No abstract available
Thu May 28, 2020 03:00
Objectives: To evaluate morphological properties of the zygomaticus major (ZMj) and demonstrate its detailed anatomical relationships with the orbicularis oculi (OOc) and the parotid duct (PD). Methods: Fifteen formalin fixed adult cadaver heads (7 males /8 females) aged between 45 and 92 years were dissected to reveal the ZMj, OOc, PD. Shape, lengths and thickness of the ZMj, positional relationships of the ZMj with respect to the OOc and PD (overlap, neighboring, being separate) were...
Thu May 28, 2020 03:00
Objectives: To test the effect of systemic chemotherapy on cancer-specific mortality (CSM) in patients with adenocarcinoma of the urinary bladder (ADKUB). Materials and Methods: Within the Surveillance, Epidemiology, and End Results registry (2004 to 2016), we identified patients with localized (T2-3N0M0), regional (T4N0M0/TanyN1-3M0), and metastatic (TanyNanyM1) ADKUB. Temporal trends, Kaplan-Meier plots, and multivariable Cox regression models were used before and after 1:1 propensity...
Wed May 27, 2020 03:00
Objectives: Despite the initial clinical benefit, resistance to antiangiogenic therapies develops through the activation of alternative pathways. We measured plasma levels of circulating angiogenic factors to explore their predictive role in metastatic renal cell carcinoma (mRCC) patients treated with pazopanib. Materials and Methods: mRCC patients receiving first-line pazopanib were prospectively enrolled. The levels of circulating interleuchine (IL)-6, IL-8, stromal derived factor-1,...
Wed May 27, 2020 03:00
No abstract available
Wed May 27, 2020 03:00
Objective: To evaluate the treatment efficacy of transcutaneous electrical nerve stimulation (TENS) in patients with tinnitus. Data Sources: PubMed, Scopus, Web of Science, and Cochrane Library were searched for the following concepts: “Transcutaneous Electric Nerve Stimulation” and “Tinnitus.” Study Selection: Inclusion: 1) double- or single-blinded randomized controlled trials; 2) double- or single-blinded randomized comparison trials; 3) prospective or retrospective observational...
Thu May 28, 2020 03:00
Background: Stapedial myoclonus is an uncommon condition involving the rhythmic contraction of the stapedial tendon that may result in a host of symptoms, including tinnitus (1–3). There is a dearth of robust diagnostic modalities to diagnose stapedial myoclonus(4–7), and most patients are treated without definitive diagnosis(8-12). Herein, we hypothesize that stapedial myoclonus can be readily diagnosed by awake otoendoscopy (see Video, Supplemental Digital Content 1, http://links.lww.com/MAO/A997)....
Thu May 28, 2020 03:00
Microvascular decompression (MVD) is curative treatment for primary Hemifacial Spasm, in cases where a vascular loop impinges on the facial nerve. Surgical techniques for MVD may be extended to MVD of the glossopharyngeal nerve and trigeminal nerve in cases of primary glossopharyngeal neuralgia and trigeminal neuralgia. Stroke is a rare complication of these procedures that may occur during the separation of a vascular loop from nervous tissue, particularly when materials such as Teflon are used...
Thu May 28, 2020 03:00
Background: Presbycusis is an age-related sensorineural hearing loss and it may reduce quality of life. We conducted a study to establish the prevalence of high-frequency presbycusis in normal hearing individuals and to validate the role of extended high-frequency distortion product otoacoustic emission (DPOAE) in the screening. Method: A cross-sectional study was conducted among 205 normal hearing adult participants with an age range between 25 and 54 years old. Hearing analysis with extended...
Thu May 28, 2020 03:00
Objective: To present a case of pediatric cholesteatoma that invaded the petrous apex (PA) and discuss the usefulness of preoperative three-dimensional (3D) surgical simulation on a personal computer (PC) and patient-specific 3D printed model-assisted surgery. Patient: A 5-year-old boy with congenital cholesteatoma underwent a planned two-stage canal wall up mastoidectomy. The cholesteatoma had invaded the PA from a small space anterior to the superior semicircular canal (SSCC). During...
Thu May 28, 2020 03:00
Objective: To further elucidate the role of balloon Eustachian tuboplasty (BET) in tympanoplasty, we conducted a study to compare the outcomes of tympanoplasty with and without BET for the treatment of chronic suppurative otitis media (CSOM) with obstructive Eustachian tube dysfunction (OETD). Study Design: Case control study. Setting: Tertiary referral center. Patients: A total of 70 ears diagnosed with CSOM (tubotympanic type) and OETD were included in this study....
Thu May 28, 2020 03:00
Objectives/Hypothesis: This study aims to 1) report revision cochlear implantation (CI) rates at a high-volume CI center, 2) describe classifications for revision CI, 3) analyze audiologic and surgical outcomes in patients who undergo revision CI, and 4) describe a new subcategory of soft failures, named presumed soft failures. Study Design: Retrospective case series. Setting: Tertiary care otologic center. Patients: Adults and children undergoing revision CI from...
Thu May 28, 2020 03:00
Objective: We describe three rare cases of spontaneous intracranial hypotension (SIH) presenting with symptoms of endolymphatic hydrops (EH) and perform a literature review to bring attention to a rare link between SIH and EH. Patient: A 59-year-old female presented with postural headache, aural fullness, vertigo, hearing loss, and abnormal electrocochleography after being diagnosed with SIH by magnetic resonance imaging. The site of cerebrospinal fluid leak was identified in this individual....
Thu May 28, 2020 03:00
Objective: To review outcomes of stapes surgery in patients with concurrent otosclerosis and superior semicircular canal dehiscence. Study Design: Retrospective case series. Setting: : Tertiary referral center. Patients: Patients with concurrent otosclerosis and superior canal dehiscence, confirmed by computed tomography (CT) imaging. Intervention(s): Stapes surgery for conductive hearing loss. Main Outcome Measure(s): : Postoperative air-bone gap...
Thu May 28, 2020 03:00
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Gastric cancer is one of the most commonly occurring cancers worldwide. Investigation of long noncoding RNAs is of increasing interest, particularly in relation to their contribution to progression and prognosis of gastric cancers; however, insufficient studies been performed investigating the part of long noncoding RNAs play in gastric cancer carcinogenesis. Patterns of dysregulated long noncoding RNA and messenger...
Fri May 29, 2020 13:13
Abstract Background Anti‐IgE (omalizumab) has been used for the treatment of moderate‐to‐severe asthma that is not controlled by inhaled steroids. Despite its success, it does not always provide patients with significant clinical benefits. Objective To investigate transcriptional variations between omalizumab responders and non‐responders and to study the mechanisms of action of omalizumab. Methods The whole blood transcriptomes of moderate‐to‐severe adult asthma patients (N=45: 34...
Fri May 29, 2020 21:06
Abstract Background Dupilumab is a monoclonal anti‐IL‐4Rα antibody developed for the treatment of severe asthma (SA). An early access programme for dupilumab was opened in France in SA patients experiencing unacceptable steroids side‐effects and/or life‐threatening exacerbations. Objective To assess changes in asthma control between baseline and 12 months of treatment. Methods Multi‐centre (n = 13) retrospective real‐life cohort study. This study is registered on ClinicalTrials.gov...
Fri May 29, 2020 14:14
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs patients’ quality of life (QoL). Instruments such as the 10-item Dermatology Life Quality Index and 16-item Skindex-16 have been used to assess QoL in HS; however, it is unknown whether the shorter 3-item Skindex-mini can also provide an accurate assessment of skin-related QoL in patients with HS.ObjectivesThe aim was to assess how well the...
Fri May 29, 2020 06:55
Several specific alterations of the extracellular matrix can be considered a distinctive hallmark of cancer. In particular, a different morphology of the collagen scaffold is frequently found within the peritumoral environment. In this study, we report about a significant difference in the ultrastructural organization of collagen at the supra‐molecular level between the perilesional scaffold and the tumour area in human breast carcinoma samples. In particular, we demonstrated that Polarization‐resolved...
Fri May 29, 2020 20:21
Abstract We present a multi‐modal technique for measuring the integral refractive index and the thickness of biological cells and their organelles by integrating interferometric phase microscopy and rapid confocal fluorescence microscopy. First, the actual thickness maps of cellular compartments are reconstructed using the confocal fluorescent sections, and then the optical path difference map of the same cell is reconstructed using interferometric phase microscopy. Based on the co‐registered data,...
Fri May 29, 2020 11:33
Abstract OCT Angiography (OCTA) is a widespread tool for depth‐resolved imaging of chorioretinal vasculature with single microvessel resolution. To improve the clinical interpretation of OCTA, the conditions affecting visualization of microvessels must be defined. Here we inject a scattering plasma tracer (Intralipid) during OCTA imaging of the anesthetized rat eye. In the retina, we find that interlaminar (vertical) vessels that connect laminae have one‐fourth to one‐third the OCTA red blood cell...
Fri May 29, 2020 11:21
The most common organism in the world's oceans -- and possibly the whole planet -- harbors a virus in its DNA. This virus may have helped it survive and outcompete other organisms.
Fri May 29, 2020 22:06
A team of scientists studying the origin of SARS-CoV-2, the virus that has caused the COVID-19 pandemic, found that it was especially well-suited to jump from animals to humans by shapeshifting as it gained the ability to infect human cells.
Fri May 29, 2020 23:12
A study has for the first time provided evidence of where, when and how frequently species have adapted their ability to see in color.
Thu May 28, 2020 18:58
Future Oncology, Ahead of Print.
Fri May 29, 2020 15:56
Future Oncology, Ahead of Print.
Fri May 29, 2020 14:33
Future Oncology, Ahead of Print.
Fri May 29, 2020 11:34
Future Oncology, Ahead of Print.
Fri May 29, 2020 08:11
Future Oncology, Ahead of Print.
Fri May 29, 2020 08:11
Future Oncology, Ahead of Print.
Fri May 29, 2020 08:05
Abstract Objectives Described as an indiscriminate killer by many chroniclers, the Black Death descended on London during the 14th century. To best understand the pattern of transmission among demographic groups, models should include multiple demographic and health covariates concurrently, something rarely done when examining Black Death, but implemented in this study to identify which demographic groups had a higher susceptibility. Female predisposition to the Black Death was also explored,...
Fri May 29, 2020 17:33
Related ArticlesSurvival prediction and treatment strategies for patients with advanced laryngeal carcinoma: a population-based study. Int J Clin Oncol. 2020 May 27;: Authors: Zhu X, Heng Y, Zhou L, Zhang M, Li W, Tao L Abstract BACKGROUND: This study aimed at exploring high-risk factors associated with survival outcomes in patients with advanced primary laryngeal carcinoma and at developing and validating a survival-predicting model to help to select...
Sat May 30, 2020 07:37
Abstract In 2013, The Cancer Genome Atlas (TCGA) Research Network found four novel prognostic subgroups of endometrial carcinoma: POLE/ultramutated (POLE), microsatellite-instable/hypermutated (MSI), copy-number-low/TP53-wild-type (CNL), and copy-number-highTP53-mutant (CNH). However, poor is known regarding uncommon histotypes of endometrial cancer. We aimed to assess the genetic profile of uterine carcinosarcoma (UCS) on the light of these findings. A systematic review and meta-analysis...
Fri May 29, 2020 03:00
Abstract To report the implementation, dosimetric results of and early experiences with stereotactic accelerated partial breast irradiation (SAPBI) following breast conserving surgery (BCS) for postmenopausal low-risk St I-II invasive breast cancer (IBC) patients. Between November 2018 and August 2019, 27 patients were registered in our phase II prospective study. SAPBI was performed with Cyber-Knife (CK) M6 machine, in 4 daily fractions of 6.25 Gy to a total dose of 25 Gy. Respiratory...
Fri May 29, 2020 03:00
Abstract The human evolutionary sciences place high value on quantitative data from traditional small‐scale societies that are rapidly modernizing. These data often stem from the sustained ethnographic work of anthropologists who are today nearing the end of their careers. Yet many quantitative ethnographic data are preserved only in summary formats that do not reflect the rich and variable ethnographic reality often described in unpublished field notes, nor the deep knowledge of their collectors....
Fri May 29, 2020 17:55
The Drosophila melanogaster gene Dscam1 potentially generates 38,016 distinct isoforms via mutually exclusive splicing, which are required for both nervous and immune functions. However, the mechanism underlying splicing regulation remains obscure. Here we show apparent evolutionary signatures characteristic of competing RNA secondary structures in exon clusters 6 and 9 of Dscam1 in the two midge species (Belgica antarctica and Clunio marinus). Surprisingly, midge Dscam1 encodes only ~6,000 different...
Fri May 29, 2020 17:37
Crown-of-thorns starfish, Acanthaster planci (COTS), are common in coral reefs of Indo-Pacific Ocean. Since they are highly fecund predators of corals, periodic outbreaks of COTS cause substantial loss of healthy coral reefs. Using complete mitochondrial DNA sequences, we here examined how COTS outbreaks in the Ryukyu Archipelago, Japan are reflected by the profile of their population genetics. Population genetics of the blue starfish, Linckia laevigata, which lives in the Ryukyu Archipelago, but...
Sat May 30, 2020 00:02
It is well known that mammals and avian gut microbiota compositions are shaped by the host genomes and affect quantitative traits. The microbial architecture describes the impact of the microbiota composition on quantitative trait variation and the number and effect distribution of microbiota features. In the present study the gut microbial architecture of feed-related traits phosphorus and calcium utilization, daily gain, feed intake and feed per gain ratio in the domestic poultry model species...
Sat May 30, 2020 00:02
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