IJMS, Vol. 21, Pages 3892: Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms21113892 Authors: Yuta Koike Sayaka Kuwatsuka Katsutaro Nishimoto Daisuke Motooka Hiroyuki Murota Background: Biological treatment relieves refractory skin lesions in patients with psoriasis; however, changes in the fungal microbiome (the mycobiome) on the skin are unclear. Methods: The skin...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3879: Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer’s Disease-Related Animal Model International Journal of Molecular Sciences doi: 10.3390/ijms21113879 Authors: Yong Ho Park Soo Jung Shin Hyeon soo Kim Sang Bum Hong Sujin Kim Yunkwon Nam Jwa-Jin Kim Kyu Lim Jong-Seok Kim Jin-il Kim Seong Gak Jeon Minho Moon It has been reported that damage to the...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3888: Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms21113888 Authors: Sarah Ouahoud James C.H. Hardwick Lukas J.A.C. Hawinkels The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-β (TGF-β) superfamily, are involved in multiple biological processes such as embryonic development and maintenance of adult...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3890: Fibroblasts as a Biological Marker for Curative Resection in Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21113890 Authors: Eriko Katsuta Omar M. Rashid Kazuaki Takabe Achievement of microscopic tumor clearance (R0) after pancreatic ductal adenocarcinoma (PDAC) surgery is determined by cancer biology rather than operative technique. Fibroblasts are known to play pro-cancer roles; however, a small subset...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3891: Protective Effect of Angiotensin 1–7 on Sarcopenia Induced by Chronic Liver Disease in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21113891 Authors: Francisco Aguirre Johanna Abrigo Francisco Gonzalez Andrea Gonzalez Felipe Simon Claudio Cabello-Verrugio Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular alterations...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3873: Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops International Journal of Molecular Sciences doi: 10.3390/ijms21113873 Authors: Vítězslav Plocek Libuše Váchová Vratislav Šťovíček Zdena Palková Multicellular structures formed by yeasts and other microbes are valuable models for investigating the processes of cell–cell interaction and pattern formation, as well as cell signaling and differentiation. These...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3887: M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133+ Cancer Stem Cells and Decreasing M2 Macrophage Population International Journal of Molecular Sciences doi: 10.3390/ijms21113887 Authors: Young Woo Eom Rokeya Akter Wanlu Li Suji Lee Soonjae Hwang Jiye Kim Mee-Yon Cho We have previously reported that adipose tissue-derived stem cells...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3886: A New Era in Endothelial Injury Syndromes: Toxicity of CAR-T Cells and the Role of Immunity International Journal of Molecular Sciences doi: 10.3390/ijms21113886 Authors: Eleni Gavriilaki Ioanna Sakellari Maria Gavriilaki Achilles Anagnostopoulos Immunotherapy with chimeric antigen receptor T (CAR-T cells) has been recently approved for patients with relapsed/refractory B-lymphoproliferative neoplasms. Along with great efficacy in patients with poor...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3885: Adipose-Derived Stem Cells Promote Intussusceptive Lymphangiogenesis by Restricting Dermal Fibrosis in Irradiated Tissue of Mice International Journal of Molecular Sciences doi: 10.3390/ijms21113885 Authors: Ryohei Ogino Kenji Hayashida Sho Yamakawa Eishin Morita Currently, there is no definitive treatment for lymphatic disorders. Adipose-derived stem cells (ADSCs) have been reported to promote lymphatic regeneration in lymphedema models, but the mechanisms...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3889: Employing Nanostructured Scaffolds to Investigate the Mechanical Properties of Adult Mammalian Retinae Under Tension International Journal of Molecular Sciences doi: 10.3390/ijms21113889 Authors: Kantida Juncheed Bernd Kohlstrunk Sabrina Friebe Valentina Dallacasagrande Patric Maurer Andreas Reichenbach Stefan G. Mayr Mareike Zink Numerous eye diseases are linked to biomechanical dysfunction of the retina. However, the underlying forces...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3874: Early OA Stage Like Response Occurs after Dynamic Stretching of Human Synovial Fibroblasts International Journal of Molecular Sciences doi: 10.3390/ijms21113874 Authors: Ute Nazet Susanne Grässel Jonathan Jantsch Peter Proff Agnes Schröder Christian Kirschneck As events triggering early osteoarthritis onset can be related to mechanical stress and proinflammatory signaling, we investigated the effect of different mechanical strain protocols on...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3883: Mitochondrial Inheritance in Phytopathogenic Fungi—Everything Is Known, or Is It? International Journal of Molecular Sciences doi: 10.3390/ijms21113883 Authors: Hector Mendoza Michael H. Perlin Jan Schirawski Mitochondria are important organelles in eukaryotes that provide energy for cellular processes. Their function is highly conserved and depends on the expression of nuclear encoded genes and genes encoded in the organellar genome. Mitochondrial DNA...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3882: The Impact of Single- and Double-Strand DNA Breaks in Human Spermatozoa on Assisted Reproduction International Journal of Molecular Sciences doi: 10.3390/ijms21113882 Authors: Ashok Agarwal Cătălina Barbăroșie Rafael Ambar Renata Finelli Several cellular insults can result in sperm DNA fragmentation either on one or both DNA strands. Oxidative damage, premature interruption of the apoptotic process and defects in DNA compaction during spermatogenesis...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3884: Syndecan-1 Facilitates the Human Mesenchymal Stem Cell Osteo-Adipogenic Balance International Journal of Molecular Sciences doi: 10.3390/ijms21113884 Authors: Chieh Yu Ian W. Peall Son H. Pham Rachel K. Okolicsanyi Lyn R. Griffiths Larisa M. Haupt Bone marrow-derived human mesenchymal stems cells (hMSCs) are precursors to adipocyte and osteoblast lineage cells. Dysregulation of the osteo-adipogenic balance has been implicated in pathological...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3880: Post-Burn Pruritus International Journal of Molecular Sciences doi: 10.3390/ijms21113880 Authors: Bo Young Chung Han Bi Kim Min Je Jung Seok Young Kang In-Suk Kwak Chun Wook Park Hye One Kim Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient....
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3876: The Sulphur Response in Wheat Grain and Its Implications for Acrylamide Formation and Food Safety International Journal of Molecular Sciences doi: 10.3390/ijms21113876 Authors: Sarah Raffan Joseph Oddy Nigel G. Halford Free (soluble, non-protein) asparagine concentration can increase many-fold in wheat grain in response to sulphur deficiency. This exacerbates a major food safety and regulatory compliance problem for the food industry because free asparagine...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3877: Effect of Proton Pump Inhibitors on Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21113877 Authors: Takamitsu Sasaki Shiori Mori Shingo Kishi Rina Fujiwara-Tani Hitoshi Ohmori Yukiko Nishiguchi Yudai Hojo Isao Kawahara Chie Nakashima Kiyomu Fujii Yi Luo Hiroki Kuniyasu Proton pump inhibitors (PPIs) are administered commonly to aged people; however, their effect on colorectal cancer (CRC) has...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3878: A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21113878 Authors: Willy Roque Alexandra Boni Jose Martinez-Manzano Freddy Romero Pulmonary fibrosis is a chronic and progressive lung disease characterized by the activation of fibroblasts and the irreversible deposition of connective tissue matrices that leads to altered...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3871: Regulators of Epithelial Sodium Channels in Aldosterone-Sensitive Distal Nephrons (ASDN): Critical Roles of Nedd4L/Nedd4-2 and Salt-Sensitive Hypertension International Journal of Molecular Sciences doi: 10.3390/ijms21113871 Authors: Tomoaki Ishigami Tabito Kino Shintaro Minegishi Naomi Araki Masanari Umemura Hisako Ushio Sae Saigoh Michiko Sugiyama Ubiquitination is a representative, reversible biological process of the post-translational...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3881: Production of Active Recombinant Hyaluronidase Inclusion Bodies from Apis mellifera in E. coli Bl21(DE3) and characterization by FT-IR Spectroscopy International Journal of Molecular Sciences doi: 10.3390/ijms21113881 Authors: Andreas Schwaighofer Sarah Ablasser Laurin Lux Julian Kopp Christoph Herwig Oliver Spadiut Bernhard Lendl Christoph Slouka The bacterium E. coli is one of the most important hosts for recombinant protein production....
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3872: Transcriptome Analysis of Maternal Gene Transcripts in Unfertilized Eggs of Misgurnus anguillicaudatus and Identification of Immune-Related Maternal Genes International Journal of Molecular Sciences doi: 10.3390/ijms21113872 Authors: Chan-Hee Kim Eun Jeong Kim Chaehwa Seo Yoon Kwon Nam Maternal genes are important in directing early development and determining egg quality in fish. We here report the de novo transcriptome from four tissue libraries...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3870: Time-Course Transcriptome of Parageobacillus thermoglucosidasius DSM 6285 Grown in the Presence of Carbon Monoxide and Air International Journal of Molecular Sciences doi: 10.3390/ijms21113870 Authors: Habibu Aliyu Teresa Mohr Don Cowan Pieter de Maayer Anke Neumann Parageobacillus thermoglucosidasius is a metabolically versatile, facultatively anaerobic thermophile belonging to the family Bacillaceae. Previous studies have shown that this bacterium...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3869: Animal Models Used in Hepatitis C Virus Research International Journal of Molecular Sciences doi: 10.3390/ijms21113869 Authors: Keith A. Berggren Saori Suzuki Alexander Ploss The narrow range of species permissive to infection by hepatitis C virus (HCV) presents a unique challenge to the development of useful animal models for studying HCV, as well as host immune responses and development of chronic infection and disease. Following earlier studies in...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3875: Continuum Models of Membrane Fusion: Evolution of the Theory International Journal of Molecular Sciences doi: 10.3390/ijms21113875 Authors: Sergey A. Akimov Rodion J. Molotkovsky Peter I. Kuzmin Timur R. Galimzyanov Oleg V. Batishchev Starting from fertilization, through tissue growth, hormone secretion, synaptic transmission, and sometimes morbid events of carcinogenesis and viral infections, membrane fusion regulates the whole life of high organisms....
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3862: Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies International Journal of Molecular Sciences doi: 10.3390/ijms21113862 Authors: Jayant Patwa Swaran Jeet Singh Flora Heavy metals are considered a continuous threat to humanity, as they cannot be eradicated. Prolonged exposure to heavy metals/metalloids in humans has been associated with several health risks, including neurodegeneration,...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3867: Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise International Journal of Molecular Sciences doi: 10.3390/ijms21113867 Authors: Dean-Chuan Wang Hwai-Ting Lin Yi-Ju Lee Hsien-Fu Yu Sin-Ru Wu Muhammad Usama Qamar Early-life exposure to di-(2-ethylhexyl)-phthalate (DEHP) has been suggested to relate to hyperactivity, lack of attention, and working...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3868: Emerging Roles of Gemin5: From snRNPs Assembly to Translation Control International Journal of Molecular Sciences doi: 10.3390/ijms21113868 Authors: Encarnacion Martinez-Salas Azman Embarc-Buh Rosario Francisco-Velilla RNA-binding proteins (RBPs) play a pivotal role in the lifespan of RNAs. The disfunction of RBPs is frequently the cause of cell disorders which are incompatible with life. Furthermore, the ordered assembly of RBPs and RNAs in ribonucleoprotein...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3866: β-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21113866 Authors: Chih-Cheng Wu Cheng-Yi Chang Kuei-Chung Shih Chih-Jen Hung Ya-Yu Wang Shih-Yi Lin Wen-Ying Chen Yu-Hsiang Kuan Su-Lan Liao Wen-Yi Wang Chun-Jung Chen Chronic treatment involving opioids exacerbates both the risk and severity of ischemic stroke. We...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3865: Transglutaminase 2 Has Metabolic and Vascular Regulatory Functions Revealed by In Vivo Activation of Alpha1-Adrenergic Receptor International Journal of Molecular Sciences doi: 10.3390/ijms21113865 Authors: Kinga Lénárt Attila Pap Róbert Pórszász Anna V. Oláh László Fésüs András Mádi The multifunctional tissue transglutaminase has been demonstrated to act as α1-adrenergic receptor-coupled G protein with GTPase activity in several cell...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3864: When Good Guys Turn Bad: Bone Marrow’s and Hematopoietic Stem Cells’ Role in the Pathobiology of Diabetic Complications International Journal of Molecular Sciences doi: 10.3390/ijms21113864 Authors: Maria Cristina Vinci Elisa Gambini Beatrice Bassetti Stefano Genovese Giulio Pompilio Diabetes strongly contributes to the development of cardiovascular disease, the leading cause of mortality and morbidity in these patients. It is widely accepted that...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3863: The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease International Journal of Molecular Sciences doi: 10.3390/ijms21113863 Authors: Hideki Fujii Norifumi Kawada Japan Study Group of NAFLD (JSG-NAFLD) Japan Study Group of NAFLD (JSG-NAFLD) Nonalcoholic fatty liver disease (NAFLD) consists of the entire spectrum of fatty liver disease in patients without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL)...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3861: Sex Differences in Proatherogenic Cytokine Levels International Journal of Molecular Sciences doi: 10.3390/ijms21113861 Authors: Stella Bernardi Barbara Toffoli Federica Tonon Morena Francica Elena Campagnolo Tommaso Ferretti Sarah Comar Fabiola Giudici Elisabetta Stenner Bruno Fabris Background: It has been shown that sex affects immunity, including cytokine production. Given that atherosclerosis is an inflammatory disease promoted...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3858: Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease International Journal of Molecular Sciences doi: 10.3390/ijms21113858 Authors: Estefanía de Gregorio Anna Colell Albert Morales Montserrat Marí Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause approximately 2 million deaths...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3859: Positional Correlation Natural Vector: A Novel Method for Genome Comparison International Journal of Molecular Sciences doi: 10.3390/ijms21113859 Authors: Lily He Rui Dong Rong Lucy He Stephen S.-T. Yau Advances in sequencing technology have made large amounts of biological data available. Evolutionary analysis of data such as DNA sequences is highly important in biological studies. As alignment methods are ineffective for analyzing large-scale data...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3860: Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight International Journal of Molecular Sciences doi: 10.3390/ijms21113860 Authors: Claudia Riccardi Albert Meyer Jean-Jacques Vasseur Domenico Cavasso Irene Russo Krauss Luigi Paduano François Morvan Daniela Montesarchio NU172—a 26-mer oligonucleotide able to bind exosite I of human thrombin and inhibit its activity—was...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3857: Genome-Wide Characterization of GRAS Family and Their Potential Roles in Cold Tolerance of Cucumber (Cucumis sativus L.) International Journal of Molecular Sciences doi: 10.3390/ijms21113857 Authors: Xiaohong Lu Wenqian Liu Chenggang Xiang Xiaojun Li Qing Wang Tao Wang Zixi Liu Jiali Zhang Lihong Gao Wenna Zhang Cucumber (Cucumis sativus L.) is one of the most important cucurbit vegetables but is often subjected to stress during cultivation....
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3856: Translational Potential of Metabolomics on Animal Models of Inflammatory Bowel Disease—A Systematic Critical Review International Journal of Molecular Sciences doi: 10.3390/ijms21113856 Authors: Lina Almind Knudsen Rasmus Desdorf Sören Möller Signe Bek Sørensen Axel Kornerup Hansen Vibeke Andersen In the development of inflammatory bowel disease (IBD), the gut microbiota has been established as a key factor. Recently, metabolomics has become...
Fri May 29, 2020 03:00
IJMS, Vol. 21, Pages 3855: Fetal Middle Cerebral Artery Pulsatility Index in No-Risk Pregnancies: Effects of Auditory Stimulation and Pregnancy Order International Journal of Molecular Sciences doi: 10.3390/ijms21113855 Authors: Ljiljana Jeličić Svetlana Janković Mirjana Sovilj Tatjana Adamović Ivana Bogavac Aleksandar Gavrilović Miško Subotić Pulsatility index (PI) values in a fetal middle cerebral artery (MCA) were compared in no-risk pregnancies to examine the differences...
Fri May 29, 2020 03:00
IJNS, Vol. 6, Pages 45: A Visit with Dr. Louis Woolf, Recognizing His 100th Birthday and His Contributions to the Diagnosis and Treatment of Phenylketonuria International Journal of Neonatal Screening doi: 10.3390/ijns6020045 Authors: R. Rodney Howell Graham Sinclair One of the most dramatic discoveries in metabolic disease research was that of Ashbørn Følling, who in 1934, published his research outlining unusual biochemical findings in a set of siblings with...
Sat May 30, 2020 03:00
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