΑ, καθώς επίσης του Ινστιτούτου Φράνσις Κρικ και του...
Tue Mar 31, 2020 11:51
Όσο ο ιός εξαπλώνεται, επιβάλλοντας πρωτόγνωρες καταστάσεις, συναισθήματα και συμπεριφορές, δημιουργείται η ανάγκη να προσδιορίσουμε εκ νέου λέξεις και έννοιες, γράφει σε άρθρο του για το Αθηναϊκό Πρακτορείο ο ψυχίατρος-ερευνητής Γιώργος Κωνσταντακόπουλος. Σπίτι: Ο χώρος όπου θα απομονωθείς για να προφυλαχτείς. Αδιάφορο αν είναι 300 ή 30 τετραγωνικά, αν βρίσκεσαι εκεί με τους αγαπημένους σου ή μόνος στους τέσσερις τοίχους ή παστωμένος με άλλα τρία άτομα σε ένα δωμάτιο. Οικογένεια: Παλαιότερα ένα...
Tue Mar 31, 2020 10:26
Οι επιστήμονες έκαναν ακόμη ένα βήμα για τη δημιουργία μηχανών που καταλαβαίνουν τι λέει ένας άνθρωπος, αναλύοντας μόνο τα εγκεφαλικά κύτταρά του και μετατρέποντας, στη συνέχεια, αυτόματα, σε γραπτό κείμενο, τις προτάσεις του. Ερευνητές στις ΗΠΑ δημιούργησαν έναν αλγόριθμο τεχνητής νοημοσύνης, ο οποίος μπορεί να αποκωδικοποιήσει τη νευρωνική δραστηριότητα του εγκεφάλου και να τη «μεταφράσει» σε πραγματικό χρόνο σε προτάσεις με μεγάλη ακρίβεια (σφάλμα μόνο 3%), κάτι που επιτυγχάνεται για πρώτη φορά...
Tue Mar 31, 2020 09:40
Abstract Age-related phenotypic changes of cerebromicrovascular endothelial cells lead to dysregulation of cerebral blood flow and blood-brain barrier disruption, promoting the pathogenesis of vascular cognitive impairment (VCI). In recent years, endothelial cell senescence has emerged as a potential mechanism contributing to microvascular pathologies opening the avenue to the therapeutic exploitation of senolytic drugs in preclinical studies. However, difficulties with the detection...
Tue Mar 31, 2020 03:00
Abstract This study aimed to determine how gender composition affects the group creative process. Participants were recruited into dyads with different gender compositions (female–male dyad, F–M; female–female, F–F; male–male, and M–M) to solve two problems. One problem demanded creativity alternative use task (AUT) and the other did not object characteristic task. Functional near-infrared spectroscopy (fNIRS)-based hyperscanning was used to record interpersonal neural responses....
Tue Mar 31, 2020 03:00
Abstract Pain serves to protect against bodily threat, and therefore initiates protective responses such as attending toward threat-relevant information. Since pain is often exacerbated by executing movements, these motor actions may serve as cues for pain. Up to date, however, pain-related attention during movement remains largely unexplored. While it has been shown that the preparation of a pain-related movement leads to enhanced processing of somatosensory information, it is...
Tue Mar 31, 2020 03:00
Publication date: Available online 31 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Josip Tomic, Andre Alcon, Philipp Metzler, Norbert Jakse, Wolfgang Zemann, Monika Schanbacher, Tomislav A. Zrnc
Tue Mar 31, 2020 18:48
Publication date: Available online 30 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Jesper Jansen, Leander Dubois, Thomas J.J. Maal, Maarten P. Mourits, Hinke Marijke Jellema, Patricia Neomagus, Jan de Lange, Lidy J.C. Hartman, Peter J.J. Gooris, Alfred G. Becking
Tue Mar 31, 2020 18:48
Publication date: Available online 30 March 2020Source: Clinical NeurophysiologyAuthor(s): Luke Chen
Tue Mar 31, 2020 18:44
Publication date: April 2020Source: American Journal of Infection Control, Volume 48, Issue 4Author(s):
Tue Mar 31, 2020 18:37
Publication date: April 2020Source: American Journal of Infection Control, Volume 48, Issue 4Author(s):
Tue Mar 31, 2020 18:37
Publication date: April 2020Source: American Journal of Infection Control, Volume 48, Issue 4Author(s):
Tue Mar 31, 2020 18:37
Publication date: April 2020Source: American Journal of Infection Control, Volume 48, Issue 4Author(s):
Tue Mar 31, 2020 18:37
Publication date: April 2020Source: American Journal of Infection Control, Volume 48, Issue 4Author(s):
Tue Mar 31, 2020 18:37
Objective: We analyzed the long-term changes in speech perception ability of pediatric cochlear implants (CIs) to evaluate the effect of the age at the time of surgery. Study Design: Retrospective. Setting: Tertiary care academic center. Patients: One hundred fourteen prelingually deaf children with CI use duration >10 years. Main Outcome Measures: Categories of auditory performance (CAP) scores and monosyllabic word recognition scores using the Asan-Samsung...
Mon Mar 30, 2020 03:00
Objective: To evaluate the performance changes after sequential bilateral cochlear implantation in a pediatric population of bimodal cochlear implant (CI) users. To evaluate the factors which influence the parental and recipient decision to discontinue hearing aid use and seek a second implant. Study Design: Retrospective case review, within-subject comparison. Setting: Tertiary referral center. Patients: Thirty-one pediatric (
Mon Mar 30, 2020 03:00
Objective: To determine if Menière's disease is associated with fluctuations in afferent excitability in four human subjects previously implanted with vestibular stimulators. Study design: Longitudinal repeated measures. Setting: Tertiary referral center, human vestibular research laboratory. Patients: Four human subjects with previously uncontrolled Menière's disease unilaterally implanted in each semicircular canal with a vestibular stimulator. One subject had only two canals implanted....
Mon Mar 30, 2020 03:00
Abstract Background Access to treatment for glioblastoma (GBM) can be impacted by multiple demographic parameters. Barriers specific to the Hispanic population of the United States (US) are not fully understood. Therefore, the aim of this study was to elucidate geographic disparities for access to GBM treatment in the US Hispanic population. Methods ...
Tue Mar 31, 2020 03:00
Abstract Purpose Immunotherapy has gained traction in the treatment of solid tumors but the immunological landscape of pituitary adenomas is not well defined. We sought to investigate the immunological composition in pituitary adenomas using RNA deconvolution (CIBERSORTx) on an existing gene expression dataset for pituitary adenomas. Methods We applied...
Tue Mar 31, 2020 03:00
Cholesterol oxidase is an alcohol oxidoreductase flavoprotein with wide biotechnological applications. The current work describes the isolation of a potential cholesterol oxidase producing streptomycete from Egyptian soil. The isolated strain produced cholesterol oxidase in submerged culture using a medium containing glucose, yeast extract, malt extract, and CaCO3 with the addition of cholesterol as an inducer. The isolated strain was identified as Streptomyces rochei NAM-19 based on 16S rRNA sequencing...
Tue Mar 31, 2020 16:35
MicroRNAs (miRNAs) are short and noncoding RNA fragments that bind to the messenger RNA. They have different roles in many physiological or pathological processes. MicroRNA-21, one of the first miRNAs discovered, is encoded by the MIR21 gene and is located on the chromosomal positive strand 17q23.2. MicroRNA-21 is transcribed by polymerase II and has its own promoter sequence, although it is in an intron. It is intra- and extracellular and can be found in many body fluids, alone or combined with...
Tue Mar 31, 2020 16:20
Colon cancer is the third most common cancer, with a high incidence and mortality. Construction of a specific and sensitive prediction model for prognosis is urgently needed. In this study, profiles of patients with colon cancer with clinical and gene expression data were downloaded from Gene Expression Omnibus and The Cancer Genome Atlas (TCGA). CXC chemokines in patients with colon cancer were investigated by differential expression gene analysis, overall survival analysis, receiver operating characteristic...
Tue Mar 31, 2020 16:05
Enterotoxigenic Escherichia coli (ETEC) K88 is a zoonotic pathogen. Previous studies have shown that lactic acid bacteria (LAB) have great potential in promoting health and resisting pathogenic infections; however, relatively little research has been done on the Pediococcus genus of LAB. This study is aimed at exploring the mechanisms imparted by Pediococcus acidilactici P25 against ETEC K88 in Caenorhabditis elegans. The probiotic performance of P25 was investigated in vitro. Colonization of K88...
Tue Mar 31, 2020 14:05
Phospholipase D1 Ameliorates Apoptosis in Chronic Renal Toxicity Caused by Low-Dose Cadmium Exposure
Exposure to cadmium (Cd), a common heavy metal used in industry, can result in long-term chronic toxicity. It has been well characterized that kidneys are the main organs that are targeted by toxicity, which can cause apoptosis, necrosis, and atrophy of renal tubular epithelial cells. However, the molecular mechanisms associated with Cd toxicity remain unclear. In this study, the expression of renal proteins in Sprague-Dawley rats exposed to chronic Cd was analyzed with iTRAQ proteomics. Bioinformatics...
Tue Mar 31, 2020 14:05
Purpose. This study was performed to investigate the association of CEP55 expression with liver cancer and explore potential underlying mechanisms. Materials and Methods. Data obtained from The Cancer Genome Atlas (TCGA) was used to investigate CEP55 expression, its prognostic value, the potential mechanisms of its upregulation, CEP55-related pathways, and its biological functions in liver cancer. Data from Gene Expression Omnibus (GEO) and International Cancer Genome Consortium (ICGC) was used to...
Tue Mar 31, 2020 14:05
Systemic sclerosis can affect multiple internal organs, including the liver and lungs. Nintedanib, an antifibrotic approved for treatment of interstitial lung disease associated with systemic sclerosis, may have activity outside of the lungs. This study explored the effect of preventive and therapeutic nintedanib treatment in a 3-week carbon tetrachloride (CCL4)-induced (500 mg/kg/day twice weekly for 3 weeks) model of hepatic inflammation and fibrosis in C57Bl/6 mice (aged 8 weeks, per group)....
Tue Mar 31, 2020 14:05
Background. Alzheimer’s disease (AD) is a common health condition affecting senile people and leads to severe cognitive dysfunctions. Acupuncture has been shown to be a possible alternative natural remedy for AD in some animal studies. Objective. To perform a systematic review to identify the effect of verum-acupuncture compared with sham-acupuncture on learning and memory performance among animal models of AD. Methods. Experimental animal studies of treating AD via verum- and sham- acupuncture were...
Tue Mar 31, 2020 11:50
Conditions: Thyroid Carcinoma; Radioactive Iodine LevelIntervention: Drug: Artificial TearsSponsor: Vanderbilt-Ingram Cancer CenterNot yet recruiting
Tue Mar 31, 2020 17:34
Publication date: Available online 30 March 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Emanuel Della-Torre, Tommaso Germanò, Giuseppe Alvise Ramirez, Lorenzo Dagna, Mona Rita Yacoub
Tue Mar 31, 2020 17:07
Publication date: Available online 30 March 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Yechan Kyung, Min Hwan Choi, Yoo Jung Jeon, Ju Suk Lee, Jun Hwa Lee, Seon Hui Jo, Sung Hoon Kim
Tue Mar 31, 2020 17:07
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