Chemosensors, Vol. 8, Pages 25: Development of a New Analytical Method for Determination of Veterinary Drug Oxyclozanide by Electrochemical Sensor and Its Application to Pharmaceutical Formulation Chemosensors doi: 10.3390/chemosensors8020025 Authors: Ersin Demir Hulya Silah A novel highly selective, sensitive and simple analytical technique was recommended for the investigation of anthelmintic veterinary drug oxyclozanide based on square wave anodic stripping voltammetry (SWASV)...
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Chemosensors, Vol. 8, Pages 26: Silver Nanoparticles as Colorimetric Sensors for Water Pollutants Chemosensors doi: 10.3390/chemosensors8020026 Authors: Paolo Prosposito Luca Burratti Iole Venditti This review provides an up-to-date overview on silver nanoparticles-based materials suitable as optical sensors for water pollutants. The topic is really hot considering the implications for human health and environment due to water pollutants. In fact, the pollutants present in the...
12h
Abstract The growing role of precision medicine in hepatocellular carcinoma (HCC) is expected to ameliorate the poor prognosis and high mortality of this highly malignant disease; however, it is faced with challenges such as the low frequency of tissue biopsy. Hence, attention is turning to the circulating tumor DNA (ctDNA), an important component of liquid biopsy. Obtaining molecular information about cancer from blood provides a good prospect in precision oncology including molecular...
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Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study, we apply proteomics and phosphoproteomics to investigate the downstream effectors of mTORC2 in brown adipocytes. We compare wild-type controls to isogenic cells with an induced knockout of the mTORC2 subunit RICTOR (Rictor-iKO) by stimulating each with insulin...
25m
In bottom-up mass spectrometry-based proteomics, relative protein quantification is often achieved with data-dependent acquisition (DDA), data-independent acquisition (DIA), or selected reaction monitoring (SRM). These workflows quantify proteins by summarizing the abundances of all the spectral features of the protein (e.g., precursor ions, transitions or fragments) in a single value per protein per run. When abundances of some features are inconsistent with the overall protein profile (for technological...
25m
Drug resistance is a major obstacle to curative cancer therapies, and increased understanding of the molecular events contributing to resistance would enable better prediction of therapy response, as well as contribute to new targets for combination therapy. Here we have analyzed the early molecular response to epidermal growth factor receptor (EGFR) inhibition using RNA sequencing data covering 13 486 genes and mass spectrometry data covering 10 138 proteins. This analysis revealed a massive response...
25m
Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study, we apply proteomics and phosphoproteomics to investigate the downstream effectors of mTORC2 in brown adipocytes. We compare wild-type controls to isogenic cells with an induced knockout of the mTORC2 subunit RICTOR (Rictor-iKO) by stimulating each with insulin...
8h
In bottom-up mass spectrometry-based proteomics, relative protein quantification is often achieved with data-dependent acquisition (DDA), data-independent acquisition (DIA), or selected reaction monitoring (SRM). These workflows quantify proteins by summarizing the abundances of all the spectral features of the protein (e.g., precursor ions, transitions or fragments) in a single value per protein per run. When abundances of some features are inconsistent with the overall protein profile (for technological...
8h
Drug resistance is a major obstacle to curative cancer therapies, and increased understanding of the molecular events contributing to resistance would enable better prediction of therapy response, as well as contribute to new targets for combination therapy. Here we have analyzed the early molecular response to epidermal growth factor receptor (EGFR) inhibition using RNA sequencing data covering 13 486 genes and mass spectrometry data covering 10 138 proteins. This analysis revealed a massive response...
9h
IntroductionDespite the high prevalence of musculoskeletal injuries, there is a shortage of data quantifying the risk factors attributable to cumulative occupational demands among UK Military personnel. We developed a new comprehensive questionnaire that examines occupational and operational physical loading during military service. The aim of this study was to examine the test–retest reliability of the Military Physical Loading Questionnaire (MPLQ).MethodsIntraclass correlation coefficients (ICC)...
4h
Tissue Engineering Part A, Ahead of Print.
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Tissue Engineering Part A, Ahead of Print.
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Spanish flu: A pandemic of influenza A (H1N1) in 1918-19 that caused the highest number of known flu deaths. More than 500,000 people died in the United States, and 20 million to 50 million people may have died worldwide. Many people died within the first few days after infection and others died of complications soon after. Nearly half of those who died were young, healthy adults. Also known as Spanish influenza. The Spanish flu pandemic is the catastrophe against which all modern pandemics are...
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Abstract Real-world data on regimens for relapsed/refractory multiple myeloma (RRMM) represent an important component of therapeutic decision-making. This multi-centric, retrospective, observational study conducted by the treating physicians evaluated the effectiveness and safety of ixazomib-lenalidomide-dexamethasone (IRd) in 155 patients who received ixazomib via early access programs in Greece, the UK, and the Czech Republic. Median age was 68 years; 17% had an Eastern Cooperative...
1h
Abstract The utilization of natural zeolite (NZ) as an adsorbent for NH4+ removal was investigated. Three types of NZ (i.e., NZ01, NZ02, and NZ03) were characterized, and their NH4+ adsorption process in aqueous solution was evaluated. The effect of pH towards NH4+ adsorption showed that the NZ01 has the highest NH4+ adsorption capacity compared with other natural zeolites used. The application of NZ01 for a simultaneous removal of NH4+ and turbidity in synthetic NH4+-kaolin suspension...
2h
Abstract Hydrogeochemical understanding of groundwater is essential for the effective management of groundwater. This study has been carried out to have concrete data for the seasonal variations in hydrogeochemistry of groundwater in central Tamilnadu forming a complex geological terrain with a varied lithology. A total of 244 groundwater samples were collected during four different seasons, viz, southwest monsoon (SWM), summer (SUM), postmonsoon (POM), and northeast monsoon (NEM)...
4h
Abstract It is very necessary to produce bio-activated carbon for special use with easy procedure and low cost. One kind of huge surface area microporous bio-material was successfully prepared from agricultural residues (peanut shell, Arachis hypogaea Linn.) and beneficially applied to control elemental mercury (Hg0) in simulated coal-fired flue gas in this study. The possible effects of experimental factors including activator, reaction temperature, and flue components were investigated....
5h
Abstract On the basis of resource carrying capacity, this study used the revised theory of relative resource carrying capacity, took Guiyang as the study object, and calculated relative carrying capacities of natural resources, economic resources, environmental resources, and social resources from 2003 to 2017. Natural resources were composed of three indicators (energy resources, water resources, and land resources). Human capital resources were incorporated into social resources....
7h
Abstract The effects of mixtures of nanoparticles (NPs) and other chemicals have been poorly studied in terrestrial invertebrates. In this study, we investigated the effects of binary mixtures of goethite (α-FeOOH) NPs and metallic (Cd and Pb) or organic (chlorpyrifos, CPF) contaminants in Eisenia andrei earthworms. We used the filter paper contact test to evaluate (i) the uptake of NPs in organisms exposed to the mixtures of NPs+Metals and NPs+CPF and (ii) the potential effects...
9h
Abstract Purpose Predicting thermal protein stability is of major interest in the development of protein-based biopharmaceuticals. Therefore, this study provides a predictive tool for determining transition enthalpies, which can be used for ranking different proteins according to their thermal stability. Methods Unfolding and aggregation profiles...
2h
Abstract Purpose Abiraterone acetate (AbA) is a poorly water-soluble drug with an oral bioavailability of <10% and a significant pharmaceutical food effect. We aimed to develop a more efficient oral solid-state lipid-based formulation for AbA using a supersaturated silica-lipid hybrid (super-SLH) approach to achieve high drug loading, improve in vitro solubilization and mitigate the food effect, while gaining a mechanistic insight...
10h
Bottlenose dolphins in Shark Bay, Australia form alliances and coordinate the timing of their clicking noises to attract females and deter other males
2h
Wine tears – the drops that form inside a glass after wine is swirled in a glass – are caused by the formation of an unstable shock wave
7h
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
9h
New York City is the epicentre of the coronavirus outbreak in the US and hospitals are already struggling to treat everyone with covid-19, though the outbreak may not peak for three weeks
9h
The Permian extinction, which wiped out almost all complex life, may have been caused by the undersides of continents slipping off into Earth’s interior
9h
Tropical seas are ecological hotspots where predators should be active and easy to catch – but 50 years of data shows sharks are easier to catch in cooler seas
11h
Inside a mountain in the Arctic, Microsoft is building a backup of open-source software that it says will keep the code safe for 1000 years
11h
The new coronavirus has led to a drastic reduction in air pollution and greenhouse gas emissions, but no credible environmentalists say the response to the pandemic is a solution to climate change
13h
Fundamental limits on space and time mean that the motion of three black holes is impossible to predict, even with the most powerful computer that could ever be built
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A shrimp-like creature found 6 kilometres down in the Pacific Ocean’s deepest trench has been named Eurythenes plasticus after the microplastics found in its gut
21h
Abstract This study was aimed to design a simple and novel prototype device for the production of polymeric microparticles. To prove the effectiveness of this device, benznidazole microparticles using chitosan as carrier and NaOH, KOH, or SLS as counter ions were used. For comparison, benznidazole microparticles were prepared by the conventional dripping technique (syringe and gauge) using the same excipients. Microparticles were characterized in terms of encapsulation efficiency,...
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Abstract Low solubility of active pharmaceutical compounds (APIs) remains an important challenge in dosage form development process. In the manuscript, empirical models were developed and analyzed in order to predict dissolution of bicalutamide (BCL) from solid dispersion with various carriers. BCL was chosen as an example of a poor water-soluble API. Two separate datasets were created: one from literature data and another based on in-house experimental data. Computational experiments...
11h
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