Related ArticlesWhat will radiation oncology look like in 2050? A look at a changing professional landscape in Europe and beyond. Mol Oncol. 2020 May 28;: Authors: Baumann M, Ebert N, Kurth I, Bacchus C, Overgaard J Abstract The number of newly diagnosed cancers per year is predicted to almost double in the next two decades worldwide, and it remains unclear if and when this alarming trend will level off or even reverse. As such, cancer is very likely...
Fri May 29, 2020 14:30
Related ArticlesFactors affecting enrollment in randomized controlled trials conducted for patients with metastatic breast cancer. Jpn J Clin Oncol. 2020 May 28;: Authors: Ohsumi S, Mukai H, Takahashi M, Hozumi Y, Akabane H, Park Y, Tokunaga E, Takashima T, Watanabe T, Sagara Y, Kaneko T, Ohashi Y Abstract BACKGROUND: It is critical to obtain informed consent from eligible patients to complete clinical trials. We investigated the factors that affect...
Fri May 29, 2020 14:30
Related ArticlesPatient-specific multi-omics models and the application in personalized combination therapy. Future Oncol. 2020 May 28;: Authors: John A, Qin B, Kalari KR, Wang L, Yu J Abstract The rapid advancement of high-throughput technologies and sharp decrease in cost have opened up the possibility to generate large amount of multi-omics data on an individual basis. The development of high-throughput -omics, including genomics, epigenomics, transcriptomics,...
Fri May 29, 2020 14:30
Related ArticlesAnti-HER2 therapy for breast cancer in older patients. Future Oncol. 2020 May 28;: Authors: Goldner M, Franzoi MA, Lago LD, Pondé N Abstract Older patients now form between 30 and 40% of breast cancer (BC) patients. Managing older patients with BC is particularly challenging due to the limited availability of high-quality evidence. In this review we discuss the available evidence on the efficacy and safety of anti-HER2 agents in older...
Fri May 29, 2020 14:30
Related ArticlesClinical Course after a First Episode of Heart Failure: Insights from the Framingham Heart Study. Eur J Heart Fail. 2020 May 28;: Authors: Velagaleti RS, Larson MG, Enserro D, Song RJ, Vasan RS Abstract AIMS: We sought to describe the frequency/type/timing of clinical events, and delineate patterns in their transitions, after a first episode of heart failure (HF). METHODS AND RESULTS: In 1036 Framingham participants with new-onset...
Fri May 29, 2020 14:30
Related ArticlesPatient-derived xenografts as compatible models for precision oncology. Lab Anim Res. 2020;36:14 Authors: Cho SY Abstract Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-tumoral heterogeneity) and heterogeneity within a patient (intra-tumoral heterogeneity). Precision oncology is a diagnostic and therapeutic approach for cancers based on the stratification of patients using genomic and molecular...
Fri May 29, 2020 14:30
Related ArticlesHow can Australia integrate routine genetic sequencing in oncology: a qualitative study through an implementation science lens. Genet Med. 2020 May 28;: Authors: O'Shea R, Rankin NM, Kentwell M, Gleeson M, Salmon L, Tucker KM, Lewis S, Taylor N Abstract PURPOSE: This study sought to determine genetics and oncology specialists' views of integrating BRCA1 and BRCA2 testing in epithelial ovarian and breast cancer into routine practice. ...
Fri May 29, 2020 14:30
Related ArticlesAll India Ophthalmological Society - Oculoplastics Association of India consensus statement on preferred practices in oculoplasty and lacrimal surgery during the COVID-19 pandemic. Indian J Ophthalmol. 2020 Jun;68(6):974-980 Authors: Ali MJ, Hegde R, Nair AG, Bajaj MS, Betharia SM, Bhattacharjee K, Chhabra AK, Das JK, Dudeja G, Grover AK, Honavar SG, Kim U, Mahesh L, Mukherjee B, Sethi A, Sharma M, Singh U Abstract Oculoplastic surgeries...
Fri May 29, 2020 14:30
Related ArticlesConsensus Statement on Proton Therapy in Mesothelioma. Pract Radiat Oncol. 2020 May 24;: Authors: Zeng J, Badiyan SN, Garces YI, Wong T, Zhang X, Simone CB, Chang JY, Knopf AC, Mori S, Iwata H, Meijers A, Li H, Bues M, Liu W, Schild SE, Rengan R, International Particle Therapy Co-operative Group (PTCOG) Thoracic Subcommittee Abstract Radiation therapy for mesothelioma remains challenging, as normal tissue toxicity limits the amount of...
Fri May 29, 2020 14:30
Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples.
Related ArticlesLiquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples. J Exp Clin Cancer Res. 2020 May 27;39(1):95 Authors: Russano M, Napolitano A, Ribelli G, Iuliani M, Simonetti S, Citarella F, Pantano F, Dell'Aquila E, Anesi C, Silvestris N, Argentiero A, Solimando A, Vincenzi B, Tonini G, Santini D Abstract In a large number of cancer types, treatment selection depends on the presence of specific tumor...
Fri May 29, 2020 14:30
Related ArticlesSingle-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient. Genome Med. 2020 May 27;12(1):47 Authors: Lee HW, Chung W, Lee HO, Jeong DE, Jo A, Lim JE, Hong JH, Nam DH, Jeong BC, Park SH, Joo KM, Park WY Abstract BACKGROUND: Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to...
Fri May 29, 2020 14:30
Related ArticlesPatterns of recurrence in anal cancer: a detailed analysis. Radiat Oncol. 2020 May 27;15(1):125 Authors: Nilsson MP, Nilsson ED, Johnsson A, Leon O, Gunnlaugsson A, Scherman J Abstract BACKGROUND: Anal cancer is a rare disease, which might be the reason for the "one size fits all" approach still used for radiotherapy target contouring. To refine and individualize future guidelines, detailed and contemporary pattern of recurrence studies...
Fri May 29, 2020 14:30
Related Articles2019 Pediatric Initiative Network: Progress, Proceedings, and Plans. J Adolesc Young Adult Oncol. 2020 May 27;: Authors: Nahata L, Gomez-Lobo V, Meacham L, Appiah L, Childress K, Hoefgen H, Dwiggins M, Whiteside S, Bjornard K, Rios J, Anazodo A, Finlayson C, Frias O, Woodruff T, Moravek M Abstract Impairment of fertility and sexual/reproductive health are common after oncologic therapy, and are known to have negative impacts on romantic...
Fri May 29, 2020 14:30
Related ArticlesA Narrative Review on the Use of Photobiomodulation Therapy for the Prevention and Management of Acute Radiodermatitis: Proposed Mechanisms, Current Clinical Outcomes, and Preliminary Guidance for Clinical Studies. Photobiomodul Photomed Laser Surg. 2020 May 27;: Authors: Robijns J, Lodewijckx J, Bensadoun RJ, Mebis J Abstract Objective: A narrative review of the available scientific evidence to identify the current proposals relating...
Fri May 29, 2020 14:30
Related ArticlesEvaluation of Common Variants in the AKNA Gene and Susceptibility to Knee Osteoarthritis Among the Han Chinese. Genet Test Mol Biomarkers. 2020 May 28;: Authors: Zhao T, Ma C, Xie B, Zhao B, Wang W, Liu J Abstract Background: Osteoarthritis (OA) is a complex degenerative joint disease that is associated with both genetic and environmental factors. The AKNA gene, located at 9q32, has recently been identified as being associated with knee...
Fri May 29, 2020 14:30
Related ArticlesInfluence of the pandemic dissemination of COVID-19 on radiotherapy practice: A flash survey in Germany, Austria and Switzerland. PLoS One. 2020;15(5):e0233330 Authors: Reuter-Oppermann M, Müller-Polyzou R, Wirtz H, Georgiadis A Abstract BACKGROUND: The COVID-19 pandemic has already changed our globalised world and its long-term impact is not yet known. It is apparent that businesses and institutions are increasingly affected. COVID-19...
Fri May 29, 2020 14:30
Related ArticlesCorrection: Treatment patterns and survival in HER2-positive early breast cancer: a whole-of-population Australian cohort study (2007-2016). Br J Cancer. 2020 May 29;: Authors: Tang M, Schaffer A, Kiely BE, Daniels B, Simes RJ, Lee CK, Pearson SA Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.PMID: 32472094 [PubMed - as supplied by publisher]
Sun May 31, 2020 13:22
Related ArticlesIntracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial. J Clin Oncol. 2020 May 29;:JCO2000775 Authors: Lin NU, Borges V, Anders C, Murthy RK, Paplomata E, Hamilton E, Hurvitz S, Loi S, Okines A, Abramson V, Bedard PL, Oliveira M, Mueller V, Zelnak A, DiGiovanna MP, Bachelot T, Chien AJ, O'Regan R, Wardley A, Conlin A, Cameron D,...
Sat May 30, 2020 17:23
Related ArticlesPathologic evaluation of response to neoadjuvant therapy drives treatment changes and improves long-term outcomes for breast cancer patients. Breast J. 2020 May 29;: Authors: Bossuyt V, Spring L Abstract Systemic therapy for breast cancer may be given before (neoadjuvant) or after (adjuvant) surgery. When neoadjuvant systemic therapy is given, response to treatment can be evaluated. However, some prognostic information (for example, pathologic...
Sat May 30, 2020 13:25
Related ArticlesCharacterization of KIF20A as a prognostic biomarker and therapeutic target for different subtypes of breast cancer. Int J Oncol. 2020 May 07;: Authors: Nakamura M, Takano A, Thang PM, Tsevegjav B, Zhu M, Yokose T, Yamashita T, Miyagi Y, Daigo Y Abstract The aim of the present study was to identify novel prognostic biomarkers and therapeutic targets for breast cancer; thus, genes that are frequently overexpressed in several types of breast...
Sat May 30, 2020 13:25
Related ArticlesImproved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: diarrheal toxicity in the CONTROL trial. Ann Oncol. 2020 May 25;: Authors: Barcenas CH, Hurvitz SA, Di Palma JA, Bose R, Chien AJ, Iannotti N, Marx G, Brufsky A, Litvak A, Ibrahim E, Alvarez RH, Ruiz-Borrego M, Chan N, Manalo Y, Kellum A, Trudeau M, Thirlwell M, Saenz JG, Hunt D, Bryce R, McCulloch L, Rugo HS, Tripathy D, Chan A, CONTROL Study Investigators ...
Fri May 29, 2020 17:34
Related ArticlesPhase I dose-escalation trial of tucatinib in combination with trastuzumab in patients with HER2-positive breast cancer brain metastases. Ann Oncol. 2020 May 24;: Authors: Metzger O, Leone JP, Li T, Tan-Wasielewski Z, Trippa L, Barry WT, Younger J, Lawler E, Walker L, Freedman RA, Tolaney SM, Krop I, Winer EP, Lin NU Abstract BACKGROUND: Brain metastases are frequent in HER2-positive breast cancer. ONT-380 (tucatinib) is a potent selective...
Fri May 29, 2020 13:35
Related ArticlesCYP19A1 gene expression in the peripheral blood of Brazilian women with breast cancer relapse. BMC Cancer. 2020 May 27;20(1):480 Authors: Barros-Oliveira MDC, Costa-Silva DR, Campos-Verdes LC, Pereira RO, Silva RA, Moura-Borges PT, Sousa EB, Pinho-Sobral AL, Lopes-Costa PV, Dos Santos AR, Soares-Lopes IMR, Viana JL, Melo MA, Manes Neto F, Coelho EG, Pires E Cruz MDS, Costa-Silva V, Gebrim LH, Da Silva BB Abstract BACKGROUND: The CYP19A1...
Fri May 29, 2020 13:35
Related ArticlesExecutive summary of EPOS 2020 including integrated care pathways. Rhinology. 2020 May 30;: Authors: Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitzma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J Abstract The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012(1-3). The core objective of the EPOS2020 guideline is to...
Sun May 31, 2020 15:15
Related ArticlesSuppression Head Impulse Paradigm (SHIMP) in evaluating the vestibulo-saccadic interaction in patients with vestibular neuritis. Eur Arch Otorhinolaryngol. 2020 May 29;: Authors: Manzari L, Tramontano M Abstract PURPOSE: Evaluate the potential clinical application of the Suppression Head Impulse Paradigm (SHIMP) in evaluating the vestibulo-saccadic interaction in patients with vestibular neuritis (VN). METHODS: A retrospective...
Sun May 31, 2020 13:18
Related ArticlesChange in Warthin's tumor incidence: a 20-year joinpoint trend analysis. Eur Arch Otorhinolaryngol. 2020 May 29;: Authors: Tunç O, Gönüldaş B, Arslanhan Y, Kanlıkama M Abstract PURPOSE: The incidence of Warthin's tumor (WT) has increased worldwide. In this study, we aimed to evaluate the incidence of WT in our hospital, which provides health care for an extremely large population. METHODS: We retrospectively evaluated 573 patients,...
Sun May 31, 2020 13:18
Related ArticlesMicro-metastasis and isolated tumour cells: the span between elective neck dissection versus neck observation in early oral cancer. Eur Arch Otorhinolaryngol. 2020 May 28;: Authors: Subash A, Singh A, Sinha P Abstract Early oral squamous cell carcinoma (SCC) has a propensity for lymph-node metastasis. To address or not to address the neck electively during the ablative surgery has been an ongoing debate. In recent years, some practice-changing...
Sat May 30, 2020 13:23
Related ArticlesClaviculotracheopexy for complex airway reconstructions. Eur Arch Otorhinolaryngol. 2020 May 28;: Authors: Sandu K, Vinckenbosch-Jaballah P, Duchoud L Abstract PURPOSE: Revision surgery for correcting benign laryngotracheal stenosis is challenging and it gets complicated in patients with comorbidities. To improve results in such cases, we describe a new technique of stabilizing the trachea by splinting it to the clavicle on both sides....
Sat May 30, 2020 13:23
Related ArticlesCochlear implantation in prelingually deaf children with white matter lesions. Eur Arch Otorhinolaryngol. 2020 May 28;: Authors: Chen S, Zheng W, Li H, Zhong M, Wei R, Zhang B, Tong B, Qiu J, Yao K Abstract OBJECTIVE: White matter lesions (WMLs) are the most common central nervous system changes observed during cochlear implant evaluation. However, its clinical significance in cochlear implantation (CI) remains unclear. The purpose of...
Fri May 29, 2020 13:27
Related ArticlesChronic cough related to the upper airway cough syndrome: one entity but not always the same. Eur Arch Otorhinolaryngol. 2020 May 27;: Authors: Dąbrowska M, Arcimowicz M, Grabczak EM, Truba O, Rybka A, Białek-Gosk K, Klimowicz K, Jamróz B, Niemczyk K, Krenke R Abstract PURPOSE: Upper airway cough syndrome (UACS), described as chronic cough (CC) associated with allergic (AR), non-allergic rhinitis (NAR) or chronic rhinosinusitis (CRS),...
Fri May 29, 2020 13:27
Related ArticlesMechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients. EMBO Mol Med. 2020 May 30;: Authors: Stebbing J, Krishnan V, de Bono S, Ottaviani S, Casalini G, Richardson PJ, Monteil V, Lauschke VM, Mirazimi A, Youhanna S, Tan YJ, Baldanti F, Sarasini A, Terres JAR, Nickoloff BJ, Higgs RE, Rocha G, Byers NL, Schlichting DE, Nirula A, Cardoso A, Corbellino M, Sacco Baricitinib Study Group Abstract Baricitinib,...
Sun May 31, 2020 17:19
Related ArticlesFunctional training with blood occlusion influences muscle quality indices in older adults. Arch Gerontol Geriatr. 2020 May 16;90:104110 Authors: Bigdeli S, Dehghaniyan MH, Amani-Shalamzari S, Rajabi H, Gahreman DE Abstract OBJECTIVES: This study aimed to determine if functional training with blood flow restriction (BFR) has a greater effect on muscle quality indices and performance of older men when compared to functional training without...
Sun May 31, 2020 17:19
Related ArticlesAirway remodelling with spatial correlations: Implications for asthma pathogenesis. Respir Physiol Neurobiol. 2020 May 27;:103469 Authors: Pascoe CD, Green FHY, Elliot JG, James AL, Noble PB, Donovan GM Abstract Airway remodelling is a cardinal feature of asthma in which airways undergo structural changes - in particular, increased airway smooth muscle mass and total airway wall area. Remodelling has long been thought to have functional...
Sun May 31, 2020 17:19
Related ArticlesSalvianolic acid B decreases interleukin-1β-induced colitis recurrence in mice. Chin Med J (Engl). 2020 May 28;: Authors: Feng PP, Fang XS, Zhao SH, Fu JY, Zhang HT, Yi YL, Li CY, Jiang CL, Chen DP Abstract BACKGROUND: Degree of mucosal recovery is an important indicator for evaluating the therapeutic effects of drugs in treatment of inflammatory bowel disease (IBD). Increasing evidences have proved that tight junction (TJ) barrier dysfunction...
Sun May 31, 2020 17:19
Related ArticlesPropionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr-/- .Leiden mice. FASEB J. 2020 May 30;: Authors: Tengeler AC, Gart E, Wiesmann M, Arnoldussen IAC, van Duyvenvoorde W, Hoogstad M, Dederen PJ, Verweij V, Geenen B, Kozicz T, Kleemann R, Morrison MC, Kiliaan AJ Abstract The obesity epidemic increases the interest to elucidate impact of short-chain fatty acids...
Sun May 31, 2020 13:18
Related ArticlesTASK channels: channelopathies, trafficking, and receptor-mediated inhibition. Pflugers Arch. 2020 May 29;: Authors: Inoue M, Matsuoka H, Harada K, Mugishima G, Kameyama M Abstract TWIK-related acid-sensitive K+ (TASK) channels contribute to the resting membrane potential in various kinds of cells, such as brain neurons, smooth muscle cells, and endocrine cells. Loss-of-function mutations at multiple sites in the KCNK3 gene encoding for...
Sun May 31, 2020 13:18
Related ArticlesCorrection to: Role of PUMA in the methamphetamine-induced migration of microglia. Metab Brain Dis. 2020 May 29;: Authors: Zhao L, Du L, Zhang Y, Chao J, Duan M, Yao H, Shen C, Zhang Y Abstract In the original publication of this article, wrong western blot images were inadvertently included in Fig. 2 and Fig. 3. The corrected figures are shown below. The authors declare that these amendments do not change the results or conclusions of...
Sun May 31, 2020 13:18
Related ArticlesThe mycotoxin deoxynivalenol activates GABAergic neurons in the reward system and inhibits feeding and maternal behaviours. Arch Toxicol. 2020 May 29;: Authors: Csikós V, Varró P, Bódi V, Oláh S, Világi I, Dobolyi A Abstract Deoxynivalenol (DON) or vomitoxin, is a trichothecene mycotoxin produced mainly by Fusarium graminearum and culmorum. Mycotoxins or secondary metabolic products of mold fungi are micro-pollutants, which may affect...
Sun May 31, 2020 13:18
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