Exosomes are small membrane vesicles that retain various substances such as proteins, nucleic acids, and small RNAs. Exosomes play crucial roles in many physiological and pathological processes, including innate immunity. Innate immunity is an important process that protects the organism through activating pattern recognition receptors (PRRs), which then can induce inflammatory factors to resist pathogen invasion. Toll-like receptor (TLR) is one member of PRRs and is important in pathogen clearance...
Wed May 27, 2020 14:50
Objective. To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods. Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographic, clinical and therapeutic data were collected and statistically analysed after having clustered patients according to different times at disease onset, penetrance of mutations, dosage...
Wed May 27, 2020 13:50
Wed May 27, 2020 23:35
The aim of this study was to compare the efficacy and safety of the different local anaesthetic agents for the extraction of impacted lower third molars. A network meta-analysis was performed of all published reports of randomized controlled clinical trials assessing efficacy (anaesthetic success and absence of need for supplementary anaesthesia during the surgical procedure) and/or safety (number of adverse events) of anaesthetic agents. Three electronic databases were searched, from their earliest...
Wed May 27, 2020 03:00
Oral rehabilitation after treatment for head and neck cancer can be challenging. Implant-supported rehabilitation can considerably improve oral health-related quality of life, but there is a dearth of contemporary evidence of reported outcomes and trends in this cohort. In this study we retrospectively investigated the outcomes of 115 patients (376 dental implants) with a mean (range) follow up of 3.91(0.11-12.76) years. We considered survival of the implants, percentage of those used for prosthetic...
Wed May 27, 2020 03:00
The frequency of genetic variants associated with attention-deficit/hyperactivity disorder (ADHD) has decreased progressively in the evolutionary human lineage from the Paleolithic to the present day, according to new research.
Wed May 27, 2020 19:33
The interaction between 'transfer RNAs' and the enzymes that help them in protein synthesis has always been the key area of interest for understanding the evolution of the genetic code. Now, a team of scientists reports that a subunit of 'alanyl-tRNA synthetase' enzyme of the primitive microorganism Nanoarchaeum equitans can mimic the super-primitive tRNA 'aminoacylation' independent of the presence of a special 'G3:U70' base pair, a property previously unseen in primitive organisms.
Tue May 26, 2020 23:11
One of the most promising theories for the evolution of human speech has finally received support from chimpanzee communication.
Wed May 27, 2020 03:35
Publication date: Available online 26 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Tatsurou Tanaka, Ray Tanaka, Andy Wai Kan Yeung, Michael M Bornstein, Shun Nishimura, Masafumi Oda, Manabu Habu, Osamu Takahashi, Daigo Yoshiga, Teppei Sago, Ikuya Miyamoto, Masaaki Kodama, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Takaaki Joujima, Yuichi Miyamura, Yasuhiro Morimoto
Wed May 27, 2020 23:52
Publication date: Available online 27 May 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nazan Degirmenci, Selahattin Tugrul, Seda Sezen Goktas, Erol Senturk, Omer Faruk Calim, Remzi Dogan, Alper Yenigun, Orhan Ozturan
Wed May 27, 2020 23:50
Publication date: Available online 27 May 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Leila Chew, Brooke M. Su-Velez, Jessa E. Miller, Alisha N. West
Wed May 27, 2020 23:50
Publication date: Available online 26 May 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nigel Wang, Glenn Isaacson
Wed May 27, 2020 23:50
Publication date: Available online 26 May 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Leila Ghayedlou, Akram Ahmadi, Ali Ghorbani, Farhad Torabinezhad, Mohammad Reza Keyhani, Seyed Basir Hashemi
Wed May 27, 2020 23:50
Publication date: Available online 26 May 2020Source: NeuroImageAuthor(s): Wei Xiong, Xiaoxue Gao, Zhewen He, Hongbo Yu, Huiying Liu, Xiaolin Zhou
Wed May 27, 2020 23:49
Publication date: Available online 26 May 2020Source: NeuroImageAuthor(s): Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quidé, Melissa Green, Cynthia Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley
Wed May 27, 2020 23:49
Publication date: Available online 26 May 2020Source: NeuroImageAuthor(s): Daouia I. Larabi, Remco J. Renken, Joana Cabral, Jan-Bernard C. Marsman, André Aleman, Branislava Ćurčić-Blake
Wed May 27, 2020 23:49
Publication date: Available online 26 May 2020Source: Hearing ResearchAuthor(s): Jana Van Canneyt, Jan Wouters, Tom Francart
Wed May 27, 2020 22:41
BACKGROUND There is no established standard of care for treatment of nail unit squamous cell carcinoma (SCC). OBJECTIVE The aim of the study is to further characterize the clinical characteristics and diagnostic considerations of nail unit SCC and to examine the outcomes of patients with nail unit SCC treated with Mohs micrographic surgery (MMS). MATERIALS AND METHODS A retrospective review was conducted of patients treated for nail unit SCC with MMS from January 1, 2006, to December...
Wed May 27, 2020 22:38
No abstract available
Wed May 27, 2020 22:38
BACKGROUND Mohs micrographic surgery (MMS) is a cost-effective treatment for nonmelanoma skin cancer that bundles costs for surgical excision, tissue processing, and histopathological interpretation. A comprehensive MMS bundle would include all aspects of an episode of care (EOC), including costs of reconstruction, preoperative, and postoperative care. OBJECTIVE To assess the feasibility of an alternative payment model for MMS and reconstruction. METHODS Retrospective chart review and...
Wed May 27, 2020 22:38
BACKGROUND Knowledge regarding the inpatient burden of cutaneous squamous cell carcinoma (cSCC) is limited. OBJECTIVE To provide nationally representative estimates for hospitalization characteristics due to cSCC and determine predictors for increased length of stay (LOS) and cost of care. METHODS/MATERIALS A retrospective cohort study of the 2009 to 2015 National Inpatient Sample. Weighted multivariate logistic/linear regression models were created to evaluate sociodemographic factors...
Wed May 27, 2020 22:38
No abstract available
Wed May 27, 2020 22:38
BACKGROUND The Mohs Appropriate Use Criteria (MAUC) have come into question recently regarding the most appropriate treatment for superficial basal cell carcinoma (sBCC). At the heart of this debate is the limited body of evidence describing tumor behavior of sBCC based on clinical factors relevant to the MAUC. OBJECTIVE To determine whether sBCC is more likely to harbor aggressive subtypes in high-risk anatomical locations and in immunocompromised patients. MATERIALS AND METHODS A single...
Wed May 27, 2020 22:38
BACKGROUND An adipose-derived stem cell–conditioned medium (ADSC-CM) reportedly exerts skin-rejuvenating and hair growth-promoting effects. In the therapeutic application of ADSC-CM for alopecia, changes to the interfollicular scalp remain unclear although some evidence has indicated hair growth-promoting effects. OBJECTIVE To evaluate the effects of ADSC-CM not only on hair follicles, but also on the interfollicular scalp. METHODS Forty patients (21 men, 19 women; age range, 23–74 years)...
Wed May 27, 2020 22:38
No abstract available
Wed May 27, 2020 22:38
No abstract available
Wed May 27, 2020 22:38
BACKGROUND Subclinical extension (SCE) of basal cell carcinomas (BCCs) may be responsible for incomplete resection of the tumor. The aggressive histological patterns (micronodular, infiltrative, and morpheaform) have greater tendencies toward invading surrounding tissues in an irregular pattern. OBJECTIVE To determine the SCE of small facial aggressive BCCs excised using Mohs micrographic surgery (MMS). MATERIALS AND METHODS An observational case series study. Data of patients with facial...
Wed May 27, 2020 22:38
No abstract available
Wed May 27, 2020 22:38
BACKGROUND Patients are often concerned about the cosmetic appearance of scars following Mohs micrographic surgery (MMS), including residual erythema. However, few studies have compared the cosmetic outcomes between different suturing techniques. OBJECTIVE To compare the erythema intensity (EI) associated with interrupted sutures (IS) and continuous sutures (CS), and the degree of its reduction over time. MATERIALS AND METHODS Mohs micrographic surgery patients were randomized to have...
Wed May 27, 2020 22:38
No abstract available
Wed May 27, 2020 22:38
BACKGROUND As the practice of dermatology becomes increasingly procedurally based, there is a concordant rise in musculoskeletal injury (MSI) risk. Dermatologic surgeons are most susceptible and, although the majority suffer from MSI, few have received any formal ergonomics training. This stems from a lack of awareness of this troubling trend and a paucity of research and education on the ergonomics of dermatologic surgery. OBJECTIVE To highlight pertinent ergonomics principles and strategies...
Wed May 27, 2020 22:38
BACKGROUND Typical prophylactic coverage of suspected cutaneous surgical-site infections (SSIs) predominantly covers gram-positive bacteria. Data regarding the frequency of infection with unusual bacteria, not covered by prophylaxis, are not available. OBJECTIVE A retrospective 10-year review of culture-positive infections at a single academic site was performed. MATERIALS AND METHODS All positive bacterial culture results at the Washington University Center for Dermatologic and Cosmetic...
Wed May 27, 2020 22:38
BACKGROUND Androgenic alopecia (AGA) is a common hair loss disorder. Studies have demonstrated successful treatment with platelet-rich plasma (PRP) in men, but studies in women are few. OBJECTIVE To evaluate PRP in the treatment of AGA in women, compared with topical minoxidil. MATERIALS AND METHODS Twenty women with AGA received topical minoxidil for 12 weeks and injectable PRP for 12 weeks in a randomized crossover design with an 8-week washout between treatments. Standardized TrichoScan...
Wed May 27, 2020 22:38
BACKGROUND The appearance and symptoms of scars can cause significant distress to patients. OBJECTIVE To assess and compare efficacy of the 1,500-nm nonablative fractional laser (NAFL) and 10,600-nm ablative fractional laser (AFL) in reducing symptoms and improving the appearance of traumatic or surgical scars. MATERIALS AND METHODS Single-center prospective, randomized, blinded, split-scar study was conducted on 100 patients with a scar obtained through trauma or surgery. Three treatments...
Wed May 27, 2020 22:38
No abstract available
Wed May 27, 2020 22:38
BACKGROUND In recent years, fractional ablative lasers at low density have proven to be the centerpiece in a multimodality approach to treating hypertrophic burn scars. OBJECTIVE To determine the safety and efficacy of fractional ablative erbium-doped yttrium aluminium garnet (Er:YAG) laser in the treatment of hypertrophic burn scars. METHODS Eleven patients received 3 fractional ablative Er:YAG laser to hypertrophic burn scars at 400 to 800 μm, density 11%, no coagulation, and single...
Wed May 27, 2020 22:38
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