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Abstract In this paper, it is argued that science of discontinua represents a major paradigm shift in how scientific research is done. First, a historical perspective is given, followed by key aspects of discontinuum simulations and its potential in aiding research and development. This is followed by a philosophical perspective on equivalence of matter and information as inspired by Aristotle’s quest for souls in living things such as cells. Finally, the universality of the discontinuum...
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Microbial Drug Resistance, Ahead of Print.
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Leukemia, Published online: 28 May 2020; doi:10.1038/s41375-020-0875-0Primary therapy and relative survival in classical Hodgkin lymphoma: a nationwide population-based study in the Netherlands, 1989–2017
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Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02868A, CommunicationBing Wei, Xianbao Sun, Dongbao Yao, Chengxu Li, Shiyan Xiao, Yijun Guo, Haojun LiangHomogeneous DNA-only keypad locks were built with multi-stranded scalable junction substrates and a series of double-stranded eliminators to differentially process correctly- and wrongly-added DNA inputs, respectively. Unlike conventional strategies that...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02952A, CommunicationZhili Wen, Lucas Jose Karas, Chia-Hua Wu, Judy WuPhotoacids like substituted naphthalenes (X = OH, NH3+, COOH) are aromatic in the S0 state and antiaromatic in the S1 state. Nucleus independent chemical shifts analyses reveal that deprotonation relieves...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Advance ArticleDOI: 10.1039/D0CC90229B, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yu Zhang, Wei Shen, Peng Zhang, Li Chen, Chunsheng XiaoTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Advance ArticleDOI: 10.1039/D0CC90228D, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Fatimat O. Badmus, Joshua A. Malone, Frank R. Fronczek, Rendy KartikaTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC03091K, CommunicationZi-Biao Zhao, Xiang Li, Mu-Wang Chen, Zongbao Kent Zhao, Yong-Gui ZhouUsing ureas as transfer catalysts through hydrogen bonding activation, biomimetric asymmetric reduction of benzoxazinones and quinoxalinones with chiral and regenerable NAD(P)H models was described, giving the chiral dihydrobenzoxazinones and dihydroquinoxalinones...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02921A, CommunicationGuangzhe Li, Chengdong Wang, Yueqing Li, Kun Shao, Guo Yu, Shisheng Wang, Xiuhan Guo, Weijie Zhao, Hiroyuki NakamuraZinc(II)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with two types of carbon pronucleophiles (nitromethane as a sp3 carbon pronucleophile and phenylacetylenes as sp carbon pronucleophiles) proceeded to give the 2-substituted...The content of this RSS...
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02619K, CommunicationYui Kondo, Kazunori Nagao, Hirohisa OhmiyaIn this communication, we reports chrial copper/NHC-catalyzed reaction between aromatic aldehydes and propargylic phosphates using a silylboronate, providing enantioenriched chiral a-allenic alcohols with complete regioselectivity and moderate to high enantioselectivity. The...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02902E, CommunicationPierre Milbeo, Matthieu Simon, Claude Didierjean, Emmanuel Wenger, Emmanuel Aubert, Jean Martinez, Muriel Amblard, Monique Calmès, Baptiste LegrandThe insertion of cyclic building blocks in oligoureas to stabilize or modulate the properties of the 12/14-helix was often fruitless. We herein propose a fully compatible highly constrained building block...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/C9CC08884A, CommunicationLei Zhang, Junyu Chen, Xiahe Chen, Xiangyun Zheng, Jian Zhou, Tianshuo Zhong, Zhiwei Chen, Yun-Fang Yang, Xinpeng Jiang, Yuan-Bin She, Chuanming YuRh(III)-catalyzed coupling of phenylhydrazines with 1- alkynylcyclobutanols was realized through a hydrazine-directed C−H functionalization pathway. This [4+1] annulation, based on the cleavage of Csp-Csp triple bond in alkynylcyclobutanol, provides a...The content of this RSS...
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02505D, CommunicationPascal Freund, Irena Senkovska, Bin Zheng, Volodymyr Bon, Beate Krause, Guillame Maurin, Stefan KaskelWe evaluate experimentally the force exerted by flexible metal-organic frameworks through expansion for a representative model system, namely MIL-53(Al). The results obtained are compared with data collected from intrusion experiments...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Advance ArticleDOI: 10.1039/D0CC02582H, Communication Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Colette J. Whitfield, Alice M. Banks, Gema Dura, John Love, Jonathan E. Fieldsend, Sarah A. Goodchild, David A. Fulton, Thomas P. HowardFabrication of macro-scale polysaccharide, proteinaceous, micellular and covalently crosslinked hydrogels for housing cell-free protein synthesis reactions.To cite this article before page numbers...
Chem. Commun., 2020, Advance ArticleDOI: 10.1039/D0CC90222E, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Satrialdi, Reina Munechika, Vasudevanpillai Biju, Yuta Takano, Hideyoshi Harashima, Yuma YamadaTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02959A, CommunicationShreedhar Gautam, Vinicius Romero Gonçales, Rafael N.P. Colombo, Wenxian Tang, Susana Cordoba de Torresi, Peter Reece, Richard Tilley, John Justin GoodingLight-activated electrochemistry (LAE) consists of employing a focused light beam to illuminate a semiconducting area and make it electrochemically active. Here, we show how to reduce the electrochemical spatial resolution...The content of this RSS Feed (c) The Royal Society...
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02604B, CommunicationChun-Leung Kwok, Shun-Cheung Cheng, Pui-Yu Ho, Shek-Man Yiu, Wai-Lun Man, Vonika Ka-Man Au, Po-Keung Tsang, Chi-Fai Leung, Chi-Chiu Ko, Marc RobertThe photocatalytic generation of a NADH synthetic analogue, i.e. 1-benzyl-1,4-dihydronicotinamide (1,4-BNAH) has been studied using cobalt diimino-dioxime complexes and the BF2-bridged derivative as catalysts. 1,4-BNAH was produced in both aqueous...The content of this RSS Feed...
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/C9CC09902F, CommunicationZhenni Su, Yunqiu Feng, Rong Zou, Xianfan Qiu, Jian Wang, Chuanzhou TaoA copper-catalyzed borylative amidation of vinyl arenes with isocyanates and bis(pinacolato)diboron has been developed. This new protocol, which can be performed at gram-scale, utilizes isocyanates as simple precursors to provide...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC01916J, Communication Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ahmed Shaukat, Eduardo Anaya-Plaza, Sofia Julin, Veikko Linko, Tomás Torres, Andres De la Escosura, Mauri A. KostiainenIn this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents...
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC01921F, CommunicationJingxin Mo, Meiying Li, Xianjue Chen, Qinghua LiUnprecedented nano-carbon hybrids consisting of exfoliated ultrathin graphite (or single-walled carbon nanotubes) with pristine C60 molecules attached on the surfaces have been produced in water in the presence of p-phosphonic...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02224A, CommunicationNaoya Ryu, Tsutomu Kawaguchi, Hiroshi Yanagita, Yutaka Okazaki, Thierry Buffeteau, Kyohei Yoshida, Tomohiro Shirosaki, Shoji Nagaoka, Makoto Takafuji, Hirotaka Ihara, Reiko OdaWe demonstrate the induction of chirally arranged organic dye-linked polysilsesquioxane through a sol–gel transcription using a chiral supramolecular template. The chiral arrangement was confirmed by electronic and vibrational circular dichroism...The...
Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC02969F, CommunicationMasazumi Tamura, Yingai Li, Keiichi TomishigeCu oxide-modified CeO2 (CuOx-CeO2) with 2 wt% Cu loading amount was the most effective and reusable heterogeneous catalyst for selective one-pot imine synthesis from methylarenes and anilines via direct oxidation...The content of this RSS Feed (c) The Royal Society of Chemistry
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Abstract Purpose of Review The novel Coronavirus (2019-nCoV, COVID-19) is historically one of the most severe acute respiratory syndromes and pandemics to affect the globe in the twenty-first century. Originating in Wuhan, the virus rapidly spread and impacted subsets of populations with initial unclear risk factors contributing to worsening morbidity and mortality. Patients with diagnosis of cancer and undergoing treatment further...
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Metabolic Syndrome and Related Disorders, Ahead of Print.
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IJMS, Vol. 21, Pages 3822: Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21113822 Authors: Shoman Wild Hemmendinger Graille Sauvain Hopf Guseva Canu Isoprostanes are physiopathologic mediators of oxidative stress, resulting in lipid peroxidation. 8-isoprostane seems particularly useful for measuring oxidative stress...
IJMS, Vol. 21, Pages 3820: Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21113820 Authors: Tang Thompson Taylor Oláhová The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an intricate process, which—given their dual-genetic control—requires tight co-regulation of two evolutionarily distinct gene expression...
IJMS, Vol. 21, Pages 3821: Molecular Aspects and Treatment of Iron Deficiency in the Elderly International Journal of Molecular Sciences doi: 10.3390/ijms21113821 Authors: Romano Paglia Bellanti Villani Sangineto Vendemiale Serviddio Iron deficiency (ID) is the most frequent nutritional deficiency in the whole population worldwide, and the second most common cause of anemia in the elderly. The prevalence of anemia is expecting to rise shortly, because...
IJMS, Vol. 21, Pages 3817: Erythropoietin Mediated Bone Loss in Mice Is Dose-Dependent and Mostly Irreversible International Journal of Molecular Sciences doi: 10.3390/ijms21113817 Authors: Albert Kolomansky Sahar Hiram-Bab Nathalie Ben-Califa Tamar Liron Naamit Deshet-Unger Moshe Mittelman Howard Oster Martina Rauner Ben Wielockx Drorit Neumann Yankel Gabet Recent studies have demonstrated that erythropoietin (EPO) treatment in mice results...
IJMS, Vol. 21, Pages 3818: Phosphorylation Sites in Protein Kinases and Phosphatases Regulated by Formyl Peptide Receptor 2 Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21113818 Authors: Annunziata Parisi Esposito Fabbrocini Ammendola Cattaneo FPR1, FPR2, and FPR3 are members of Formyl Peptides Receptors (FPRs) family belonging to the GPCR superfamily. FPR2 is a low affinity receptor for formyl peptides and it is considered the...
IJMS, Vol. 21, Pages 3810: Association of A Novel Splice Site Mutation in P/Q-Type Calcium Channels with Childhood Epilepsy and Late-Onset Slowly Progressive Non-Episodic Cerebellar Ataxia International Journal of Molecular Sciences doi: 10.3390/ijms21113810 Authors: Claudia Stendel Maria Cristina D’Adamo Manuela Wiessner Marina Dusl Marta Cenciarini Silvia Belia Ehsan Nematian-Ardestani Peter Bauer Jan Senderek Thomas Klopstock Mauro Pessia ...
IJMS, Vol. 21, Pages 3819: Steroids and TRP Channels: A Close Relationship International Journal of Molecular Sciences doi: 10.3390/ijms21113819 Authors: Méndez-Reséndiz Enciso-Pablo González-Ramírez Juárez-Contreras Rosenbaum Morales-Lázaro Transient receptor potential (TRP) channels are remarkable transmembrane protein complexes that are essential for the physiology of the tissues in which they are expressed. They function as non-selective cation channels...
IJMS, Vol. 21, Pages 3816: Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo International Journal of Molecular Sciences doi: 10.3390/ijms21113816 Authors: Holmen Olofsson Jensen Idorn thor Straten Recent advances in clinical oncology is based on exploiting the capacity of the immune system to combat cancer: immuno-oncology. Thus, immunotherapy of cancer is now used to treat a variety of malignant diseases. A striking feature is that even patients with late-stage...
IJMS, Vol. 21, Pages 3815: Disruption of the Auxin Gradient in the Abscission Zone Area Evokes Asymmetrical Changes Leading to Flower Separation in Yellow Lupine International Journal of Molecular Sciences doi: 10.3390/ijms21113815 Authors: Kućko Wilmowicz Pokora Alché How auxin transport regulates organ abscission is a long-standing and intriguing question. Polar auxin transport across the abscission zone (AZ) plays a more important role in the regulation of abscission...
IJMS, Vol. 21, Pages 3813: Empowering Shotgun Mass Spectrometry with 2DE: A HepG2 Study International Journal of Molecular Sciences doi: 10.3390/ijms21113813 Authors: Kiseleva Ponomarenko Poverennaya One of the major goals of the Chromosome-Centric Human Proteome Project (C-HPP) is to catalog and annotate a myriad of heterogeneous proteoforms, produced by ca. 20 thousand genes. To achieve a detailed and personalized understanding into proteomes, we suggest using a customized...
IJMS, Vol. 21, Pages 3812: Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19 International Journal of Molecular Sciences doi: 10.3390/ijms21113812 Authors: Orienti Gentilomi Farruggia At present, there is no vaccine or effective standard treatment for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (or coronavirus disease-19 (COVID-19)), which frequently leads to lethal pulmonary inflammatory responses. COVID-19 pathology...
IJMS, Vol. 21, Pages 3811: The FT-IR and Raman Spectroscopies as Tools for Biofilm Characterization Created by Cariogenic Streptococci International Journal of Molecular Sciences doi: 10.3390/ijms21113811 Authors: Gieroba Krysa Wojtowicz Wiater Pleszczyńska Tomczyk Sroka-Bartnicka Fourier transform infrared (FT-IR) and Raman spectroscopy and mapping were applied to the analysis of biofilms produced by bacteria of the genus Streptococcus. Bacterial...
IJMS, Vol. 21, Pages 3814: Urinary MicroRNAs as Potential Markers for Non-Invasive Diagnosis of Bladder Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21113814 Authors: Erdmann Salomo Klimova Heberling Lohse-Fischer Fuehrer Thomas Roeder Froehner Wirth Fuessel Currently, voided urine cytology (VUC) serves as the gold standard for the detection of bladder cancer (BCa) in urine. Despite its high specificity, VUC...
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