Abstract This post hoc Poisson regression analysis investigated the relationship between mean volume voided and incontinence episodes/24 h after fixed frequency adjustment in children with overactive bladder from the LION study, a phase 3, double-blind, randomised, placebo-controlled, sequential, dose-titration solifenacin trial. Patients were aged 5–< 12 years with ≥ 4 episodes of daytime incontinence during a 7-day pre-baseline diary period. The dependent variable was the...
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Background/Aim: To investigate the outcomes of laparoscopic surgery in colorectal cancer patients with dialysis. Patients and Methods: Fourteen dialysis (dialysis group) and 567 non-dialysis (non-dialysis group) patients who underwent laparoscopic and open surgery for colorectal cancer between April 2008 and December 2015 were included. Short-term and long-term outcomes were compared between the groups. A 1:2 propensity score matching was performed to compare long-term outcomes. Results: All the...
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Background/Aim: To develop a nomogram for predicting the pathological tumor response to preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer based on pre-treatment magnetic resonance imaging (MRI) and blood test characteristics. Patients and Methods: This retrospective study included 514 patients who underwent MRI and received preoperative CRT followed by surgical resection. Pathological tumor response was assessed as good [Dworak tumor regression grade (TRG) 3 or 4] or poor (TRG...
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JPM, Vol. 10, Pages 21: Applications of Machine Learning Predictive Models in the Chronic Disease Diagnosis Journal of Personalized Medicine doi: 10.3390/jpm10020021 Authors: Gopi Battineni Getu Gamo Sagaro Nalini Chinatalapudi Francesco Amenta This paper reviews applications of machine learning (ML) predictive models in the diagnosis of chronic diseases. Chronic diseases (CDs) are responsible for a major portion of global health costs. Patients who suffer from these diseases...
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Abstract Thrombocytopenia‐Absent Radius (TAR) syndrome is characterized by radial defect and neonatal thrombocytopenia. It is caused by bi‐allelic variants of RBM8A gene (1q21.1) with the association of a null allele and a hypomorphic non‐coding variant. RBM8A encodes Y14, a core protein of the Exon Junction Complex involved in mRNA maturation. To date, only two hypomorphic variants have been identified. We report on a cohort of 26 patients affected with TAR syndrome and carrying biallelic variants...
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Abstract microRNAs (miRNAs) are short noncoding RNAs that can repress the expression of protein‐coding messenger RNAs (mRNAs) by binding to the 3'UTR of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3'UTR of the mRNAs can disrupt miRNA regulation. In this study, we presented dbMTS, a database for miRNA target site SNVs and their functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization...
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Abstract CACNA1H genetic variants were originally reported in a childhood absence epilepsy cohort. Subsequently, genetic testing for CACNA1H became available and is currently offered by commercial laboratories. However, the current status of CACNA1H as a monogenic cause of epilepsy is controversial, highlighted by ClinGen's recent re‐classification of CACNA1H as disputed. We analyzed published CACNA1H variants and those reported in ClinVar and found none would be classified as pathogenic or likely...
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Social grooming is often exchanged between individuals in many primate species. Rates of bidirectional (or simultaneous mutual) grooming vary across primate species, and its function is not yet fully understood. For example, mutual grooming is frequent in chimpanzees but rare in most primate species including wild bonobos. There are, however, no quantitative data available in captive bonobos. Therefore, through the direct comparison between captive bonobos and chimpanzees, this study aimed to (i)...
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Abstract Purpose Napabucasin is a cancer stemness inhibitor that targets a number of oncogenic pathways, including signal transducer and activator of transcription 3 (STAT3). Phase 1/2 studies suggest tolerability and anti-tumor activity in various types of cancer; a Phase 3 study of napabucasin plus standard therapy in colorectal cancer is ongoing. This is a Phase 1 dose-escalation study in patients with advanced solid tumors, and the...
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CT does have a crucial part to play in COVID-19 cases. That's the view of top...Read more on AuntMinnieEurope.comRelated Reading: ESR creates YouTube playlist for COVID-19 events Kuhl: COVID-19 is a crisis of biblical proportions Can ultrasound be used effectively for COVID-19? Europe seeks to harness power of AI in COVID-19 crisis How radiology can get ready for coronavirus crisis
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The global COVID-19 crisis is leading to murmurings of budget cuts, or at least...Read more on AuntMinnieEurope.comRelated Reading: Is teleradiology's growth sustainable beyond 2020? 10 factors to consider when selecting AI vendors Why EMRs will not replace imaging IT Mamma Mia! What's the secret to Sectra's success? Radiology business intelligence takes root in Europe
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A sonographer who reportedly fell on the stomach of a pregnant woman has been...Read more on AuntMinnieEurope.comRelated Reading: U.K. radiographer gets struck off register for hate crime Radiologist who lied on CV gets struck off register Dr. Maria Klusmann found not guilty in fraud trial Fraud trial of pediatric radiologist begins in London U.K. radiologist admits to fraud charges in overtime case
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ABSTRACT Background Tripartite motif‐containing protein 21 (Trim21) is an E3 ubiquitin‐protein ligase that plays pivotal roles in various diseases. However, its role in mediating keratinocyte inflammation, which is a hallmark of psoriasis, has not been thoroughly elucidated. Objectives To clarify whether Trim21 plays a pivotal role in regulating keratinocyte inflammation in psoriasis, while focusing on identifying key Trim21 substrates involved in mediating proinflammatory cytokine...
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ABSTRACT Neutrophilic leukemoid reaction (NLR) is defined as a leukocyte count with more than 50 g/L polymorphonuclear neutrophils (PMNs) in the absence of haematological malignancy. Inductive treatments and severe infections are among the main causes of NLR. Paraneoplastic neutrophilic leukemoid reaction (PNLR) is a rare cause of NLR, whose pathomechanism is unclear, with most cases described in patients with solid malignancies. We report the case of a PNLR that occurred during a metastatic melanoma...
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Background The objective of this study was to characterize the prevalence and risk of pain, pain interference, and recurrent pain in adult survivors of childhood cancer in comparison with siblings. Methods This study analyzed longitudinal data from survivors (n = 10,012; 48.7% female; median age, 31 years [range, 17‐57 years]; median time since diagnosis, 23 years) and siblings (n = 3173) from the Childhood Cancer Survivor Study. Survivors were diagnosed between 1970 and 1986 at 1 of...
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Abstract Purpose The proportion of older populations living with cancer is on the increase. Maintaining or improving their quality of life (QoL) has become an important goal in the treatment of cancer and has become an endpoint in clinical trials. Melatonin regulates a wide variety of physiological functions and is involved in the initiation of sleep and the improvement of QoL. With age, the secretion of melatonin decreases and could lead...
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Abstract Quercus salicina Blume (QS) is an oak species that is indigenous to Japan and Korea. Historically, extracts of leaves, stems, barks and buds from the QS tree had been extensively utilized as herbal medicines. As rich sources of natural antioxidants, QS extracts could prevent oxidative stress and the occurrence of related neurodegenerative diseases. In pharmaceutical applications, decoction or infusion of comminuted QS powder is prepared as an herbal tea for oral use....
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Abstract The main aim of this study was to investigate the dosimetric characteristics of the INTRABEAM ® system in the presence of air gaps between the surface of applicators (APs) and tumor bed. Additionally, the effect of tissue heterogeneities was another focus. Investigating the dosimetric characteristics of the INTRABEAM® system is essential to deliver the required dose to the tumor bed correctly and reduce the delivered dose to the ribs and lung. Choosing the correct AP size...
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Abstract Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism. Adipokines may not only contribute to AT dysfunction and obesity, but also in fat browning, a process that induces a phenotypic switch from energy-storing white adipocytes to thermogenic brown fat–like cells....
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