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OBJECTIVE: This study aimed to investigate the effect of miR-126 on intracranial aneurysm (IA) and its predictive value for aneurysm rupture. PATIENTS AND METHODS: Altogether 102 patients (patient group) with IA diagnosed in the Jinhua Municipal Central Hospital from July 2016 to April 2018, and 80 healthy people (normal group) who underwent physical examination during the same period were collected. QRT-PCR was used to detect the expression of miR-126 in serum, analyze the expression of miR-126...
Tue Mar 31, 2020 13:39
Studies have begun to show that muscles and bones play a role in the regulation of biological functions through a combination of biomechanical and biochemical signals. In vivo and ex vivo imaging techniques are crucial in the understanding of the morphology and architecture of muscle and bone for further understanding of musculoskeletal physiology and pathophysiology. This systematic review of the literature summarizes current knowledge and outlines new insights into the functions of muscle and bone...
Tue Mar 31, 2020 13:39
OBJECTIVE: Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease that affect both white and gray matter. The relapsing and the eventually progressive course of MS is heterogeneous; thus, a confident long-term prediction of individual prognosis is not possible yet. Recent studies have demonstrated the role of long non-coding RNA (lncRNAs) as potential biomarkers that could provide information to predict disease activity and progression. PATIENTS AND METHODS: By qRT-PCR, we analysed...
Tue Mar 31, 2020 13:39
Related ArticlesElectrographic seizures and ictal-interictal continuum (IIC) patterns in critically ill patients. Epilepsy Behav. 2020 Mar 26;106:107037 Authors: Zafar SF, Subramaniam T, Osman G, Herlopian A, Struck AF Abstract Critical care long-term continuous electroencephalogram (cEEG) monitoring has expanded dramatically in the last several decades spurned by technological advances in EEG digitalization and several key clinical findings: 1-Seizures...
Tue Mar 31, 2020 13:56
Related ArticlesRescuing Kv10.2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats. Epilepsy Behav. 2020 Mar 26;106:106894 Authors: Liu Y, Duan Y, Du D, Chen F Abstract Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling...
Tue Mar 31, 2020 13:56
Related ArticlesFoiling epilepsy in a brain at risk. Science. 2019 Dec 13;366(6471):1304 Authors: Couzin-Frankel J PMID: 31831652 [PubMed - indexed for MEDLINE]
Tue Mar 31, 2020 13:56
Related ArticlesEpilepsy's next frontier. Science. 2019 Dec 13;366(6471):1300-1304 Authors: Couzin-Frankel J PMID: 31831651 [PubMed - indexed for MEDLINE]
Tue Mar 31, 2020 13:56
Related ArticlesDifferences in Incidence and Risks of Suicide Attempt and Suicidal Drug Overdose between Patients with Epilepsy with and without Comorbid Depression. Int J Environ Res Public Health. 2019 11 15;16(22): Authors: Lin CY, Harnod T, Lin CL, Shen WC, Kao CH Abstract Objective: To determine the differences in the incidences and risks of suicide attempt (SA) and suicidal drug overdose (SDO) between patients with epilepsy with and without comorbid...
Tue Mar 31, 2020 13:56
Related ArticlesA serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity. BMC Pharmacol Toxicol. 2019 11 05;20(1):64 Authors: Han X, Wang J Abstract BACKGROUND: The adverse drug reactions (ADRs) related to clonazepam are mild, and only two cases of myotoxicity induced by clonazepam have been reported, with both patients recovering well. We present a unique case of a serious ADR outcome after taking clonazepam. ...
Tue Mar 31, 2020 13:56
Related ArticlesPreparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice. Molecules. 2019 Nov 02;24(21): Authors: Qushawy M, Prabahar K, Abd-Alhaseeb M, Swidan S, Nasr A Abstract Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-SLN) in order to enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs were prepared...
Tue Mar 31, 2020 13:56
Related ArticlesEffect of Ethosuximide on Audiogenic Epilepsy in Krushinsky-Molodkina Rats. Bull Exp Biol Med. 2019 Aug;167(4):464-466 Authors: Fedotova IB, Perepelkina OV, Nikolaev GM, Surina NM, Poletaeva II Abstract The anticonvulsant effect of ethosuximide (T-type calcium channel blocker) was evaluated in Krushinsky-Molodkina rats predisposed to audiogenic epilepsy. Ethosuximide given with drinking water (300 mg/kg/day) over 45 days slightly reduced...
Tue Mar 31, 2020 13:56
Related ArticlesConserved cell types with divergent features in human versus mouse cortex. Nature. 2019 09;573(7772):61-68 Authors: Hodge RD, Bakken TE, Miller JA, Smith KA, Barkan ER, Graybuck LT, Close JL, Long B, Johansen N, Penn O, Yao Z, Eggermont J, Höllt T, Levi BP, Shehata SI, Aevermann B, Beller A, Bertagnolli D, Brouner K, Casper T, Cobbs C, Dalley R, Dee N, Ding SL, Ellenbogen RG, Fong O, Garren E, Goldy J, Gwinn RP, Hirschstein D, Keene CD, Keshk M, Ko AL,...
Tue Mar 31, 2020 13:56
Related ArticlesLovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model. eNeuro. 2019 May/Jun;6(3): Authors: Muscas M, Louros SR, Osterweil EK Abstract The cholesterol-lowering drug lovastatin corrects neurological phenotypes in animal models of fragile X syndrome (FX), a commonly identified genetic cause of autism and intellectual disability (ID). The therapeutic efficacy of lovastatin is being tested in clinical trials...
Tue Mar 31, 2020 13:56
Related ArticlesLacosamide Overdose: A Case of QRS Prolongation and Seizure. J Emerg Med. 2019 Jun;56(6):652-656 Authors: Ng PC, Schimmel J, Wang GS Abstract BACKGROUND: Lacosamide is a third-generation antiepileptic drug. Its likely mechanism of action is via neuronal sodium channel blockade, via a unique manner compared with other antiepileptic drugs that block sodium channels. A paucity of information exists regarding lacosamide overdosage. Lacosamide...
Tue Mar 31, 2020 13:56
Related ArticlesImplications of de novo mutations in guiding drug discovery: A study of four neuropsychiatric disorders. J Psychiatr Res. 2019 03;110:83-92 Authors: So HC, Wong YH Abstract Recent studies have suggested an important role of de novo mutations (DNMs) in neuropsychiatric disorders. As DNMs are not subject to elimination due to evolutionary pressure, they are likely to have greater disruptions on biological functions. While a number of sequencing...
Tue Mar 31, 2020 13:56
Related ArticlesSelf-Directed Violence After Medical Emergency Department Visits Among Youth. Am J Prev Med. 2019 02;56(2):205-214 Authors: Wang J, Xie H, Holland KM, Sumner SA, Balaji AB, David-Ferdon CF, Crosby AE Abstract INTRODUCTION: Identifying medical encounters that precede self-directed violence may allow for important prevention opportunities. This study examined the risk of self-directed violence after visiting the emergency department for...
Tue Mar 31, 2020 13:56
Related ArticlesThe many faces of peroxisomal disorders: Lessons from a large Arab cohort. Clin Genet. 2019 02;95(2):310-319 Authors: Alshenaifi J, Ewida N, Anazi S, Shamseldin HE, Patel N, Maddirevula S, Al-Sheddi T, Alomar R, Alobeid E, Ibrahim N, Hashem M, Abdulwahab F, Jacob M, Alhashem A, Alzaidan HI, Seidahmed MZ, Alhashemi N, Rawashdeh R, Eyaid W, Al-Hassnan ZN, Rahbeeni Z, Alswaid A, Hadid A, Qari A, Mohammed DA, El Khashab HY, Alfadhel M, Abanemai M, Sunbul...
Tue Mar 31, 2020 13:56
Related ArticlesIncreased mortality and morbidity in patients with chronic hypoparathyroidism: A population-based study. Clin Endocrinol (Oxf). 2019 02;90(2):285-292 Authors: Vadiveloo T, Donnan PT, Leese CJ, Abraham KJ, Leese GP Abstract OBJECTIVES: A population-based study was undertaken to determine the mortality and morbidity for people with hypoparathyroidism compared to the general population. METHODS: In this study, patients identified...
Tue Mar 31, 2020 13:56
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