Related ArticlesSAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model. Braz J Med Biol Res. 2020;53(4):e9175 Authors: Li R, He M, Wu B, Zhang P, Zhang Q, Chen Y Abstract α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are...
Wed May 27, 2020 15:11
Related ArticlesExcitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus. Brain. 2019 11 01;142(11):3482-3501 Authors: Burman RJ, Selfe JS, Lee JH, van den Berg M, Calin A, Codadu NK, Wright R, Newey SE, Parrish RR, Katz AA, Wilmshurst JM, Akerman CJ, Trevelyan AJ, Raimondo JV Abstract Status epilepticus is defined as a state of unrelenting seizure activity. Generalized convulsive status epilepticus is associated...
Wed May 27, 2020 15:11
Related ArticlesAbstract goal representation in visual search by neurons in the human pre-supplementary motor area. Brain. 2019 11 01;142(11):3530-3549 Authors: Wang S, Mamelak AN, Adolphs R, Rutishauser U Abstract The medial frontal cortex is important for goal-directed behaviours such as visual search. The pre-supplementary motor area (pre-SMA) plays a critical role in linking higher-level goals to actions, but little is known about the responses...
Wed May 27, 2020 15:11
Related ArticlesThe addition of a lipid-rich dietary supplement eliminates seizure-like activity and paralysis in the drosophila bang sensitive mutants. Epilepsy Res. 2019 09;155:106153 Authors: Radlicz C, Chambers A, Olis E, Kuebler D Abstract OBJECTIVE: To investigate the effect that a diet supplemented with KetoCal 4:1, a commercially available dietary formula consisting of a 4:1 ratio of fats to carbohydrates plus proteins, had on the seizure-like...
Wed May 27, 2020 15:11
Related ArticlesPredominantly nocturnal seizures post temporal lobectomy: Characteristics of an unusual outcome group. Epilepsy Res. 2019 09;155:106154 Authors: Samarasekera SR, Wynd AW, McIntosh AM, Berkovic SF Abstract PURPOSE: To describe the characteristics of a patient group who, after temporal lobectomy for predominantly diurnal seizures, experience a postoperative conversion from diurnal to predominantly nocturnal seizures, and compare this group...
Wed May 27, 2020 15:11
Epileptogenicity and surgical outcome in post stroke drug resistant epilepsy in children and adults.
Related ArticlesEpileptogenicity and surgical outcome in post stroke drug resistant epilepsy in children and adults. Epilepsy Res. 2019 09;155:106155 Authors: Marchi A, Pennaroli D, Lagarde S, McGonigal A, Bonini F, Carron R, Lépine A, Villeneuve N, Trebuchon A, Pizzo F, Scavarda D, Bartolomei F Abstract OBJECTIVE Post-stroke epilepsy (PSE) represents a rare etiology in patients undergoing pre-surgical evaluation for epilepsy. Refractory PSE has been...
Wed May 27, 2020 15:11
Related ArticlesGluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels. Mol Brain. 2019 05 15;12(1):50 Authors: Wu Z, Huo Q, Ren L, Dong F, Feng M, Wang Y, Bai Y, Lüscher B, Li ST, Wang GL, Long C, Wang Y, Wu G, Chen G Abstract Neonatal seizures are different from adult seizures, and many antiepileptic drugs that are effective in adults often fail to treat neonates. Here, we report that gluconate inhibits neonatal...
Wed May 27, 2020 15:11
Related ArticlesAmiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT Book. 2020 5 Authors: De Angelis F, Connick P, Parker RA, Plantone D, Doshi A, John N, Stutters J, MacManus D, Prados F, Marshall I, Solanky B, Samson RS, Barkhof F, Ourselin S, Braisher M, Ross M, Cranswick G, Pavitt SH, Gnanapavan S, Giovannoni G, Wheeler-Kingshott CAMG, Hawkins C, Sharrack B, Bastow R, Weir CJ, Stallard N, Chandran S, Chataway...
Wed May 27, 2020 15:11
Related ArticlesATYPICAL or INTERSTITIAL, take your PIC. J Physiol. 2020 May 26;: Authors: Hashitani H, Lang RJ PMID: 32452038 [PubMed - as supplied by publisher]
Wed May 27, 2020 14:58
Related ArticlesTraining of a discrete motor skill in humans is accompanied by increased excitability of the fastest corticospinal connections at movement onset. J Physiol. 2020 May 26;: Authors: Wiegel P, Leukel C Abstract KEY POINTS: The primary motor cortex (M1) is fundamentally important for the acquisition of skilled motor behaviours. We tested the excitability changes of distinct M1 circuits at movement onset with TMS H-reflex conditioning. Human...
Wed May 27, 2020 14:58
Related ArticlesElbow proprioception is normal in patients with a congenital absence of functional muscle spindles. J Physiol. 2020 May 26;: Authors: Smith L, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Macefield VG Abstract KEY POINTS: Individuals with Hereditary Sensory & Autonomic Neuropathy type III (HSAN III), also known as Riley-Day syndrome or Familial Dysautonomia, do not have functional muscle spindle afferents but do have essentially normal...
Wed May 27, 2020 14:58
211 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/05/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed May 27, 2020 14:58
Related ArticlesThe Effects of Self-Esteem, Coping, and Voice-Related Quality of Life on Communicative Participation Before and After BOTOX® Treatment for Spasmodic Dysphonia. J Voice. 2020 May 23;: Authors: Engelhoven AER, Zraick RI, Bursac Z, Tulunay-Ugur O, Hadden K Abstract OBJECTIVES/HYPOTHESIS: The purpose of this study was to (1) investigate the percent change in communicative participation in individuals with spasmodic dysphonia (SD) pre- and...
Wed May 27, 2020 14:58
Related ArticlesThyroglossal Duct Cyst Occupying Posterior Hyoid Space with Endolaryngeal Extension Presenting After Neck Trauma. Ann Otol Rhinol Laryngol. 2020 Jun;129(6):628-632 Authors: Bosco S, Cohn JE, Evarts M, Papajohn P, Lesser R Abstract OBJECTIVE: Thyroglossal duct cysts are the most common congenital neck mass. They typically present as a painless midline neck mass in a child or young adult, but may also present later in adulthood when the...
Wed May 27, 2020 14:58
Related ArticlesUsing autoregressive-dynamic conditional correlation model with residual analysis to extract dynamic functional connectivity. J Neural Eng. 2020 May 26;: Authors: Hakimdavoodi H, Amirmazlaghani M Abstract OBJECTIVE: Statistical methods that simultaneously model temporal and spatial variations of fMRI data are promising tools for dynamic functional connectivity (FC) estimation. Although different approaches are available, they need to...
Wed May 27, 2020 14:47
Related ArticlesSputtered porous Pt for wafer-scale manufacture of low-impedance flexible microelectrodes. J Neural Eng. 2020 May 26;: Authors: Fan B, Rodriguez A, Vercosa D, Kemere C, Robinson J Abstract Objective Recording electrical activity from individual cells in vivo is a key technology for basic neuroscience and has growing clinical applications. To maximize the number of independent recording channels as well as the longevity, and quality of...
Wed May 27, 2020 14:47
Related ArticlesNeonatal EEG sleep stage classification based on deep learning and HMM. J Neural Eng. 2020 May 26;: Authors: Ghimatgar H, Kazemi K, Helfroush MS, Pillay K, Dereymaeker A, Jansen K, De Vos M, Aarabi A Abstract Automatic sleep stage scoring is of great importance for investigating sleep architecture during infancy. In this work, we introduce a novel multichannel approach based on deep learning networks and hidden Markov models (HMM) to...
Wed May 27, 2020 14:47
Summary The G protein coupled receptor, Endothelin receptor B (EDNRB), is an important regulator of melanocyte survival and proliferation. It acts by stimulating downstream heterotrimeric G proteins, such as Gαq and Gα11. Constitutively active, oncogenic versions of Gαq and Gα11 drive melanomagenesis, but the role of Ednrb in the context of these mutant G proteins has not been previously examined. In this paper, we used a knock‐in mouse allele at the Rosa26 locus to force oncogenic GNAQQ209L expression...
Tue May 26, 2020 21:10
In the 21st century, human civilization has witnessed three major epidemics caused by Coronaviruses namely severe acute respiratory syndrome coronavirus (SARS CoV) in 2003, Middle East respiratory syndrome coronavirus (MERS CoV) in 2012 and 2019 novel coronavirus (2019 nCoV) or coronavirus disease (COVID 19) in 2019. Among these, COVID-19 has greater transmission and mortality rate. 2019 nCoV belongs to a large family of positive sense single-stranded RNA viruses (+ssRNA) that can be isolated in...
Mon May 25, 2020 16:04
62 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/05/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed May 27, 2020 14:32
Related ArticlesImplementation of Preoperative Screening Protocols in Otolaryngology During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 May 26;:194599820931041 Authors: Urban MJ, Patel TR, Raad R, LoSavio P, Stenson K, Al-Khudari S, Nielsen T, Husain I, Smith R, Revenaugh PC, Wiet RM, Papagiannopoulos P, Batra PS, Tajudeen BA Abstract OBJECTIVE: To highlight emerging preoperative screening protocols and document workflow challenges and successes...
Wed May 27, 2020 14:25
Related ArticlesData Mining Identifies Six Proteins that Can Act as Prognostic Markers for Head and Neck Squamous Cell Carcinoma. Cell Transplant. 2020 Jan-Dec;29:963689720929308 Authors: Wu ZH, Yun-Tang, Cheng Q Abstract Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor of the upper aerodigestive tract affecting the oral cavity, lips, paranasal sinuses, larynx, and nasopharynx. Proteogenomics combines proteomics and genomics and employs...
Wed May 27, 2020 14:25
Related ArticlesMechanical loading induces HIF-1α expression in chondrocytes via YAP. Biotechnol Lett. 2020 May 25;: Authors: Jing X, Yang X, Zhang W, Wang S, Cui X, Du T, Li T Abstract OBJECTIVES: To investigate the role of YAP in cyclic mechanical stress induced up-regulation of HIF-1α in rat cartilage chondrocytes. RESULTS: Our in vitro and in vivo experiments demonstrated that cyclic mechanical stress promoted HIF-1α and YAP proteins expression...
Wed May 27, 2020 14:25
Related ArticlesTwo enemies, one fight: An update of oral cancer in patients with Fanconi anemia. Cancer. 2019 Nov 15;125(22):3936-3946 Authors: Amenábar JM, Torres-Pereira CC, Tang KD, Punyadeera C Abstract Fanconi anemia (FA) is a rare inherited genetic condition that may lead to bone marrow failure, leukemia, and/or solid tumors. It is caused by the loss of function of at least 1 gene of the FA/BRCA pathway, which is necessary for DNA repair. Patients...
Wed May 27, 2020 14:25
Related ArticlesAn up-to-date overview of computational polypharmacology in modern drug discovery. Expert Opin Drug Discov. 2020 May 26;:1-20 Authors: Chaudhari R, Fong LW, Tan Z, Huang B, Zhang S Abstract INTRODUCTION: In recent years, computational polypharmacology has gained significant attention to study the promiscuous nature of drugs. Despite tremendous challenges, community-wide efforts have led to a variety of novel approaches for predicting...
Wed May 27, 2020 14:22
Related ArticlesAn update on the use of molecular modeling in dendrimers design for biomedical applications: are we using its full potential? Expert Opin Drug Discov. 2020 May 26;:1-10 Authors: Zloh M, Barata TS Abstract INTRODUCTION: Dendrimers are well-defined hyperbranched polymers built from a variety of different monomers and with tuneable properties that make them suitable for different biomedical applications. Their three-dimensional (3D) structure...
Wed May 27, 2020 14:22
Related ArticlesAntibacterial medicinal chemistry - what can we design for? Expert Opin Drug Discov. 2020 May 26;:1-9 Authors: Parkes AL Abstract INTRODUCTION: The need for new antibacterial agents continues to grow, but success in development of antibiotics in recent years has been limited. To improve the chances that new compounds will progress into clinical trials and beyond, it is vital that we consider as early as possible in the process the various...
Wed May 27, 2020 14:22
Related ArticlesThe preclinical discovery and development of opicapone for the treatment of Parkinson's disease. Expert Opin Drug Discov. 2020 May 26;:1-11 Authors: Ettcheto M, Busquets O, Sánchez-Lopez E, Cano A, Manzine PR, Verdaguer E, Olloquequi J, Auladell C, Folch J, Camins A Abstract INTRODUCTION: Opicapone (OPC) is a well-established catechol-O-methyltransferase (COMT) inhibitor that is approved for the treatment of Parkinson's disease (PD) associated...
Wed May 27, 2020 14:22
Related ArticlesFear of Negative Evaluation and Student Anxiety in Community College Active-Learning Science Courses. CBE Life Sci Educ. 2020 Jun;19(2):ar20 Authors: Downing VR, Cooper KM, Cala JM, Gin LE, Brownell SE Abstract Student anxiety is a growing concern for colleges and universities. As science classrooms transition from traditional lecture to active learning, researchers have sought to understand how active learning affects undergraduate anxiety....
Wed May 27, 2020 14:19
Related ArticlesCommunicating Complex STEM Program Evaluation to Diverse Stakeholders. CBE Life Sci Educ. 2020 Jun;19(2):es4 Authors: Reeves PM, Bobrownicki A, Bauer M, Graham MJ Abstract Visual representations, such as pathway models, are increasingly being used to both communicate higher education science, technology, engineering, and mathematics (STEM) education program evaluation plans as well as accurately represent complex programs and the systems...
Wed May 27, 2020 14:19
Related ArticlesGender Differences in Student Participation in an Active-Learning Classroom. CBE Life Sci Educ. 2020 Jun;19(2):ar12 Authors: Aguillon SM, Siegmund GF, Petipas RH, Drake AG, Cotner S, Ballen CJ Abstract Overwhelming evidence demonstrating the benefits of active-learning pedagogy has led to a shift in teaching that requires students to interact more in the classroom. To date, few studies have assessed whether there are gender-specific differences...
Wed May 27, 2020 14:19
Related ArticlesScientific Societies Fostering Inclusive Scientific Environments through Travel Awards: Current Practices and Recommendations. CBE Life Sci Educ. 2020 Jun;19(2):es3 Authors: Segarra VA, Vega LR, Primus C, Etson C, Guillory AN, Edwards A, Flores SC, Fry C, Ingram SL, Lawson M, McGee R, Paxson S, Phelan L, Suggs K, Vuong E, Hammonds-Odie L, Leibowitz MJ, Zavala M, Lujan JL, Ramirez-Alvarado M Abstract Diversity-focused committees continue...
Wed May 27, 2020 14:19
Related Articles"Accepting Evolution Means You Can't Believe in God": Atheistic Perceptions of Evolution among College Biology Students. CBE Life Sci Educ. 2020 Jun;19(2):ar21 Authors: Barnes ME, Dunlop HM, Sinatra GM, Hendrix TM, Zheng Y, Brownell SE Abstract Although many scientists agree that evolution does not make claims about God/god(s), students might assume that evolution is atheistic, and this may lead to lower evolution acceptance. In study...
Wed May 27, 2020 14:19
Related ArticlesThe Academic Career Readiness Assessment: Clarifying Hiring and Training Expectations for Future Biomedical Life Sciences Faculty. CBE Life Sci Educ. 2020 Jun;19(2):ar22 Authors: Clement L, Dorman JB, McGee R Abstract We describe here the development and validation of the Academic Career Readiness Assessment (ACRA) rubric, an instrument that was designed to provide more equity in mentoring, transparency in hiring, and accountability in...
Wed May 27, 2020 14:19
Related ArticlesA novel nuclear marker and development of an ARMS-PCR assay targeting the metallopeptidase 10 (nas 10) locus to identify the species of the Anisakis simplex (s. l.) complex (Nematoda, Anisakidae). Parasite. 2020;27:39 Authors: Palomba M, Paoletti M, Webb SC, Nascetti G, Mattiucci S Abstract The genus Anisakis represents one of the most widespread groups of ascaridoid nematodes in the marine ecosystem. Three closely related taxa are...
Wed May 27, 2020 14:19
Abstract Background Combined oral contraception was used in many studies for treatment of acne and hirsutism. However, levonorgestrel (LNG) alone has not been evaluated before. Objective To evaluate the efficacy of oral contraceptive pills containing LNG and EE compared with LNG only for the treatment of acne and hirsutism in a randomized, controlled prospective clinical trial. Methods Eighty females (20 with acne, 20 with hirsutism and 40 healthy females) received LNG + EE or LNG...
Tue May 26, 2020 19:19
ABSTRACT Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic, cicatricial alopecias. Clinically, LPP presents with multifocal patchy alopecia, while FFA, considered a variant of LPP, results in hairline recession. Frontal recession in FFA may progress as far as the mid‐scalp and infrequently beyond. Treatment to arrest the inflammatory process can be challenging and response variable. We report a case of recalcitrant lichen planopilaris and frontal fibrosing alopecia demonstrating...
Tue May 26, 2020 18:50
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