Microorganisms, Vol. 8, Pages 827: Virulence Potential of a Multidrug-Resistant Escherichia coli Strain Belonging to the Emerging Clonal Group ST101-B1 Isolated from Bloodstream Infection Microorganisms doi: 10.3390/microorganisms8060827 Authors: Santos Silva Valiatti Santos Santos-Neto Cayô Streling Nodari Gales Nishiyama-Jr. Carvalho Gomes Escherichia coli EC121 is a multidrug-resistant (MDR) strain isolated from a bloodstream infection...
Microorganisms, Vol. 8, Pages 826: Overexpression of lpxT Gene in Escherichia coli Inhibits Cell Division and Causes Envelope Defects without Changing the Overall Phosphorylation Level of Lipid A Microorganisms doi: 10.3390/microorganisms8060826 Authors: Falchi Di Lorenzo Pizzoccheri Casino Paroni Forti Molinaro Briani LpxT is an inner membrane protein that transfers a phosphate group from the essential lipid undecaprenyl pyrophosphate (C-55PP) to the lipid...
Microorganisms, Vol. 8, Pages 825: Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830) Microorganisms doi: 10.3390/microorganisms8060825 Authors: Bell-Sakyi Mohd Jaafar Monsion Luu Denison Carpenter Attoui Mertens Culicoides biting midges (Diptera: Ceratopogonidae) transmit arboviruses of veterinary or medical importance, including bluetongue virus (BTV) and Schmallenberg virus, as well as causing severe irritation to...
Microorganisms, Vol. 8, Pages 824: Human Metapneumovirus Establishes Persistent Infection in Lung Microvascular Endothelial Cells and Primes a Th2-Skewed Immune Response Microorganisms doi: 10.3390/microorganisms8060824 Authors: Antonella Bugatti Stefania Marsico Manuela Fogli Sara Roversi Serena Messali Daniela Bosisio Cinzia Giagulli Arnaldo Caruso Silvano Sozzani Simona Fiorentini Francesca Caccuri Human Metapneumovirus (HMPV) is a major cause of lower...
Microorganisms, Vol. 8, Pages 823: Dry-Caribbean Bacillus spp. Strains Ameliorate Drought Stress in Maize by a Strain-Specific Antioxidant Response Modulation Microorganisms doi: 10.3390/microorganisms8060823 Authors: Andres Moreno-Galván Felipe A. Romero-Perdomo German Estrada-Bonilla Carlos Henrique Salvino Gadelha Meneses Ruth R. Bonilla Drought is a global problem for crop productivity. Therefore, the objective of this research was to evaluate five dry-Caribbean Bacillus...
Microorganisms, Vol. 8, Pages 822: Lanthanide-Dependent Methanol and Formaldehyde Oxidation in Methylobacterium aquaticum Strain 22A Microorganisms doi: 10.3390/microorganisms8060822 Authors: Patcha Yanpirat Yukari Nakatsuji Shota Hiraga Yoshiko Fujitani Terumi Izumi Sachiko Masuda Ryoji Mitsui Tomoyuki Nakagawa Akio Tani Lanthanides (Ln) are an essential cofactor for XoxF-type methanol dehydrogenases (MDHs) in Gram-negative methylotrophs. The Ln3+ dependency...
Microorganisms, Vol. 8, Pages 821: Pathogenesis-Targeted Preventive Strategies for Multidrug Resistant Ventilator-Associated Pneumonia: A Narrative Review Microorganisms doi: 10.3390/microorganisms8060821 Authors: Cotoia Spadaro Gambetti Koulenti Cinnella Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection in the intensive care unit (ICU), accounting for relevant morbidity and mortality among critically ill patients, especially when caused...
Microorganisms, Vol. 8, Pages 820: Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus Microorganisms doi: 10.3390/microorganisms8060820 Authors: Couté Kraut Zimmermann Büscher Hesse Bruley De Andrea Wangen Hahn Marschall Plachter The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex...
Microorganisms, Vol. 8, Pages 816: Probiotic Cocktail Identified by Microbial Network Analysis Inhibits Growth, Virulence Gene Expression, and Host Cell Colonization of Vancomycin-Resistant Enterococci Microorganisms doi: 10.3390/microorganisms8060816 Authors: Sun Lee Tsai Ho Fang The prevalence of vancomycin resistant enterococcus (VRE) carrier-state has been increasing in patients of intensive care unit and it would be a public health threat. Different research groups...
Microorganisms, Vol. 8, Pages 818: Differentiation of Leishmania (L.) infantum, Leishmania (L.) amazonensis and Leishmania (L.) mexicana Using Sequential qPCR Assays and High-Resolution Melt Analysis Microorganisms doi: 10.3390/microorganisms8060818 Authors: Ceccarelli Diotallevi Buffi De Santi Fernández-Figueroa Rangel-Escareño Muñoz-Montero Becker Magnani Galluzzi Leishmania protozoa are the etiological agents of visceral, cutaneous and mucocutaneous...
Microorganisms, Vol. 8, Pages 817: Bioactive Secondary Metabolites from Trichoderma spp. against Phytopathogenic Fungi Microorganisms doi: 10.3390/microorganisms8060817 Authors: Khan Najeeb Hussain Xie Li Phytopathogenic fungi, causing significant economic and production losses, are becoming a serious threat to global food security. Due to an increase in fungal resistance and the hazardous effects of chemical fungicides to human and environmental health, scientists are...
Microorganisms, Vol. 8, Pages 819: Cultivable Bacterial Communities in Brines from Perennially Ice-Covered and Pristine Antarctic Lakes: Ecological and Biotechnological Implications Microorganisms doi: 10.3390/microorganisms8060819 Authors: Rizzo Conte Azzaro Papale Rappazzo Battistel Roman Lo Giudice Guglielmin The diversity and biotechnological potentialities of bacterial isolates from brines of three Antarctic lakes of the Northern Victoria Land (namely...
Microorganisms, Vol. 8, Pages 815: Salmonella Heterogeneously Expresses Flagellin during Colonization of Plants Microorganisms doi: 10.3390/microorganisms8060815 Authors: Azhar A. Zarkani Nieves López-Pagán Maja Grimm María Antonia Sánchez-Romero Javier Ruiz-Albert Carmen R. Beuzón Adam Schikora Minimally processed or fresh fruits and vegetables are unfortunately linked to an increasing number of food-borne diseases, such as salmonellosis. One of the relevant virulence...
Microorganisms, Vol. 8, Pages 814: Spatial Variation in Bacterioplankton Communities in the Pearl River, South China: Impacts of Land Use and Physicochemical Factors Microorganisms doi: 10.3390/microorganisms8060814 Authors: Lei Zhou Weiyuan Chen Jijia Sun Li Liu Xiande Huang River ecosystems are critical for human and environmental health, with bacterioplankton playing a vital role in biogeochemical cycles. Unveiling the spatial patterns of bacterioplankton communities in...
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Molecules, Vol. 25, Pages 2560: Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications Molecules doi: 10.3390/molecules25112560 Authors: Karatoprak Küpeli Akkol Genç Bardakci Yücel Sobarzo-Sánchez Combretastatins are a class of closely related stilbenes (combretastatins A), dihydrostilbenes (combretastatins B), phenanthrenes (combretastatins C) and macrocyclic lactones (combretastatins D) found in the bark of Combretum...
Molecules, Vol. 25, Pages 2573: Catalyst-Solvent System for PASE Approach to Hydroxyquinolinone-Substituted Chromeno[2,3-b]pyridines Its Quantum Chemical Study and Investigation of Reaction Mechanism Molecules doi: 10.3390/molecules25112573 Authors: Fedor V. Ryzhkov Yuliya E. Ryzhkova Michail N. Elinson Stepan V. Vorobyev Artem N. Fakhrutdinov Anatoly N. Vereshchagin Mikhail P. Egorov The Pot, Atom, and Step Economy (PASE) approach is based on the Pot economy principle...
Molecules, Vol. 25, Pages 2571: Synthesis, Molecular Recognition Study and Liquid Membrane-Based Applications of Highly Lipophilic Enantiopure Acridino-Crown Ethers Molecules doi: 10.3390/molecules25112571 Authors: Ádám Golcs Bálint Árpád Ádám Viola Horváth Tünde Tóth Péter Huszthy New highly lipophilic enantiopure crown ethers containing a heterocyclic unit have been synthesized. Phase transport, UV-Vis- and fluorescence spectrophotometric investigations as well as electrochemical...
Molecules, Vol. 25, Pages 2572: Isolation of Isocoumarins and Flavonoids as α-Glucosidase Inhibitors from Agrimonia pilosa L. Molecules doi: 10.3390/molecules25112572 Authors: Park Kang Agrimonia pilosa L. (AP) showed potent α-glucosidase inhibitory (AGI) activity, but it is uncertain what phytochemicals play a key factor. The phytochemical study of AP based on AGI activity led to the isolation of four isocoumarins; agrimonolide (1), agrimonolide-6-O-β-d-glucopyranoside...
Molecules, Vol. 25, Pages 2567: Rice-Associated Rhizobacteria as a Source of Secondary Metabolites against Burkholderia glumae Molecules doi: 10.3390/molecules25112567 Authors: Giann Carlos Peñaloza Atuesta Walter Murillo Arango Jordi Eras Diego Fernándo Oliveros Jonh Jairo Méndez Arteaga Various diseases, including bacterial panicle blight (BPB) and sheath rot, threaten rice production. It has been established that Burkholderia glumae (B. glumae) is the causative agent of...
Molecules, Vol. 25, Pages 2570: Effects of Thermal Treatment on Natural Clinoptilolite-Rich Zeolite Behavior in Simulated Biological Fluids Molecules doi: 10.3390/molecules25112570 Authors: Cadar Senila Hoaghia Scurtu Miu Levei This study presents the effect of thermal treatment (450, 500, 600, 750, and 800 °C) on a Romanian clinoptilolite-rich natural zeolite, along with the interaction of raw and thermally treated zeolites with simulated gastric fluid (SGF,...
Molecules, Vol. 25, Pages 2569: Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus Molecules doi: 10.3390/molecules25112569 Authors: Silva Latruffe Gaetano The health benefits of moderate wine consumption have been extensively studied during the last few decades. Some studies have demonstrated protective associations between moderate drinking and several diseases including oral cavity cancer (OCC). However, due to the various adverse effects related to...
Molecules, Vol. 25, Pages 2565: Preparation of KI/Hydroxyapatite Catalyst from Phosphate Rocks and Its Application for Improvement of Biodiesel Production Molecules doi: 10.3390/molecules25112565 Authors: Widayat Widayat Hadiyanto Hadiyanto Permadi Wisnu Aji Wardani Ummi Az Zuhra Jedy Prameswari The main aim of this work was to investigate the suitability of a KI/KIO3 impregnated hydroxyapatite (HAP) catalyst derived from natural phosphate rocks for biodiesel production....
Molecules, Vol. 25, Pages 2568: Bioactive C17 and C18 Acetylenic Oxylipins from Terrestrial Plants as Potential Lead Compounds for Anticancer Drug Development Molecules doi: 10.3390/molecules25112568 Authors: Christensen Bioactive C17 and C18 acetylenic oxylipins have shown to contribute to the cytotoxic, anti-inflammatory, and potential anticancer properties of terrestrial plants. These acetylenic oxylipins are widely distributed in plants belonging to the families Apiaceae, Araliaceae,...
Molecules, Vol. 25, Pages 2566: Bioassay Guided Isolation and Docking Studies of a Potential β-Lactamase Inhibitor from Clutia myricoides Molecules doi: 10.3390/molecules25112566 Authors: Mahmoud A. Elfaky Ali M. El-Halawany Abdulrahman E. Koshak Khalid Z. Alshali Moustafa E. El-Araby Maan T. Khayat Hossam M. Abdallah Infectious diseases are the second major cause of death worldwide, and the ability to resist multiple classes of antibiotics is the key factor in enabling...
Molecules, Vol. 25, Pages 2564: Anion Inhibition Studies of the Beta-Carbonic Anhydrase from Escherichia coli Molecules doi: 10.3390/molecules25112564 Authors: Sonia Del Prete Viviana De Luca Alessio Nocentini Andrea Scaloni Margaret D. Mastrolorenzo Claudiu T. Supuran Clemente Capasso The interconversion of CO2 and HCO3− is catalyzed by a superfamily of metalloenzymes, known as carbonic anhydrases (CAs, EC 4.2.1.1), which maintain the equilibrium between...
Molecules, Vol. 25, Pages 2563: Synthesis of Hierarchical Zeolites with Morphology Control: Plain and Hollow Spherical Beads of Silicalite-1 Nanosheets Molecules doi: 10.3390/molecules25112563 Authors: Kassem Moukahhal Bénédicte Lebeau Ludovic Josien Anne Galarneau Joumana Toufaily Tayssir Hamieh T. Jean Daou Binderless pure silica zeolites (zeosils) spheres and hollow spheres with a diameter of 20 µm composed of silicalite-1 nanosheets particles were prepared...
Molecules, Vol. 25, Pages 2561: Fluctuation Imaging of LRRK2 Reveals That the G2019S Mutation Alters Spatial and Membrane Dynamics Molecules doi: 10.3390/molecules25112561 Authors: Sanstrum Goo Holden Delgado Nguyen Lee James Mutations within the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are the most common genetic cause of autosomal and sporadic Parkinson’s disease (PD). LRRK2 is a large multidomain kinase that has reported interactions with several...
Molecules, Vol. 25, Pages 2562: Transiently Expressed Mistletoe Lectin II in Nicotiana benthamiana Demonstrates Anticancer Activity In Vitro Molecules doi: 10.3390/molecules25112562 Authors: Milena Mazalovska J. Calvin Kouokam Mistletoe (Viscum album) extracts have been used as alternative and complementary therapeutic preparations in multiple cancers for decades. Mistletoe lectins (ML-I, ML-II, and ML-III) are considered to be the main anticancer components of such preparations....
Molecules, Vol. 25, Pages 2558: Glycyrrhetinic Acid Liposomes and Hyalurosomes on Spanish Broom, Flax, and Hemp Dressings to Heal Skin Wounds Molecules doi: 10.3390/molecules25112558 Authors: Angela Abruzzo Concettina Cappadone Giovanna Farruggia Barbara Luppi Federica Bigucci Teresa Cerchiara The focus of this work was to prepare Spanish Broom, flax, and hemp dressings impregnated with glycyrrhetinic acid (GA) liposomes or hyalurosomes to promote the healing process and...
Molecules, Vol. 25, Pages 2559: Using Sewage Sludge Ash as an Efficient Adsorbent for Pb (II) and Cu (II) in Single and Binary Systems Molecules doi: 10.3390/molecules25112559 Authors: Bogdan Adrian Militaru Rodica Pode Lavinia Lupa Winfried Schmidt Agnes Tekle-Röttering Norbert Kazamer Incineration of sewage sludge produces every year huge amounts of sewage sludge ash. Due to its porosity and composition, sewage sludge ash can be used as an adsorbent for heavy metal ions...
Molecules, Vol. 25, Pages 2557: Biobased Cryogels from Enzymatically Oxidized Starch: Functionalized Materials as Carriers of Active Molecules Molecules doi: 10.3390/molecules25112557 Authors: Antonella Caterina Boccia Guido Scavia Ilaria Schizzi Lucia Conzatti Starch recovered from an agrifood waste, pea pods, was enzymatically modified and used to prepare cryogels applied as drug carriers. The enzymatic modification of starch was performed using the laccase/(2,2,6,6-tetramethylpiperidin-1-yl)oxyl...
Molecules, Vol. 25, Pages 2556: Determination and Identification of Antibiotic Drugs and Bacterial Strains in Biological Samples Molecules doi: 10.3390/molecules25112556 Authors: Pauter Szultka-Młyńska Buszewski Antibiotics were initially natural substances. However, nowadays, they also include synthetic drugs, which show their activity against bacteria, killing or inhibiting their growth and division. Thanks to these properties, many antibiotics have quickly found practical...
Molecules, Vol. 25, Pages 2555: Nitrosative Stress and Its Association with Cardiometabolic Disorders Molecules doi: 10.3390/molecules25112555 Authors: Pérez-Torres Manzano-Pech Rubio-Ruíz Soto Guarner-Lans : Reactive nitrogen species (RNS) are formed when there is an abnormal increase in the level of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) and/or by the uncoupled endothelial nitric oxide synthase (eNOS). The presence of high concentrations...
Molecules, Vol. 25, Pages 2554: Effect of Blanching Pomegranate Seeds on Physicochemical Attributes, Bioactive Compounds and Antioxidant Activity of Extracted Oil Molecules doi: 10.3390/molecules25112554 Authors: Kaseke Opara Fawole This study investigated the effect of blanching pomegranate seeds (PS) on oil yield, refractive index (RI), yellowness index (YI), conjugated dienes (K232), conjugated trienes (K270), total carotenoid content (TCC), total phenolic compounds (TPC)...
Molecules, Vol. 25, Pages 2552: The Use of Macro, Micro, and Trace Elemental Profiles to Differentiate Commercial Single Vineyard Pinot noir Wines at a Sub-Regional Level Molecules doi: 10.3390/molecules25112552 Authors: Tanabe Nelson Boulton Ebeler Hopfer The compositional authentication of wine is of great interest, as the geographic origin of the grapes is often associated with quality, uniqueness, and authenticity. Previous elemental fingerprinting studies mainly...
Molecules, Vol. 25, Pages 2553: Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles Molecules doi: 10.3390/molecules25112553 Authors: Ting Marras Mitchell Campagna Tirrell A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer...
Molecules, Vol. 25, Pages 2551: A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity Molecules doi: 10.3390/molecules25112551 Authors: Laura M. Alcântara Thalita C. S. Ferreira Vanessa Fontana Eric Chatelain Carolina B. Moraes Lucio H. Freitas-Junior High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum...
Molecules, Vol. 25, Pages 2550: Magnetic Elements for Neuromorphic Computing Molecules doi: 10.3390/molecules25112550 Authors: Tomasz Blachowicz Andrea Ehrmann Neuromorphic computing is assumed to be significantly more energy efficient than, and at the same time expected to outperform, conventional computers in several applications, such as data classification, since it overcomes the so-called von Neumann bottleneck. Artificial synapses and neurons can be implemented into conventional...
Molecules, Vol. 25, Pages 2549: Gas Phase Computational Study of Diclofenac Adsorption on Chitosan Materials Molecules doi: 10.3390/molecules25112549 Authors: Anna Kaczmarek-Kędziera Environmental pollution with non-steroidal anti-inflammatory drugs and their metabolites exposes living organisms on their long-lasting, damaging influence. Hence, the ways of non-steroidal anti-inflammatory drugs (NSAIDs) removal from soils and wastewater is sought for. Among the potential adsorbents, biopolymers...
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