Purpose. To identify the predicting factors for union and infection after applying the induced membrane technique (IMT) for segmental tibial defects. Methods. A systematic review was carried out following the PRISMA guidelines. All databases were searched for articles published between January 2000 and February 2018 using the keywords “Masquelet technique” and “induced membrane technique.” Studies in English reporting more than 5 cases with accessible individual patient data were included. A meta-analysis...
Wed May 27, 2020 15:05
Genome-Wide Analysis Reveals Genetic Potential for Aromatic Compounds Biodegradation of Sphingopyxis
Members of genus Sphingopyxis are frequently found in diverse eco-environments worldwide and have been traditionally considered to play vital roles in the degradation of aromatic compounds. Over recent decades, many aromatic-degrading Sphingopyxis strains have been isolated and recorded, but little is known about their genetic nature related to aromatic compounds biodegradation. In this study, bacterial genomes of 19 Sphingopyxis strains were used for comparative analyses. Phylogeny showed an ambiguous...
Wed May 27, 2020 15:05
Aims. Tenofovir (TDF) is an antiviral drug with potential risk of kidney injury. The study is aimed at comparing the incidence of acute kidney injury (AKI) between TDF and entecavir (ETV) treatment in hepatitis B virus- (HBV-) related acute on chronic liver failure (ACLF). Methods. Treatment-naive patients with HBV-related ACLF were included. Propensity score matching was used to balance the baseline characteristics between ETV and TDF groups. The risk of AKI and the efficacy of TDF and ETV were...
Wed May 27, 2020 15:05
Recently, polysaccharides from Bletilla striata, a member of the orchidaceous family, aroused the wide interest of people, especially their isolation, chemical properties, and bioactivities. It is reported that these polysaccharides are the most important biologically active components of B. striata, exhibiting various biological activities, such as immunomodulatory, antioxidant, antifibrotic, and hemostatic effects. This review appraised the available literatures which described different aspects...
Wed May 27, 2020 15:05
Objective. The aim of this study is to establish a large animal (dog) model that can be referred clinically for autologous homologous cranioplasty. Methods. Our large skull defect dog model was established by emulating the decompressive craniectomy with 22 adult beagle dogs. The autologous bones were taken out from the dogs and divided into two groups, the freeze-drying (FD) group and the single freezing (SF) group. They were then stored in the bone bank at -20°C after being irradiated with 25 KGy....
Wed May 27, 2020 15:05
This protocol demonstrates how to measure resting state functional connectivity in the human prefrontal cortex using a custom-made diffuse correlation spectroscopy instrument. The report also discuss practical aspects of the experiment as well as detailed steps for analyzing the data.
Wed May 27, 2020 21:00
Here, we present a protocol for parametrizing a tight-binding excitonic Hamiltonian for calculating optical absorption spectra and optoelectronic properties of molecular materials from first-principles quantum chemical calculations.
Wed May 27, 2020 20:21
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundThe McGill Faculty of Medicine implemented a new undergraduate medical curriculum in 2013 with additional preclinical lectures in dermatology. At the time of writing, no Canadian prospective study has been published on undergraduate dermatology training in the context of a complete curricular renewal.ObjectivesOur study was designed to determine the impact of increasing preclinical teaching in dermatology on medical students’ diagnostic...
Wed May 27, 2020 07:33
Publication date: July 2020Source: European Journal of Cancer, Volume 134Author(s): Jean-Marie Michot, Julien Lazarovici, Ashley Tieu, Stéphane Champiat, Anne-Laure Voisin, Mikael Ebbo, Bertrand Godeau, Marc Michel, Vincent Ribrag, Olivier Lambotte
Wed May 27, 2020 20:22
Publication date: July 2020Source: European Journal of Cancer, Volume 134Author(s): Patrick Schöffski, Olivier Mir, Bernd Kasper, Zsuzsanna Papai, Jean-Yves Blay, Antoine Italiano, Charlotte Benson, Katerina Kopeckova, Nasim Ali, Palma Dileo, Axel LeCesne, Franka Menge, Sophie Cousin, Eva Wardelmann, Agnieszka Wozniak, Sandrine Marreaud, Saskia Litiere, Facundo Zaffaroni, Axelle Nzokirantevye, Isabelle Vanden Bempt
Wed May 27, 2020 20:22
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-019-10717-9Upstream open reading frames (uORFs), located in 5’ untranslated regions, are regulators of downstream protein translation. Here, Whiffin et al. use the genomes of 15,708 individuals in the Genome Aggregation Database (gnomAD) to systematically assess the deleteriousness of variants creating or disrupting uORFs.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-019-12438-5Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue of MNVs and estimate their global mutation rate.
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Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16414-2DNA methylation is an epigenetic marker in all domains of life. Here, Jeudy et al., using single-molecule realtime sequencing, determine DNA methylation patterns in giant viruses and evolutionary analysis of virus encoded DNA methyltransferases suggests that they affect viral fitness.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16494-0Strong but flexible graphene tends to wrinkle, which compromises some properties. Here the authors report a solid plasticization method to prepare continuous graphene papers with high crystalline order, achieving high strength, stiffness, electrical and thermal conductivities.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16444-wUntil now, the transcriptome of preimplantation mouse embryos has only been analysed by short-read sequencing. Here, the authors perform long-read sequencing to provide a more detailed transcriptome of the preimplantation mouse embryo, identifying various novel transcripts, for example Kdm4dl.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16432-0The relative contribution of fallopian tube (FT) or ovarian surface epithelium (OSE) to high-grade serous ovarian cancer (HG-SOC) development is unclear. Here, the authors establish organoid models from murine oviductal and OSE tissues that allow cancer modeling via CRISPR-Cas9 genome editing, and report a dual origin of murine HG-SOC.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16567-0Glycosylation plays a key role in shielding of immunogenic epitopes on viral spike (S) proteins. Here Watanabe et al. report that glycans of coronavirus SARS and MERS S proteins are heterogeneously distributed and do not form an efficacious high-density global shield which would ensure efficient immune evasion.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16459-3Phonon polaritons hold promises for nanophotonic applications but external control of phonon polaritons remains challenging. Here, the authors achieve reversible and non-volatile switching of phonon polariton by modifying crystal structure and lattice vibrations via hydrogenation.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16437-9Controlling light with planar elements requires full polarization channels and reconstruction of optical signals. Here, the authors have demonstrated a general method relying on pixelated metasurfaces that enables wavefront shaping with arbitrary output polarization, allowing full utilization of polarization channels.
Wed May 27, 2020 03:00
Nature Communications, Published online: 27 May 2020; doi:10.1038/s41467-020-16454-8The mechanisms regulating regeneration of the earthworm are unclear. Here, the authors use genomic and transcriptomic analysis of the earthworm Eisenia andrei together with Hi-C analysis to identify genes involved and show activation of LINE2 transposable elements on regeneration.
Wed May 27, 2020 03:00
Opinion statement Several studies have investigated the prognosis of soft tissue sarcomas and the influence of a variety of factors, such as size, histology subtype, malignancy grade, site, margins, on overall survival, recurrence-free survival, incidence of local and distant spreading. The impact of genomic and expression profiling on long-term outcomes of patients with sarcomas has been also evaluated in order to fill the knowledge gap of this heterogeneous disease. Nomograms...
Wed May 27, 2020 03:00
Opinion statement Cardiovascular diseases are a common cause of morbidity and mortality in cancer survivors. Furthermore, some cancer therapies are now being increasingly recognized to have negative cardiovascular effects, or cardiotoxicity. Exercise therapy has been found to improve cardiorespiratory fitness in patients with cancer as well as attenuate the cardiotoxic effects of cancer therapy. It is the centerpiece for cardiac and pulmonary rehabilitation programs. It is also...
Wed May 27, 2020 03:00
Opinion statement As the use of neoadjuvant systemic therapy (NAST) increases, the optimal management of the axilla has become increasingly complex. Consensus among professional organizations is that those patients with clinically negative axillary nodes who are being considered for NAST should undergo a sentinel lymph node (SLN) biopsy following NAST. If a positive SLN is subsequently identified, an axillary lymph node dissection (ALND) is the current standard of care. For...
Wed May 27, 2020 03:00
Opinion statement The treatment of advanced GIST is rapidly evolving with the development of novel molecular compounds such as avapritinib and ripretinib, but also promising results have been achieved with cabozantinib in a phase II trial. The availability of over five lines of treatment for patients with advanced GIST is likely to completely shift the current second-line and third-line treatment options, and will also potentially enable a personalised approach to treatment....
Wed May 27, 2020 03:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00419G, PaperAlvaro Garcia Cruz, Todd Cowen, Annelies Voorhaar, Elena Piletska, Sergey PiletskyA novel molecularly imprinted polymer nanoparticle-based assay (MINA) performed in magnetic microplates was developed as an improved high-quality alternative to existing antibody-based immunoassays. MINA is a generic technology that can...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed May 27, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00649A, PaperStefano Materazzi, Patrizia Caprari, Elena Carcassi, Giuseppina Gullifa, Sara Massimi, Roberta RisolutiSystematic screening for congenital erythrocyte disorders is not a common practice, due to a lack in the accuracy of the methods and to the costs of the analyses. As a...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed May 27, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00664E, PaperKuangwen Hsieh, Guojie Zhao, Jeff Tza-Huei WangDevelopment CRISPR/Cas-based in vitro diagnostic devices, or CRISPR/Cas-Dx, has become an intensely researched area. Among the different classes of CRISPR/Cas-Dx, the class based on the Cas12a enzyme (i.e., CRISPR/Cas12a-Dx or...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed May 27, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00924E, PaperYong-Ill Lee, Qi Ou, Salah Mahmoud Tawfik, xinfeng ZhangAn increasing number of patients are living with Alzheimer's disease (AD); thus, the need for a method to detect AD early and sensitively has become urgent, and the demand for...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed May 27, 2020 02:00
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