Pharmaceutics, Vol. 12, Pages 485: Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation Pharmaceutics doi: 10.3390/pharmaceutics12060485 Authors: Usama A. Fahmy Shaimaa M. Badr-Eldin Osama A. A. Ahmed Hibah M. Aldawsari Singkome Tima Hani Z. Asfour Mohammed W. Al-Rabia Aya A. Negm Muhammad H. Sultan Osama A. A. Madkhali Nabil A. Alhakamy Flibanserin...
Wed May 27, 2020 03:00
Pharmacy, Vol. 8, Pages 91: Are We Meeting the Demand for Pharmacist-Led Antimicrobial Stewardship Programs during Postgraduate Training-Year 1 (PGY1)? Pharmacy doi: 10.3390/pharmacy8020091 Authors: McGee Mason-Callaway Rollins In the United States of America, pharmacists play a pivotal role in antimicrobial stewardship; training from postgraduate residency may hone knowledge and skills gained from didactic pharmacy education. Specifically, the first year of postgraduate training,...
Wed May 27, 2020 03:00
Plants, Vol. 9, Pages 681: Mechanisms of Copper Tolerance, Accumulation, and Detoxification in the Marine Macroalga Ulva compressa (Chlorophyta): 20 Years of Research Plants doi: 10.3390/plants9060681 Authors: Alejandra Moenne Melissa Gómez Daniel Laporte Daniela Espinoza Claudio A. Sáez Alberto González Copper induces an oxidative stress condition in the marine alga Ulva compressa that is due to the production of superoxide anions and hydrogen peroxide, mainly in organelles....
Wed May 27, 2020 03:00
Plants, Vol. 9, Pages 682: Effects of pH and Mineral Nutrition on Growth and Physiological Responses of Trembling Aspen (Populus tremuloides), Jack Pine (Pinus banksiana), and White Spruce (Picea glauca) Seedlings in Sand Culture Plants doi: 10.3390/plants9060682 Authors: Feng Xu Maryamsadat Vaziriyeganeh Janusz J. Zwiazek Responses of trembling aspen (Populus tremuloides), jack pine (Pinus banksiana), and white spruce (Picea glauca) seedlings to root zone pH ranging from 5 to...
Wed May 27, 2020 03:00
Plants, Vol. 9, Pages 679: Reactive Oxygen Species (ROS) and Nucleic Acid Modifications During Seed Dormancy Plants doi: 10.3390/plants9060679 Authors: Kai Katsuya-Gaviria Elena Caro Néstor Carrillo-Barral Raquel Iglesias-Fernández The seed is the propagule of higher plants and allows its dissemination and the survival of the species. Seed dormancy prevents premature germination under favourable conditions. Dormant seeds are only able to germinate in a narrow range of conditions....
Wed May 27, 2020 03:00
Plants, Vol. 9, Pages 680: Essential Oil Chemical Variability in Oliveria decumbens (Apiaceae) from Different Regions of Iran and Its Relationship with Environmental Factors Plants doi: 10.3390/plants9060680 Authors: Akbar Karami Tahereh Khoushbakht Hassan Esmaeili Filippo Maggi Oliveria decumbens Vent. (Apiaceae) is an annual herb resistant to harsh environmental conditions, which has got numerous pharmacological, food and feed, and cosmetic applications. In the present study,...
Wed May 27, 2020 03:00
Plants, Vol. 9, Pages 677: Initial Survival and Development of Planted European Beech (Fagus sylvatica L.) and Small-Leaved Lime (Tilia cordata Mill.) Seedlings Competing with Black Cherry (Prunus serotina Ehrh.) Plants doi: 10.3390/plants9060677 Authors: Sarah L. Hasstedt Peter Annighöfer Black cherry (Prunus serotina Ehrh.) is considered one of the most invasive tree species in central Europe and causes problems for both nature conservation and silviculture. Besides mechanical control...
Wed May 27, 2020 03:00
Plants, Vol. 9, Pages 676: Evaluation of Nitrogen Nutrition in Diminishing Water Deficiency at Different Growth Stages of Maize by Chlorophyll Fluorescence Parameters Plants doi: 10.3390/plants9060676 Authors: Attila Simkó Gáspár Soma Gáspár László Kiss Péter Makleit Szilvia Veres Efficient nitrogen (N) nutrition has been reported to have the potential to alleviate the drought stress damages by maintaining metabolic activities even at low tissue water potential. The goal...
Wed May 27, 2020 03:00
Plants, Vol. 9, Pages 678: Solanales Stem Biomechanical Properties Are Primarily Determined by Morphology Rather Than Internal Structural Anatomy and Cell Wall Composition Plants doi: 10.3390/plants9060678 Authors: Ilana Shtein Alex Koyfman Amnon Schwartz Zoë A. Popper Benny Bar-On Self-supporting plants and climbers exhibit differences in their structural and biomechanical properties. We hypothesized that such fundamental differences originate at the level of the material...
Wed May 27, 2020 03:00
Robotics, Vol. 9, Pages 42: Laparoscopic Robotic Surgery: Current Perspective and Future Directions Robotics doi: 10.3390/robotics9020042 Authors: Longmore Naik Gargiulo Just as laparoscopic surgery provided a giant leap in safety and recovery for patients over open surgery methods, robotic-assisted surgery (RAS) is doing the same to laparoscopic surgery. The first laparoscopic-RAS systems to be commercialized were the Intuitive Surgical, Inc. da Vinci and the Computer Motion...
Wed May 27, 2020 03:00
Robotics, Vol. 9, Pages 41: Real-Time Cable Force Calculation beyond the Wrench-Feasible Workspace Robotics doi: 10.3390/robotics9020041 Authors: Roland Boumann Tobias Bruckmann Under special circumstances, a cable-driven parallel robot (CDPR) may leave its wrench-feasible-workspace. Standard approaches for the computation of set-point cable forces are likely to fail in this case. The novel nearest corner method for calculating appropriate cable forces when the CDPR is outside of...
Wed May 27, 2020 03:00
Sci, Vol. 2, Pages 36: On Singular Perturbation of Neutron Point Kinetics in the Dynamic Model of a PWR Nuclear Power Plant Sci doi: 10.3390/sci2020036 Authors: Xiangyi Chen Asok Ray This short communication makes use of the principle of singular perturbation to approximate the ordinary differential equation (ODE) of prompt neutron (in the point kinetics model) as an algebraic equation. This approximation is shown to yield a large gain in computational efficiency without compromising...
Wed May 27, 2020 03:00
Social Sciences, Vol. 9, Pages 90: The Maturity of Humanitarian Logistics against Recurrent Crises Social Sciences doi: 10.3390/socsci9060090 Authors: Jesus Gonzalez-Feliu Mario Chong Jorge Vargas-Florez Irineu de Brito Jr. Carlos Osorio-Ramirez Eric Piatyszek Renato Quilche Altamirano This paper provides a framework to analyze the maturity of humanitarian logistics systems to face crisis situations related to recurrent events, and thus to identify the main areas of...
Wed May 27, 2020 03:00
Sports, Vol. 8, Pages 76: Can Countermovement Jump Neuromuscular Performance Qualities Differentiate Maximal Horizontal Deceleration Ability in Team Sport Athletes? Sports doi: 10.3390/sports8060076 Authors: Harper Cohen Carling Kiely This investigation aimed to determine the countermovement jump (CMJ) neuromuscular performance (NMP) qualities that differentiate between athletes with high or low horizontal deceleration ability. Twenty-seven male university team sport athletes...
Wed May 27, 2020 03:00
Stats, Vol. 3, Pages 107-119: A Brief Overview of Restricted Mean Survival Time Estimators and Associated Variances Stats doi: 10.3390/stats3020010 Authors: Szilárd Nemes Erik Bülow Andreas Gustavsson Restricted Mean Survival Time ( R M S T ) experiences a renaissance and is advocated as a model-free, easy to interpret alternative to proportional hazards regression and hazard rates with implication in causal inference. Estimation of R M S T and associated variance...
Tue May 26, 2020 03:00
Toxics, Vol. 8, Pages 38: E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis Toxics doi: 10.3390/toxics8020038 Authors: Anas Ashour Hashim Alhussain Umar Bin Rashid Labiba Abughazzah Ishita Gupta Ahmed Malki Semir Vranic Ala-Eddin Al Al Moustafa E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a “healthy method” of tobacco consumption. The adverse outcomes...
Wed May 27, 2020 03:00
Toxins, Vol. 12, Pages 351: Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug–Bug Interaction? Toxins doi: 10.3390/toxins12060351 Authors: Lu Dai Björn K. Meijers Bert Bammens Henriette de de Loor Leon J. Schurgers Abdul Rashid Qureshi Peter Stenvinkel Pieter Evenepoel Gut microbial metabolism is not only an important source of uremic toxins but may also help to maintain...
Wed May 27, 2020 03:00
Toxins, Vol. 12, Pages 352: Vitamin E-Bonded Membranes Do Not Influence Markers of Oxidative Stress in Hemodialysis Patients with Homozygous Glutathione Transferase M1 Gene Deletion Toxins doi: 10.3390/toxins12060352 Authors: Petar Djuric Sonja Suvakov Tatjana Simic Dragana Markovic Djurdja Jerotic Aleksandar Jankovic Ana Bulatovic Jelena Tosic Tosic Dragovic Tatjana Damjanovic Jelena Marinkovic Radomir Naumovic Nada Dimkovic Background: Increased oxidative...
Wed May 27, 2020 03:00
Toxins, Vol. 12, Pages 350: The Effect of Zearalenone on the Cytokine Environment, Oxidoreductive Balance and Metabolism in Porcine Ileal Peyer’s Patches Toxins doi: 10.3390/toxins12060350 Authors: Kazimierz Obremski Wojciech Trybowski Paweł Wojtacha Magdalena Gajęcka Józef Tyburski Łukasz Zielonka The aim of the present study was to determine the effect of zearalenone (ZEN), administered per os to gilts at doses equivalent to 50%, 100%, and 150% of no-observed-adverse-effect...
Wed May 27, 2020 03:00
TropicalMed, Vol. 5, Pages 86: Challenges in Tuberculosis Clinical Trials in the Face of the COVID-19 Pandemic: A Sponsor’s Perspective Tropical Medicine and Infectious Disease doi: 10.3390/tropicalmed5020086 Authors: Rusen The COVID-19 pandemic has caused unforeseen and extreme changes in societal and health system functioning not previously experienced in most countries in a lifetime. The impact of the pandemic on clinical trials can be especially profound given their complexities...
Wed May 27, 2020 03:00
TropicalMed, Vol. 5, Pages 85: Identification of Mutations in Antimalarial Resistance Gene Kelch13 from plasmodium falciparum Isolates in Kano, Nigeria Tropical Medicine and Infectious Disease doi: 10.3390/tropicalmed5020085 Authors: Umar F. Abubakar Ruqayya Adam Muhammad M. Mukhtar Abdullahi Muhammad Adamu A. Yahuza Sulaiman S. Ibrahim Malaria control relies on first-line treatments that use artemisinin-combination therapies (ACT). Unfortunately, mutations in the plasmodium...
Wed May 27, 2020 03:00
TropicalMed, Vol. 5, Pages 84: Monitoring Insecticide Susceptibility in Aedes Aegypti Populations from the Two Biggest Cities, Ouagadougou and Bobo-Dioulasso, in Burkina Faso: Implication of Metabolic Resistance Tropical Medicine and Infectious Disease doi: 10.3390/tropicalmed5020084 Authors: Moussa Namountougou Dieudonné Diloma Soma Mahamoudou Balboné Didier Alexandre Kaboré Mahamadi Kientega Aristide Hien Ahmed Coulibaly Parfait Eric Ouattara Benson Georges Meda Samuel...
Wed May 27, 2020 03:00
Urban Science, Vol. 4, Pages 27: The "Paris-end" of Town? Deriving Urban Typologies Using Three Imagery Types Urban Science doi: 10.3390/urbansci4020027 Authors: Kerry A. Nice Jason Thompson Jasper S. Wijnands Gideon D. P. A. Aschwanden Mark Stevenson Urban typologies allow areas to be categorised according to form and the social, demographic, and political uses of the areas. The use of these typologies and finding similarities and dissimilarities between cities enables better...
Wed May 27, 2020 03:00
Vaccines, Vol. 8, Pages 252: Chimeric Vaccines Designed by Immunoinformatics-Activated Polyfunctional and Memory T Cells That Trigger Protection against Experimental Visceral Leishmaniasis Vaccines doi: 10.3390/vaccines8020252 Authors: Rory Cristiane Fortes De Brito Jeronimo Conceição Ruiz Jamille Mirelle de Oliveira Cardoso Thais Lopes Valentim Di Paschoale Ostolin Levi Eduardo Soares Reis Fernando Augusto Siqueira Mathias Rodrigo Dian de Oliveira Aguiar-Soares Bruno...
Wed May 27, 2020 03:00
Vaccines, Vol. 8, Pages 251: The Potency of an Anti-MERS Coronavirus Subunit Vaccine Depends on a Unique Combinatorial Adjuvant Formulation Vaccines doi: 10.3390/vaccines8020251 Authors: George Tai Du Lustigman Vaccination is one of the most successful strategies to prevent human infectious diseases. Combinatorial adjuvants have gained increasing interest as they can stimulate multiple immune pathways and enhance the vaccine efficacy of subunit vaccines. We investigated...
Wed May 27, 2020 03:00
Viruses, Vol. 12, Pages 588: Spatial–Temporal Variations in Atmospheric Factors Contribute to SARS-CoV-2 Outbreak Viruses doi: 10.3390/v12060588 Authors: Raffaele Fronza Marina Lusic Manfred Schmidt Bojana Lucic The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has reached over five million confirmed cases worldwide, and numbers are still growing at a fast rate. Despite the wide outbreak...
Wed May 27, 2020 03:00
Viruses, Vol. 12, Pages 586: Are We Ready for NGS HIV Drug Resistance Testing? The Second “Winnipeg Consensus” Symposium Viruses doi: 10.3390/v12060586 Authors: Ji Sandstrom Paredes Harrigan Brumme Avila Rios Noguera-Julian Parkin Kantor HIV drug resistance is a major global challenge to successful and sustainable antiretroviral therapy. Next-generation sequencing (NGS)-based HIV drug resistance (HIVDR) assays enable more sensitive and quantitative detection...
Wed May 27, 2020 03:00
Viruses, Vol. 12, Pages 587: Structural Insights into APOBEC3-Mediated Lentiviral Restriction Viruses doi: 10.3390/v12060587 Authors: Delviks-Frankenberry Desimmie Pathak Mammals have developed clever adaptive and innate immune defense mechanisms to protect against invading bacterial and viral pathogens. Human innate immunity is continuously evolving to expand the repertoire of restriction factors and one such family of intrinsic restriction factors is the APOBEC3 (A3) family...
Wed May 27, 2020 03:00
Viruses, Vol. 12, Pages 585: Evidence of the Mechanism by Which Polyomaviruses Exploit the Extracellular Vesicle Delivery System during Infection Viruses doi: 10.3390/v12060585 Authors: Simone Giannecchini Increasing evidence suggests that human viruses can hijack extracellular vesicles (EVs) to deliver proteins, mRNAs, microRNAs (miRNAs) and whole viral particles during viral persistence in the host. Human polyomavirus (PyV) miRNAs, which downregulate large T-antigen expression and...
Wed May 27, 2020 03:00
Viruses, Vol. 12, Pages 584: Shedding Light on the Role of Extracellular Vesicles in HIV Infection and Wound Healing Viruses doi: 10.3390/v12060584 Authors: Aseel Alqatawni Adhikarimayum Lakhikumar Sharma Beatrice Attilus Mudit Tyagi Rene Daniel Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function,...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1532: Flood Inundation Mapping in an Ungauged Basin Water doi: 10.3390/w12061532 Authors: Sofia Sarchani Konstantinos Seiradakis Paulin Coulibaly Ioannis Tsanis An increase in severe precipitation events of higher intensity are expected to occur in the southeastern Mediterranean due to intensification of the hydrological cycle caused by climate change. Results of the climate change model’s precipitation data for the period 1970–2100...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1531: Nitrogen and Phosphorus Loads in Greek Rivers: Implications for Management in Compliance with the Water Framework Directive Water doi: 10.3390/w12061531 Authors: Konstantinos Stefanidis Aikaterini Christopoulou Serafeim Poulos Emmanouil Dassenakis Elias Dimitriou Reduction of nutrient loadings is often prioritized among other management measures for improving the water quality of freshwaters within the catchment. However, urban point sources and...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1533: Application of Wavelet De-Noising for Travel-Time Based Hydraulic Tomography Water doi: 10.3390/w12061533 Authors: Huichen Yang Rui Hu Pengxiang Qiu Quan Liu Yixuan Xing Ran Tao Thomas Ptak Travel-time based hydraulic tomography is a promising method to characterize heterogeneity of porous-fractured aquifers. However, there is inevitable noise in field-scale experimental data and many hydraulic signal travel times, which are derived from...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1527: Changes in Extreme Precipitation across 30 Global River Basins Water doi: 10.3390/w12061527 Authors: Feng Wang Wu Yin Qian Zhan Extreme precipitation can cause disasters such as floods, landslides and crop destruction. A further study on extreme precipitation is essential for enabling reliable projections of future changes. In this study, the trends and frequency distribution changes in extreme precipitation across different major river...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1529: Assessment of Factors Affecting the Removal Efficiency of Suspended Solids and Particulate Matters for Pretreatment Units in a Stormwater Management Facility Water doi: 10.3390/w12061529 Authors: Seung Won Lee Juwan Lee Sung Min Cha Non-point source (NPS) pollution is one of the primary sources of contamination in aquatic systems, such as rivers and lakes. Various techniques and devices, including low impact development (LID) and best management practice...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1526: Connectivity of Ephemeral and Intermittent Streams in a Subtropical Atlantic Forest Headwater Catchment Water doi: 10.3390/w12061526 Authors: Alondra B.A. Perez Perez Camyla Innocente dos Santos João H.M. Sá Pedro F. Arienti Pedro L.B. Chaffe Stream network extension and contraction depend on landscape features and the characteristics of precipitation events. Although this dependency is widely recognized, the interaction among overland-flow generation...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1528: Analysis and Prediction of Dammed Water Level in a Hydropower Reservoir Using Machine Learning and Persistence-Based Techniques Water doi: 10.3390/w12061528 Authors: C. Castillo-Botón D. Casillas-Pérez C. Casanova-Mateo L. M. Moreno-Saavedra B. Morales-Díaz J. Sanz-Justo P. A. Gutiérrez and S. Salcedo-Sanz This paper presents long- and short-term analyses and predictions of dammed water level in a hydropower reservoir. The long-term analysis...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1525: A Method to Improve the Flood Maps Forecasted by On-Line Use of 1D Model
Water, Vol. 12, Pages 1525: A Method to Improve the Flood Maps Forecasted by On-Line Use of 1D Model Water doi: 10.3390/w12061525 Authors: Pasquale G. F. Filianoti Angelo Nicotra Antonino Labate Demetrio A. Zema Forecasting floods in urban areas during a heavy rainfall is the aim of every early warning system. 2D-models produce the most accurate flood maps, but they are practically useless as quasi real-time tools, because their run times are comparable to times of propagation...
Wed May 27, 2020 03:00
Water, Vol. 12, Pages 1530: Coupling Persulfate-Based AOPs: A Novel Approach for Piroxicam Degradation in Aqueous Matrices Water doi: 10.3390/w12061530 Authors: Antonios Stathoulopoulos Dionissios Mantzavinos Zacharias Frontistis The activated persulfate degradation of piroxicam, a non-steroidal anti-inflammatory drug (NSAID) belonging to oxicams, was investigated. Persulfate was activated with thermal energy or (UV-A and simulated solar) irradiation. Using 250 mg/L sodium persulfate...
Wed May 27, 2020 03:00
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