Antibiotics, Vol. 9, Pages 287: Discovery of a Novel Mutation in DNA Gyrase and Changes in the Fluoroquinolone Resistance of Helicobacter pylori over a 14-Year Period: A Single Center Study in Korea Antibiotics doi: 10.3390/antibiotics9060287 Authors: Su Yeon Rhie Jae Yong Park Tae-Seop Shin Jeong Wook Kim Beom Jin Kim Jae Gyu Kim The efficacy of fluoroquinolone-based eradication therapy largely depends on the fluoroquinolone resistance of H. pylori. The aim of this study...
Wed May 27, 2020 03:00
Antibiotics, Vol. 9, Pages 286: The Gut of Healthy Infants in the Community as a Reservoir of ESBL and Carbapenemase-Producing Bacteria Antibiotics doi: 10.3390/antibiotics9060286 Authors: Saleem Allana Hale Diaz Salinas Salinas Qureshi Hotwani Rahman Khan Zaidi Seed Arshad The recent rapid rise of multi-drug resistant Enterobacteriaceae (MDR-E) is threatening the treatment of common infectious diseases. Infections with such strains lead...
Wed May 27, 2020 03:00
Antibiotics, Vol. 9, Pages 285: Antimicrobial Resistance in Humans and Animals: Rapid Review of Psychological and Behavioral Determinants Antibiotics doi: 10.3390/antibiotics9060285 Authors: Julie A. Chambers Margaret Crumlish David A. Comerford Ronan E. O’Carroll A rapid review of current evidence examining psychological issues regarding the use of antibiotics and antimicrobials and resistance to these in both human and animal populations was conducted. Specific areas of interest...
Wed May 27, 2020 03:00
Antioxidants, Vol. 9, Pages 459: Effect of Quamoclit angulata Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice Antioxidants doi: 10.3390/antiox9060459 Authors: Ji Eun Park Heaji Lee Hyunkyung Rho Seong Min Hong Sun Yeou Kim Yunsook Lim Type 2 diabetes mellitus (T2DM) is caused by abnormalities of controlling blood glucose and insulin homeostasis. Especially, hyperglycemia causes hyper-inflammation...
Wed May 27, 2020 03:00
Antioxidants, Vol. 9, Pages 461: Flavones’ and Flavonols’ Antiradical Structure–Activity Relationship—A Quantum Chemical Study Antioxidants doi: 10.3390/antiox9060461 Authors: Spiegel Andruniów Sroka Flavonoids are known for their antiradical capacity, and this ability is strongly structure-dependent. In this research, the activity of flavones and flavonols in a water solvent was studied with the density functional theory methods. These included examination of flavonoids’...
Wed May 27, 2020 03:00
Antioxidants, Vol. 9, Pages 458: Insight of Polyphenol Oxidase Enzyme Inhibition and Total Polyphenol Recovery from Cocoa Beans Antioxidants doi: 10.3390/antiox9060458 Authors: Said Toro-Uribe Jhair Godoy-Chivatá Arley René Villamizar-Jaimes María de Jesús Perea-Flores Luis J. López-Giraldo A full factorial design (ascorbic acid/l-cysteine inhibitors, temperature, and time as factors) study was conducted to enhance inhibition of polyphenol oxidase (PPO) activity without decreasing...
Wed May 27, 2020 03:00
Antioxidants, Vol. 9, Pages 460: Caffeine and NAD+ Improve Motor Neural Integrity of Dissociated Wobbler Cells In Vitro Antioxidants doi: 10.3390/antiox9060460 Authors: Zwilling Theiss Matschke Amyotrophic lateral sclerosis (ALS) is a common degenerative disease of the central nervous system concerning a progressive loss of upper and lower motor neurons. While 5%–10% of patients are diagnosed with the inherited form of the disease, the vast majority of patients suffer...
Wed May 27, 2020 03:00
Atmosphere, Vol. 11, Pages 558: Heat Vulnerability and Heat Island Mitigation in the United States Atmosphere doi: 10.3390/atmos11060558 Authors: Jungmin Lim Mark Skidmore Heat waves are the deadliest type of natural hazard among all weather extremes in the United States. Given the observed and anticipated increase in heat risks associated with ongoing climate change, this study examines community vulnerability to extreme heat and the degree to which heat island mitigation (HIM) actions...
Wed May 27, 2020 03:00
Atmosphere, Vol. 11, Pages 555: Study on the Pollution Characteristics and Sources of Ozone in Typical Loess Plateau City Atmosphere doi: 10.3390/atmos11060555 Authors: Bin Li Zhuangzhi Zhou Zhigang Xue Peng Wei Yanjun Ren Liyuan Cao Xinyu Feng Qingchen Yao Jinghua Ma Peng Xu Xuan Chen Ground-level ozone is a secondary pollutant produced by photochemical reactions and it adversely affects plant and human health. Taiyuan City, a typical city on the loess...
Wed May 27, 2020 03:00
Atmosphere, Vol. 11, Pages 556: Distribution and Drivers of Marine Isoprene Concentration across the Southern Ocean Atmosphere doi: 10.3390/atmos11060556 Authors: Pablo Rodríguez-Ros Pau Cortés Charlotte Mary Robinson Sdena Nunes Christel Hassler Sarah-Jeanne Royer Marta Estrada M. Montserrat Sala Rafel Simó Isoprene is a biogenic trace gas produced by terrestrial vegetation and marine phytoplankton. In the remote oceans, where secondary aerosols are mostly biogenic,...
Wed May 27, 2020 03:00
Atmosphere, Vol. 11, Pages 557: Smart Farming Techniques for Climate Change Adaptation in Cyprus Atmosphere doi: 10.3390/atmos11060557 Authors: Adamides Kalatzis Stylianou Marianos Chatzipapadopoulos Giannakopoulou Papadavid Vassiliou Neocleous Smart farming based on Internet of Things (IoT) technologies enables crop farmers to collect real-time data related to irrigation and plant protection processes, aiming to increase production volume, improve product...
Wed May 27, 2020 03:00
Atmosphere, Vol. 11, Pages 554: Growth Response of Endemic Black Pine Trees to Meteorological Variations and Drought Episodes in a Mediterranean Region Atmosphere doi: 10.3390/atmos11060554 Authors: Proutsos Tigkas Weather variations affect natural ecosystems, while in regions where climate change is anticipated to intensify extreme events such as droughts, the vitality of vulnerable species may be reduced. The sensitivity of key-species to the climatic conditions may illustrate...
Wed May 27, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 94: Burnout among Academic Clinicians as It Correlates with Workload and Demographic Variables Behavioral Sciences doi: 10.3390/bs10060094 Authors: Aussama K. Nassar Susan Reid Kamyar Kahnamoui Faiz Tuma Abdul Waheed Meghan McConnell Burnout syndrome (BOS) in academic physicians is a psychological state resulting from prolonged exposure to job stressors. It leads to a decline in overall job performance, which could result in misjudgment...
Wed May 27, 2020 03:00
Biology, Vol. 9, Pages 112: Metabolomic Reprogramming Detected by 1H-NMR Spectroscopy in Human Thyroid Cancer Tissues Biology doi: 10.3390/biology9060112 Authors: Metere Graves Chirico Caramujo Pisanu Iorio Thyroid cancer cells demonstrate an increase in oxidative stress and decreased antioxidant action, but the effects of this increased oxidative stress on cell function remain unknown. We aimed to identify changes in the metabolism of thyroid cancer cells caused...
Wed May 27, 2020 03:00
Biomolecules, Vol. 10, Pages 824: Extracellular Vesicles: Current Analytical Techniques for Detection and Quantification Biomolecules doi: 10.3390/biom10060824 Authors: Serrano-Pertierra Oliveira-Rodríguez Matos Gutiérrez Moyano Salvador Rivas Blanco-López Since their first observation, understanding the biology of extracellular vesicles (EV) has been an important and challenging field of study. They play a key role in the intercellular communication and...
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Biomolecules, Vol. 10, Pages 822: Reduce, Reuse and Recycle in Protein Chromatography: Development of an Affinity Adsorbent from Waste Paper and Its Application for the Purification of Proteases from Fish By-Products Biomolecules doi: 10.3390/biom10060822 Authors: Georgios E. Premetis Nikolaos E. Labrou In the present study, we report the development of a cellulose-based affinity adsorbent and its application for the purification of proteases from fish by-products. The affinity adsorbent...
Wed May 27, 2020 03:00
Biomolecules, Vol. 10, Pages 823: Valorization of Hemp Core Residues: Impact of NaOH Treatment on the Flexural Strength of PP Composites and Intrinsic Flexural Strength of Hemp Core Fibers Biomolecules doi: 10.3390/biom10060823 Authors: Fabiola Vilaseca Ferran Serra-Parareda Eduardo Espinosa Alejandro Rodríguez Pere Mutjé Marc Delgado-Aguilar Hemp core is a lignocellulosic residue in the production chain of hemp strands. Huge amounts of hemp core are gathered annually...
Wed May 27, 2020 03:00
Biomolecules, Vol. 10, Pages 821: Mercury Exposure Assessment in Mother–Infant Pairs from Continental and Coastal Croatia Biomolecules doi: 10.3390/biom10060821 Authors: Sekovanić Piasek Orct Sulimanec Grgec Matek Sarić Stasenko Jurasović The main source of mercury (Hg) exposure in the general population is fish. Another possible source is dental amalgam. Here, we compare the levels of Hg and selenium (Se) in samples of maternal and fetal origin collected shortly...
Wed May 27, 2020 03:00
Biomolecules, Vol. 10, Pages 819: Autocrine TGF-β1 Maintains the Stability of Foxp3+ Regulatory T Cells via IL-12Rβ2 Downregulation Biomolecules doi: 10.3390/biom10060819 Authors: Choi Na Kuen Kim Chung Transforming growth factor beta 1 (TGF-β1) is an immunosuppresive cytokine that plays an essential role in immune homeostasis. It is well known that regulatory T (Treg) cells express TGF-β1; however, the role of autocrine TGF-β1 in the development,...
Wed May 27, 2020 03:00
Biomolecules, Vol. 10, Pages 820: An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody Biomolecules doi: 10.3390/biom10060820 Authors: Kim Nguyen Kwon Sung Lim Kang Lee Seo Kim Chang Shim Kim AIMP2-DX2, an exon 2-deleted splice variant of AIMP2 (aminoacyl-tRNA synthetase-interacting multifunctional protein 2), is highly expressed in lung cancer and involved in tumor progression in vivo. Oncogenic function...
Wed May 27, 2020 03:00
Biosensors, Vol. 10, Pages 55: CO2 Laser Photoacoustic Spectrometer for Measuring Acetone in the Breath of Lung Cancer Patients Biosensors doi: 10.3390/bios10060055 Authors: Mitrayana Apriyanto Satriawan A CO2 laser has the advantages of being high in power and having many laser lines in the 9–11 µm infrared region. Thus, a CO2 laser photoacoustic spectrometer (PAS) can have a multi-component measurement capability for many gas compounds that have non-zero...
Wed May 27, 2020 03:00
Brain Sciences, Vol. 10, Pages 326: The Relationship between Emotionally Laden Landmarks, Spatial Abilities, and Personality Traits: An Exploratory Study Brain Sciences doi: 10.3390/brainsci10060326 Authors: Francesco Ruotolo Filomena L. Sbordone Ineke J.M. van der Ham Separate research lines have shown that the way we process spatial information is influenced by individual factors, such as personality traits and basic spatial abilities. Alongside, recent studies suggest that environmental...
Wed May 27, 2020 03:00
Brain Sciences, Vol. 10, Pages 324: Kappa Free Light Chains and IgG Combined in a Novel Algorithm for the Detection of Multiple Sclerosis Brain Sciences doi: 10.3390/brainsci10060324 Authors: Monika Gudowska-Sawczuk Joanna Tarasiuk Alina Kułakowska Jan Kochanowicz Barbara Mroczko Background: It is well known that the cerebrospinal fluid (CSF) concentrations of free light chains (FLC) and immunoglobulin G (IgG) are elevated in multiple sclerosis patients (MS). Therefore, in...
Wed May 27, 2020 03:00
Brain Sciences, Vol. 10, Pages 325: The Neuropsychological Profile of Attention Deficits of Patients with Obstructive Sleep Apnea: An Update on the Daytime Attentional Impairment Brain Sciences doi: 10.3390/brainsci10060325 Authors: Paola Angelelli Luigi Macchitella Domenico Maurizio Toraldo Elena Abbate Chiara Valeria Marinelli Michele Arigliani Michele De Benedetto Introduction: Patients with obstructive sleep apnea (OSA) suffer from several neurocognitive disturbances....
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1380: Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study Cancers doi: 10.3390/cancers12061380 Authors: Yiyi Ji Lukas Winter Lucila Navarro Min-Chi Ku João S. Periquito Michal Pham Werner Hoffmann Loryn E. Theune Marcelo Calderón Thoralf Niendorf Thermal magnetic resonance (ThermalMR) accommodates radio frequency (RF)-induced temperature modulation, thermometry, anatomic and...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1378: PARP Inhibitors in the Treatment of Early Breast Cancer: The Step Beyond? Cancers doi: 10.3390/cancers12061378 Authors: Anthony Gonçalves Alexandre Bertucci François Bertucci Exquisitely exploiting defects in homologous recombination process, poly(ADP-ribose) polymerase (PARP) inhibitors have recently emerged as a promising class of therapeutics in human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer with germline breast...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1377: Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support Cancers doi: 10.3390/cancers12061377 Authors: Yasser Perera Alice Melão Ailyn C. Ramón Dania Vázquez Daniel Ribeiro Silvio E. Perea João T. Barata Despite remarkable advances in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), relapsed cases are still a major challenge. Moreover,...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1379: The Role of Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer Risk Cancers doi: 10.3390/cancers12061379 Authors: Ippokratis Messaritakis Asimina Koulouridi Maria Sfakianaki Konstantinos Vogiatzoglou Nikolaos Gouvas Elias Athanasakis John Tsiaoussis Evangelos Xynos Dimitriοs Mavroudis Maria Tzardi John Souglakos Vitamin D deficiency has been associated with increased colorectal cancer (CRC) incidence risk and mortality....
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1375: The Tumor Suppressor TGFBR3 Blocks Lymph Node Metastasis in Head and Neck Cancer Cancers doi: 10.3390/cancers12061375 Authors: Wei-Yu Fang Yi-Zih Kuo Jang-Yang Chang Jenn-Ren Hsiao Hung-Ying Kao Sen-Tien Tsai Li-Wha Wu The TGF-β type III receptor (TGFBR3) is an essential constituent of the TGF-β signaling. In this study, we observed a down-regulation of TGFBR3 in oral cancer, a subtype of head and neck cancer (HNC), and...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1374: Vav1 is Essential for HIF-1α Activation via a Lysosomal VEGFR1-Mediated Degradation Mechanism in Endothelial Cells Cancers doi: 10.3390/cancers12061374 Authors: Jaewoo Hong Yongfen Min Todd Wuest P. Charles Lin The vascular response to hypoxia and ischemia is essential for maintaining homeostasis during stressful conditions and is particularly critical for vital organs such as the heart. Hypoxia-inducible factor-1 (HIF-1) is a central regulator...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1376: Liquid Biopsy in Colorectal Carcinoma: Clinical Applications and Challenges Cancers doi: 10.3390/cancers12061376 Authors: Drahomír Kolenčík Stephanie N. Shishido Pavel Pitule Jeremy Mason James Hicks Peter Kuhn Colorectal carcinoma (CRC) is characterized by wide intratumor heterogeneity with general genomic instability and there is a need for improved diagnostic, prognostic, and therapeutic tools. The liquid biopsy provides a noninvasive route...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1371: Progression-Dependent Altered Metabolism in Osteosarcoma Resulting in Different Nutrient Source Dependencies Cancers doi: 10.3390/cancers12061371 Authors: Fritsche-Guenther Gloaguen Kirchner Mertins Tunn Kirwan Osteosarcoma (OS) is a primary malignant bone tumor and OS metastases are mostly found in the lung. The limited understanding of the biology of metastatic processes in OS limits the ability for effective treatment. Alterations...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1373: Soluble PD-L1 in NSCLC Patients Treated with Checkpoint Inhibitors and Its Correlation with Metabolic Parameters Cancers doi: 10.3390/cancers12061373 Authors: Angelo Castello Sabrina Rossi Luca Toschi Luigi Mansi Egesta Lopci We investigated the role of soluble PD-L1 (sPD-L1) in non-small cell lung carcinoma (NSCLC) patients treated with immune checkpoint inhibitors (ICI) and analyzed its association with clinical outcomes and metabolic parameters...
Wed May 27, 2020 03:00
Cancers, Vol. 12, Pages 1372: RNA-Sequencing of Tumor-Educated Platelets, a Novel Biomarker for Blood-Based Sarcoma Diagnostics Cancers doi: 10.3390/cancers12061372 Authors: Kimberley M. Heinhuis Sjors G.J.G. In ‘t Veld Govert Dwarshuis Daan van den Broek Nik Sol Myron G. Best Frits van Coevorden Rick L. Haas Jos H. Beijnen Winan J. van Houdt Tom Würdinger Neeltje Steeghs Sarcoma is a heterogeneous group of rare malignancies arising from mesenchymal tissues....
Wed May 27, 2020 03:00
Cells, Vol. 9, Pages 1340: Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers Cells doi: 10.3390/cells9061340 Authors: Blank Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes. These include the nuclear envelope assembly and stability, mechanotransduction and chromatin organization, transcription, DNA replication, damage repair, and genomic integrity maintenance....
Wed May 27, 2020 03:00
Cells, Vol. 9, Pages 1341: Endothelial TRPV1 as an Emerging Molecular Target to Promote Therapeutic Angiogenesis Cells doi: 10.3390/cells9061341 Authors: Sharon Negri Pawan Faris Vittorio Rosti Maria Rosa Antognazza Francesco Lodola Francesco Moccia Therapeutic angiogenesis represents an emerging strategy to treat ischemic diseases by stimulating blood vessel growth to rescue local blood perfusion. Therefore, injured microvasculature may be repaired by stimulating resident...
Wed May 27, 2020 03:00
Cells, Vol. 9, Pages 1336: The Network of Angiotensin Receptors in Breast Cancer Cells doi: 10.3390/cells9061336 Authors: Acconcia The renin-angiotensin system (RAS) is a network of proteins regulating many aspects of human physiology, including cardiovascular, pulmonary, and immune system physiology. The RAS is a complicated network of G-protein coupled receptors (GPCRs) (i.e., AT1R, AT2R, MASR, and MRGD) orchestrating the effects of several hormones (i.e., angiotensin II, angiotensin...
Wed May 27, 2020 03:00
Cells, Vol. 9, Pages 1338: RELMα is Induced in Airway Epithelial Cells by Oncostatin M Without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo Cells doi: 10.3390/cells9061338 Authors: Ho Yip Lao Botelho Richards Resistin-like molecule alpha (RELMα) and YM-1 are secreted proteins implicated in murine models of alternatively activated macrophage (AA/M2) accumulation and Th2-skewed inflammation. Since the gp130 cytokine Oncostatin M (OSM) induces a Th2-like...
Wed May 27, 2020 03:00
Cells, Vol. 9, Pages 1337: Transposon-Based CAR T Cells in Acute Leukemias: Where are We Going? Cells doi: 10.3390/cells9061337 Authors: Magnani Tettamanti Alberti Pisani Biondi Serafini Gaipa Chimeric Antigen Receptor (CAR) T-cell therapy has become a new therapeutic reality for refractory and relapsed leukemia patients and is also emerging as a potential therapeutic option in solid tumors. Viral vector-based CAR T-cells initially drove these successful efforts;...
Wed May 27, 2020 03:00
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