Τετάρτη 27 Μαΐου 2020


Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma
Abstract Background The TFAP2 family of transcription factors, regulating gene expression related to vertebrate evolution, have been studied extensively in human cancer. However, the distinct roles of each TFAP2 in the expression and prognostic significance of lung carcinoma have not been elucidated yet. Objective This study is aimed to identify the...
Latest Results for Genes & Genomics
7h
The characteristic of the synonymous codon usage and phylogenetic analysis of hepatitis B virus
Abstract Background Hepatitis B virus (HBV) infection is a crucial medical issue worldwide. The dependence of HBV replication on host cell machineries and their co-evolutionary interactions prompt the codon usage pattern of viral genes to translation selection and mutation pressure. Objective The evolutionary characteristics of HBV and the natural...
Latest Results for Genes & Genomics
7h
Pediatric patient transport in a child-specific device
Always make sure you secure pediatric patients in a pediatric specific car seat during transport
EMS1 Tips
7h
Evolutionary causes and consequences of bacterial antibiotic persistence
Nature Reviews Microbiology, Published online: 27 May 2020; doi:10.1038/s41579-020-0378-zAntibiotic persistence is a threat to effective treatment of bacterial infections. In this Review, Bakkeren, Diard and Hardt discuss the evolutionary forces that have favoured the development of persisters in populations and the consequences for spread of resistance and virulence determinants.
Nature Reviews Microbiology - Issue - nature.com science feeds
8h
Heparanase, cell signaling, and viral infections
Abstract Heparanase (HPSE) is a multifunctional protein endowed with many non-enzymatic functions and a unique enzymatic activity as an endo-β-d-glucuronidase. The latter allows it to serve as a key modulator of extracellular matrix (ECM) via a well-regulated cleavage of heparan sulfate side chains of proteoglycans at cell surfaces. The cleavage and associated changes at the ECM cause release of multiple signaling molecules with important cellular and pathological functions. New...
Latest Results for Cellular and Molecular Life Sciences
8h
Programmed genome rearrangements in ciliates
Abstract Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex. The transformation from germline to soma genome involves massive DNA elimination mediated by non-coding RNAs, chromosome fragmentation, as well as...
Latest Results for Cellular and Molecular Life Sciences
8h
Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas
Abstract Long non-coding RNAs (lncRNAs) are a largely uncharacterized group of non-coding RNAs with diverse regulatory roles in various biological processes. Recent observations have elucidated the functional roles of lncRNAs in cutaneous biology, e.g. in proliferation and differentiation of epidermal keratinocytes and in cutaneous wound repair. Furthermore, the role of lncRNAs in keratinocyte-derived skin cancers is emerging, especially in cutaneous squamous cell carcinoma (cSCC),...
Latest Results for Cellular and Molecular Life Sciences
17h
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases
Abstract Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK class II members, DYRK2 is considered a unique protein due to its role in disease. According to the post-transcriptional and post-translational modifications, DYRK2 expression greatly differs among human tissues. Regarding its mechanism of action, this kinase performs direct phosphorylation...
Latest Results for Cellular and Molecular Life Sciences
20h
Lactobacillus fermentum and Lactobacillus plantarum bioremediation ability assessment for copper and zinc
Abstract Some probiotic strains, such as Lactobacillus spp., are options for the removal of heavy metals from food, water and soil. Although copper or zinc are essential for use in many biochemical processes, they are toxic at high concentrations. The purpose of the current study was to evaluate two Lactobacillus strains for their application in the bioremediation of copper and zinc from aqueous solution. The biomass of Lactobacillus fermentum and Lactobacillus plantarum were treated...
Latest Results for Archives/ /of/ /Microbiology
8h
Metatranscriptomic analysis of modified atmosphere packaged poultry meat enables prediction of Brochothrix thermosphacta and Carnobacterium divergens in situ metabolism
Abstract In this study, in situ-expressed metabolic routes of Brochothrix (B.) thermosphacta and Carnobacterium (C.) divergens were evaluated based on a metatranscriptomic dataset from bacteria growing on MAP chicken meat (O2/CO2; N2/CO2). Both species exhibited no (C. divergens) or minor transcription regulation (B. thermosphacta) within their main metabolic routes in response to different atmospheres. Both employ pathways related to glucose and ribose. Gluconeogenesis from lipid-borne...
Latest Results for Archives/ /of/ /Microbiology
12h
Author Correction: Respiratory virus shedding in exhaled breath and efficacy of face masks
Nature Medicine, Published online: 27 May 2020; doi:10.1038/s41591-020-0946-9Author Correction: Respiratory virus shedding in exhaled breath and efficacy of face masks
Nature Medicine - Issue - nature.com science feeds
8h
The effect of LRRK2 loss-of-function variants in humans
Nature Medicine, Published online: 27 May 2020; doi:10.1038/s41591-020-0893-5Analysis of large genomic datasets, including gnomAD, reveals that partial LRRK2 loss of function is not strongly associated with diseases, serving as an example of how human genetics can be leveraged for target validation in drug discovery.
Nature Medicine - Issue - nature.com science feeds
8h
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma
Nature Medicine, Published online: 27 May 2020; doi:10.1038/s41591-020-0900-xMultiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions
Nature Medicine - Issue - nature.com science feeds
8h
Case 19-2020: A 74-Year-Old Man with Acute Respiratory Failure and Unclear Goals of Care
Presentation of Case. Dr. Kathy M. Tran: A 74-year-old man with mantle-cell lymphoma was admitted to this hospital during the coronavirus disease 2019 (Covid-19) pandemic because of acute respiratory failure. One day before this admission, productive cough and dyspnea developed. The next day, when…
The New England Journal of Medicine: Search Results in Infectious Disease
8h
Remdesivir — An Important First Step
Beigel et al. have provided in the Journal the first report of an effective treatment for Covid-19, resulting from a rigorously designed and conducted clinical trial. It is remarkable that a randomized, placebo-controlled trial of a potential antiviral treatment for a disease whose pathogenesis is…
The New England Journal of Medicine: Search Results in Infectious Disease
8h
Where Do the Children Play?
We are both physician trainees — a cardiology fellow and a general surgery resident — in New York City. We are one of the nearly 10,000 dual-physician couples nationwide who, over the past 30 years, have embarked on the arduous journey of medical training together. Like many of our colleagues…
The New England Journal of Medicine: Search Results in Infectious Disease
8h
Hospitalization and Mortality among Black Patients and White Patients with Covid-19
Surveillance of the clinical characteristics and outcomes of hospitalized patients with coronavirus disease 2019 (Covid-19) is imperative for elucidating the epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States. As of May 13, 2020, the United States…
The New England Journal of Medicine: Search Results in Infectious Disease
8h
Long-Term Care Policy after Covid-19 — Solving the Nursing Home Crisis
Nursing homes have been caught in the crosshairs of the coronavirus pandemic. As of early May 2020, Covid-19 had claimed the lives of more than 28,000 nursing home residents and staff in the United States. But U.S. nursing homes were unstable even before Covid-19 hit. They were like tinderboxes,…
The New England Journal of Medicine: Search Results in Infectious Disease
8h
FDA Approves New Biologic for Atopic Dermatitis in Children
Dupilumab (Dupixent) injection has been approved for adults since 2017. The new indication is for children whose atopic dermatitis is not adequately controlled with topical prescription therapies. FDA Approvals
Medscape Dermatology Headlines
8h
Does a gender have something to do with clinical pictures of primary spontaneous pneumothorax?
Abstract Objective Primary spontaneous pneumothorax is relatively rarer in women than in men. In addition, women develop secondary spontaneous pneumothorax, such as lymphangioleiomyomatosis, which is rare and difficult to diagnose. Therefore, the clinical characteristics of primary spontaneous pneumothorax in women remain unknown presently. We compared the clinical characteristics of primary spontaneous pneumothorax between the two...
Latest Results for General Thoracic and Cardiovascular Surgery
8h
Strategies to Achieve Spinal Fusion in Multilevel Anterior Cervical Spine Surgery: An Overview
Abstract Background Anterior cervical fusion offers surgeons a safe and reliable surgical option for single-level and multilevel pathology; however, multilevel fusions pose a higher risk of complications than single-level fusions, including possible pseudoarthrosis, adjacent segment disease, sagittal imbalance, and construct subsidence. Various techniques can be used to mitigate risk in multilevel anterior cervical fusion. ...
Latest Results
8h
Surgical Strategies for the Treatment of Lumbar Pseudarthrosis in Degenerative Spine Surgery: A Literature Review and Case Study
Abstract Background Pseudarthrosis after lumbar fusion can generate pain and disability and often requires revision. However, results of revision procedures have historically been relatively poor. Questions/Purpose The aim of this review was to examine the current evidence related to the management of lumbar pseudarthrosis, with a focus on revision...
Latest Results
8h
Posterior Fusion for the Subaxial Cervical Spine: A Review of the Major Techniques
Abstract Posterior fusion is a powerful tool to address pathology of the cervical spine, but the decision to fuse at any level should be made with great care. Various methods and constructs for posterior cervical fusion exist, all of which aim to restore the posterior tension band’s ability to resist flexion forces. We identified articles regarding posterior fusion of the subaxial cervical spine in MEDLINE, Google Scholar, and PubMed. This article is a narrative review of earlier...
Latest Results
8h
History of Spinal Fusion: Where We Came from and Where We Are Going
Abstract Spinal fusion surgery is performed all over the world to help patients with cervical and thoracolumbar pathology. As outcomes continue to improve in patients with spine-related pathology, it is important to understand how we got to modern day spinal fusion surgery. Scientific innovations have ranged from the first spinal fusions performed with basic instrumentation in the late nineteenth century to contemporary tools such as pedicle screws, bone grafts, and interbody...
Latest Results
8h
Technologies to Enhance Spinal Fusion: Bench to Bedside
Latest Results
8h
Current Concepts in Spinal Fusion: A Special Issue
Latest Results
8h
Etiology-Based Classification of Adjacent Segment Disease Following Lumbar Spine Fusion
Abstract Background Adjacent segment disease (ASDz) is a potential complication following lumbar spinal fusion. A common nomenclature based on etiology and ASDz type does not exist and is needed to assist with clinical prognostication, decision making, and management. Questions/Purposes The objective of this study was to develop an etiology-based...
Latest Results
8h
Minimally Invasive Spine Lumbar Surgery in Obese Patients: A Systematic Review and Meta-Analysis
Abstract Background Transforaminal lumbar interbody fusion (TLIF) is the treatment of choice for lumbar spinal stenosis and spondylolisthesis. The procedure can be performed through a traditional open approach (O-TLIF) or through minimally invasive techniques (MI-TLIF). Spinal surgeries in obese patients can pose risks, including increased rates of infection and thromboembolic events. ...
Latest Results
8h
Etiology of Lumbosacral Radiculoplexopathy: Sacral Insufficiency Fracture on Magnetic Resonance Imaging
Abstract Background Sacral insufficiency fracture (SIF) can cause lumbosacral radiculoplexopathy (LSRP) and is probably under-recognized. Symptoms may include nonspecific lumbar spine or buttock pain that is exacerbated by physical activity and alleviated with rest. The frequency of LSRP secondary to SIF has not been reported. Questions/Purposes ...
Latest Results
8h
The Importance of Surface Technology in Spinal Fusion
Latest Results
8h
Awake Endoscopic Transforaminal Lumbar Interbody Fusion: A Technical Note
Abstract Background Advances in modern spinal fusion techniques have allowed for less peri-operative morbidity and more rapid recovery from surgery. The addition of endoscopy to minimally invasive surgery (MIS) fusion techniques represents the latest progression of efforts to minimize the impact of surgical intervention. Technique MIS transforaminal...
Latest Results
8h
The Advances in the Science and Clinical Practice of Spinal Fusion Are Real
Latest Results
8h
Lateral Lumbar Interbody Fusion: What Is the Evidence of Indirect Neural Decompression? A Systematic Review of the Literature
Abstract Background In the past decade, lateral lumbar interbody fusion (LLIF) has gained in popularity. A proposed advantage is the achievement of indirect neural decompression. However, evidence of the effectiveness of LLIF in neural decompression in lumbar degenerative conditions remains unclear. Questions/Purposes We sought to extrapolate...
Latest Results
8h
Cranial facet joint injuries in percutaneous lumbar pedicle screw placement: a matched-pair analysis comparing intraoperative 3D navigation and conventional fluoroscopy
Abstract Purpose The violation of the cranial adjacent facet is a frequent complication in lumbar instrumentations and can induce local pain and adjacent segment disease. Minimally invasive screw implantation is often stated as risk factor in comparison with open approaches. Percutaneous pedicle screw placement (PPSP) can be performed using single X-ray images (fluoroscopy) or intraoperative 3D navigation. The study compares top-level...
Latest Results for European Spine Journal
8h
Correction to: Nucleus replacement could get a new chance with annulus closure
Unfortunately, Fig. 7 and last paragraph of the result section have been incorrectly published. The complete corrected Fig. 7 and last paragraph of the results part (IDP measurements) have been as follows.
Latest Results for European Spine Journal
14h
The non-specific and sex-differential effects of vaccines
Nature Reviews Immunology, Published online: 27 May 2020; doi:10.1038/s41577-020-0338-xIn this Viewpoint article, members of the Optimmunize consortium discuss the evidence for non-specific and sex-differential effects of vaccines and how this information might inform vaccine design and policy, including in relation to the COVID-19 pandemic.
Nature Reviews Immunology - Issue - nature.com science feeds
8h
Brain–spleen link tunes immunity
Nature Reviews Immunology, Published online: 27 May 2020; doi:10.1038/s41577-020-0347-9A pathway connecting the brain and spleen allows neural activity to modulate adaptive immune responses.
Nature Reviews Immunology - Issue - nature.com science feeds
13h
Risk factors for death from COVID-19
Nature Reviews Immunology, Published online: 27 May 2020; doi:10.1038/s41577-020-0351-0Risk factors for death from COVID-19
Nature Reviews Immunology - Issue - nature.com science feeds
13h

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