Presentation of Case. Dr. Kathy M. Tran: A 74-year-old man with mantle-cell lymphoma was admitted to this hospital during the coronavirus disease 2019 (Covid-19) pandemic because of acute respiratory failure. One day before this admission, productive cough and dyspnea developed. The next day, when…
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Egg-laying behavior in Caenorhabditis elegans is a well-known model for investigating fundamental cellular processes. In egg-laying, muscle contraction is the relaxation of the vulval muscle to extrude eggs from the vulva. Unlike skeletal muscle, vulval muscle lacks visible striations of the sarcomere. Therefore, vulval muscle must counteract the mechanical stress, caused by egg extrusion and body movement, from inducing cell-shape distortion by maintaining its cytoskeletal integrity. However, the...
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The increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost dependence on androgen receptor (AR) signaling. These AR independent tumors may also transdifferentiate to express neuroendocrine lineage markers and are termed neuroendocrine prostate cancer (NEPC). Recent evidence suggests kinase signaling may be an...
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Abstract Mutations in the additional sex combs like 1 (ASXL1) gene are frequently involved in clonal hematopoiesis and are connected with an increased risk of hematologic cancer. These aberrations are frequently detected in a number of different hematological neoplasms including acute myeloid leukemia (AML). Patients harboring ASXL1 mutations tend to have a poor prognosis and poor response to therapy. Here, we report the coexistence of four different mutations in ASXL1 gene in...
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Abstract Osteopetrosis is a severe and frequently fatal condition characterized by the formation of thick, dense bone, with a concomitant loss of bone marrow spaces secondary to defective osteoclast function or development. Clinical symptoms include pancytopenia, hepatosplenomegaly, fractures, cranial nerve impingement, and increased cranial pressure, among others. The condition requires rapid diagnosis and clinical intervention, as hematopoietic stem cell transplantation performed...
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WEDNESDAY, May 27, 2020 -- Repetitive mild traumatic brain injuries (mTBI) are associated with elevated exosomal and plasma levels of neurofilament light (NfL) chain, according to a study published online May 27 in Neurology. Vivian A. Guedes,...
WEDNESDAY, May 27, 2020 -- The COVID-19 pandemic poses risks to children's health, well-being, and development as parents struggle to provide for their families, according to a survey released by the Urban Institute. The Urban Institute's Health...
WEDNESDAY, May 27, 2020 -- All-cause mortality and stroke are comparable at 30 days and one year after transcatheter aortic valve replacement (TAVR) among patients with bicuspid and tricuspid valve stenosis, according to a study published online May...
WEDNESDAY, May 27, 2020 -- Lung cancer patients who are given the opportunity to be informed of their diagnosis have a longer median survival time, according to a study published in the May issue of Psycho-Oncology. Tong Su, Ph.D., of the College...
WEDNESDAY, May 27, 2020 -- Internal fixation surgery to treat closed humeral shaft fracture does not significantly improve 12-month outcomes versus nonoperative functional bracing, according to a study published in the May 12 issue of the Journal of...
WEDNESDAY, May 27, 2020 -- For patients admitted with heart failure, palliative care is associated with fewer readmissions and less mechanical ventilation, according to a study published online May 27 in the Journal of the American Heart...
WEDNESDAY, May 27, 2020 -- African-American patients have an increased likelihood of hospitalization for COVID-19, according to a report published online May 21 in Health Affairs. Kristen M.J. Azar, R.N., M.P.H., from the Sutter Health Center for...
WEDNESDAY, May 27, 2020 -- A new artificial intelligence algorithm can predict risk for age-related macular degeneration (AMD), according to a study published in the April issue of Translational Vision Science and Technology. Alauddin Bhuiyan,...
WEDNESDAY, May 27, 2020 -- Neuroimaging features of COVID-19 are variable among patients with acute neurological symptoms but are dominated by acute ischemic infarcts, according to a research letter published online May 21 in Radiology. Using a...
WEDNESDAY, May 27, 2020 -- In 2018, half of U.S. hospitals had the capacity to conduct telehealth-based outpatient visits, while only one in four had tele-intensive care unit (tele-ICU) capabilities, according to a research letter published online...
WEDNESDAY, May 27, 2020 -- Patients initiating hemodialysis often are prescribed opioids and short-acting benzodiazepines, which are associated with increased mortality risk, according to a study published online May 26 in the Clinical Journal of...
WEDNESDAY, May 25, 2020 -- For adults with dissociative seizures, cognitive behavioral therapy plus standardized medical care is not associated with a reduced frequency of monthly seizures but does improve secondary outcomes, according to a study...
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Abstract A 75-year-old woman was diagnosed with anemia during hospitalization for the treatment of right superior ophthalmic arteriovenous fistula. Colonoscopy revealed an entire circumference of type 2 tumor in the ascending colon. Computed tomography showed ascending colon wall thickening, a tumor with a maximum diameter of 32 mm on the right external iliac artery and multiple low-density nodules in the spleen. We performed right hemicolectomy with D3 lymph node dissection,...
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Abstract Purpose of Review The novel Coronavirus (2019-nCoV, COVID-19) is historically one of the most severe acute respiratory syndromes and pandemics to affect the globe in the twenty-first century. Originating in Wuhan, the virus rapidly spread and impacted subsets of populations with initial unclear risk factors contributing to worsening morbidity and mortality. Patients with diagnosis of cancer and undergoing treatment further...
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Analytical ChemistryDOI: 10.1021/acs.analchem.9b05759
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01676
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01073
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00275
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01507
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05135
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01237
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00918
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01534
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Abstract We studied patterns of ectoparasite species turnover and pairwise ectoparasite-host interactions across space and time in fleas and mites harboured by small mammals using a novel metric, zeta diversity (similarity between multiple communities). We asked whether the zeta diversity of parasites and their interactions with hosts follow a similar spatial or temporal trend. We found substantial differences in some (zeta decline and retention rate) but not in other (zeta decay)...
Abstract Leishmaniasis is responsible for approximately 65,000 annual deaths. Despite the mortality data, drugs available for the treatment of patients are insufficient and have moderate therapeutic efficacy in addition to serious adverse effects, which makes the development of new drugs urgent. To achieve this goal, the integration of kinetic and DSF assays against parasitic validated targets, along with phenotypic assays, can help the identification and optimization of bioactive...
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ACS NanoDOI: 10.1021/acsnano.0c02488
ACS NanoDOI: 10.1021/acsnano.0c03184
ACS NanoDOI: 10.1021/acsnano.9b08015
ACS NanoDOI: 10.1021/acsnano.0c00607
ACS NanoDOI: 10.1021/acsnano.9b10214
ACS NanoDOI: 10.1021/acsnano.0c03311
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