Related ArticlesLaparoscopic management of pelvic organ prolapse recurrence after open sacrocervicopexy. Int Urogynecol J. 2020 Mar 28;: Authors: Grinstein E, Gluck O, Veit-Rubin N, Deval B Abstract In this narrated video we present a case of pelvic organ prolapse (POP) recurrence 12 years after sacrocervicopexy, outline our management and suggest an optimal laparoscopic surgical technique that may reduce the risk of future recurrence. A 71-year-old...
Tue Mar 31, 2020 13:37
Related ArticlesPredictors of hospital readmission among older adults with cancer. J Geriatr Oncol. 2020 Mar 25;: Authors: Burhenn P, Sun CL, Scher KS, Hsu J, Pandya P, Chui CY, Arsenyan A, Mitani D, Morrison R, Katheria V, Hurria A Abstract OBJECTIVE: Older adults with cancer are at higher risk for costly and potentially dangerous hospital readmissions. Identifying risk factors for readmission in this population is important for future prevention of...
Tue Mar 31, 2020 13:37
Related ArticlesSmall molecules, big impact: 20 years of targeted therapy in oncology. Lancet. 2020 Mar 28;395(10229):1078-1088 Authors: Bedard PL, Hyman DM, Davids MS, Siu LL Abstract The identification of molecular targets and the growing knowledge of their cellular functions have led to the development of small molecule inhibitors as a major therapeutic class for cancer treatment. Both multitargeted and highly selective kinase inhibitors are used...
Tue Mar 31, 2020 13:37
Related ArticlesIs the Vision of Radioligand Therapy for Prostate Cancer Becoming a Reality? An Overview of the Phase III VISION Trial and Its Importance for the Future of Theranostics. J Nucl Med. 2019 11;60(11):1504-1506 Authors: Rahbar K, Bodei L, Morris MJ Abstract Prostate-specific membrane antigen (PSMA) is of considerable interest as a target for diagnostics and therapy of prostate cancer patients. PSMA-targeted imaging has demonstrable value...
Tue Mar 31, 2020 13:37
Related ArticlesGrowth and Characterization of Irradiated Organoids from Mammary Glands. J Vis Exp. 2019 05 03;(147): Authors: Hacker BC, Gomez JD, Batista CAS, Rafat M Abstract Organoids derived from the digested tissue are multicellular three-dimensional (3D) constructs that better recapitulate in vivo conditions than cell monolayers. Although they cannot completely model in vivo complexity, they retain some functionality of the original organ. In...
Tue Mar 31, 2020 13:37
Related ArticlesDOTA-MGS5, a New Cholecystokinin-2 Receptor-Targeting Peptide Analog with an Optimized Targeting Profile for Theranostic Use. J Nucl Med. 2019 07;60(7):1010-1016 Authors: Klingler M, Summer D, Rangger C, Haubner R, Foster J, Sosabowski J, Decristoforo C, Virgolini I, von Guggenberg E Abstract Molecular imaging and targeted radiotherapy with radiolabeled cholecystokinin-2 receptor (CCK2R) targeting peptide probes holds high promise to...
Tue Mar 31, 2020 13:37
Publication date: Available online 29 March 2020Source: European Journal of Surgical OncologyAuthor(s): Bart C. Bongers, Cornelis H.C. Dejong, Marcel den Dulk
Tue Mar 31, 2020 13:36
The winter oilseed ecotype is more tolerant to low temperature than the spring ecotype. Transcriptome and metabolome analyses of leaf samples of five spring Brassica napus L. (B. napus) ecotype lines and five winter B. napus ecotype lines treated at 4 °C and 28 °C were performed. A total of 25,460 differentially expressed genes (DEGs) of the spring oilseed ecotype and 28,512 DEGs of the winter oilseed ecotype were identified after cold stress; there were 41 differentially expressed metabolites (DEMs)...
Tue Mar 31, 2020 03:00
Cryptoclidids are a major clade of plesiosauromorph plesiosaurians best known from the Middle—Late Jurassic, but little is known regarding their turnover into the Early Cretaceous. Of the known cryptoclidid genera, most preserve only a limited amount of cranial material and of these Cryptoclidus eurymerus, displays the most complete, but compressed cranium. Thus, the lack of knowledge of the cranial anatomy of this group may hinder the understanding of phylogenetic interrelationships, which are currently...
Tue Mar 31, 2020 03:00
The NAC family is one of the largest transcription factor families unique to plants, which regulates the growth and development, biotic and abiotic stress responses, and maturation and senescence in plants. In this study, PheNAC3, a NAC gene, was isolated and characterized from moso bamboo (Phyllostachys edulis). PheNAC3 belong to the NAC1 subgroup and has a conserved NAC domain on the N-terminus, which with 88.74% similarity to ONAC011 protein. PheNAC3 localized in the nucleus and exhibited transactivation...
Tue Mar 31, 2020 03:00
Background Eukaryotic genes typically form independent evolutionary lineages through either speciation or gene duplication events. Generally, gene copies resulting from speciation events (orthologs) are expected to maintain similarity over time with regard to sequence, structure and function. After a duplication event, however, resulting gene copies (paralogs) may experience a broader set of possible fates, including partial (subfunctionalization) or complete loss of function, as well as gain of...
Tue Mar 31, 2020 03:00
Abstract The morbidity and mortality of prostate carcinoma has increased in recent years and has become the second most common ale malignant carcinoma worldwide. The interaction mechanisms between different genes and signaling pathways, however, are still unclear. Methods Variation analysis of GSE38241, GSE69223, GSE46602 and GSE104749 were realized by GEO2R in Gene Expression Omnibus database. Function enrichment was analyzed by DAVID.6.8. Furthermore, the PPI network and the significant...
Tue Mar 31, 2020 03:00
Background Lauric acid (LA), a common constituent of coconut oil, is used as food additives and supplements in various formulations. Despite various potential pharmacological properties, no scientific evidence on its dose-related toxicity and safety is available till date. Objective The current study was conducted to evaluate acute oral toxicity of LA on normal rats. Methods...
Tue Mar 31, 2020 03:00
Esophageal cancer is a common malignant tumor in the world, and the aim of this study was to screen key genes related to the development of esophageal cancer using a variety of bioinformatics analysis tools and analyze their biological functions. The data of esophageal squamous cell carcinoma from the Gene Expression Omnibus (GEO) were selected as the research object, processed and analyzed to screen differentially expressed microRNAs (miRNAs) and differential methylation genes. The competing endogenous...
Tue Mar 31, 2020 03:00
Background Although the studies of barefoot running have intensified, it is still missing longitudinal work analyzing the effects of barefoot running on the phases of plantar support. The objective of this research was to analyze the modifications undergone by the Total Foot Contact (TFC) phase and its Flat Foot Phase (FFP) in subjects beginning the practice of barefoot running, in its acute and chronic effects. Methods A total of 28 subjects were divided into the Barefoot Group (BFGr)...
Tue Mar 31, 2020 03:00
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