IJERPH, Vol. 17, Pages 3848: The Urban-Rural Disparity in the Status and Risk Factors of Health Literacy: A Cross-Sectional Survey in Central China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17113848 Authors: Wenna Wang Yulin Zhang Beilei Lin Yongxia Mei Zhiguang Ping Zhenxiang Zhang Health literacy is the ability of individuals to access, process, and understand health information to make decisions regarding treatment and their...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3968: Reduced Fecal Calprotectin and Inflammation in a Murine Model of Atopic Dermatitis Following Probiotic Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21113968 Authors: Kim Kim Kang Won Hong Her Atopic dermatitis (AD) is one of the most common skin diseases with inflammation, chronic relapses, and intense pruritus. Its pathogenesis includes genetic susceptibility, an abnormal epidermal lipid barrier, and an increased...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3965: Copper Coordination Compounds as Biologically Active Agents International Journal of Molecular Sciences doi: 10.3390/ijms21113965 Authors: Olga Krasnovskaya Alexey Naumov Dmitry Guk Peter Gorelkin Alexander Erofeev Elena Beloglazkina Alexander Majouga Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3967: Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone International Journal of Molecular Sciences doi: 10.3390/ijms21113967 Authors: Viktor A. Timoshnikov Tatyana V. Kobzeva Nikolay E. Polyakov George J. Kontoghiorghes Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic acid is...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3966: Oxytocin Controls Chondrogenesis and Correlates with Osteoarthritis International Journal of Molecular Sciences doi: 10.3390/ijms21113966 Authors: Roux Pisani Gillet Fontas Yahia Djedaini Ambrosetti Michiels Panaia-Ferrari Breuil Pinzano Amri This study investigated the relationship of oxytocin (OT) to chondrogenesis and osteoarthritis (OA). Human bone marrow and multipotent adipose-derived stem cells were cultured...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3964: Synthesis and Diels–Alder Reactivity of 4-Fluoro-4-Methyl-4H-Pyrazoles International Journal of Molecular Sciences doi: 10.3390/ijms21113964 Authors: Abularrage Levandowski Raines 4H-Pyrazoles are emerging scaffolds for “click” chemistry. Late-stage fluorination with Selectfluor® is found to provide a reliable route to 4-fluoro-4-methyl-4H-pyrazoles. 4-Fluoro-4-methyl-3,5-diphenyl-4H-pyrazole (MFP) manifested 7-fold lower...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3963: Modulation of VEGF Expression and Oxidative Stress Response by Iodine Deficiency in Irradiated Cancerous and Non-Cancerous Breast Cells International Journal of Molecular Sciences doi: 10.3390/ijms21113963 Authors: Jessica Vanderstraeten Bjorn Baselet Jasmine Buset Naziha Ben Ben Said Christine de Ville de de Ville de Goyet Marie-Christine Many Anne-Catherine Gérard Hanane Derradji Breast cancer remains a major concern and its physiopathology...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3962: Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms21113962 Authors: Junko Hori Tomoyuki Kunishige Yuji Nakano The eye is provided with immune protection against pathogens in a manner that greatly reduces the threat of inflammation-induced vision loss. Immune-mediated inflammation and allograft rejection are greatly reduced...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3959: P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells International Journal of Molecular Sciences doi: 10.3390/ijms21113959 Authors: Wilkaniec Cieślik Murawska Babiec Gąssowska-Dobrowolska Pałasz Jęśko Adamczyk The purinergic P2X7 receptor (P2X7R) belongs to a family of trimeric ion channels that are gated by extracellular adenosine 5′-triphosphate...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3960: Mapping Quantitative Trait Loci for 1000-Grain Weight in a Double Haploid Population of Common Wheat International Journal of Molecular Sciences doi: 10.3390/ijms21113960 Authors: Liu Wu Gan Chen Liu Fedak Cao Chi Liu Zhang Zhang Thousand-grain weight (TGW) is a very important yield trait of crops. In the present study, we performed quantitative trait locus (QTL) analysis of TGW in a doubled haploid population obtained...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3961: Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract International Journal of Molecular Sciences doi: 10.3390/ijms21113961 Authors: Sakaguchi Miyado Iwamoto Okada Yoshida Kang Suzuki Yoshida Kawano Semenogelin 1 (SEMG1), a main component of human seminal plasma, is a multi-functional protein involved in the regulation of sperm motility and fertility. SEMG1 is orthologous to mouse seminal vesicle...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3957: Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes International Journal of Molecular Sciences doi: 10.3390/ijms21113957 Authors: Tong Lee Lee Wu Tsou Lu Shih Hwang Chou Arginine vasopressin (Avp) is a conserved pleiotropic hormone that is known to regulate both water reabsorption and ion balance; however, many of the mechanisms underlying...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3958: Human Neural Stem Cells Encoding ChAT Gene Restore Cognitive Function via Acetylcholine Synthesis, Aβ Elimination, and Neuroregeneration in APPswe/PS1dE9 Mice International Journal of Molecular Sciences doi: 10.3390/ijms21113958 Authors: Dongsun Park Ehn-Kyoung Choi Tai-Hyoung Cho Seong Soo Joo Yun-Bae Kim In Alzheimer disease (AD) patients, degeneration of the cholinergic system utilizing acetylcholine for memory acquisition is observed. Since...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3955: β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21113955 Authors: Jesus Fernandez-Abascal Elda Chiaino Maria Frosini Gavin P. Davey Massimo Valoti The 1-methyl-4-phenylpyridinium (MPP+) is a parkinsonian-inducing toxin that promotes neurodegeneration of dopaminergic cells by directly targeting complex I of mitochondria. Recently,...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3956: Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease International Journal of Molecular Sciences doi: 10.3390/ijms21113956 Authors: Khare Palakurthi Shah Palakurthi Khare : Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3954: Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response International Journal of Molecular Sciences doi: 10.3390/ijms21113954 Authors: Pawłowska Kwaśniewska Mazerska Augustin Activity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3953: Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis International Journal of Molecular Sciences doi: 10.3390/ijms21113953 Authors: Dong-Ru Ho Pey-Jium Chang Wei-Yu Lin Yun-Ching Huang Jian-Hui Lin Kuo-Tsai Huang Wai-Nga Chan Chih-Shou Chen Non-bacterial prostatitis is an inflammatory disease that is difficult to treat. Oligonucleotide aptamers are well known for their stability and flexibility...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3952: Genomic Analysis of Vavilov’s Historic Chickpea Landraces Reveals Footprints of Environmental and Human Selection International Journal of Molecular Sciences doi: 10.3390/ijms21113952 Authors: Alena Sokolkova Sergey V. Bulyntsev Peter L. Chang Noelia Carrasquilla-Garcia Anna A. Igolkina Nina V. Noujdina Eric von Wettberg Margarita A. Vishnyakova Douglas R. Cook Sergey V. Nuzhdin Maria G. Samsonova A defining challenge of the 21st...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3951: DFNA5 (GSDME) c.991-15_991-13delTTC: Founder Mutation or Mutational Hotspot? International Journal of Molecular Sciences doi: 10.3390/ijms21113951 Authors: Kevin T. Booth Hela Azaiez Richard J. H. Smith Deafness due to mutations in the DFNA5 gene is caused by the aberrant splicing of exon 8, which results in a constitutively active truncated protein. In a large family of European descent (MORL-ADF1) segregating autosomal dominant nonsyndromic hearing...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3950: The Cytotoxicity and Genotoxicity of Three Dental Universal Adhesives—An In Vitro Study International Journal of Molecular Sciences doi: 10.3390/ijms21113950 Authors: Adam Wawrzynkiewicz Wioletta Rozpedek-Kaminska Grzegorz Galita Monika Lukomska-Szymanska Barbara Lapinska Jerzy Sokolowski Ireneusz Majsterek Dental universal adhesives are considered an useful tool in modern dentistry as they can be used in different etching techniques, allow...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3948: Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide International Journal of Molecular Sciences doi: 10.3390/ijms21113948 Authors: Haitham Amal Guanyu Gong Hongmei Yang Brian A. Joughin Xin Wang Charles G. Knutson Maryam Kartawy Igor Khaliulin John S. Wishnok Steven R. Tannenbaum Background: Accumulating public health and epidemiological...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3949: NF-κB and Its Role in Checkpoint Control International Journal of Molecular Sciences doi: 10.3390/ijms21113949 Authors: Annika C. Betzler Marie-Nicole Theodoraki Patrick J. Schuler Johannes Döscher Simon Laban Thomas K. Hoffmann Cornelia Brunner Nuclear factor-κB (NF-κB) has been described as one of the most important molecules linking inflammation to cancer. More recently, it has become clear that NF-κB is also...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3947: Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21113947 Authors: Dorota Zurawa-Janicka Jarek Kobiela Tomasz Slebioda Rafal Peksa Marcin Stanislawowski Piotr Mieczyslaw Wierzbicki Tomasz Wenta Barbara Lipinska Zbigniew Kmiec Wojciech Biernat Andrzej Jacek Lachinski Zbigniew Sledzinski HtrA...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3946: Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability International Journal of Molecular Sciences doi: 10.3390/ijms21113946 Authors: Wioletta Olejarz Dominika Łacheta Grażyna Kubiak-Tomaszewska Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins. MMPs may modulate various cellular and signaling pathways in atherosclerosis...
Sun May 31, 2020 03:00
IJMS, Vol. 21, Pages 3945: Editorial of Special Issue “Frontiers in the Actin Cytoskeleton” International Journal of Molecular Sciences doi: 10.3390/ijms21113945 Authors: Francisco Rivero The actin cytoskeleton is of fundamental importance for eukaryotic cell homeostasis [...]
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3944: The Synergistic Effect of Co-Treatment of Methyl Jasmonate and Cyclodextrins on Pterocarpan Production in Sophora flavescens Cell Cultures International Journal of Molecular Sciences doi: 10.3390/ijms21113944 Authors: Kim Jeong Park Park Lee Lee Kim Ha Kim Kim Ryu Jeong Kim Pterocarpans are derivatives of isoflavonoids, found in many species of the family Fabaceae. Sophora flavescens Aiton is a promising traditional...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3943: Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility International Journal of Molecular Sciences doi: 10.3390/ijms21113943 Authors: Sciarra Franceschini Campolo Gianfrilli Pallotti Paoli Isidori Venneri : Infertility represents a growing health problem in industrialized countries. Thus, a greater understanding of the molecular networks involved in this disease could be critical for the development of...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3942: Protein Glycation in Plants—An Under-Researched Field with Much Still to Discover International Journal of Molecular Sciences doi: 10.3390/ijms21113942 Authors: Rabbani Al-Motawa Thornalley Recent research has identified glycation as a non-enzymatic post-translational modification of proteins in plants with a potential contributory role to the functional impairment of the plant proteome. Reducing sugars with a free aldehyde or ketone group such as...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3913: Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21113913 Authors: Óscar M. Bautista-Aguilera Lhassane Ismaili Mourad Chioua Rudolf Andrys Monika Schmidt Petr Bzonek María Ángeles Martínez-Grau Christopher D. Beadle Tatiana Vetman Francisco López-Muñoz Isabel Iriepa Bernard Refouvelet Kamil Musilek José Marco-Contelles...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3941: Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology International Journal of Molecular Sciences doi: 10.3390/ijms21113941 Authors: Meldolesi NOVA1 and NOVA2, the two members of the NOVA family of alternative splicing factors, bind YCAY clusters of pre-mRNAs and assemble spliceosomes to induce the maintenance/removal of introns and exons, thus governing the development of mRNAs. Members of other splicing families operate...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3940: The Structural Basis of the Binding of Various Aminopolycarboxylates by the Periplasmic EDTA-Binding Protein EppA from Chelativorans sp. BNC1 International Journal of Molecular Sciences doi: 10.3390/ijms21113940 Authors: Lewis Greene Sattler Youn Xun Kang The widespread use of synthetic aminopolycarboxylates, such as ethylenediaminetetraacetate (EDTA), as chelating agents has led to their contamination in the environment as stable metal–chelate...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3935: The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications International Journal of Molecular Sciences doi: 10.3390/ijms21113935 Authors: Kerstin Rastädter David J. Wurm Oliver Spadiut Julian Quehenberger The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3939: A Microarray Screening Platform with an Experimental Conditions Gradient Generator for the High-Throughput Synthesis of Micro/Nanosized Calcium Phosphates International Journal of Molecular Sciences doi: 10.3390/ijms21113939 Authors: Xiaoyu Li Zhifeng Shi Lei Liu Guanglin Zhu Jianhua Zhou Xuetao Shi Yingjun Wang Calcium phosphates (CaP) represent an impressive kind of biomedical material due to their excellent biocompatibility, bioactivity,...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3937: Current Approaches and Applications in Avian Genome Editing International Journal of Molecular Sciences doi: 10.3390/ijms21113937 Authors: Joonbum Lee Dong-Hwan Kim Kichoon Lee Advances in genome-editing technologies and sequencing of animal genomes enable researchers to generate genome-edited (GE) livestock as valuable animal models that benefit biological researches and biomedical and agricultural industries. As birds are an important species in biology...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3938: Quantification of Uncoupled Spin Domains in Spin-Abundant Disordered Solids International Journal of Molecular Sciences doi: 10.3390/ijms21113938 Authors: Walder Alam Materials often contain minor heterogeneous phases that are difficult to characterize yet nonetheless significantly influence important properties. Here we describe a solid-state NMR strategy for quantifying minor heterogenous sample regions containing dilute, essentially uncoupled nuclei...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3910: Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21113910 Authors: Amit Sharma Hongde Liu Fabian Tobar-Tosse Tikam Chand Dakal Michael Ludwig Frank G. Holz Karin U. Loeffler Ullrich Wüllner Martina C. Herwig-Carl Emerging evidence suggests an inverse association between cancer and neurodegenerative diseases (NDD). Although...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3924: Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation International Journal of Molecular Sciences doi: 10.3390/ijms21113924 Authors: Jessica Hedderich Karima El Bagdadi Peter Angele Susanne Grässel Andrea Meurer Rainer H. Straub Frank Zaucke Zsuzsa Jenei-Lanzl Bone marrow-derived mesenchymal stem cells (BMSCs) represent an alternative to...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3934: Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair International Journal of Molecular Sciences doi: 10.3390/ijms21113934 Authors: Mateusz Kciuk Karol Bukowski Beata Marciniak Renata Kontek Genomic DNA is constantly damaged by factors produced during natural metabolic processes as well as agents coming from the external environment. Considering such a wide array of damaging agents, eukaryotic cells have evolved a DNA damage...
Sat May 30, 2020 03:00
IJMS, Vol. 21, Pages 3909: License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity International Journal of Molecular Sciences doi: 10.3390/ijms21113909 Authors: Angélica Díaz-Basabe Francesco Strati Federica Facciotti Invariant Natural Killer T (iNKT) cells are a non-conventional, innate-like, T cell population that recognize lipid antigens presented by the cluster of differentiation (CD)1d molecule. Although iNKT cells are mostly known for mediating several...
Sat May 30, 2020 03:00
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