Fri May 29, 2020 21:59
Fri May 29, 2020 21:53
Fri May 29, 2020 21:39
Alopecia areata is an autoimmune form of non‐scarring hair loss Aim: to assess the serum concentration of IFN‐γ and CD8 cell expression in lesional skin biopsies in correlation with the disease severity, activity, duration and trichoscopic findings in patients with alopecia areata. Patients and methods: the study included 30 patients with AA and 15 age and sex matched healthy controls. Trichoscopy was performed and Photographs were captured for the alopecic areas, ELIZA technique was used for serum...
Fri May 29, 2020 20:22
Abstract Periorbital hyperpigmentation is a common dermatological condition that presents as dark periorbital area beneath the lower eyelids and is commonly found in females belonging to the age group of 16‐45 years. The data presented in this review includes studies conducted on patients with a clinical/ histological diagnosis of periorbital hyperpigmentation or melasma. Many diverse topical depigmenting agents comprising of an array of naturally obtained actives like arabinoxylans, α‐arbutin,...
Fri May 29, 2020 19:10
Abstract Aiming to explore the main factors affecting the occurrence of dandruff in healthy people (nondisease‐induced scalp desquamation).This study analysed the fungal microbial diversity of the scalp in Chinese teenage volunteers and measured scalp sebum secretion, the scalp pH value, and scalp transepidermal water loss (TEWL). The amount and size of dandruff were measured, and the main factors that influence dandruff in the normal population were identified using principal component analysis....
Fri May 29, 2020 15:14
Publication date: Available online 30 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): S.A.R. Nouraei, M. Girgis, J. Shorthouse, K. El-Boghdadly, I. Ahmad
Sun May 31, 2020 12:27
Objectives The aim of this study was to analyze the association between obstructive sleep apnea (OSA) severity and various cardiopulmonary coupling (CPC) parameters in children with OSA. Study design Retrospective cross‐sectional study. Methods A cross‐sectional study was conducted among 117 children (aged 7.96 ± 3.54 years, 86 male) who underwent both full‐night polysomnography (PSG) and CPC for suspicion of sleep‐disordered breathing (SDB). We analyzed the association between various...
Sat May 30, 2020 21:35
Objectives/Hypothesis This study aimed to assess the role of capnography in objectively evaluating breathing routes during drug‐induced sleep endoscopy (DISE) and further elucidate the relationship between breathing route, obstructive sleep apnea (OSA) severity, and DISE findings. Study Design Prospective observational study. Methods Nighty‐five patients with established OSA were recruited for this study from May 2017 to May 2019. DISE was performed in the operating room. Sedation was...
Sat May 30, 2020 21:24
ABSTRACT In this communication we would like to share our experience in managing TORS patients during COVID‐19 pandemia
Fri May 29, 2020 19:29
Fri May 29, 2020 19:20
Background Subtyping chronic rhinosinusitis (CRS) by tissue eosinophilia has prognostic and therapeutic implications, and is difficult to predict using peripheral eosinophil counts or polyp status alone. The objective of this study was to test machine learning for prediction of eosinophilic CRS (eCRS). Methods Input variables were defined as peripheral eosinophil count, urinary leukotriene E4 (uLTE4) level, and polyp status. The output was diagnosis of eCRS, defined as tissue eosinophil count...
Sat May 30, 2020 13:23
Background Recent studies have demonstrated a dramatic increase in the use of balloon sinus dilation (BSD) in the United States. However, the use of BSD specifically in revision sinus surgery has not been investigated. This study addresses the question of how BSD is utilized as a tool in revision sinus surgery. Methods Data from MarketScan (Truven Health) over a 5‐year period (2012‐2016) were analyzed. Patients who underwent a sinus procedure with a minimum of 2 years of follow‐up were included....
Fri May 29, 2020 21:45
Fri May 29, 2020 21:44
Background There is no consensus regarding the best route of intranasal delivery of corticosteroids in the treatment of chronic rhinosinusitis (CRS). The study objective of this work was to compare the impact of mometasone furoate nasal spray (MFNS) vs mometasone nasal irrigation in the management of CRS patients who have not undergone sinus surgery. Methods A double‐blind, placebo‐controlled, randomized clinical trial was conducted in adults with CRS. Individuals with nasal polyps and/or...
Fri May 29, 2020 21:37
Comparison of core features in four Developmental Encephalopathies in the Rett Natural History Study
Objective Rett Syndrome, CDKL5 ‐Deficiency Disorder, FOXG1 Disorder, and MECP2 Duplication Disorder are Developmental Encephalopathies with shared and distinct features. Though historically linked, no direct comparison has been performed. The first head‐to‐head comparison of clinical features in these conditions is presented. Methods Comprehensive clinical information was collected from 793 individuals enrolled in the Rett Syndrome and Related Disorders Natural History Study. Clinical features...
Sat May 30, 2020 16:58
Studies of the phenotype and population distribution of rare genetic forms of parkinsonism are required, now that gene‐targeting approaches for Parkinson's disease have reached the clinical trial stage. We evaluated the frequencies of PRKN , PINK1 , and DJ‐1 mutations in a cohort of 1587 cases. Mutations were found in 14.1% of patients: 27.6% were familial and 8% were isolated. PRKN was the gene most frequently mutated in Caucasians whereas PINK1 mutations predominated in Arab‐Berber individuals....
Sat May 30, 2020 16:43
Objective To assess the association between REM sleep behavior disorder (RBD) and other determinants and incident impulse control disorder behaviors (ICBs) in patients with early Parkinson’s disease (PD) using longitudinal data from the Parkinson's Progression Markers Initiative (PPMI). Methods 401 newly‐diagnosed PD patients were prospectively evaluated at baseline (BL), month 6, and annually for 5 years. Probable RBD (pRBD) was assessed with the RBD Screening Questionnaire and dichotomized...
Thu May 28, 2020 20:30
Key points Exercise intolerance is common in COPD patients. In patients with COPD, we compared an interval exercise (IE) protocol (alternating 30 s at 100% peak work rate (WRpeak) with 30 s at 50% WRpeak) to moderate‐intensity constant‐load exercise (CLE) at 75% WRpeak, which yielded the same work rate. Exercise endurance time and total work output were almost two‐fold higher in IE than CLE. At exercise isotime (when work completed was the same between IE and CLE), IE was associated with less...
Sat May 30, 2020 14:24
Abstract Glutamate receptors are essential ligand‐gated ion channels in the central nervous system that mediate excitatory synaptic transmission in response to the release of glutamate from presynaptic terminals. The structural and biophysical basis underlying the function of these receptors has been studied for decades by a wide range of approaches. However recent structural, pharmacological, and genetic studies have provided new insight into the regions of this protein that are critical determinants...
Fri May 29, 2020 12:19
Fri May 29, 2020 11:00
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Sun May 31, 2020 11:32
Abstract Highly conserved, complex and interacting morphogen signalling pathways regulate adult stem cells and control cell fate determination across numerous different organs. In homeostasis, the Bone Morphogenetic Protein (BMP) pathway predominantly promotes cell differentiation. Localised expression of ligand sequestering BMP antagonists, such as Gremlin 1 (Grem1), necessarily restricts BMP activity within the stem cell niche and facilitate stemness and self‐renewal. In a new paper, Rowan et...
Sat May 30, 2020 11:18
Abstract Despite the increased awareness of differences in the inflammatory response between men and women, only limited research has focused on the biological factors underlying these sex differences. The cholesterol derivative 27‐hydroxycholesterol (27HC) has been shown to have opposite inflammatory effects in independent experiments using mouse models of atherosclerosis and non‐alcoholic steatohepatitis (NASH), pathologies characterized by cholesterol‐induced inflammation. As the sex of mice...
Fri May 29, 2020 20:55
Abstract One of the major functions of human skin is to provide protection from the environment. Whilst we cannot entirely avoid, for example, sun‐exposure, it is likely that exposure to other environmental factors could impact cutaneous function. A number of studies have identified smoking as one such factor that leads to both facial wrinkle formation and a decline in skin function. In addition to the direct physical effects of tobacco smoke on skin, its inhalation has additional profound systemic...
Fri May 29, 2020 20:29
Sat May 30, 2020 16:04
Background Significant racial differences have been observed in the incidence and clinical outcomes of diffuse large B‐cell lymphoma (DLBCL) in the United States, but to the authors' knowledge it remains unclear whether genomic differences contribute to these disparities. METHODS To understand the influences of genetic ancestry on tumor genomic alterations, the authors estimated the genetic ancestry of 1001 previously described patients with DLBCL using unsupervised model‐based Admixture global...
Fri May 29, 2020 15:17
Background Birth defects are established risk factors for childhood cancer. Nonetheless, cancer epidemiology in children with birth defects is not well characterized. Methods Using data from population‐based registries in 4 US states, this study compared children with cancer but no birth defects (n = 13,111) with children with cancer and 1 or more nonsyndromic birth defects (n = 1616). The objective was to evaluate cancer diagnostic characteristics, including tumor type, age at diagnosis,...
Fri May 29, 2020 15:17
Sat May 30, 2020 16:25
Abstract Adamantinoma‐like Ewing Sarcoma (ALES) is a rare subtype of Ewing sarcoma family of tumors (EFTs) which are defined by their EWSR1 gene rearrangements. We present a case of a 15‐year old female with a swelling in her anterior neck of 4 months duration which had recently begun to rapidly grow in size. Fine needle aspiration showed a small blue round cell tumor with immunoreactivity for cytokeratin, CD99 and FLI1. Material for molecular testing was available on the resection specimen. Demonstration...
Sat May 30, 2020 16:19
Sat May 30, 2020 22:59
Fri May 29, 2020 20:13
Fri May 29, 2020 20:13
Fri May 29, 2020 20:13
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