Related ArticlesCochlear implantation in prelingually deaf children with white matter lesions. Eur Arch Otorhinolaryngol. 2020 May 28;: Authors: Chen S, Zheng W, Li H, Zhong M, Wei R, Zhang B, Tong B, Qiu J, Yao K Abstract OBJECTIVE: White matter lesions (WMLs) are the most common central nervous system changes observed during cochlear implant evaluation. However, its clinical significance in cochlear implantation (CI) remains unclear. The purpose...
Fri May 29, 2020 13:30
Related ArticlesChronic cough related to the upper airway cough syndrome: one entity but not always the same. Eur Arch Otorhinolaryngol. 2020 May 27;: Authors: Dąbrowska M, Arcimowicz M, Grabczak EM, Truba O, Rybka A, Białek-Gosk K, Klimowicz K, Jamróz B, Niemczyk K, Krenke R Abstract PURPOSE: Upper airway cough syndrome (UACS), described as chronic cough (CC) associated with allergic (AR), non-allergic rhinitis (NAR) or chronic rhinosinusitis (CRS),...
Fri May 29, 2020 13:30
Related ArticlesQuassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform. Commun Biol. 2020 May 27;3(1):267 Authors: Pei Y, Hwang N, Lang F, Zhou L, Wong JH, Singh RK, Jha HC, El-Deiry WS, Du Y, Robertson ES Abstract Development of novel PI3K inhibitors is an important strategy to overcome their resistance and poor tolerability in clinical trials. The quassinoid family member Brusatol shows specific...
Fri May 29, 2020 13:30
Related ArticlesPredictive value of genetic variants XRCC1 rs1799782, APEX1 rs1760944, and MUTYH rs3219489 for adjuvant concurrent chemoradiotherapy outcomes in oral squamous cell carcinoma patients. Pharmacogenomics J. 2020 May 27;: Authors: Senghore T, Chien HT, Wang WC, Chen YX, Young CK, Huang SF, Yeh CC Abstract Genetic variations in DNA base excision repair (BER) genes may affect tumor sensitivity to chemotherapy and radiotherapy. Thus, we...
Fri May 29, 2020 13:30
Related ArticlesImmune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma. Int J Oral Sci. 2020 May 28;12(1):16 Authors: Mei Z, Huang J, Qiao B, Lam AK Abstract With the understanding of the complex interaction between the tumour microenvironment and immunotherapy, there is increasing interest in the role of immune regulators in the treatment of head and neck squamous cell carcinoma (HNSCC). Activation of T cells and immune...
Fri May 29, 2020 13:30
Related ArticlesImpact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to the American Joint Committee on Cancer eighth edition. Endocr J. 2020 May 28;: Authors: Moritani S Abstract This study investigated the impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to changes in the American Joint Committee...
Fri May 29, 2020 13:30
Related ArticlesSalvage surgery for structural local recurrence of papillary thyroid cancer: recurrence patterns and surgical outcome. Endocr J. 2020 May 27;: Authors: Otsuki N, Shimoda H, Morita N, Furukawa T, Teshima M, Shinomiya H, Nibu KI Abstract To clarify the patterns of the recurrence and to assess the oncological and functional outcomes after salvage surgery for the patients with structural local recurrence of papillary thyroid cancer (PTC),...
Fri May 29, 2020 13:30
Related ArticlesHypofractionated palliative volumetric modulated arc radiotherapy with the Radiation Oncology Study Group 8502 "QUAD shot" regimen for incurable head and neck cancer. Radiat Oncol. 2020 May 27;15(1):123 Authors: Toya R, Saito T, Yamaguchi K, Matsuyama T, Watakabe T, Matsumoto T, Yoshida R, Hirosue A, Murakami D, Orita Y, Nakayama H, Oya N Abstract BACKGROUND: To review a single institutional experience of the Radiation Therapy Oncology...
Fri May 29, 2020 13:30
Related ArticlesIdentification of a novel SDHB c.563 T > C mutation responsible for Paraganglioma syndrome and genetic analysis of the SDHB gene in China: a case report. BMC Med Genet. 2020 May 27;21(1):116 Authors: Chen H, Yao W, He Q, Yu X, Bian B Abstract BACKGROUND: Pheochromocytoma/paraganglioma (PPGL) is a rare neuroendocrine tumor. Succinate dehydrogenase (SDH) deficiency has been confirmed to be associated with PPGL in various studies....
Fri May 29, 2020 13:30
Related ArticlesReadability of Printed Online Education Materials on Pituitary Tumors: Untangling a Web of Complexity. Am J Rhinol Allergy. 2020 May 27;:1945892420927288 Authors: Ye MJ, Alwani MM, Harper JL, Buren LMV, Bandali EH, Illing EA, Shipchandler TZ, Ting JY Abstract BACKGROUND: Patients are increasingly turning to the internet for health education. Due to the complex pathophysiology, clinic-diagnostic profile, and management spectrum of...
Fri May 29, 2020 13:30
Related ArticlesDeep and sustained radiological response after MEK-RAF inhibition in HRAS mutant apocrine carcinoma of the scalp. Eur J Cancer. 2019 11;122:9-11 Authors: Scaranti M, Nava Rodrigues D, Banerji U PMID: 31600639 [PubMed - indexed for MEDLINE]
Fri May 29, 2020 13:30
Related ArticlesNasal polyposis and future risk of sinonasal malignancy. J Allergy Clin Immunol. 2019 10;144(4):933-934 Authors: Eschenbacher WH, Borish L PMID: 31472164 [PubMed - indexed for MEDLINE]
Fri May 29, 2020 13:30
Related ArticlesSNAI1 Promotes the Cholangiocellular Phenotype, but not Epithelial-Mesenchymal Transition, in a Murine Hepatocellular Carcinoma Model. Cancer Res. 2019 11 01;79(21):5563-5574 Authors: Xu M, Wang J, Xu Z, Li R, Wang P, Shang R, Cigliano A, Ribback S, Solinas A, Pes GM, Evert K, Wang H, Song X, Zhang S, Che L, Pascale RM, Calvisi DF, Liu Q, Chen X Abstract Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has limited...
Fri May 29, 2020 13:30
Related ArticlesBEAVR: a browser-based tool for the exploration and visualization of RNA-seq data. BMC Bioinformatics. 2020 May 29;21(1):221 Authors: Perampalam P, Dick FA Abstract BACKGROUND: The use of RNA-sequencing (RNA-seq) in molecular biology research and clinical settings has increased significantly over the past decade. Despite its widespread adoption, there is a lack of simple and interactive tools to analyze and explore RNA-seq data. Many...
Sun May 31, 2020 13:04
Related ArticlesA Bayesian data fusion based approach for learning genome-wide transcriptional regulatory networks. BMC Bioinformatics. 2020 May 29;21(1):219 Authors: Sauta E, Demartini A, Vitali F, Riva A, Bellazzi R Abstract BACKGROUND: Reverse engineering of transcriptional regulatory networks (TRN) from genomics data has always represented a computational challenge in System Biology. The major issue is modeling the complex crosstalk among transcription...
Sun May 31, 2020 13:04
Related ArticlesThe corrected gene proximity map for analyzing the 3D genome organization using Hi-C data. BMC Bioinformatics. 2020 May 29;21(1):222 Authors: Ye C, Paccanaro A, Gerstein M, Yan KK Abstract BACKGROUND: Genome-wide ligation-based assays such as Hi-C provide us with an unprecedented opportunity to investigate the spatial organization of the genome. Results of a typical Hi-C experiment are often summarized in a chromosomal contact map, a...
Sun May 31, 2020 13:04
Related ArticlesTesting the advantages and disadvantages of short- and long- read eukaryotic metagenomics using simulated reads. BMC Bioinformatics. 2020 May 29;21(1):220 Authors: Pearman WS, Freed NE, Silander OK Abstract BACKGROUND: The first step in understanding ecological community diversity and dynamics is quantifying community membership. An increasingly common method for doing so is through metagenomics. Because of the rapidly increasing popularity...
Sun May 31, 2020 13:04
Related ArticlesExtracting chemical reactions from text using Snorkel. BMC Bioinformatics. 2020 May 27;21(1):217 Authors: Mallory EK, de Rochemonteix M, Ratner A, Acharya A, Re C, Bright RA, Altman RB Abstract BACKGROUND: Enzymatic and chemical reactions are key for understanding biological processes in cells. Curated databases of chemical reactions exist but these databases struggle to keep up with the exponential growth of the biomedical literature....
Fri May 29, 2020 16:43
Rejuvenation Research, Ahead of Print.
Fri May 29, 2020 10:00
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Abstract Coronavirus Disease 2019 (COVID‐19) has been declared a pandemic. We conducted a systematic review to reveal the contribution of dermatologists in COVID‐19 research. 298 articles were included and classified into cutaneous manifestations of COVID‐19, operating experience against COVID‐19, mechanisms and treatment of COVID‐19, disinfection and personal protective equipment(PPE)‐related skin diseases and other topics. The value of these articles and their impact on clinical impact were discussed...
Sat May 30, 2020 20:14
Sat May 30, 2020 19:54
Abstract Time to improvement is a crucial characteristic for effective treatments of chronic inflammatory conditions, such as psoriasis. Apremilast is a recently approved drug, belonging to the small molecule phosphodiesterase 4 inhibitors, whose optimal safety and efficacy profile is somewhat affected by slow activity rate in clinical trials. Real world case series are suggesting a more consistent improvement, and with this additional personal investigation on 48 patients, we signal that 58% of...
Sat May 30, 2020 19:38
Abstract Introduction Αndrogenetic alopecia (AGA) is the most common hair disorder, affecting approximately 50% of men and women. A topical lotion that contains two patented formulas (Redensyl® and Sepicontrol A5®), has been introduced as an alternative approach to standard therapies for AGA. Methods Forty‐four patients with AGA were randomized either to apply the active lotion or the vehicle, twice daily for 24 weeks. Subjects were evaluated at 0, 12, and 24 weeks by clinical examination,...
Sat May 30, 2020 19:26
The world is facing a viral pandemic of a new coronavirus called COVID‐19. Pentoxifylline is a methyl‐xanthine and it inhibits phosphodiesterase IV (PDE IV). This drug is known for its unique features as an immunomodulatory and anti‐inflammatory agent, also it could have antiviral affects. This is a scoping review, in which all related articles on COVID‐19 and the probable benefits of Pentoxifylline against COVID‐19 pathogenesis, in Medline, Scopus, Web of Sciences and Google Scholar up to March...
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