Related ArticlesEvaluation of a speech pathology service delivery model for patients at low dysphagia risk during radiotherapy for HNC. Support Care Cancer. 2020 Apr;28(4):1867-1876 Authors: Moroney LB, Ward EC, Helios J, Crombie J, Burns CL, Blake C, Comans T, Chua B, Kenny L, Hughes BGM Abstract PURPOSE: There are no evidence-based guidelines informing which patients with head and neck cancer (HNC) require regular speech pathology (SP) support during...
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Infantile diarrhea is a serious public health problem around worldwide and results in millions of deaths each year. The levels and sources of dietary protein are potential sources of diarrhea, but the relationship between the pathogenesis causes of infantile diarrhea and protein intake remains poorly understood. Many studies have indicated that the key to understanding the relationship between the protein in the diet and the postweaning diarrhea of piglets is to explore the influences of protein...
Sun May 31, 2020 18:50
Progranulin (PGRN), which plays an anti-inflammatory role in acute lung injury (ALI), is promising as a potential drug. Studies have shown that regulatory T cells (Tregs) and interleukin- (IL-) 10 can repress inflammation and alleviate tissue damage during ALI. In this study, we built a lipopolysaccharide- (LPS-) induced ALI mouse model to illustrate the effect of PGRN on regulation of Treg differentiation and modulation of IL-10 promoting macrophage polarization. We found that the proportion of...
Sun May 31, 2020 13:50
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a protein involved in the regulation of RNA processing, cell metabolism, migration, proliferation, and apoptosis. However, the effect of hnRNPA2/B1 on injured endothelial cells (ECs) remains unclear. We investigated the effect of hnRNPA2/B1 on lipopolysaccharide- (LPS-) induced vascular endothelial injury in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms. LPS was used to induce EC injury, and the roles of...
Sat May 30, 2020 14:35
Human strongyloidiasis a soil-transmitted infection caused by Strongyloides stercoralis is one of the most neglected amongst the so-called Neglected Tropical Diseases (NTDs). S. stercoralis is a nematode, which is distributed worldwide; it has been estimated that it could affect millions of people, mainly in tropical and subtropical endemic regions. The difficulties of diagnosis lead to infection rates being underreported. Asymptomatic patients have chronic infections that can lead to severe hyperinfection...
Sun May 31, 2020 19:05
Background. Early detection is crucial for the prognosis of patients with autoimmune liver disease (AILD). Due to the relatively low incidence, developing screening tools for AILD remain a challenge. Aims. To analyze clinical characteristics of AILD patients at initial presentation and identify clinical markers, which could be useful for disease screening and early detection. Methods. We performed observational retrospective study and analyzed 581 AILD patients who were hospitalized in the gastroenterology...
Sun May 31, 2020 18:50
Aims. Talin-1 is a cytoskeletal protein that binds integrin, thereby leading to integrin activation and affecting focal adhesions. Recently, talin-1 expression was reported to be downregulated in human atherosclerotic plaques. However, blood levels of soluble talin-1 (sTalin-1) in patients with atherosclerotic disease, such as coronary artery disease (CAD), have not been elucidated. Methods. We measured plasma sTalin-1 levels in 349 patients undergoing elective coronary angiography. The severity...
Fri May 29, 2020 11:35
Feline infectious peritonitis (FIP) is an important feline viral disease, causing an overridden inflammatory response that results in a high mortality rate, primarily in young cats. Curcumin is notable for its biological activities against various viral diseases; however, its poor bioavailability has hindered its potential in therapeutic application. In this study, curcumin was encapsulated in chitosan nanoparticles to improve its bioavailability. Curcumin-encapsulated chitosan (Cur-CS) nanoparticles...
Sun May 31, 2020 19:05
Differential Expression and Prognostic Value of Cytoplasmic and Nuclear Cyclin D1 in Prostate Cancer
Cyclin D1 (CCND1) has been revealed as a key regulating protein in cell cycle (G1 phase) and plays a critical role in promoting tumor development. The purpose of our study was to investigate the associations between CCND1 and biochemical recurrence of prostate cancer (PCa). We performed immunostaining of CCND1 on a tissue microarray and evaluated the CCND1 expression levels based on the intensity and extent of staining. The clinical data was collected, and the follow-up data was received by searching...
Sun May 31, 2020 19:05
To profile the landscape of methylation N6 adenosine (m6A) RNA regulators in colonic adenocarcinoma (COAD) and to explore potential diagnostic and prognostic biomarkers, we assessed the differential expression patterns of m6A RNA methylation regulators between 418 COAD patients and 41 controls based on profiling from The Cancer Genome Atlas (TCGA) database. We plotted the receiver operating characteristic (ROC) curves and calculated the area under the curve (AUC) values to estimate the discrimination...
Sat May 30, 2020 18:50
The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane...
Sat May 30, 2020 13:35
Objective. To compare the difference in clinical and radiographic outcomes between anterior transcorporeal and transdiscal percutaneous endoscopic cervical discectomy (ATc-PECD/ATd-PECD) approaches for treating patients with cervical intervertebral disc herniation (CIVDH). Method. We selected 77 patients with single-segment CIVDH and received ATc-PECD or ATd-PECD in the Second Affiliated Hospital of Chongqing Medical University between March 1, 2010, and July 1, 2015. 35 patients suffered from ATc-PECD,...
Sat May 30, 2020 13:20
TRAF2 is a crucial adaptor protein involved in various signaling pathways. However, its biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we found that TRAF2 was overexpressed in nasopharyngeal carcinoma (NPC) cells. Knockdown of TRAF2 with shRNA significantly suppressed NPC cell proliferation and colony formation. The growth of xenograft tumor significantly reduced after TRAF2 was silenced. Conversely, the ectopic overexpression of TRAF2 significantly...
Sat May 30, 2020 12:05
Background. Musculoskeletal disorders (MSDs) are commonly observed among workers around the world. These diseases not only affect the health of workers, their quality of life, and their performance, but the effects of such diseases also represent a great burden for the health and social systems. These issues are even more prevalent in developing countries, and nurses are no exception. Many studies worldwide have shown a high prevalence of work-related MSDs in each body position among nurses. However,...
Sat May 30, 2020 09:20
Experimental research results of hydrodynamic noise of pulsating flow through a bileaflet mechanical mitral valve are presented. The pulsating flow of pure water corresponds to the diastolic mode of the cardiac rhythm heart. The valve was located between the model of the left atrium and the model of the left ventricle of the heart. A coordinate device, on which a block of miniature sensors of absolute pressure and pressure fluctuations was installed, was located inside the model of the left ventricle....
Sat May 30, 2020 08:50
Intervertebral disc (IVD) degeneration is associated with local inflammation and increased expression of neurotrophins. Acidic microenvironment is believed to cause the progression of IVD degeneration. However, there is a paucity of information regarding the relationship between acidic microenvironment and the inflammation and expression of neurotrophins in IVD. G-protein-coupled receptor 4 (GPR4) is a pH-sensing receptor, which can activate the inflammation and increase the expression levels of...
Sat May 30, 2020 08:50
Background. A potential long-term complication of lumbar fusion is the development of adjacent segment disease (ASD), which may require surgical intervention and adversely affect outcomes. A high incidence of recurrent ASD was reported in patients who underwent the second (repeat) PLIF for symptomatic ASD. Herein, a feasible method, oblique lumbar interbody fusion combined with transforaminal endoscopic lumbar discectomy (OLIF-TELD) for dealing with adjacent lumbar disc herniation with upward or...
Sat May 30, 2020 08:35
All drugs usually have side effects, which endanger the health of patients. To identify potential side effects of drugs, biological and pharmacological experiments are done but are expensive and time-consuming. So, computation-based methods have been developed to accurately and quickly predict side effects. To predict potential associations between drugs and side effects, we propose a novel method called the Triple Matrix Factorization- (TMF-) based model. TMF is built by the biprojection matrix...
Fri May 29, 2020 11:20
Fungi play essential roles in many ecological processes, and taxonomic classification is fundamental for microbial community characterization and vital for the study and preservation of fungal biodiversity. To cope with massive fungal barcode data, tools that can implement extensive volumes of barcode sequences, especially the internal transcribed spacer (ITS) region, are necessary. However, high variation in the ITS region and computational requirements for processing high-dimensional features remain...
Fri May 29, 2020 11:20
Diligence, technological progress, and a little luck have together solved a 20-year mystery in the cosmos. (CSIRO/Alex Cherney/)J. Xavier Prochaska is a professor of Astronomy & Astrophysics at the University of California, Santa Cruz. Jean-Pierre Macquart is an associate professor of Astrophysics at Curtin University. This story originally featured on The Conversation.In the late 1990s, cosmologists made a prediction about how much ordinary matter there should be in the universe. About 5 percent,...
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tk (Jonathon Kambouris/)In the 1970s, Polaroid made instant photography irresistibly simple: Press one button to capture and print a cherished memory (or questionable decision). To this day, the Polaroid Originals company relies on the same dual-layer film, chemicals, and clever engineering as those early cameras did to develop each square. This is how shots come about—no shaking necessary.Press the shutter button to expose the top film square in an eight-count pack. A photo-sensitive coating on...
Sun May 31, 2020 18:00
Can you make the blue center disappear? (Shutterstock/)We know you are bored at home right now—we are too. Here are some puzzles and brainteasers to challenge your family and friends with, either in person or over video chat. Tie your shoes a little too snug in the morning, and, by lunchtime, that uncomfortable feeling will be nearly gone. Sensations—smells, sights, feelings—that stay stagnant for too long tend to fade away. The same goes for this blue dot fixed in its green milieu. Stare it down...
Sun May 31, 2020 16:00
Your laptop might look super cool and shiny, but it might only take a video editing program to make it run like your grandpa's old truck. (Daniel Korpai / Unsplash/)We usually demand a lot from our computers and expect them to handle everything we throw at them, so it’s frustrating when things start to get slow. Everyone knows loud noises and excessive heat are bad signs, but sometimes identifying the problem can be trickier than just placing your hand on your machine.Fortunately, modern-day operating...
Sat May 30, 2020 16:30
In a large review in The Lancet, people who took hydroxychloroquine had a higher mortality rate than those with COVID-19 who didn’t take the medication. (Pixabay/)Hydroxychloroquine has had a bit of a notorious reputation since the drug was first proposed as a treatment for COVID-19. Without much experience to go on, researchers and doctors jumped into trials in the hopes that the medicine would be able to combat the novel virus, and politicians, including President Trump, publicly touted its potential...
Sat May 30, 2020 01:00
Spray it all away. (Amazon/)Sweeping, mopping, and scrubbing can get tedious when cleaning larger scale property like a car or the inside of a pool. With a power washer, you can get big cleaning jobs done quickly and easily. Does the front of your house look haggard? Hose it down in a matter of minutes. Homeowners everywhere rely on power washers for efficient maintenance, because no one wants to spend a day getting grime out of a wooden deck. Power washers are enjoyable to use, and they make those...
Fri May 29, 2020 21:51
Fossils collected from the Mygatt-Moore Quarry, which lies near the border between Colorado and Utah and dates back to around 150 million years ago, bore an unusually high number of bite marks. (Brian Engh/)A series of bite marks on fossilized bones from present-day Colorado reveal that the Jurassic dinosaur Allosaurus was not above eating members of its own species. The findings are the first direct evidence of cannibalism for this group of predatory dinosaurs, paleontologists reported May 27 in...
Fri May 29, 2020 21:00
A great backyard cool-down. (Jelleke Vanooteghem via Unsplash/)Odds are your parents figured out in your early years that a garden hose was the simplest thing to simultaneously occupy you and keep you from overheating. Now you can do the same for your kids but with a lot more style and finesse. Splash pads come in a dazzling array of shapes and sizes, and frankly offer some delightful designs that might make you decide you don’t need the excuse of a Caribbean beach to make you put on your bathing...
Fri May 29, 2020 20:38
All you need to whip up these classic cocktails at home is a mixing glass (or a Mason jar) and a butter knife. (Erik Delanoy/)This story was originally featured on Saveur.In the midst of the rampant, countrywide shuttering of bars and restaurants due to COVID-19, there are few ties left to the proverbial night out. Some places are permitting the sale of to-go cocktails, but most of us are stuck playing bartender at home. Herein lies the inception of the “quarantini”: an inevitable portmanteau celebrating...
Fri May 29, 2020 19:06
Monopoly is great, but it can't be the only option available. (Naassom Azevedo via Unsplash/)Spending weekends inside with your family isn’t always easy, especially when you’ve exhausted your three go-to entertainment options: Movie nights, board games, and everyone retreating to separate corners of the house to stare at their phones.There are other options, however. Here are some games and activities that think outside the board game and help bring family time up a notch no matter how long it lasts.Don’t...
Fri May 29, 2020 17:47
This addendum appeared on a Trump tweet early Friday morning. (Twitter/)This afternoon, President Trump signed an executive order to address what he sees as a bias against people with conservative politics by removing some legal protections afforded to social media platforms. The focus of the order falls clearly on Section 230 of the 1996 Communications Decency Act, which states that sites can moderate user content without taking on full responsibility as a publisher—which has long been a controversial...
Fri May 29, 2020 17:06
We really appreciate the authors’ interest and valuable comments on our recent article entitled “Comparison of intraosseous and submucosal dexamethasone injection in mandibular third molar surgery: a split-mouth randomized clinical trial”1. The authors establish two concerns regarding our study. The first is the creation of a drilling hole for the intraosseous injection. The other is the mechanism of this injection technique.
Sun May 31, 2020 03:00
The 30-day readmission rate is a highly scrutinized metric of quality surgical care, because readmission is costly and perceived to be avoidable with planning and patient education. Head and neck surgery patients generally have multiple risk factors for readmission, as readmitted patients are generally older, with more co-morbidities, lower socio-economic status, and a history of multiple emergency department visits and readmissions. A retrospective cohort study was implemented to determine the incidence...
Fri May 29, 2020 03:00
Atrial fibrillation (AF) is the most common postoperative arrhythmia and can cause increased length of stay, costs, morbidity, and mortality. Little information exists about postoperative AF after major head and neck surgery, but it is thought to occur more frequently than after surgery at other extra-thoracic sites. A retrospective cohort study was implemented, including patients who had undergone major head and neck surgery and who had follow-up records covering a minimum of 60 days postoperative.
Fri May 29, 2020 03:00
Background. Early sickle cell disease (SCD) diagnosis has shown promise in combating SCD in many countries. The aim of this study was to assess the practice and perception of early SCD diagnosis among a group of parents and physicians in Nigeria. Patients and Methods. This was a cross-sectional descriptive study conducted to assess the opinions and practice of early diagnosis of SCD among 135 physicians caring for SCD patients and 164 mothers of children with SCD in a southwestern state of Nigeria....
Sun May 31, 2020 17:50
Cell proliferation and angiogenesis are of utmost importance for healing to take place. The KI67 and EGFR proteins are markers of cell proliferation, while CD31 and factor VIII are markers of angiogenesis. To elucidate the mechanism responsible for delayed healing of the gastric injury in old age, we analyzed the expression of these markers in rats of different months during the healing of an acetic acid-induced gastric ulcer. Male Wistar rats (aged 3, 6, 12, and 18 months) divided into four groups,...
Sun May 31, 2020 17:50
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Tianhao Wu, Yuexiang Lu, Jie Liu, Sichun Zhang, Xinrong Zhang
Sun May 31, 2020 22:23
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Camelia Berghian-Grosan, Dana Alina Magdas
Sat May 30, 2020 15:35
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Matic Bergant, Janez Ščančar, Radmila Milačič
Fri May 29, 2020 21:12
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Xiaoya Bi, Lijun Luo, Libo Li, Xiaohong Liu, Bainian Chen, Tianyan You
Fri May 29, 2020 21:12
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