Molecular packing of organic luminogens governs their photophysical behavior. In their Communication (DOI: https://doi.org/10.1002/anie.20191339310.1002/anie.201913393), E. Hamzehpoor and D. F. Perepichka report a series of highly emissive azatriangulenetrione (TANGO) solids whose luminescent properties are controlled by the size of substituents. The co‐alignment of carbonyl groups in sterically unencumbered TANGO derivatives leads to room temperature phosphorescence (triplet emission) with quantum...
Tue May 26, 2020 12:58
NHC‐boryl radicals are generated by single‐electron oxidation of NHC‐BH3 complexes using a photoredox catalytic system. New reaction modes of NHC‐boryl radicals were determined for the facile synthesis of highly elaborated organoboron molecule. Key: N ‐heterocyclic carbene (NHC), leaving group (LG). Abstract Radical borylation using N ‐heterocyclic carbene (NHC)‐BH3 complexes as boryl radical precursors has emerged as an important synthetic tool for organoboron assembly. However, the majority...
Tue May 26, 2020 12:58
The Guerbet reaction was discovered more than 100 years ago. In combination with Noyori's catalyst, the first asymmetric version of the Guerbet reaction has now been achieved by C. Wang and co‐workers who describe this development in their Research Article (DOI: https://doi.org/10.1002/anie.20200310410.1002/anie.202003104).
Tue May 26, 2020 12:58
A graphdiyne–cobalt nitride electrocatalyst (GDY/Co2N) with rationally designed and constructed interface shows high selectivity and efficiency for ammonia synthesis at ambient pressures and room temperatures in both acidic and neutral conditions. The unique GDY electronic character plays a critical role for promoting the superior electronic activity and ECNRR performance simultaneously. Abstract A freestanding 3D graphdiyne–cobalt nitride (GDY/Co2N) with a highly active and selective interface...
Tue May 26, 2020 12:56
1,5‐Disubstituted 1,2,3‐triazoles can be used to mimic disulfide bonds and overcome their redox instability. As T. Durek, D. J. Craik, and co‐workers show in their Communication (DOI: https://doi.org/10.1002/anie.20200343510.1002/anie.202003435), the triazole motif can be incorporated into backbone cyclic peptides based on the sunflower trypsin inhibitor‐1 scaffold. NMR and X‐ray structural analyses show that the triazole linkage has exceptional mimicry, whilst maintaining activity and improving...
Tue May 26, 2020 12:56
Whole living cells were used as the template in a dynamic combinatorial chemistry system. The amplified member of the dynamic library showed strong and selective binding to the main glycosaminoglycan of the extracellular matrix of the corresponding cell. This work demonstrates the power of dynamic covalent screening in chemical biology, even in highly challenging biorelevant media. Abstract Dynamic covalent chemistry combines in a single step the screening and synthesis of ligands for biomolecular...
Tue May 26, 2020 12:55
TB or not TB : The antimycobacterial compound GaMF1 inhibits the mycobacterial F‐ATP synthase by binding to a specific loop of subunit γ, preventing ATP synthesis. GaMF1 is active against multidrug‐resistant Mycobacterium tuberculosis strains and increases the potency of the TB drug bedaquiline and its analogues, thereby offering potential for an efficient multidrug combination. Medicinal chemistry efforts gave analogues with nanomolar potency. Abstract The F1FO‐ATP synthase is required for...
Tue May 26, 2020 12:55
The weakly coordinating anion [Al{OC(CF3)3}4]− was crucial for the selective formation of a supramolecule with a significant number of vacant metal sites. This novel approach results in the cationic supersphere [(Cp′′Fe(η5‐P5))12{CuNCMe}8]8+ possessing 12 vacant positions potentially available for heterometals, which is the absolute maximum possible for pentaphosphaferrocene‐based supramolecules with a fullerene topology. Abstract An unprecedented cationic supramolecule [(Cp′′Fe(η5‐P5))12{CuNCMe}8]8+...
Tue May 26, 2020 12:55
A highly efficient method for protein functionalization with commonly used bioorthogonal motifs for Diels–Alder cycloaddition with inverse electron demand (DAinv) is presented. This technology enables fast and routine access to tailored and hitherto inaccessible protein chimeras. Abstract Bioorthogonal chemistry holds great potential to generate difficult‐to‐access protein–protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation...
Tue May 26, 2020 12:54
“My favorite drink is good red wine. I can never resist chocolate …” Find out more about Cyrille Boyer in his Author Profile.
Tue May 26, 2020 12:54
No longer black‐and‐white : A patterned superwetting membrane that showed a reversible transition between anisotropic and isotropic wettability under different conditions was developed for functional diversity (see picture). The material could act as a responsive permeable membrane and signal‐expression membrane for responsive liquid separation or permeation as well as real‐time liquid signal expression. Abstract Superwetting membranes with responsive properties have attracted heightened attention...
Tue May 26, 2020 12:53
A basis of organic chemistry is supplying valuable compounds from easily obtainable inexpensive materials. A dinuclear zinc‐3,3′‐(R ,S ,S )‐bis(aminoimino)binaphthoxide (di‐Zn ) complex enabled a first successful and general catalytic asymmetric iodoesterification of simple alkenes. The integrated fundamental forces of metal ionic bond, hydrogen bond, halogen bond, and π‐π stacking play a quartet on the single reaction sphere of di‐Zn catalyst. Abstract Catalytic asymmetric iodoesterification...
Tue May 26, 2020 12:53
A photoactivatable prodrug approach overcomes the deactivation of drugs based on gold complexes caused by off‐target binding to serum albumin. In their Research Article (DOI: https://doi.org/10.1002/anie.20200052810.1002/anie.202000528), T. Zou et al. show that gold(III) hydride complexes are inert towards serum albumin in the dark. Once they enter tumor tissues, their thiol reactivity can be photochemically activated, thereby leading to potent inhibition of tumor thiol enzymes through the formation...
Tue May 26, 2020 12:53
All in one : Highly efficient multisegment native chemical ligation (NCL) has been developed by exploiting the Fmoc group to temporarily mask the N‐terminal Cys of the peptide thioester fragments. Fmoc removal and NCL are achieved in the same reaction mixture through pH adjustments in presence of 20 % piperidine. The simplicity and inherent robustness of this method make it an attractive approach for the high‐yielding total synthesis of proteins. Abstract We report an operationally simple method...
Tue May 26, 2020 12:53
The mutated core sequence of an Aβ peptide is shown to undergo non‐equilibrium polymerization driven by hydrophobic collapse. The paracrystalline packing of β‐sheets increases the proximity of the aromatic residues in the assembled state, contributing to temporal control over its electronic properties. Abstract Hydrophobic collapse plays crucial roles in protein functions, from accessing the complex three‐dimensional structures of native enzymes to the dynamic polymerization of non‐equilibrium...
Tue May 26, 2020 12:52
The self‐immolative, amplified release of small molecules, in response to a nucleic‐acid signal, from 1D, 2D, and 3D assemblies using the hybridization chain reaction (HCR) is demonstrated. These assemblies effectively separate the reactive groups, enabling the release small molecules in response to a biomarker of interest, and could find applications in biosensing, imaging, and drug delivery. Abstract Triggering the release of small molecules in response to unique biomarkers is important...
Tue May 26, 2020 12:52
Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most curren...
Wed May 27, 2020 03:00
Radiotherapy dose and target volume prescriptions for anal squamous cell carcinoma (ASCC) vary considerably in daily practice and guidelines, including those from NCCN, UK, Australasian, and ESMO. We conducted...
Mon May 25, 2020 03:00
Aim/Objectives/Background: The American College of Radiology (ACR) and the American Society for Radiation Oncology (ASTRO) have jointly developed the following practice parameter for image-guided radiation therapy (IGRT). IGRT is radiation therapy that employs imaging to maximize accuracy and precision throughout the entire process of treatment delivery with the goal of optimizing accuracy and reliability of radiation therapy to the target, while minimizing dose to normal tissues. Methods:...
Fri May 22, 2020 03:00
Abstract Background There has been great interest recently in the mechanisms of cell‐to‐cell communication through microvesicles (MV). These structures are produced by many different cell types and can modulate cellular activity by induction of epigenetic alterations. These vesicles may promote tumor mass increase either by stimulating cell proliferation via growth factors or by inhibiting apoptosis, which reinforces the role of such vesicles as important modulators of tumor progression. ...
Tue May 26, 2020 22:55
Enasidenib is an FDA-approved isocitrate dehydrogenase 2 (IDH2) inhibitor, which is used in the treatment of acute myeloid leukemia (AML). We present a case of AML with an IDH2 mutation treated with a regimen of enasidenib and 5-azacitidine, where thyroiditis was noted to be a part of differentiation syndrome. The patient is a 77-year-old woman with IDH2-mutated AML who had initially been started on 100 mg of enasidenib and then presented with dyspnea and was diagnosed with pleural effusion – a common...
Wed May 27, 2020 11:05
Abstract Objectives To compare the stability of apically tapered and straight (non‐tapered cylindrical) implants at the time of immediate placement and to histologically evaluate the healing outcomes after 6 weeks. Materials and Methods The second maxillary incisors were extracted bilaterally in nine dogs. After randomization, apically tapered and straight implants with a 3.3 mm shoulder diameter were inserted into the extraction sockets. The implant stability quotient (ISQ) of the implants...
Tue May 26, 2020 13:46
Objectives CD8+(or CD4+) CD25+fork‐head box transcription factor (Foxp3)+ regulatory T cells (CD8+ or CD4+ Tregs) all play a significant role in immune homeostasis and tolerance. However, the role of CD8+ Tregs in allergic rhinitis (AR) have not been clearly elucidated. The present study was aimed to assess the influence of CD8+ Tregs on peripheral blood mononuclear cells (PBMCs) from AR patients. Study Design Prospective cross‐sectional study. Methods Patients with AR were enrolled....
Tue May 26, 2020 18:41
Objectives: Cochlear implantation in early-deafened patients, implanted as adolescents or adults, is not always advised due to poor expected outcomes. In order to judge whether such reluctance is justified, the current systematic review aimed to gather all available evidence on postoperative outcomes obtained by early-deafened patients using a state-of-the art cochlear implant (CI). Design: Five electronic databases (PubMed, Embase, the Cochrane library, CINAHL, and PsycInfo) were systematically...
Thu May 21, 2020 03:00
Objectives: Following the loss of vestibular function, some patients functionally improve and are minimally bothered by their loss of peripheral function while others remain more symptomatic and are unable to return to their activities of daily living. To date, the mechanisms for functional improvement remain poorly understood. The purpose of the present study was to examine the association between corrective saccades and measures of handicap, dynamic visual acuity, gait, and falls. Design:...
Thu May 21, 2020 03:00
The following narrative chronicles the unlikely events of the author, an editorial director of an oncology publication, whose experience with cancer was purely academic in nature until 2 family members were diagnosed simultaneously with breast cancer and melanoma, respectively. The perspective‐altering encounters from inside the healthcare system revealed critical lessons regarding the importance of patient‐centered care as key to empowering patients and creating a sense of peace for survivors.
Tue May 26, 2020 17:02
Background The current study was performed to identify factors that are present at the time of breast cancer (BC) diagnosis that are associated with a higher rate of central nervous system metastasis (CNSm). Methods The authors analyzed a database of patients with a confirmed diagnosis of BC who were referred for a neuro‐oncology consultation at the National Cancer Institute in Mexico City, Mexico, from June 2009 to June 2017. Information was collected prospectively and included demographic,...
Tue May 26, 2020 15:53
Background Regorafenib is an oral multikinase inhibitor targeting angiogenesis, oncogenesis, and cancer proliferation/metastasis. This study evaluated the efficacy of regorafenib in refractory biliary tract cancer (BTC) in a multi‐institutional phase 2 study. Methods Patients with BTC who progressed on at least 1 line of systemic therapy received regorafenib at 160 mg daily for 21 days on and 7 days off. The primary endpoint was 6‐month overall survival (OS), and the secondary endpoints were...
Tue May 26, 2020 15:50
Background Approximately 50% of children with cancer in the United States who are aged <15 years receive primary treatment on a therapeutic clinical trial. To the authors' knowledge, it remains unknown whether trial enrollment has a clinical benefit compared with the best alternative standard therapy and/or off trial (ie, clinical trial effect). The authors conducted a retrospective matched cohort study to compare the morbidity and mortality of pediatric patients with cancer who are treated on...
Tue May 26, 2020 15:50
Background The current study was conducted to investigate the patterns of metastases in men with metastatic prostatic ductal adenocarcinoma (DAC) and recurrence patterns after therapy. Methods All patients with a new diagnosis of DAC with de novo metastases and those with localized disease who developed metastases after treatment and were treated at the study institution from January 2005 to November 2018 were included. All patient and tumor characteristics and outcome data were collected....
Tue May 26, 2020 15:50
Abstract Accidents resulting in widespread dispersal of radioactive materials have given rise to a need for materials that are convenient in allowing individual dose assessment. The present study examines natural Dead Sea salt adopted as a model thermoluminescence dosimetry system. Samples were prepared in two different forms, loose-raw and loose-ground, subsequently exposed to 60Co gamma-rays, delivering doses in the range 2–10 Gy. Key thermoluminescence (TL) properties were examined,...
Wed May 27, 2020 03:00
AbstractMass deworming against soil-transmitted helminthiasis, including Ascaris lumbricoides (AL), is one of the largest public health interventions in low- and middle-income countries. The prevalence of A. lumbricoides in Tanzania is 6.8%. We present a 3-year-old male of a known Tanzanian nomadic tribe (Masaai tribe) with history of missed deworming, who was brought to the emergency department with a 3-day history of constipation, nonprojectile, bilious vomiting, generalized abdominal distension...
Tue May 26, 2020 03:00
Background: Transcranial motor evoked potential (TcMEP) monitoring is conventionally performed during surgical procedures without or with minimal neuromuscular blockade (NMB) because of its potential interference with signal interpretation. However, full blockade offers increased anesthetic management options and facilitates surgery. Here, the feasibility of TcMEP interpretation was assessed during full NMB in adult neurosurgical patients. Methods: Patients undergoing cervical or lumbar...
Fri May 22, 2020 03:00
Therapeutic Hypothermia and Temperature Management, Ahead of Print.
Fri May 22, 2020 10:00
Therapeutic Hypothermia and Temperature Management, Ahead of Print.
Fri May 22, 2020 10:00
Wed May 27, 2020 03:00
Abstract Purpose of Review In amyotrophic lateral sclerosis (ALS), sleep disruption is frequently present and substantially adds to disease burden. This review aims to summarize current knowledge on causes, pathophysiology, and treatment of sleep disturbances in ALS. Recent Findings Motor neuron degeneration and muscle weakness may lead...
Wed May 27, 2020 03:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue May 26, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Fri May 22, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Fri May 22, 2020 10:00
Wed May 27, 2020 03:00
Future Oncology, Ahead of Print.
Tue May 26, 2020 12:52
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