Smoke inhalation injury increases overall burn mortality by up to 20 times. Current therapy remains supportive with a failure to identify an optimal or targeted treatment protocol for smoke inhalation injury. ...
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Hepatitis B virus (HBV) remains a major cause of chronic hepatitis and hepatocellular carcinoma, and miRNAs play important roles in HBV pathogenesis. Our previous study has shown that miR-328-3p is upregulated...
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As the most common form of lymphoma, diffuse large B-cell lymphoma (DLBCL) is a clinical highly heterogeneous disease with variability in therapeutic outcomes and biological features. It is a challenge to iden...
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To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas.
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The relevance of formant-based measures has been noted across a spectrum of medical, technical, and linguistic applications. Therefore, the primary aim of the study was to evaluate the effect of ageing on vowel articulation, as the previous research revealed contradictory findings. The secondary aim was to provide normative acoustic data for all Czech monophthongs.
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Laryngopharyngeal reflux (LPR) is a prevalent condition in both general otolaryngology and laryngology. Scientists are faced with both the diagnostic and therapeutic controversies and the many “gray” areas related to LPR. Among those shades of gray are the poorly understood impact of diet and lifestyle, the lack of recognition/understanding of the variability in pH of the refluxate (acid, nonacid, and mixed and the impact this has on treatment options), and the nonspecific presenting signs and symptoms...
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Metastatic neuroendocrine carcinoma often presents as carcinoma of unknown primary. Although most cases display immunohistochemical positivity for neuroendocrine markers, subsets of cases display reduced or ne...
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We employed an integrative strategy to present subtractive and comparative metabolic and genomic-based findings of therapeutic targets against Streptococcus parauberis. For the first time, we not only identified potential targets based on genomic and proteomic database analyses but also recommend a new antimicrobial drug for the treatment of olive flounder (Paralichthys olivaceus) infected with S. parauberis. To do that, 102 total annotated metabolic pathways of this bacterial strain were extracted...
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Abstract Purpose In patient with breast cancer (BC), 18F-FDG PET/CT is widely used for assessing skeletal metastatic involvement. Also 18F-NaF PET imaging is considered an accurate modality for detecting bone metastases. We aimed to review current literature on comparative performances of 18F-FDG and 18F-NaF PET imaging for assessing bone metastases from BC. Methods ...
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by Thalia Salinas, Francéline Duby, Véronique Larosa, Nadine Coosemans, Nathalie Bonnefoy, Patrick Motte, Laurence Maréchal-Drouard, Claire Remacle
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Publication date: Available online 30 March 2020Source: CryobiologyAuthor(s): Ilija Šćekić, Zoran Marinović, Jelena Lujić, Tamás Müller, Nevena Kitanović, Béla Urbányi, Ákos Horváth
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Publication date: Available online 30 March 2020Source: CryobiologyAuthor(s): Hongwei Bai, Yingchun Zhang, Shan Tian, Rui Hu, Yu Liang, Jiangang Gao, Yunshan Wang, Bin Wu
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Abstract In the period 2013–2015, PM2.5 and PM10 outdoor and indoor concentrations were measured on 23 days in cold half-year periods, in Kraków, Poland. Air pollution is still a serious health hazard for the inhabitants as Kraków is located in a concave landform and smog episodes occur often in the city during the heating periods, due to poor natural ventilation and frequent air temperature inversions. The PM10 and PM2.5 concentrations were studied for very good and very poor...
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Panch phoron is a mixture of five spices containing an equal proportion of Foeniculum vulgare (fennel), Trigonella foenum-graecum Linn (fenugreek), Nigella sativa (black cumin), Cuminum cyminum (cumin) and Brassi...
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Particulate matter (PM) can cause various negative acute and chronic diseases of the respiratory system, including the upper airways. Curcumin has been reported to have anti-inflammatory and anti-oxidative eff...
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Few studies have evaluated the association between the risk of coronary artery disease (CAD) and the use of Chinese herbal products (CHP) in patients with rheumatoid arthritis (RA). This study investigated the...
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Researchers found that patients with cancer demonstrated deteriorating conditions and poor outcomes from the COVID-19 infection. (Source: CancerNetwork)
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Researchers determined that artificial intelligence could help predict responses to systemic therapies for patients with non-small cell lung cancer by utilizing CT scans. (Source: CancerNetwork)
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Panel Discussion: Some Aspects of the Management of Patients with X-Linked Hypophosphataemic Rickets
Abstract X-linked hypophosphataemia (XLH) rickets is a rare disease frequently misdiagnosed and mismanaged. Despite having clinical guidelines that offers some therapeutic recommendations based on the clinical experience of experts, physicians still have questions about some important aspects of the diagnosis and treatment of XLH, such as when the disease should be suspected, who should be in charge of the diagnosis, what should be done once the disease is diagnosed, or what therapeutic...
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Abstract Rickets and osteomalacia are two related conditions linked by the lack of mineralization of bone tissue due to a disturbance of calcium and phosphate homeostasis. Some of the most characteristic features of rickets are skeletal deformities, fractures, linear and continuous periosteal reaction, and enlargement of the metaphyseal space in an irregular and frayed form. However, these radiological findings are not exclusive to these diseases, but may also originate in children...
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Abstract Hypophosphataemic rickets (HR) is a group of rare disorders caused by excessive renal phosphate wasting in which the participation of fibroblast growth factor 23 (FGF23) can be prominent. These diseases pose therapeutic challenges with important consequences for growth and bone development in childhood, with higher risk of fractures and poorer bone healing, dental problems, and nephrolithiasis or nephrocalcinosis. In some cases, the diagnostic delay can be very long;...
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Abstract Beyond its functions in locomotion, support and protection of vital organs, bone also interacts with other organs to adjust mineral balance in response to physiological requirements. Bone remodelling is a continuous process of bone resorption and formation for the purpose of maintaining healthy bone mass and growth. Any derangement in this process can cause bone disorders with important clinical consequences. The most prominent features of bone diseases in children include...
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Abstract Rare diseases are heterogeneous life-threatening or seriously debilitating conditions that affect < 1 in 2000 individuals, and most have a genetic component. The diagnostic process is usually based on classic clinical practices, such as physical examination, personal and family history (inheritance pattern), laboratory tests and image studies, but diagnosis can be delayed several years after the initiation of symptoms. The advances in molecular genetics that have taken...
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Abstract Low levels of phosphate in blood secondary to a lack of phosphorous reabsorption in the renal tubule cause hypophosphataemic rickets. To increase blood calcium levels, bone calcium is released into the bloodstream by increasing the activity of osteoclasts in the bones. These alterations in bone metabolism lead to delayed growth and small height, diffuse bone pain, bone fragility with microfractures, and frequent fractures and bone deformities. Although management of some...
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Abstract Ten percent of the adult population has chronic kidney disease (CKD), which is diagnosed when the glomerular filtration rate (GFR) is below 60 mL/min per 1.73 m2 or when albuminuria is above 30 mg/day. The numerical thresholds were chosen because they are associated with an increased risk of CKD progression or premature death within a wider scenario of accelerated aging. Indeed, CKD is one of the fastest growing causes of death worldwide. A decreased GFR is associated...
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Abstract Conventional treatment of X-linked hypophosphataemia (XLH) consists in the oral administration of phosphate plus calcitriol supplements. Although this therapy has reduced bone deformities and even achieved adequate patient growth, overtreatment or low adherence could lead to subsequent consequences that may compromise the efficacy of the therapy. Some of the complications associated with phosphate and vitamin D treatment are abdominal discomfort, diarrhoea, hypokalaemia,...
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Abstract Hypophosphataemic rickets is a heterogeneous group of entities characterized by rickets or osteomalacia due to a phosphate deficit caused mainly by decreased renal reabsorption. They are also characterized by defective intestinal absorption of calcium and rickets or osteomalacia unresponsive to cholecalciferol. These metabolic alterations lead to growth retardation, bone pain and deformities, and short stature. For a correct diagnosis and treatment of all forms of rickets,...
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Abstract Metabolic skeletal dysplasias comprise an extensive group of diseases capable of causing changes, usually progressive, in the bone and are due to hereditary disorders in many cases. The diagnosis and treatment of these diseases are not without difficulty, both because of their rarity and their possible confusion with more common diseases. A paradigmatic case of these metabolic skeletal dysplasias is X-linked hypophosphataemic rickets, which causes phosphaturia, a condition...
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Abstract Fibroblast growth factor 23 (FGF23) is a protein produced by mature osteoblasts involved in mineral homeostasis by binding to its receptor complex FGFR/Klotho located mainly in the kidneys. Although this protein participates in numerous biological processes, increase in the levels of FGF23 is responsible for many pathologies, such as X-linked hypophosphataemia (XLH), chronic kidney disease, cardiovascular disease or even mortality. For this reason, both FGF23 and its...
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Abstract Fractures are the result of the application of a greater force on bone than its strength. Therefore, to understand fracture physiopathology, it is essential to know bone strength determinants. These include bone mineral density (BMD), bone spatial structure (bone geometry and microarchitecture) and bone mechanical and tissue properties. While BMD and bone spatial structure can be easily evaluated through imaging technology, assessment of bone tissue and mechanical properties...
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Abstract X-linked hypophosphataemia (XLH) is the most prevalent form of hereditary rickets characterized by an alteration of phosphate metabolism which frequently leads to the appearance of fractures, bone deformities and growth delay. Although the mechanism of growth impairment in patients with XLH still needs to be clarified, it is known that this alteration is not due to genetic or endocrine factors. A potential explanation for the impairment of growth in this disease is the...
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Publication date: Available online 30 March 2020Source: Cellular SignallingAuthor(s): Greer K. Arthur, Lauren C. Ehrhardt-Humbert, Douglas B. Snider, Corey Jania, Stephen L. Tilley, Dean D. Metcalfe, Glenn Cruse
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Fatigue, sleep disturbance and altered mood are frequently reported in patients with primary antibody deficiency syndrome (PADS) on adequate immunoglobulin replacement therapy. This study aimed to determine th...
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Obesity is a multifactorial chronic condition associated with genetic, behavioral and environmental factors. Understanding the role of the built and social environment in Quality of Life (QOL) is critical to r...
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Trapeziometacarpal (TMC) osteoarthritis can be painful and cause disability for patients. Total joint replacement of the TMC joint provides a pseudo arthrosis with good restoration of the thumb motion and pain...
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Publication date: Available online 30 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): B. Movahedian Attar, S.M. Razavi, M. Daneshmand, A. Davoudi
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Publication date: Available online 30 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Coopman, J. Fennis, H. Ghaeminia, G. Van de Vyvere, C. Politis, T.J.M. Hoppenreijs
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I signed up to be a volunteer section leader. You can too! But do it ASAP -- Read more on ScientificAmerican.com
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Without federal investment, the current disruption could slow down U.S. economic growth for decades to come -- Read more on ScientificAmerican.com
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